EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000196586 (Gene tree)
Gene ID: 4646
Gene Symbol: MYO6
Alias: KIAA0389|DFNA22|DFNB37
Full Name: myosin VI
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 170,362 bases
Position: chr6:75,749,176-75,919,537
Accession: 7605
RBP type: non-canonical RBP
Summary: This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19558455	A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus.	J Neurochem	2009 Sep	Takarada T	doi: 10.1111/j.1471-4159.2009.06225.x

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000430435	MYO6-205	522	-	ENSP00000399406	174 (aa)	-	Q5JVM0
ENST00000369981	MYO6-203	8692	-	ENSP00000358998	1295 (aa)	-	E7EW20
ENST00000369985	MYO6-204	8575	-	ENSP00000359002	1262 (aa)	-	Q9UM54
ENST00000615563	MYO6-207	4026	-	ENSP00000478013	1262 (aa)	-	Q9UM54
ENST00000627432	MYO6-208	4074	XM_005248719	ENSP00000487348	1294 (aa)	XP_005248776	A0A0D9SGC1
ENST00000369977	MYO6-202	5597	XM_005248722	ENSP00000358994	1285 (aa)	XP_005248779	Q9UM54
ENST00000369975	MYO6-201	5387	XM_005248726	ENSP00000358992	1253 (aa)	XP_005248783	A0A0A0MRM8
ENST00000462633	MYO6-206	611	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000196586's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000196586	Blood Pressure	3.6060206E-005	-
ENSG00000196586	Blood Pressure	4.5413945E-005	-
ENSG00000196586	Blood Pressure	4.5243568E-005	-
ENSG00000196586	Blood Pressure	5.8106760E-005	-
ENSG00000196586	Blood Pressure	2.7658198E-006	-
ENSG00000196586	Blood Pressure	3.2499902E-006	-
ENSG00000196586	Blood Pressure	4.0710352E-006	-
ENSG00000196586	Blood Pressure	5.6434315E-006	-
ENSG00000196586	Hypertension	3E-10	21626137
ENSG00000196586	Hypertension	3E-10	21626137
ENSG00000196586	Prostatic Neoplasms	4E-8	25217961

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000196586	rs9443189	6	75786165	G	Prostate cancer	25217961	[1.05-1.11]	1.08	EFO_0001663
ENSG00000196586	rs149740635	6	75783454	C	Stem cell factor levels	27989323	[0.68-1.67] SD units increase	1.177	EFO_0008291
ENSG00000196586	rs1280049	6	75826616	A	Intelligence	29942086	z-score increase	5.494	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196586's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001726	ruffle	9852149.16507995.	IDA	Component
GO:0003774	motor activity	-	ISS	Function
GO:0003779	actin binding	10519557.	TAS	Function
GO:0005515	protein binding	11447109.11967127.15837803.16908842.22323290.	IPI	Function
GO:0005516	calmodulin binding	-	ISS	Function
GO:0005516	calmodulin binding	12857860.	TAS	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	16507995.	IDA	Component
GO:0005654	nucleoplasm	16949370.	IDA	Component
GO:0005737	cytoplasm	9852149.16507995.16949370.	IDA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005765	lysosomal membrane	-	TAS	Component
GO:0005794	Golgi apparatus	16507995.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005884	actin filament	-	ISS	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005902	microvillus	-	IEA	Component
GO:0005905	clathrin-coated pit	-	IEA	Component
GO:0005938	cell cortex	-	ISS	Component
GO:0006886	intracellular protein transport	-	ISS	Process
GO:0006897	endocytosis	15247260.	IMP	Process
GO:0006897	endocytosis	-	ISS	Process
GO:0007605	sensory perception of sound	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016461	unconventional myosin complex	9259267.	TAS	Component
GO:0016591	RNA polymerase II, holoenzyme	16949370.	IDA	Component
GO:0030048	actin filament-based movement	-	ISS	Process
GO:0030048	actin filament-based movement	10519557.	NAS	Process
GO:0030139	endocytic vesicle	-	ISS	Component
GO:0030330	DNA damage response, signal transduction by p53 class mediator	16507995.	IDA	Process
GO:0030665	clathrin-coated vesicle membrane	-	IEA	Component
GO:0031410	cytoplasmic vesicle	16507995.	IDA	Component
GO:0031941	filamentous actin	9852149.	IDA	Component
GO:0031965	nuclear membrane	16507995.	IDA	Component
GO:0032587	ruffle membrane	-	IEA	Component
GO:0042493	response to drug	-	IEA	Process
GO:0043531	ADP binding	-	ISS	Function
GO:0045177	apical part of cell	-	IEA	Component
GO:0045334	clathrin-coated endocytic vesicle	11447109.	IDA	Component
GO:0045944	positive regulation of transcription by RNA polymerase II	16949370.	IMP	Process
GO:0048471	perinuclear region of cytoplasm	9852149.	IDA	Component
GO:0048471	perinuclear region of cytoplasm	-	ISS	Component
GO:0051015	actin filament binding	9852149.	IDA	Function
GO:0051015	actin filament binding	-	ISS	Function
GO:0051046	regulation of secretion	15837803.	IMP	Process
GO:0060001	minus-end directed microfilament motor activity	10519557.	NAS	Function
GO:0070062	extracellular exosome	19056867.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15146066	Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.	Proc Natl Acad Sci U S A	2004 May 25	Yoshida H	-
30387375	MicroRNA-5195-3p plays a suppressive role in cell proliferation, migration and invasion by targeting MYO6 in human non-small cell lung cancer.	Biosci Biotechnol Biochem	2019 Feb	Yang Q	doi: 10.1080/09168451.2018.1540288
25643992	Lentivirus-Mediated Silencing of Myosin VI Inhibits Proliferation and Cell Cycle Progression in Human Lung Cancer Cells.	Chem Biol Drug Des	2015 Oct	Yu H	doi: 10.1111/cbdd.12528
27515005	Overexpression of myosin VI regulates gastric cancer cell progression.	Gene	2016 Nov 15	Wang Z	doi: 10.1016/j.gene.2016.08.015
29022908	miR-143 and miR-145 inhibit gastric cancer cell migration and metastasis by suppressing MYO6.	Cell Death Dis	2017 Oct 12	Lei C	doi: 10.1038/cddis.2017.493.
18543251	GOLPH2 and MYO6: putative prostate cancer markers localized to the Golgi apparatus.	Prostate	2008 Sep 15	Wei S	doi: 10.1002/pros.20806.
20353999	The microRNA profile of prostate carcinoma obtained by deep sequencing.	Mol Cancer Res	2010 Apr	Szczyrba J	doi: 10.1158/1541-7786.MCR-09-0443
27044563	Downregulation of myosin VI reduced cell growth and increased apoptosis in human colorectal cancer.	Acta Biochim Biophys Sin (Shanghai)	2016 May	You W	doi: 10.1093/abbs/gmw020
26407123	Lentivirus-Mediated Knockdown of Myosin VI Inhibits Cell Proliferation of Breast Cancer Cell.	Cancer Biother Radiopharm	2015 Oct	Wang H	doi: 10.1089/cbr.2014.1759

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	75866616	Missense_Mutation	NA	E589K	0.11
BLCA	chr6	75914189	Missense_Mutation	NA	K1189T	0.08
BLCA	chr6	75855175	Missense_Mutation	novel	L372S	0.52
BLCA	chr6	75848464	Silent	novel	L337L	0.25
BLCA	chr6	75908507	Missense_Mutation	novel	L1098V	0.12
BLCA	chr6	75891246	Silent	novel	A962A	0.13
BLCA	chr6	75862661	Missense_Mutation	novel	P538T	0.51
BRCA	chr6	75914818	Missense_Mutation	novel	D1222Y	0.09
BRCA	chr6	75830530	Missense_Mutation	NA	H126Y	0.7
BRCA	chr6	75866604	Missense_Mutation	NA	A585P	0.37
BRCA	chr6	75848483	Missense_Mutation	rs199798449	V344I	0.05
BRCA	chr6	75841336	Frame_Shift_Ins	NA	I259*	0.16
BRCA	chr6	75844943	Frame_Shift_Del	rs749752357	*K289Rfs17**	0.41
BRCA	chr6	75828548	Missense_Mutation	NA	M66L	0.34
BRCA	chr6	75866571	Missense_Mutation	NA	D574H	0.43
BRCA	chr6	75857216	Missense_Mutation	NA	S448L	0.12
BRCA	chr6	75886030	Nonsense_Mutation	novel	E815*	0.26
BRCA	chr6	75886867	Missense_Mutation	NA	G844D	0.24
BRCA	chr6	75890065	Missense_Mutation	novel	M889I	0.08
BRCA	chr6	75914110	Missense_Mutation	NA	E1163K	0.44
CESC	chr6	75817529	5'UTR	rs746580223		0.4
CESC	chr6	75861083	Missense_Mutation	novel	Q512E	0.35
CESC	chr6	75828576	Missense_Mutation	novel	H75R	0.38
CESC	chr6	75855157	Missense_Mutation	novel	N366S	0.11
CESC	chr6	75908601	Missense_Mutation	rs779885818	R1129H	0.88
CESC	chr6	75840627	Missense_Mutation	rs140235734	R199H	0.36
CESC	chr6	75886966	Missense_Mutation	NA	S877C	0.48
CESC	chr6	75880115	Missense_Mutation	NA	G761R	0.49
CESC	chr6	75919491	3'Flank	novel		0.42
COAD	chr6	75892532	Splice_Region	NA	A983A	0.31
COAD	chr6	75822836	Missense_Mutation	NA	D58Y	0.28
COAD	chr6	75911671	Splice_Site	NA	X1138_splice	0.5
COAD	chr6	75914161	Missense_Mutation	rs779535270	D1180N	0.33
COAD	chr6	75858915	Missense_Mutation	NA	H465Q	0.14
COAD	chr6	75830425	Missense_Mutation	rs573770611	A91T	0.43
COAD	chr6	75862668	Missense_Mutation	novel	D540G	0.4
COAD	chr6	75914120	Missense_Mutation	rs769185775	R1166L	0.26
COAD	chr6	75828595	Silent	novel	Y81Y	0.26
COAD	chr6	75841269	Missense_Mutation	NA	C236Y	0.57
COAD	chr6	75915091	3'UTR	novel		0.29
COAD	chr6	75892665	Missense_Mutation	NA	A1028T	0.32
COAD	chr6	75915018	3'UTR	novel		0.3
COAD	chr6	75866937	Silent	NA	Q592Q	0.6
COAD	chr6	75886061	Missense_Mutation	NA	R825Q	0.09
COAD	chr6	75898373	Splice_Region	NA	P1046P	0.19
COAD	chr6	75862607	Missense_Mutation	NA	A520T	0.23
COAD	chr6	75886891	Missense_Mutation	NA	K852T	0.22
COAD	chr6	75914161	Missense_Mutation	rs779535270	D1180N	0.28
ESCA	chr6	75848389	Missense_Mutation	novel	D312E	0.15
ESCA	chr6	75917884	3'Flank	novel		0.35
ESCA	chr6	75881791	Missense_Mutation	novel	Q797E	0.45
GBM	chr6	75908572	Silent	novel	N1119N	0.16
GBM	chr6	75830425	Missense_Mutation	rs573770611	A91T	0.18
GBM	chr6	75835900	Splice_Site	novel	X166_splice	0.23
GBM	chr6	75848379	Missense_Mutation	novel	P309H	0.05
GBM	chr6	75914944	Missense_Mutation	novel	N1264H	0.56
GBM	chr6	75914268	Silent	rs146978158	I1215I	0.2
GBM	chr6	75830423	Missense_Mutation	NA	V90A	0.1
GBM	chr6	75861029	Nonsense_Mutation	novel	E494*	0.11
GBM	chr6	75914935	Missense_Mutation	novel	Y1261H	0.25
GBM	chr6	75835921	Missense_Mutation	NA	G173A	0.28
HNSC	chr6	75892611	Missense_Mutation	rs148245729	R1010W	0.53
HNSC	chr6	75862654	Silent	novel	L535L	0.65
HNSC	chr6	75914827	Nonsense_Mutation	novel	E1225*	0.15
HNSC	chr6	75848449	Silent	novel	E332E	0.32
HNSC	chr6	75881784	Silent	novel	K794K	0.23
HNSC	chr6	75817658	Silent	novel	K37K	0.2
HNSC	chr6	75841363	Silent	novel	S267S	0.14
KIRC	chr6	75879894	Missense_Mutation	NA	Y718H	0.34
KIRC	chr6	75915083	3'UTR	novel		0.17
KIRC	chr6	75861022	Splice_Site	NA	X492_splice	0.21
KIRC	chr6	75881719	Missense_Mutation	NA	D773N	0.16
KIRP	chr6	75832933	Frame_Shift_Del	novel	*K162Nfs4**	0.32
KIRP	chr6	75892555	Missense_Mutation	NA	R991P	0.16
KIRP	chr6	75911695	Missense_Mutation	NA	S1146A	0.43
LGG	chr6	75890078	Missense_Mutation	novel	Q894E	0.07
LGG	chr6	75873267	Missense_Mutation	novel	G682S	0.27
LGG	chr6	75908600	Missense_Mutation	rs757469296	R1129C	0.37
LIHC	chr6	75817550	Translation_Start_Site	NA	M1?	0.47
LIHC	chr6	75866930	Splice_Site	NA	X591_splice	0.56
LIHC	chr6	75879865	Missense_Mutation	NA	R708Q	0.16
LIHC	chr6	75828603	Missense_Mutation	novel	D84V	0.24
LIHC	chr6	75886878	Missense_Mutation	novel	K848E	0.15
LIHC	chr6	75890260	Silent	novel	R954R	0.15
LIHC	chr6	75886079	Missense_Mutation	NA	R831K	0.44
LIHC	chr6	75890106	Missense_Mutation	NA	V903G	0.39
LIHC	chr6	75886851	Missense_Mutation	NA	G839S	0.12
LUAD	chr6	75914123	Missense_Mutation	NA	Q1167L	0.6
LUAD	chr6	75915033	3'UTR	novel		0.21
LUAD	chr6	75914927	Missense_Mutation	novel	G1258V	0.35
LUAD	chr6	75890119	Missense_Mutation	novel	E907D	0.27
LUAD	chr6	75890120	Nonsense_Mutation	novel	E908*	0.27
LUAD	chr6	75892559	Silent	NA	Q992Q	0.17
LUAD	chr6	75841343	Missense_Mutation	NA	E261K	0.07
LUAD	chr6	75866990	Missense_Mutation	novel	C610F	0.29
LUAD	chr6	75892563	Nonsense_Mutation	novel	E994*	0.31
LUAD	chr6	75841259	Missense_Mutation	novel	S233A	0.08
LUAD	chr6	75862673	Frame_Shift_Del	novel	*H542Tfs67**	0.12
LUAD	chr6	75848470	Silent	novel	R339R	0.47
LUAD	chr6	75817543	5'UTR	novel		0.05
LUAD	chr6	75908496	Missense_Mutation	NA	D1094G	0.49
LUSC	chr6	75817591	Missense_Mutation	novel	G15V	0.15
LUSC	chr6	75861036	Missense_Mutation	novel	Y496C	0.36
LUSC	chr6	75861038	Missense_Mutation	rs767084275	Q497E	0.25
LUSC	chr6	75870677	Nonsense_Mutation	NA	R659*	0.22
LUSC	chr6	75862715	Nonsense_Mutation	rs369889326	R556*	0.17
LUSC	chr6	75835903	Missense_Mutation	NA	Y167F	0.22
LUSC	chr6	75908577	Missense_Mutation	novel	K1121R	0.35
LUSC	chr6	75840619	Missense_Mutation	novel	K196N	0.36
LUSC	chr6	75830477	Missense_Mutation	NA	S108F	0.05
LUSC	chr6	75879871	Missense_Mutation	NA	S710L	0.35
LUSC	chr6	75862667	Missense_Mutation	novel	D540H	0.3
LUSC	chr6	75914219	Missense_Mutation	novel	G1199A	0.11
LUSC	chr6	75817573	Missense_Mutation	novel	A9E	0.37
LUSC	chr6	75870667	Silent	NA	L655L	0.44
LUSC	chr6	75848378	Missense_Mutation	NA	P309S	0.25
LUSC	chr6	75840607	Silent	NA	F192F	0.21
LUSC	chr6	75866936	Missense_Mutation	NA	Q592L	0.91
LUSC	chr6	75890128	Silent	novel	L910L	0.05
LUSC	chr6	75873266	Silent	NA	E681E	0.07
OV	chr6	75915041	3'UTR	novel		0.29
OV	chr6	75914992	Missense_Mutation	NA	L1280V	0.11
OV	chr6	75914065	Nonsense_Mutation	novel	Q1148*	0.06
OV	chr6	75862667	Missense_Mutation	NA	D540Y	0.17
OV	chr6	75890181	Missense_Mutation	rs760672339	R928H	0.27
OV	chr6	75840659	Missense_Mutation	novel	V210L	0.11
OV	chr6	75840660	Missense_Mutation	novel	V210A	0.11
OV	chr6	75891292	Frame_Shift_Ins	NA	*R980Tfs5**	0.29
PAAD	chr6	75914236	Nonsense_Mutation	novel	Q1205*	0.17
PRAD	chr6	75895261	Splice_Site	rs200713129	X1046_splice	0.32
PRAD	chr6	75914877	Nonsense_Mutation	novel	A1242*	0.1
PRAD	chr6	75867002	Missense_Mutation	novel	D614V	0.29
PRAD	chr6	75828606	Missense_Mutation	novel	R85I	0.35
PRAD	chr6	75858948	Silent	novel	C476C	0.13
PRAD	chr6	75891272	Missense_Mutation	novel	R971K	0.08
READ	chr6	75857131	Missense_Mutation	NA	R420G	0.2
READ	chr6	75848502	Missense_Mutation	rs377470568	I350T	0.52
READ	chr6	75817646	Silent	NA	P33P	0.32
READ	chr6	75822830	Frame_Shift_Del	NA	*D58Mfs8**	0.21
READ	chr6	75890181	Missense_Mutation	rs760672339	R928H	0.3
READ	chr6	75890075	Missense_Mutation	rs777201145	E893K	0.04
READ	chr6	75841334	Missense_Mutation	novel	D258Y	0.06
READ	chr6	75886015	Missense_Mutation	novel	I810L	0.08
READ	chr6	75828608	Missense_Mutation	novel	I86L	0.37
READ	chr6	75830445	Silent	novel	V97V	0.36
READ	chr6	75832935	Missense_Mutation	novel	K162T	0.44
READ	chr6	75862595	Splice_Site	novel	X516_splice	0.43
READ	chr6	75879879	Nonsense_Mutation	novel	E713*	0.46
SARC	chr6	75890220	Missense_Mutation	novel	E941A	0.39
SARC	chr6	75907641	Silent	novel	G1071G	0.5
SARC	chr6	75917835	3'Flank	novel		0.3
SKCM	chr6	75879933	Missense_Mutation	rs773210581	P731S	0.4
SKCM	chr6	75898372	Splice_Site	novel	X1046_splice	0.18
SKCM	chr6	75881704	Nonsense_Mutation	novel	Q768*	0.44
SKCM	chr6	75830512	Missense_Mutation	novel	L120F	0.35
SKCM	chr6	75861054	Missense_Mutation	NA	G502D	0.23
SKCM	chr6	75914143	Missense_Mutation	novel	P1174S	0.72
SKCM	chr6	75914144	Missense_Mutation	novel	P1174L	0.72
SKCM	chr6	75866531	Silent	NA	P560P	0.08
SKCM	chr6	75848353	Splice_Region	rs768772589	Y300Y	0.42
SKCM	chr6	75841290	Missense_Mutation	NA	R243K	0.81
SKCM	chr6	75840644	Nonsense_Mutation	rs557441143	R205*	0.21
SKCM	chr6	75855172	Missense_Mutation	NA	S371F	0.36
SKCM	chr6	75830477	Missense_Mutation	NA	S108F	0.31
SKCM	chr6	75840670	Missense_Mutation	NA	H213Q	0.4
SKCM	chr6	75848470	Silent	NA	R339R	0.26
SKCM	chr6	75841376	Missense_Mutation	NA	R272W	0.37
SKCM	chr6	75858939	Silent	novel	I473I	0.9
SKCM	chr6	75857209	Missense_Mutation	NA	E446K	0.17
SKCM	chr6	75841376	Missense_Mutation	NA	R272W	0.46
SKCM	chr6	75830449	Missense_Mutation	novel	P99S	0.42
SKCM	chr6	75848433	Missense_Mutation	NA	I327T	0.99
SKCM	chr6	75817543	5'UTR	novel		0.25
SKCM	chr6	75866553	Missense_Mutation	novel	H568Y	0.42
SKCM	chr6	75890128	Silent	novel	L910L	0.31
SKCM	chr6	75886962	Missense_Mutation	novel	I876V	0.63
SKCM	chr6	75891227	Splice_Site	NA	X956_splice	0.32
STAD	chr6	75914102	Missense_Mutation	NA	R1160Q	0.31
STAD	chr6	75914152	Missense_Mutation	rs146419641	R1177C	0.34
STAD	chr6	75914969	Missense_Mutation	NA	R1272Q	0.4
STAD	chr6	75881794	Missense_Mutation	NA	W798R	0.32
STAD	chr6	75895230	Splice_Site	NA	X1036_splice	0.29
STAD	chr6	75907690	Missense_Mutation	NA	T1088A	0.1
STAD	chr6	75822830	Frame_Shift_Del	NA	*D58Mfs8**	0.41
STAD	chr6	75855262	Missense_Mutation	rs747375619	G401D	0.16
STAD	chr6	75914129	Missense_Mutation	rs763284731	R1169H	0.15
STAD	chr6	75830497	Missense_Mutation	NA	Y115H	0.23
STAD	chr6	75914067	Silent	NA	Q1148Q	0.28
STAD	chr6	75914129	Missense_Mutation	rs763284731	R1169H	0.23
STAD	chr6	75914872	Missense_Mutation	rs745915772	R1240C	0.25
STAD	chr6	75822843	Missense_Mutation	novel	E60G	0.06
STAD	chr6	75841372	Silent	novel	N270N	0.36
STAD	chr6	75908601	Missense_Mutation	rs779885818	R1129H	0.32
STAD	chr6	75898401	Frame_Shift_Del	novel	L1057*	0.33
STAD	chr6	75862649	Missense_Mutation	rs757665143	R534C	0.33
STAD	chr6	75892682	Silent	rs374917329	A1033A	0.22
STAD	chr6	75817505	5'UTR	rs368566872		0.3
STAD	chr6	75873223	Missense_Mutation	novel	R667L	0.39
STAD	chr6	75890235	Missense_Mutation	rs781754117	R946H	0.15
STAD	chr6	75895261	Splice_Site	rs200713129	X1046_splice	0.39
THCA	chr6	75841295	Missense_Mutation	NA	Y245H	0.05
THYM	chr6	75890141	Frame_Shift_Del	rs765817714	*K917Nfs10**	0.32
UCEC	chr6	75881695	Nonsense_Mutation	NA	E765*	0.28
UCEC	chr6	75835932	Missense_Mutation	NA	D177Y	0.36
UCEC	chr6	75848497	Silent	NA	G348G	0.23
UCEC	chr6	75914867	Missense_Mutation	rs774624253	R1238Q	0.32
UCEC	chr6	75867093	Silent	novel	G644G	0.4
UCEC	chr6	75908601	Missense_Mutation	rs779885818	R1129H	0.26
UCEC	chr6	75908524	Missense_Mutation	NA	E1103D	0.42
UCEC	chr6	75857159	Missense_Mutation	novel	S429N	0.29
UCEC	chr6	75841264	Silent	novel	R234R	0.19
UCEC	chr6	75890141	Frame_Shift_Del	rs765817714	*K917Nfs10**	0.56
UCEC	chr6	75817556	Silent	novel	D3D	0.13
UCEC	chr6	75886061	Missense_Mutation	NA	R825Q	0.25
UCEC	chr6	75886868	Silent	NA	G844G	0.4
UCEC	chr6	75916371	3'UTR	novel		0.38
UCEC	chr6	75830425	Missense_Mutation	rs573770611	A91T	0.36
UCEC	chr6	75855245	Missense_Mutation	novel	M395I	0.37
UCEC	chr6	75890197	Missense_Mutation	novel	M933I	0.45
UCEC	chr6	75917782	3'Flank	novel		0.49
UCEC	chr6	75915890	3'UTR	novel		0.22
UCEC	chr6	75848375	Missense_Mutation	NA	D308Y	0.3
UCEC	chr6	75822851	Missense_Mutation	NA	C63R	0.4
UCEC	chr6	75840616	Silent	rs758269020	A195A	0.33
UCEC	chr6	75866571	Missense_Mutation	rs761375780	D574N	0.38
UCEC	chr6	75841335	Missense_Mutation	novel	D258A	0.33
UCEC	chr6	75914992	Missense_Mutation	NA	L1280V	0.19
UCEC	chr6	75886016	Missense_Mutation	novel	I810T	0.42
UCEC	chr6	75915786	3'UTR	novel		0.42
UCEC	chr6	75917333	3'Flank	novel		0.42
UCEC	chr6	75867049	Missense_Mutation	novel	D630Y	0.41
UCEC	chr6	75914970	Silent	rs745969764	R1272R	0.23
UCEC	chr6	75916411	3'UTR	novel		0.44
UCEC	chr6	75914195	Missense_Mutation	novel	G1191D	0.2
UCEC	chr6	75832870	Silent	novel	V140V	0.34
UCEC	chr6	75886094	Missense_Mutation	novel	R836H	0.29
UCEC	chr6	75890251	Missense_Mutation	novel	E951D	0.38
UCEC	chr6	75914077	Missense_Mutation	novel	A1152T	0.5
UCEC	chr6	75886891	Missense_Mutation	NA	K852T	0.43
UCEC	chr6	75916411	3'UTR	novel		0.32
UCEC	chr6	75917242	3'Flank	novel		0.31
UCEC	chr6	75892555	Missense_Mutation	rs529167250	R991Q	0.26
UCEC	chr6	75855139	Missense_Mutation	rs759139184	G360D	0.3
UCEC	chr6	75914129	Missense_Mutation	rs763284731	R1169H	0.43
UCEC	chr6	75917987	3'Flank	novel		0.36
UCEC	chr6	75919532	3'Flank	novel		0.25
UCEC	chr6	75841290	Missense_Mutation	NA	R243I	0.53
UCEC	chr6	75886934	Missense_Mutation	novel	E866D	0.38
UCEC	chr6	75891249	Missense_Mutation	novel	K963N	0.4
UCEC	chr6	75917376	3'Flank	novel		0.54
UCEC	chr6	75890141	Frame_Shift_Del	rs765817714	*K917Nfs10**	0.64
UCEC	chr6	75830423	Missense_Mutation	NA	V90A	0.3
UCEC	chr6	75873222	Missense_Mutation	NA	R667C	0.11
UCEC	chr6	75915786	3'UTR	novel		0.43
UCEC	chr6	75835958	Splice_Site	NA	X185_splice	0.32
UCEC	chr6	75917082	3'Flank	novel		0.27
UCEC	chr6	75867014	Missense_Mutation	rs777201018	R618Q	0.33
UCEC	chr6	75908511	Missense_Mutation	NA	A1099V	0.05
UCEC	chr6	75830491	Missense_Mutation	novel	K113Q	0.17
UCEC	chr6	75840639	Missense_Mutation	novel	S203I	0.16
UCEC	chr6	75857132	Missense_Mutation	novel	R420H	0.2
UCEC	chr6	75879916	Missense_Mutation	novel	K725T	0.19
UCEC	chr6	75917271	3'Flank	novel		0.31
UCEC	chr6	75822838	Missense_Mutation	novel	D58E	0.08
UCEC	chr6	75822841	Frame_Shift_Del	novel	E60*	0.05
UCEC	chr6	75835907	Silent	novel	L168L	0.47
UCEC	chr6	75880098	Missense_Mutation	novel	K755T	0.29
UCEC	chr6	75917884	3'Flank	novel		0.88
UCEC	chr6	75867049	Missense_Mutation	novel	D630Y	0.26
UCEC	chr6	75917361	3'Flank	novel		0.48
UCEC	chr6	75915007	Missense_Mutation	novel	K1285E	0.24
UCEC	chr6	75858966	Missense_Mutation	novel	Q482H	0.38
UCEC	chr6	75870646	Splice_Site	novel	X649_splice	0.5
UCEC	chr6	75915128	3'UTR	novel		0.53
UCEC	chr6	75907663	Missense_Mutation	rs763830362	K1079E	0.24
UCEC	chr6	75873254	Silent	novel	S677S	0.33
UCEC	chr6	75886952	Missense_Mutation	rs139542573	K872N	0.13
UCEC	chr6	75890181	Missense_Mutation	rs760672339	R928H	0.26
UCEC	chr6	75873253	Missense_Mutation	rs771235729	S677N	0.37
UCEC	chr6	75915076	3'UTR	novel		0.38
UCEC	chr6	75861071	Missense_Mutation	NA	Y508H	0.18
UCEC	chr6	75881708	Missense_Mutation	novel	I769T	0.45
UCEC	chr6	75848419	Silent	rs375754710	T322T	0.45
UCEC	chr6	75817653	Missense_Mutation	NA	Q36K	0.18
UCEC	chr6	75828563	Missense_Mutation	NA	A71S	0.32
UCEC	chr6	75915158	3'UTR	novel		0.5
UCEC	chr6	75915074	3'UTR	novel		0.13
UCEC	chr6	75830499	Silent	novel	Y115Y	0.22
UCEC	chr6	75832916	Missense_Mutation	NA	G156S	0.52
UCEC	chr6	75881816	Missense_Mutation	novel	K805R	0.49
UCEC	chr6	75886033	Missense_Mutation	novel	A816T	0.22
UCEC	chr6	75914078	Missense_Mutation	novel	A1152V	0.5
UCEC	chr6	75916411	3'UTR	novel		0.29
UCEC	chr6	75855193	Missense_Mutation	NA	L378S	0.32
UCEC	chr6	75857127	Silent	NA	N418N	0.38
UCEC	chr6	75835900	Splice_Site	novel	X166_splice	0.33
UCEC	chr6	75915942	3'UTR	rs555952286		0.45
UCEC	chr6	75891227	Splice_Site	novel	X956_splice	0.33
UCEC	chr6	75915066	3'UTR	novel		0.42
UCS	chr6	75914993	Missense_Mutation	novel	L1280P	0.6

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3088	3.4915e-05
CHOL	DEL	0.5833	0.022382
DLBC	DEL	0.2708	0.00024438
ESCA	DEL	0.2065	0.036953
LUAD	DEL	0.3527	0.0021365
MESO	DEL	0.2989	0.05642
PAAD	DEL	0.3043	0.11274
SARC	DEL	0.2685	0.0021591
SKCM	DEL	0.3896	1.5442e-06
STAD	DEL	0.127	0.0044196

Survival Analysis

Cancer	P-value	Q-value
THYM	0.003	Kaplan-Meier Survival Analysis
MESO	0.00023	Kaplan-Meier Survival Analysis
PRAD	0.045	Kaplan-Meier Survival Analysis
LUSC	0.036	Kaplan-Meier Survival Analysis
KIRP	0.015	Kaplan-Meier Survival Analysis
BLCA	0.034	Kaplan-Meier Survival Analysis
READ	0.038	Kaplan-Meier Survival Analysis
LUAD	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

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Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742