EuRBPDB

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  • Basic Information
  • Cancer Related Information

  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000196531 (Gene tree)
Gene ID
4666
Gene Symbol
NACA
Alias
SkNAC|NACA1|HSD48
Full Name
Nascent Polypeptide Associated Complex Subunit Alpha
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
19,202 bases
Position
chr12:56,712,427-56,731,628
Accession
7629
RBP type
non-canonical RBP
Summary
This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes. [provided by RefSeq, Feb 2016]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
26844700MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells.Cell Death Dis2016 Feb 4Cardinali Bdoi: 10.1038/cddis.2016.10.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000551520NACA-217544--- (aa)--
ENST00000546862NACA-206492-ENSP0000044693371 (aa)-F8W1N5
ENST00000550920NACA-215752-ENSP00000448039213 (aa)-H0YHX9
ENST00000549259NACA-212690XM_006719418ENSP00000447133198 (aa)XP_006719481F8W0W4
ENST00000548386NACA-210644--- (aa)--
ENST00000551793NACA-219768--- (aa)--
ENST00000546392NACA-204802-ENSP00000446801215 (aa)-Q13765
ENST00000549855NACA-213711-ENSP00000447764126 (aa)-F8VZ58
ENST00000454682NACA-2036629XM_006719412ENSP000004038172078 (aa)XP_006719475E9PAV3
ENST00000546917NACA-207299-ENSP000004476665 (aa)-UPI0003F48113
ENST00000548563NACA-211827-ENSP00000447705136 (aa)-F8VZJ2
ENST00000356769NACA-2012690-ENSP00000349212215 (aa)-Q13765
ENST00000552540NACA-2211074-ENSP00000447821215 (aa)-Q13765
ENST00000547914NACA-208543-ENSP0000044674572 (aa)-F8W029
ENST00000393891NACA-2021059-ENSP00000377469215 (aa)-Q13765
ENST00000550952NACA-2162922XM_017019337ENSP00000448035925 (aa)XP_016874826E9PAV3
ENST00000551775NACA-218449--- (aa)--
ENST00000550343NACA-214343--- (aa)--
ENST00000548084NACA-209542-ENSP0000044720734 (aa)-F8W0C7
ENST00000546410NACA-205600--- (aa)--
ENST00000552055NACA-220521-ENSP00000450383148 (aa)-F8VNW4
Gene Model
Click here to download ENSG00000196531's gene model file
Pathways
Pathway IDPathway NameSource
hsa04928Parathyroid hormone synthesis, secretion and actionKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196531's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs identified by RBPome
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000196531NACA100100.000ENSMUSG00000061315Naca100100.000Mus_musculus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003677DNA binding-IEAFunction
GO:0005634nucleus-IEAComponent
GO:0005854nascent polypeptide-associated complex-IEAComponent

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
7691849cis-Golgi resident proteins and O-glycans are abnormally compartmentalized in the RER of colon cancer cells.J Cell Sci1993 JulEgea G-
25209525Overexpression of the skNAC gene in human rhabdomyosarcoma cells enhances their differentiation potential and inhibits tumor cell growth and spreading.Clin Exp Metastasis2014 DecBerkholz Jdoi: 10.1007/s10585-014-9676-z

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1256719570Intronnovel0.57
BLCAchr1256719120Intronnovel0.24
BLCAchr1256720471Intronnovel0.26
BLCAchr1256716234Intronnovel0.33
BLCAchr1256717017Intronnovel0.12
BLCAchr1256718706Intronrs7643599690.36
BLCAchr1256720533Intronnovel0.47
BLCAchr1256714681Missense_MutationnovelG26E0.34
BLCAchr1256721162Intronnovel0.14
BLCAchr1256720473Intronnovel0.17
BLCAchr1256719868Intronnovel0.41
BLCAchr1256716406Intronnovel0.5
BLCAchr1256714415Missense_MutationNAE61K0.21
BLCAchr1256717265Intronnovel0.52
BLCAchr1256715975Intronnovel0.23
BLCAchr1256724479Missense_MutationnovelE15K0.76
BRCAchr1256718445IntronNA0.28
BRCAchr1256716478IntronNA0.2
BRCAchr1256720967Intronnovel0.08
BRCAchr12567124433'UTRnovel0.11
BRCAchr1256718952Intronnovel0.41
BRCAchr1256721267IntronNA0.17
BRCAchr1256724458Missense_MutationNAE22K0.28
BRCAchr1256719396IntronNA0.42
BRCAchr1256720471Intronnovel0.05
CESCchr1256713627SilentNAR97R0.22
CESCchr1256720662IntronNA0.29
CESCchr1256721270Intronnovel0.09
CESCchr1256721272Intronnovel0.09
CESCchr1256716401Intronnovel0.42
CESCchr1256720868Intronnovel0.45
CESCchr1256712906Splice_Regionrs534417377V171V0.11
CESCchr1256724506Missense_MutationnovelT6A0.21
CHOLchr1256719655Intronnovel0.35
COADchr1256719470Intronnovel0.39
COADchr1256716810Intronnovel0.22
COADchr1256718241Intronnovel0.35
COADchr1256717329Intronnovel0.36
COADchr1256719449Intronnovel0.27
COADchr1256719641Intronnovel0.24
COADchr12567125163'UTRNA0.31
COADchr1256719824Intronnovel0.23
COADchr1256720560Intronnovel0.14
COADchr1256716224Intronrs3689473980.4
COADchr1256720858Intronrs7457581530.39
COADchr1256719841Intronnovel0.22
COADchr1256716348Intronnovel0.22
COADchr1256716026IntronNA0.44
COADchr1256720551Intronnovel0.43
COADchr1256713091Missense_MutationNAT161P0.17
COADchr1256719572IntronNA0.52
COADchr1256714643Missense_MutationNAE39K0.43
COADchr1256719351Intronnovel0.24
COADchr12567125163'UTRNA0.49
COADchr1256717340Intronnovel0.52
COADchr1256720541IntronNA0.53
COADchr12567125163'UTRNA0.12
COADchr1256721416Intronrs7511932190.13
COADchr12567125203'UTRnovel0.15
COADchr1256716938Intronrs7674051210.32
COADchr1256720522IntronNA0.34
COADchr1256720761IntronNA0.16
COADchr1256719491Intronrs1402748390.35
COADchr1256712793Missense_MutationNAA209V0.12
COADchr1256720754IntronNA0.47
COADchr1256721390Intronnovel0.52
COADchr1256718330Intronnovel0.4
COADchr1256721096Intronnovel0.11
DLBCchr1256724468SilentnovelQ18Q0.47
ESCAchr1256716678Intronnovel0.22
ESCAchr1256720967Intronnovel0.43
ESCAchr1256719847Intronrs7660014400.32
ESCAchr1256718795Intronnovel0.1
ESCAchr1256713184Missense_MutationnovelD130N0.43
GBMchr1256721418Intronnovel0.11
GBMchr1256714382Missense_MutationNAS72G0.2
GBMchr12567125223'UTRnovel0.27
GBMchr1256717358Intronnovel0.52
GBMchr1256712801Missense_MutationnovelI206M0.1
GBMchr1256716230Intronnovel0.17
GBMchr1256715885Intronnovel0.34
HNSCchr1256713077Missense_MutationnovelE165D0.16
HNSCchr1256714365SilentnovelR77R0.18
HNSCchr1256716406Intronnovel0.23
HNSCchr1256718396Intronnovel0.45
HNSCchr1256718675Intronnovel0.25
HNSCchr1256719213Intronnovel0.4
HNSCchr1256719980Intronrs7573758360.32
HNSCchr1256718250Intronnovel0.26
HNSCchr1256718239Intronrs7809754380.26
HNSCchr1256720330Intronnovel0.08
HNSCchr1256720332Intronnovel0.06
HNSCchr1256720879Intronnovel0.06
HNSCchr1256718262Intronnovel0.41
HNSCchr1256713665Missense_MutationnovelL85V0.08
HNSCchr1256718653Intronrs5558578210.26
HNSCchr1256720879Intronnovel0.05
HNSCchr1256713122SilentNAV150V0.14
HNSCchr1256720662IntronNA0.17
HNSCchr1256719917Intronnovel0.25
HNSCchr1256719971Intronnovel0.51
HNSCchr1256717381Intronnovel0.28
HNSCchr1256718814Intronnovel0.22
HNSCchr1256721399Intronnovel0.31
KICHchr1256721191Intronrs7739451900.32
KICHchr1256719169Intronnovel0.47
KIRCchr1256720885IntronNA0.3
KIRCchr1256716313IntronNA0.41
KIRCchr1256718482IntronNA0.26
KIRCchr1256719346Intronnovel0.08
KIRCchr1256724527Splice_Regionrs7704042590.36
KIRPchr1256720421Intronnovel0.61
KIRPchr1256718483Intronrs5671092460.3
KIRPchr1256716931Intronnovel0.3
LAMLchr1256721245Intronnovel0.32
LGGchr1256716802Intronnovel0.18
LGGchr1256716819Intronnovel0.14
LGGchr1256718441Intronnovel0.11
LGGchr1256721221Intronnovel0.1
LGGchr1256719081Intronnovel0.47
LIHCchr1256713632Missense_MutationnovelI96V0.37
LIHCchr1256717027Intronnovel0.33
LIHCchr1256718096Intronnovel0.6
LIHCchr1256719742Intronnovel0.16
LIHCchr1256719819IntronNA0.1
LIHCchr1256720256Intronnovel0.21
LUADchr1256721404Intronnovel0.29
LUADchr1256712851Missense_MutationnovelV190L0.06
LUADchr1256717059Intronnovel0.1
LUADchr1256719058Intronnovel0.26
LUADchr1256721306Intronnovel0.15
LUADchr1256721030Intronnovel0.06
LUADchr1256721032Intronnovel0.06
LUADchr1256724531Splice_Regionnovel0.29
LUADchr1256716132Intronnovel0.2
LUADchr1256718192Intronnovel0.47
LUADchr12567124783'UTRnovel0.06
LUADchr1256720562Intronnovel0.18
LUADchr1256714366Missense_MutationnovelR77Q0.17
LUADchr1256719902Intronnovel0.18
LUADchr1256720029Intronnovel0.19
LUADchr1256720032Intronnovel0.18
LUADchr1256714434SilentNAA54A0.25
LUSCchr1256713651SilentnovelT89T0.25
LUSCchr1256716839Intronnovel0.08
LUSCchr1256718646Intronnovel0.29
LUSCchr1256713149Missense_MutationnovelE141D0.27
LUSCchr1256719276Intronnovel0.3
LUSCchr1256721124Intronnovel0.18
LUSCchr1256719696Intronnovel0.26
LUSCchr1256713612SilentnovelI102I0.31
LUSCchr1256718253Intronnovel0.41
LUSCchr1256718518IntronNA0.38
LUSCchr1256717038Intronnovel0.28
LUSCchr1256714425SilentnovelA57A0.32
LUSCchr1256720941Intronnovel0.23
LUSCchr1256720634Intronrs7541741820.38
LUSCchr1256716452Intronrs1445224480.21
OVchr1256718736Intronnovel1
OVchr1256721390Intronrs7667006080.23
OVchr1256721047Intronnovel0.07
OVchr1256718993Intronnovel0.52
OVchr1256713188Missense_MutationNAI128M0.17
OVchr1256720770Intronnovel0.05
OVchr1256718822Intronnovel0.09
PAADchr1256716981Intronnovel0.06
PAADchr1256716134Intronnovel0.08
PAADchr1256716939Intronnovel0.21
PAADchr1256719822Intronnovel0.22
PAADchr1256720619Intronrs7636287200.17
PAADchr1256721381Intronnovel0.07
PAADchr1256714385Missense_MutationNAR71W0.07
PRADchr1256718281IntronNA0.31
PRADchr1256716189Intronrs7752698820.48
PRADchr1256716386Intronnovel0.36
PRADchr1256719697Intronnovel0.43
READchr1256712829Missense_MutationNAR197Q0.28
READchr1256712790Missense_MutationnovelI210S0.06
READchr1256718910Intronnovel0.38
SARCchr1256719780Intronnovel0.46
SARCchr1256714388Missense_MutationnovelS70C0.35
SKCMchr1256719396Intronnovel0.33
SKCMchr1256718776Intronrs5719108420.63
SKCMchr1256720639Intronnovel0.55
SKCMchr1256716634Intronnovel0.29
SKCMchr1256718403Intronnovel0.48
SKCMchr1256717345Intronrs7489347620.27
SKCMchr1256718738Intronnovel0.3
SKCMchr1256717112Intronnovel0.27
SKCMchr1256716784Intronrs7796097730.3
SKCMchr1256717670Intronnovel0.36
SKCMchr1256718236Intronrs7515048540.3
SKCMchr1256718750Intronnovel0.32
SKCMchr1256718751Intronnovel0.34
SKCMchr1256719029Intronnovel0.18
SKCMchr1256720064Intronrs7505115640.14
SKCMchr1256717546Intronnovel0.19
SKCMchr1256719476Intronnovel0.1
SKCMchr1256717205Intronrs5745521100.58
SKCMchr1256718950Intronnovel0.19
SKCMchr1256717524Intronnovel0.24
SKCMchr1256720935Intronnovel0.1
SKCMchr1256718545IntronNA0.32
SKCMchr1256716571Intronnovel0.17
SKCMchr1256716572Intronnovel0.18
SKCMchr1256717415Intronnovel0.27
SKCMchr1256718337IntronNA0.25
SKCMchr1256720838Intronnovel0.34
SKCMchr1256716149Intronnovel0.24
SKCMchr1256717596Intronnovel0.16
SKCMchr1256718766Intronrs3762344800.35
SKCMchr1256716992Intronnovel0.35
SKCMchr1256718868Intronnovel0.27
SKCMchr1256718263Intronnovel0.4
SKCMchr1256720626Intronnovel0.31
SKCMchr1256717544Intronnovel0.18
SKCMchr1256720226Intronnovel0.51
SKCMchr1256716592Intronnovel0.27
SKCMchr1256718332Intronnovel0.24
SKCMchr1256716803Intronnovel0.23
SKCMchr1256721300Intronrs750596690.41
SKCMchr1256717544Intronnovel0.36
SKCMchr1256715924Intronnovel0.32
SKCMchr1256717176IntronNA0.36
SKCMchr1256720916Intronnovel0.1
SKCMchr1256717560Intronnovel0.19
SKCMchr1256717526Intronnovel0.53
SKCMchr1256719389Intronnovel0.34
SKCMchr1256715981Intronnovel0.37
SKCMchr1256721228Intronnovel0.37
SKCMchr1256721151Intronnovel0.5
SKCMchr1256717337Intronnovel0.75
SKCMchr1256718497Intronnovel0.56
SKCMchr1256721107Intronrs7703844990.18
SKCMchr1256718909Intronnovel0.19
SKCMchr1256720625Intronrs7569601950.51
SKCMchr1256718958Intronnovel0.25
SKCMchr1256718780Intronnovel0.34
SKCMchr1256718546Intronnovel0.65
SKCMchr1256717483Intronnovel0.15
SKCMchr1256716419Intronnovel0.26
SKCMchr1256717616Intronnovel0.36
SKCMchr1256720569Intronnovel0.3
SKCMchr1256716994Intronnovel0.21
SKCMchr1256720955Intronrs3725753370.18
SKCMchr1256718251Intronnovel0.25
STADchr1256719275Intronnovel0.25
STADchr12567125163'UTRNA0.12
STADchr1256719830Intronnovel0.09
STADchr1256718972Intronrs3696531070.21
STADchr12567125163'UTRNA0.34
STADchr1256716223Intronrs7542709010.2
STADchr1256721128Intronnovel0.11
STADchr1256719379Intronnovel0.29
STADchr1256720545Intronnovel0.31
STADchr1256721191Intronrs7739451900.36
STADchr1256720634Intronrs7541741820.33
STADchr1256721434Intronnovel0.46
STADchr1256716224Intronrs3689473980.18
STADchr1256720040Intronnovel0.46
STADchr1256716857Intronnovel0.21
STADchr1256713189Missense_MutationNAI128T0.19
STADchr1256717623Intronrs7807613090.16
STADchr1256716224Intronrs3689473980.26
STADchr1256712846SilentNAS191S0.06
STADchr1256717612Intronnovel0.13
STADchr1256716920Intronnovel0.21
STADchr1256716851Intronnovel0.32
STADchr1256721375Intronnovel0.19
STADchr1256718572Intronrs7633004570.2
THYMchr1256716700Intronnovel0.05
UCECchr1256720184IntronNA0.27
UCECchr1256720540IntronNA0.34
UCECchr1256717097Intronnovel0.19
UCECchr1256717300Intronnovel0.26
UCECchr1256719512Intronnovel0.43
UCECchr1256714385Missense_MutationNAR71W0.32
UCECchr1256720760IntronNA0.26
UCECchr1256720875IntronNA0.35
UCECchr1256716991Intronnovel0.35
UCECchr1256713541Missense_MutationNAA126V0.43
UCECchr1256720260IntronNA0.4
UCECchr1256724469Missense_MutationNAQ18L0.29
UCECchr1256716743Intronnovel0.64
UCECchr1256713611Missense_MutationnovelL103I0.41
UCECchr1256716333Intronnovel0.33
UCECchr1256720091Intronnovel0.45
UCECchr1256716967Intronnovel0.33
UCECchr1256720380Intronnovel0.38
UCECchr1256720953Intronnovel0.38
UCECchr1256719269IntronNA0.15
UCECchr1256719799IntronNA0.21
UCECchr1256719182IntronNA0.43
UCECchr1256713665Missense_MutationnovelL85I0.12
UCECchr1256717258Intronrs3726662590.1
UCECchr1256720421IntronNA0.07
UCECchr1256718957Intronnovel0.16
UCECchr1256720506Intronnovel0.34
UCECchr1256716099Intronnovel0.1
UCECchr1256714385Missense_MutationNAR71W0.35
UCECchr1256721057Intronnovel0.28
UCECchr1256719537Intronnovel0.38
UCECchr1256720192Intronnovel0.36
UCECchr1256721459Intronnovel0.31
UCECchr1256719885Intronnovel0.45
UCECchr1256720598Intronnovel0.31
UCECchr1256719545IntronNA0.35
UCECchr1256719805Intronnovel0.45
UCECchr1256720307Intronnovel0.39
UCECchr1256716296Intronnovel0.16
UCECchr1256716938Intronrs7674051210.27
UCECchr1256718975Intronrs3726885130.09
UCECchr1256721285Intronnovel0.04
UCECchr1256720629Intronnovel0.45
UCECchr1256720898Intronnovel0.31
UCECchr1256719381Intronnovel0.32
UCECchr1256720682Intronnovel0.27
UCECchr1256717108Intronnovel0.44
UCECchr12567125163'UTRNA0.36
UCECchr1256713662Missense_MutationnovelR86W0.31
UCECchr1256717001Intronrs1870554250.16
UCECchr1256719614Intronnovel0.28
UCECchr1256720669Intronnovel0.42
UCECchr1256716452Intronrs1445224480.26
UCECchr1256719644Intronrs7679011860.41
UCECchr12567125103'UTRnovel0.5
UCECchr1256718884Intronnovel0.47
UCECchr1256720295IntronNA0.19
UCECchr12567124393'UTRnovel0.39
UCECchr1256715983Intronnovel0.3
UCECchr1256721289IntronNA0.17
UCECchr1256720452Intronnovel0.22
UCECchr1256717454Intronnovel0.55
UCECchr1256720002Intronrs7473876940.32
UCECchr1256721363Intronnovel0.36
UCECchr1256720763IntronNA0.42
UCECchr1256720633Intronrs7645421930.53
UCECchr1256717876Intronnovel0.54
UCECchr1256719152IntronNA0.33
UCECchr1256720583Intronrs7620547300.24
UCECchr1256720223Intronnovel0.46
UCECchr1256718867Intronnovel0.33
UCECchr1256719880Intronnovel0.5
UCECchr1256716205Intronnovel0.33
UCECchr1256718965IntronNA0.18
UCECchr1256714605SilentnovelA51A0.2
UCECchr1256716620Intronnovel0.35
UCECchr1256712793Missense_MutationNAA209V0.14
UCSchr1256717312Intronnovel0.3
UCSchr1256715950Intronnovel0.12
UCSchr1256720619Intronrs7636287200.43
UCSchr1256720761Intronnovel0.55
UVMchr1256719365Intronnovel0.61
UVMchr1256719423Intronnovel0.5

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCDEL0.03330.20414
DLBCAMP0.20830.085003
PCPGAMP0.08640.028953
READDEL0.07270.064633

Survival Analysis
CancerP-value Q-value
KIRC0.00019

Kaplan-Meier Survival Analysis

ESCA0.00029

Kaplan-Meier Survival Analysis

KIRP0.0023

Kaplan-Meier Survival Analysis

LAML0.0036

Kaplan-Meier Survival Analysis

KICH0.024

Kaplan-Meier Survival Analysis

UCEC0.01

Kaplan-Meier Survival Analysis

LIHC0.002

Kaplan-Meier Survival Analysis

LUAD0.0035

Kaplan-Meier Survival Analysis

UVM0.0066

Kaplan-Meier Survival Analysis

Drugs

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Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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