EuRBPDB

Description

Ensembl ID: ENSG00000196535 (Gene tree)
Gene ID: 399687
Gene Symbol: MYO18A
Alias: KIAA0216|MysPDZ
Full Name: myosin XVIIIA
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 109,289 bases
Position: chr17:29,071,124-29,180,412
Accession: 31104
RBP type: non-canonical RBP
Summary: The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000530557	MYO18A-208	1118	-	-	- (aa)	-	-
ENST00000532143	MYO18A-213	1002	-	-	- (aa)	-	-
ENST00000530254	MYO18A-207	6479	-	ENSP00000434817	27 (aa)	-	E9PN42
ENST00000529578	MYO18A-205	2667	-	-	- (aa)	-	-
ENST00000531267	MYO18A-210	334	-	-	- (aa)	-	-
ENST00000527312	MYO18A-201	573	-	-	- (aa)	-	-
ENST00000533652	MYO18A-217	542	-	-	- (aa)	-	-
ENST00000546105	MYO18A-218	1442	-	-	- (aa)	-	-
ENST00000527372	MYO18A-202	9992	-	ENSP00000437073	2054 (aa)	-	Q92614
ENST00000531892	MYO18A-212	599	-	-	- (aa)	-	-
ENST00000529889	MYO18A-206	698	-	-	- (aa)	-	-
ENST00000588791	MYO18A-220	650	-	ENSP00000465542	93 (aa)	-	K7EKB3
ENST00000590565	MYO18A-222	261	-	-	- (aa)	-	-
ENST00000528322	MYO18A-203	549	-	-	- (aa)	-	-
ENST00000585573	MYO18A-219	319	-	-	- (aa)	-	-
ENST00000531253	MYO18A-209	7504	-	ENSP00000434228	2039 (aa)	-	Q92614
ENST00000528564	MYO18A-204	589	-	ENSP00000436660	172 (aa)	-	H0YEV9
ENST00000533420	MYO18A-216	1168	-	ENSP00000490952	340 (aa)	-	A0A1B0GWJ6
ENST00000533399	MYO18A-215	336	-	-	- (aa)	-	-
ENST00000531438	MYO18A-211	565	-	-	- (aa)	-	-
ENST00000533112	MYO18A-214	7522	-	ENSP00000435932	2002 (aa)	-	Q92614
ENST00000628822	MYO18A-223	7501	-	ENSP00000486682	2038 (aa)	-	A0A0D9SFK2
ENST00000590242	MYO18A-221	637	-	-	- (aa)	-	-
ENST00000636100	MYO18A-224	1564	-	ENSP00000490367	464 (aa)	-	A0A1B0GV45

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000196535	Alcoholism	9.4200000E-006	-
ENSG00000196535	Sleep	9E-6	27126917

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000196535	rs10438797	17	29164844	T	Night sleep phenotypes	27126917	[0.11-0.28] unit decrease	0.1956	EFO_0007827
ENSG00000196535	rs12938581	17	29095758	T	Highest math class taken (MTAG)	30038396	[0.008-0.0166] unit decrease	0.0123	EFO_0004875
ENSG00000196535	rs144975552	17	29088245	G	Clopidogrel active metabolite levels	28207573	[NR] unit increase	11.96	EFO_0007966
ENSG00000196535	rs11080090	17	29175011	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000196535	MYO18A	100	94.507	ENSMUSG00000000631	Myo18a	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	19837035.24485452.25965346.	IPI	Function
GO:0005524	ATP binding	23990465.	IDA	Function
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	-	IEA	Component
GO:0005802	trans-Golgi network	19837035.	IDA	Component
GO:0006259	DNA metabolic process	-	IEA	Process
GO:0007030	Golgi organization	19837035.	IMP	Process
GO:0009986	cell surface	-	IEA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016459	myosin complex	-	IEA	Component
GO:0016477	cell migration	18854160.	IMP	Process
GO:0016887	ATPase activity	23990465.	IDA	Function
GO:0031032	actomyosin structure organization	18854160.	IMP	Process
GO:0042641	actomyosin	18854160.	IDA	Component
GO:0043030	regulation of macrophage activation	25965346.	IMP	Process
GO:0043066	negative regulation of apoptotic process	24485452.	IMP	Process
GO:0043531	ADP binding	23990465.	IDA	Function
GO:0048194	Golgi vesicle budding	19837035.	IMP	Process
GO:0050714	positive regulation of protein secretion	23345592.	IMP	Process
GO:0051015	actin filament binding	23990465.	IDA	Function
GO:0090161	Golgi ribbon formation	19837035.	IMP	Process
GO:0090164	asymmetric Golgi ribbon formation	19837035.	IMP	Process
GO:1903028	positive regulation of opsonization	21123169.	IMP	Process