EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000196730 (Gene tree)
Gene ID: 1612
Gene Symbol: DAPK1
Alias: DAPK|ROCO3
Full Name: death associated protein kinase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 211,407 bases
Position: chr9:87,497,228-87,708,634
Accession: 2674
RBP type: canonical RBP
Summary: Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000418885	RIO1	PF01163.22	0.00023	1	1
ENSP00000419026	RIO1	PF01163.22	0.00023	1	1
ENSP00000350785	RIO1	PF01163.22	0.00025	1	1
ENSP00000386135	RIO1	PF01163.22	0.00025	1	1
ENSP00000417076	RIO1	PF01163.22	0.00025	1	1
ENSP00000484267	RIO1	PF01163.22	0.00025	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496522	DAPK1-217	579	-	-	- (aa)	-	-
ENST00000497743	DAPK1-218	341	-	-	- (aa)	-	-
ENST00000463069	DAPK1-203	327	-	-	- (aa)	-	-
ENST00000358077	DAPK1-201	5743	-	ENSP00000350785	1430 (aa)	-	P53355
ENST00000469067	DAPK1-206	2499	-	-	- (aa)	-	-
ENST00000466188	DAPK1-204	1064	-	-	- (aa)	-	-
ENST00000470267	DAPK1-208	579	-	-	- (aa)	-	-
ENST00000472284	DAPK1-209	5759	-	ENSP00000417076	1430 (aa)	-	P53355
ENST00000491893	DAPK1-213	4186	-	ENSP00000419026	1364 (aa)	-	P53355
ENST00000489291	DAPK1-212	4334	-	ENSP00000417746	188 (aa)	-	F8WCQ3
ENST00000475804	DAPK1-211	567	-	-	- (aa)	-	-
ENST00000495182	DAPK1-215	626	-	-	- (aa)	-	-
ENST00000472344	DAPK1-210	548	-	-	- (aa)	-	-
ENST00000408954	DAPK1-202	5892	-	ENSP00000386135	1430 (aa)	-	P53355
ENST00000468482	DAPK1-205	487	-	-	- (aa)	-	-
ENST00000469640	DAPK1-207	5899	XM_005251757	ENSP00000418885	1364 (aa)	XP_005251814	P53355
ENST00000494010	DAPK1-214	696	-	-	- (aa)	-	-
ENST00000495281	DAPK1-216	853	-	-	- (aa)	-	-
ENST00000622514	DAPK1-219	5772	-	ENSP00000484267	1430 (aa)	-	P53355

Gene Model

Click here to download ENSG00000196730's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04140	Autophagy - animal	KEGG
hsa05200	Pathways in cancer	KEGG
hsa05219	Bladder cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000196730	Echocardiography	8.1188266484947E-6	17903301
ENSG00000196730	Personality	1.147e-005	-
ENSG00000196730	Personality	1.147e-005	-
ENSG00000196730	Calcium	6.1560000E-005	-
ENSG00000196730	Platelet Function Tests	4.8700000E-008	-
ENSG00000196730	Platelet Function Tests	4.8100000E-008	-
ENSG00000196730	Platelet Function Tests	5.5200000E-006	-
ENSG00000196730	Platelet Function Tests	5.2700000E-006	-
ENSG00000196730	Platelet Function Tests	1.1447043E-006	-
ENSG00000196730	Platelet Function Tests	5.2291851E-006	-
ENSG00000196730	Platelet Function Tests	1.3127026E-006	-
ENSG00000196730	Intelligence Tests	6.0519700E-006	-
ENSG00000196730	Intelligence Tests	1.4677100E-005	-
ENSG00000196730	Magnesium	4.0940000E-005	-
ENSG00000196730	Magnesium	3.4330000E-005	-
ENSG00000196730	Sleep	5E-6	27126917
ENSG00000196730	Cytokines	5E-7	22610502
ENSG00000196730	Vaccine Potency	5E-7	22610502
ENSG00000196730	Bronchodilator Agents	4E-6	26634245
ENSG00000196730	Lung Volume Measurements	4E-6	26634245
ENSG00000196730	Cognition	4E-6	24684796
ENSG00000196730	gemcitabine	1E-6	22293537
ENSG00000196730	Pancreatic Carcinoma	1E-6	22293537
ENSG00000196730	Arterial Pressure	4E-7	24954895
ENSG00000196730	Arterial Pressure	7E-6	24954895
ENSG00000196730	Blood Pressure	4E-7	24954895

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000196730	rs3118867	9	87646780	G	Blood pressure	24954895	[0.31-0.67] mmHg decrease	0.49	EFO_0006336
ENSG00000196730	rs3118867	9	87646780	G	Blood pressure	24954895	[0.21-0.57] mmHg decrease	0.39	EFO_0006340
ENSG00000196730	rs3118867	9	87646780	G	Blood pressure	24954895	[0.33-0.77] mmHg decrease	0.55	EFO_0006340
ENSG00000196730	rs36206051	9	87592711	T	Night sleep phenotypes	27126917	[0.052-0.13] unit increase	0.09129	EFO_0005272
ENSG00000196730	rs184522131	9	87562606	G	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.513	GO_0097366\|EFO_0004713
ENSG00000196730	rs3095748	9	87594222	G	Immune reponse to smallpox (secreted IFN-alpha)	22610502			EFO_0004645\|EFO_0004873
ENSG00000196730	rs1421001	9	87544398	A	Cognitive function	24684796	[2.49-6.15] unit increase	4.3211	EFO_0003925
ENSG00000196730	rs11141915	9	87620879	T	Response to gemcitabine in pancreatic cancer	22293537	[2.21-7.62]	4.1	GO_0036272\|EFO_0002618
ENSG00000196730	rs10117922	9	87680655	A	Ovarian cancer	30557369	[1.18-1.51]	1.3351135	EFO_0001075

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196730's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000196730	DAPK1	98	82.162	ENSAPOG00000002327	dapk1	96	76.704	Acanthochromis_polyacanthus
ENSG00000196730	DAPK1	98	75.676	ENSAPOG00000006757	dapk2b	95	69.364	Acanthochromis_polyacanthus
ENSG00000196730	DAPK1	98	99.459	ENSAMEG00000006710	-	100	96.216	Ailuropoda_melanoleuca
ENSG00000196730	DAPK1	98	72.432	ENSACIG00000002463	dapk2b	92	69.461	Amphilophus_citrinellus
ENSG00000196730	DAPK1	98	77.226	ENSACIG00000006618	dapk1	99	71.858	Amphilophus_citrinellus
ENSG00000196730	DAPK1	98	76.757	ENSAOCG00000005331	-	95	69.364	Amphiprion_ocellaris
ENSG00000196730	DAPK1	99	76.025	ENSAPEG00000009387	dapk1	99	71.636	Amphiprion_percula
ENSG00000196730	DAPK1	98	76.757	ENSAPEG00000019722	dapk2b	95	69.364	Amphiprion_percula
ENSG00000196730	DAPK1	98	74.054	ENSATEG00000007816	dapk2b	95	67.341	Anabas_testudineus
ENSG00000196730	DAPK1	98	80.541	ENSATEG00000021989	-	61	84.058	Anabas_testudineus
ENSG00000196730	DAPK1	99	91.360	ENSAPLG00000014607	DAPK1	100	90.922	Anas_platyrhynchos
ENSG00000196730	DAPK1	98	92.973	ENSACAG00000013377	DAPK1	100	88.811	Anolis_carolinensis
ENSG00000196730	DAPK1	98	76.757	ENSANAG00000025796	DAPK2	89	73.171	Aotus_nancymaae
ENSG00000196730	DAPK1	100	99.286	ENSANAG00000032154	DAPK1	100	99.286	Aotus_nancymaae
ENSG00000196730	DAPK1	100	73.936	ENSACLG00000001586	dapk2a	99	73.936	Astatotilapia_calliptera
ENSG00000196730	DAPK1	98	82.162	ENSACLG00000004772	dapk1	96	77.076	Astatotilapia_calliptera
ENSG00000196730	DAPK1	98	80.541	ENSACLG00000011302	-	61	84.058	Astatotilapia_calliptera
ENSG00000196730	DAPK1	98	80.541	ENSAMXG00000040439	-	61	84.058	Astyanax_mexicanus
ENSG00000196730	DAPK1	98	76.757	ENSAMXG00000010743	dapk2a	57	74.910	Astyanax_mexicanus
ENSG00000196730	DAPK1	98	84.865	ENSAMXG00000012193	dapk1	90	84.865	Astyanax_mexicanus
ENSG00000196730	DAPK1	98	75.676	ENSAMXG00000038379	dapk2b	86	71.875	Astyanax_mexicanus
ENSG00000196730	DAPK1	98	99.459	ENSBTAG00000000738	DAPK1	100	95.804	Bos_taurus
ENSG00000196730	DAPK1	98	76.757	ENSCJAG00000004806	DAPK2	89	73.476	Callithrix_jacchus
ENSG00000196730	DAPK1	100	99.286	ENSCJAG00000005569	DAPK1	100	99.286	Callithrix_jacchus
ENSG00000196730	DAPK1	98	99.459	ENSCAFG00000001316	DAPK1	100	95.524	Canis_familiaris
ENSG00000196730	DAPK1	98	99.459	ENSCAFG00020023375	DAPK1	100	94.825	Canis_lupus_dingo
ENSG00000196730	DAPK1	98	76.216	ENSCAFG00020009392	DAPK2	95	68.820	Canis_lupus_dingo
ENSG00000196730	DAPK1	98	76.216	ENSCHIG00000002285	DAPK2	87	69.538	Capra_hircus
ENSG00000196730	DAPK1	98	99.459	ENSCHIG00000013443	DAPK1	100	96.364	Capra_hircus
ENSG00000196730	DAPK1	98	76.757	ENSTSYG00000012419	DAPK2	95	68.451	Carlito_syrichta
ENSG00000196730	DAPK1	100	97.026	ENSTSYG00000012207	DAPK1	100	97.026	Carlito_syrichta
ENSG00000196730	DAPK1	98	79.459	ENSCAPG00000010131	-	100	83.077	Cavia_aperea
ENSG00000196730	DAPK1	86	73.913	ENSCAPG00000008062	DAPK2	95	61.408	Cavia_aperea
ENSG00000196730	DAPK1	95	94.163	ENSCAPG00000006167	DAPK1	99	87.234	Cavia_aperea
ENSG00000196730	DAPK1	98	74.054	ENSCPOG00000000890	DAPK2	95	67.705	Cavia_porcellus
ENSG00000196730	DAPK1	100	96.035	ENSCPOG00000000987	DAPK1	100	95.385	Cavia_porcellus
ENSG00000196730	DAPK1	100	99.464	ENSCCAG00000021962	DAPK1	100	99.464	Cebus_capucinus
ENSG00000196730	DAPK1	98	76.757	ENSCCAG00000026794	DAPK2	89	72.866	Cebus_capucinus
ENSG00000196730	DAPK1	98	76.757	ENSCATG00000043801	DAPK2	95	69.014	Cercocebus_atys
ENSG00000196730	DAPK1	100	99.464	ENSCATG00000033936	DAPK1	100	99.464	Cercocebus_atys
ENSG00000196730	DAPK1	98	75.135	ENSCLAG00000013163	DAPK2	89	71.646	Chinchilla_lanigera
ENSG00000196730	DAPK1	100	96.283	ENSCLAG00000006636	DAPK1	100	95.804	Chinchilla_lanigera
ENSG00000196730	DAPK1	98	76.757	ENSCSAG00000012418	DAPK2	89	79.104	Chlorocebus_sabaeus
ENSG00000196730	DAPK1	100	99.021	ENSCSAG00000007395	DAPK1	99	99.021	Chlorocebus_sabaeus
ENSG00000196730	DAPK1	98	96.757	ENSCPBG00000005312	DAPK1	100	91.469	Chrysemys_picta_bellii
ENSG00000196730	DAPK1	100	99.286	ENSCANG00000041107	DAPK1	100	99.286	Colobus_angolensis_palliatus
ENSG00000196730	DAPK1	98	76.757	ENSCANG00000039986	DAPK2	95	69.014	Colobus_angolensis_palliatus
ENSG00000196730	DAPK1	98	75.676	ENSCGRG00001014149	Dapk2	95	69.231	Cricetulus_griseus_chok1gshd
ENSG00000196730	DAPK1	98	77.297	ENSCGRG00000002758	-	89	80.515	Cricetulus_griseus_crigri
ENSG00000196730	DAPK1	98	75.676	ENSCGRG00000013909	Dapk2	95	69.231	Cricetulus_griseus_crigri
ENSG00000196730	DAPK1	98	80.541	ENSCSEG00000014457	-	59	84.058	Cynoglossus_semilaevis
ENSG00000196730	DAPK1	98	83.243	ENSCSEG00000019414	dapk1	96	76.208	Cynoglossus_semilaevis
ENSG00000196730	DAPK1	98	76.757	ENSCSEG00000002398	dapk2b	95	68.786	Cynoglossus_semilaevis
ENSG00000196730	DAPK1	98	74.054	ENSCVAG00000022652	dapk2a	57	74.113	Cyprinodon_variegatus
ENSG00000196730	DAPK1	98	81.081	ENSCVAG00000013708	dapk1	96	76.704	Cyprinodon_variegatus
ENSG00000196730	DAPK1	98	77.297	ENSCVAG00000021743	dapk2b	88	73.750	Cyprinodon_variegatus
ENSG00000196730	DAPK1	98	74.054	ENSDARG00000061096	dapk2a	60	73.540	Danio_rerio
ENSG00000196730	DAPK1	98	73.514	ENSDARG00000103666	dapk2b	87	71.875	Danio_rerio
ENSG00000196730	DAPK1	100	95.385	ENSDNOG00000002488	DAPK1	100	95.385	Dasypus_novemcinctus
ENSG00000196730	DAPK1	98	98.378	ENSDORG00000003214	Dapk1	100	95.734	Dipodomys_ordii
ENSG00000196730	DAPK1	98	79.459	ENSDORG00000012226	-	100	81.884	Dipodomys_ordii
ENSG00000196730	DAPK1	98	74.595	ENSETEG00000001356	DAPK2	96	68.732	Echinops_telfairi
ENSG00000196730	DAPK1	87	64.634	ENSEBUG00000004869	-	68	61.624	Eptatretus_burgeri
ENSG00000196730	DAPK1	98	98.919	ENSEEUG00000014241	DAPK1	86	99.524	Erinaceus_europaeus
ENSG00000196730	DAPK1	98	72.581	ENSELUG00000003738	dapk2b	97	67.143	Esox_lucius
ENSG00000196730	DAPK1	89	85.030	ENSELUG00000010912	dapk1	93	67.829	Esox_lucius
ENSG00000196730	DAPK1	98	81.081	ENSELUG00000000497	lsm7	55	84.783	Esox_lucius
ENSG00000196730	DAPK1	98	76.757	ENSFCAG00000004177	DAPK2	95	69.014	Felis_catus
ENSG00000196730	DAPK1	98	99.459	ENSFCAG00000005098	DAPK1	100	95.714	Felis_catus
ENSG00000196730	DAPK1	100	95.291	ENSFDAG00000016479	DAPK1	100	94.336	Fukomys_damarensis
ENSG00000196730	DAPK1	98	80.541	ENSFDAG00000015227	-	73	82.971	Fukomys_damarensis
ENSG00000196730	DAPK1	98	77.297	ENSFHEG00000001863	dapk2b	88	74.062	Fundulus_heteroclitus
ENSG00000196730	DAPK1	100	79.787	ENSFHEG00000022183	dapk1	96	79.787	Fundulus_heteroclitus
ENSG00000196730	DAPK1	98	80.541	ENSGALG00000037733	-	60	83.333	Gallus_gallus
ENSG00000196730	DAPK1	98	77.297	ENSGAFG00000020656	dapk2b	88	74.062	Gambusia_affinis
ENSG00000196730	DAPK1	98	72.432	ENSGACG00000010201	dapk2b	87	71.250	Gasterosteus_aculeatus
ENSG00000196730	DAPK1	98	73.514	ENSGACG00000017307	dapk2a	61	75.725	Gasterosteus_aculeatus
ENSG00000196730	DAPK1	79	74.497	ENSGAGG00000008137	DAPK2	95	70.711	Gopherus_agassizii
ENSG00000196730	DAPK1	99	91.037	ENSGAGG00000001582	DAPK1	99	92.209	Gopherus_agassizii
ENSG00000196730	DAPK1	100	99.821	ENSGGOG00000000084	DAPK1	100	99.821	Gorilla_gorilla
ENSG00000196730	DAPK1	98	76.757	ENSGGOG00000016537	-	95	68.732	Gorilla_gorilla
ENSG00000196730	DAPK1	100	73.936	ENSHBUG00000023341	dapk2a	99	73.936	Haplochromis_burtoni
ENSG00000196730	DAPK1	98	97.838	ENSHGLG00000017803	-	99	94.874	Heterocephalus_glaber_female
ENSG00000196730	DAPK1	98	75.135	ENSHGLG00000013578	DAPK2	96	67.887	Heterocephalus_glaber_female
ENSG00000196730	DAPK1	99	95.311	ENSHGLG00100006397	DAPK1	99	94.688	Heterocephalus_glaber_male
ENSG00000196730	DAPK1	98	75.135	ENSHGLG00100013869	DAPK2	95	67.887	Heterocephalus_glaber_male
ENSG00000196730	DAPK1	87	82.927	ENSHCOG00000015155	-	83	79.430	Hippocampus_comes
ENSG00000196730	DAPK1	98	74.595	ENSHCOG00000013506	dapk2b	88	72.812	Hippocampus_comes
ENSG00000196730	DAPK1	98	78.919	ENSHCOG00000000788	-	61	83.333	Hippocampus_comes
ENSG00000196730	DAPK1	94	83.616	ENSIPUG00000011874	dapk1	96	77.347	Ictalurus_punctatus
ENSG00000196730	DAPK1	98	80.000	ENSIPUG00000014879	DAPK3	61	84.058	Ictalurus_punctatus
ENSG00000196730	DAPK1	98	77.838	ENSIPUG00000021663	dapk2	87	74.375	Ictalurus_punctatus
ENSG00000196730	DAPK1	98	98.919	ENSSTOG00000015490	DAPK1	100	96.573	Ictidomys_tridecemlineatus
ENSG00000196730	DAPK1	98	76.216	ENSSTOG00000016080	DAPK2	89	72.561	Ictidomys_tridecemlineatus
ENSG00000196730	DAPK1	98	76.216	ENSJJAG00000017017	Dapk2	95	66.477	Jaculus_jaculus
ENSG00000196730	DAPK1	88	82.424	ENSJJAG00000000350	-	97	82.424	Jaculus_jaculus
ENSG00000196730	DAPK1	98	98.919	ENSJJAG00000005305	Dapk1	100	95.455	Jaculus_jaculus
ENSG00000196730	DAPK1	98	75.135	ENSKMAG00000018440	dapk2b	95	67.919	Kryptolebias_marmoratus
ENSG00000196730	DAPK1	88	84.242	ENSLBEG00000012745	dapk1	98	75.292	Labrus_bergylta
ENSG00000196730	DAPK1	98	74.054	ENSLBEG00000017027	dapk2b	88	72.500	Labrus_bergylta
ENSG00000196730	DAPK1	98	74.595	ENSLOCG00000014848	dapk2b	88	71.562	Lepisosteus_oculatus
ENSG00000196730	DAPK1	98	88.649	ENSLOCG00000011423	dapk1	100	79.986	Lepisosteus_oculatus
ENSG00000196730	DAPK1	100	96.654	ENSLAFG00000009987	DAPK1	100	96.643	Loxodonta_africana
ENSG00000196730	DAPK1	98	75.135	ENSLAFG00000000338	DAPK2	97	67.887	Loxodonta_africana
ENSG00000196730	DAPK1	100	99.301	ENSMFAG00000037117	DAPK1	100	99.286	Macaca_fascicularis
ENSG00000196730	DAPK1	98	76.757	ENSMFAG00000028166	DAPK2	95	69.014	Macaca_fascicularis
ENSG00000196730	DAPK1	98	76.757	ENSMMUG00000018177	DAPK2	95	69.014	Macaca_mulatta
ENSG00000196730	DAPK1	100	99.301	ENSMMUG00000017053	DAPK1	100	99.286	Macaca_mulatta
ENSG00000196730	DAPK1	98	77.838	ENSMNEG00000037814	DAPK2	95	69.577	Macaca_nemestrina
ENSG00000196730	DAPK1	100	99.286	ENSMNEG00000044385	DAPK1	100	99.286	Macaca_nemestrina
ENSG00000196730	DAPK1	100	99.301	ENSMLEG00000033258	DAPK1	100	99.301	Mandrillus_leucophaeus
ENSG00000196730	DAPK1	98	76.757	ENSMLEG00000033599	DAPK2	90	71.810	Mandrillus_leucophaeus
ENSG00000196730	DAPK1	98	80.541	ENSMAMG00000002171	-	61	84.058	Mastacembelus_armatus
ENSG00000196730	DAPK1	98	74.595	ENSMAMG00000007325	dapk2b	88	73.125	Mastacembelus_armatus
ENSG00000196730	DAPK1	98	82.162	ENSMZEG00005020786	dapk1	96	77.076	Maylandia_zebra
ENSG00000196730	DAPK1	87	84.146	ENSMZEG00005028140	DAPK1	99	69.969	Maylandia_zebra
ENSG00000196730	DAPK1	98	80.541	ENSMZEG00005024465	-	61	84.058	Maylandia_zebra
ENSG00000196730	DAPK1	87	77.301	ENSMGAG00000003962	DAPK2	100	78.740	Meleagris_gallopavo
ENSG00000196730	DAPK1	98	75.676	ENSMAUG00000018956	Dapk2	93	70.349	Mesocricetus_auratus
ENSG00000196730	DAPK1	98	98.378	ENSMICG00000017284	DAPK1	98	98.378	Microcebus_murinus
ENSG00000196730	DAPK1	98	76.757	ENSMICG00000011065	DAPK2	95	68.732	Microcebus_murinus
ENSG00000196730	DAPK1	98	75.676	ENSMOCG00000014779	Dapk2	95	69.231	Microtus_ochrogaster
ENSG00000196730	DAPK1	98	97.838	ENSMOCG00000016789	Dapk1	99	93.240	Microtus_ochrogaster
ENSG00000196730	DAPK1	99	72.422	ENSMMOG00000014122	dapk1	99	69.034	Mola_mola
ENSG00000196730	DAPK1	98	74.054	ENSMMOG00000003023	dapk2b	79	72.500	Mola_mola
ENSG00000196730	DAPK1	98	74.595	ENSMODG00000010926	DAPK2	58	75.704	Monodelphis_domestica
ENSG00000196730	DAPK1	98	96.757	ENSMODG00000003480	DAPK1	100	93.986	Monodelphis_domestica
ENSG00000196730	DAPK1	80	78.146	ENSMALG00000021065	dapk1	87	78.146	Monopterus_albus
ENSG00000196730	DAPK1	98	74.054	ENSMALG00000008825	dapk2b	88	73.125	Monopterus_albus
ENSG00000196730	DAPK1	98	80.541	ENSMALG00000018692	-	61	84.058	Monopterus_albus
ENSG00000196730	DAPK1	98	76.216	MGP_CAROLIEiJ_G0032377	Dapk2	89	72.205	Mus_caroli
ENSG00000196730	DAPK1	98	98.378	MGP_CAROLIEiJ_G0018615	Dapk1	100	95.175	Mus_caroli
ENSG00000196730	DAPK1	98	98.378	ENSMUSG00000021559	Dapk1	100	95.105	Mus_musculus
ENSG00000196730	DAPK1	98	76.216	ENSMUSG00000032380	Dapk2	89	72.205	Mus_musculus
ENSG00000196730	DAPK1	98	75.676	MGP_PahariEiJ_G0015242	Dapk2	89	71.601	Mus_pahari
ENSG00000196730	DAPK1	98	98.378	MGP_PahariEiJ_G0019679	Dapk1	100	95.105	Mus_pahari
ENSG00000196730	DAPK1	98	76.216	MGP_SPRETEiJ_G0033516	Dapk2	89	72.205	Mus_spretus
ENSG00000196730	DAPK1	98	98.378	MGP_SPRETEiJ_G0019494	Dapk1	100	95.175	Mus_spretus
ENSG00000196730	DAPK1	98	98.378	ENSMPUG00000002196	DAPK1	100	95.455	Mustela_putorius_furo
ENSG00000196730	DAPK1	98	76.757	ENSMPUG00000000608	DAPK2	83	73.476	Mustela_putorius_furo
ENSG00000196730	DAPK1	89	98.204	ENSMLUG00000012450	DAPK1	100	94.043	Myotis_lucifugus
ENSG00000196730	DAPK1	100	96.406	ENSNGAG00000023610	Dapk1	100	95.455	Nannospalax_galili
ENSG00000196730	DAPK1	98	80.000	ENSNBRG00000011614	-	61	83.696	Neolamprologus_brichardi
ENSG00000196730	DAPK1	95	79.330	ENSNBRG00000003426	-	93	79.330	Neolamprologus_brichardi
ENSG00000196730	DAPK1	100	99.301	ENSNLEG00000005244	DAPK1	100	99.301	Nomascus_leucogenys
ENSG00000196730	DAPK1	98	76.757	ENSNLEG00000012381	-	95	68.732	Nomascus_leucogenys
ENSG00000196730	DAPK1	89	96.429	ENSMEUG00000013493	-	78	93.684	Notamacropus_eugenii
ENSG00000196730	DAPK1	98	97.838	ENSODEG00000005070	DAPK1	99	95.521	Octodon_degus
ENSG00000196730	DAPK1	98	80.541	ENSONIG00000018617	-	61	84.058	Oreochromis_niloticus
ENSG00000196730	DAPK1	98	82.162	ENSONIG00000014229	dapk1	96	76.828	Oreochromis_niloticus
ENSG00000196730	DAPK1	98	76.216	ENSOCUG00000000435	DAPK2	96	69.014	Oryctolagus_cuniculus
ENSG00000196730	DAPK1	98	82.703	ENSORLG00000020799	dapk1	96	77.323	Oryzias_latipes
ENSG00000196730	DAPK1	98	80.541	ENSORLG00000017965	-	59	84.058	Oryzias_latipes
ENSG00000196730	DAPK1	98	72.973	ENSORLG00000007399	dapk2b	95	67.052	Oryzias_latipes
ENSG00000196730	DAPK1	98	80.541	ENSORLG00020004064	-	59	84.058	Oryzias_latipes_hni
ENSG00000196730	DAPK1	98	82.703	ENSORLG00020013739	dapk1	96	77.323	Oryzias_latipes_hni
ENSG00000196730	DAPK1	98	72.973	ENSORLG00020006496	dapk2b	95	67.052	Oryzias_latipes_hni
ENSG00000196730	DAPK1	98	72.973	ENSORLG00015020580	dapk2b	95	67.341	Oryzias_latipes_hsok
ENSG00000196730	DAPK1	98	80.541	ENSORLG00015003938	-	59	84.058	Oryzias_latipes_hsok
ENSG00000196730	DAPK1	98	82.703	ENSORLG00015005807	dapk1	96	75.960	Oryzias_latipes_hsok
ENSG00000196730	DAPK1	96	71.823	ENSORLG00015010313	DAPK2	81	73.723	Oryzias_latipes_hsok
ENSG00000196730	DAPK1	87	84.146	ENSOMEG00000010654	dapk1	97	75.240	Oryzias_melastigma
ENSG00000196730	DAPK1	99	96.671	ENSOGAG00000001345	DAPK1	99	96.671	Otolemur_garnettii
ENSG00000196730	DAPK1	98	76.216	ENSOGAG00000027766	DAPK2	58	78.182	Otolemur_garnettii
ENSG00000196730	DAPK1	100	99.790	ENSPPAG00000036602	DAPK1	100	99.780	Pan_paniscus
ENSG00000196730	DAPK1	98	76.757	ENSPPAG00000036415	DAPK2	95	68.732	Pan_paniscus
ENSG00000196730	DAPK1	98	99.459	ENSPPRG00000015066	DAPK1	100	95.893	Panthera_pardus
ENSG00000196730	DAPK1	98	76.757	ENSPPRG00000007000	DAPK2	95	69.014	Panthera_pardus
ENSG00000196730	DAPK1	98	76.757	ENSPTIG00000020724	DAPK2	95	69.014	Panthera_tigris_altaica
ENSG00000196730	DAPK1	98	99.459	ENSPTIG00000006984	DAPK1	100	95.714	Panthera_tigris_altaica
ENSG00000196730	DAPK1	100	99.860	ENSPTRG00000023384	DAPK1	100	99.853	Pan_troglodytes
ENSG00000196730	DAPK1	98	76.757	ENSPTRG00000007152	DAPK2	95	68.732	Pan_troglodytes
ENSG00000196730	DAPK1	98	99.459	ENSPANG00000024892	DAPK1	100	98.922	Papio_anubis
ENSG00000196730	DAPK1	98	76.757	ENSPANG00000016876	DAPK2	95	69.014	Papio_anubis
ENSG00000196730	DAPK1	98	74.054	ENSPKIG00000000674	DAPK2	88	72.812	Paramormyrops_kingsleyae
ENSG00000196730	DAPK1	98	80.000	ENSPKIG00000005889	-	61	82.609	Paramormyrops_kingsleyae
ENSG00000196730	DAPK1	98	66.607	ENSPKIG00000003300	-	100	63.681	Paramormyrops_kingsleyae
ENSG00000196730	DAPK1	98	96.216	ENSPSIG00000003652	DAPK1	100	90.559	Pelodiscus_sinensis
ENSG00000196730	DAPK1	98	74.595	ENSPSIG00000015800	DAPK2	82	69.186	Pelodiscus_sinensis
ENSG00000196730	DAPK1	98	74.054	ENSPMGG00000004055	dapk2b	88	70.261	Periophthalmus_magnuspinnatus
ENSG00000196730	DAPK1	98	98.378	ENSPEMG00000022627	Dapk1	99	95.455	Peromyscus_maniculatus_bairdii
ENSG00000196730	DAPK1	98	77.297	ENSPEMG00000020977	-	76	79.856	Peromyscus_maniculatus_bairdii
ENSG00000196730	DAPK1	98	75.676	ENSPEMG00000020347	Dapk2	95	69.231	Peromyscus_maniculatus_bairdii
ENSG00000196730	DAPK1	88	75.301	ENSPMAG00000001147	-	100	71.626	Petromyzon_marinus
ENSG00000196730	DAPK1	98	75.135	ENSPCIG00000029457	DAPK2	91	74.026	Phascolarctos_cinereus
ENSG00000196730	DAPK1	98	76.216	ENSPFOG00000005336	dapk2b	88	73.750	Poecilia_formosa
ENSG00000196730	DAPK1	98	80.541	ENSPFOG00000004990	-	61	84.058	Poecilia_formosa
ENSG00000196730	DAPK1	98	80.541	ENSPLAG00000015727	-	61	84.058	Poecilia_latipinna
ENSG00000196730	DAPK1	98	76.757	ENSPLAG00000007283	dapk2b	88	74.062	Poecilia_latipinna
ENSG00000196730	DAPK1	98	80.541	ENSPMEG00000014103	-	61	84.058	Poecilia_mexicana
ENSG00000196730	DAPK1	98	76.216	ENSPMEG00000014459	dapk2b	78	73.750	Poecilia_mexicana
ENSG00000196730	DAPK1	98	77.297	ENSPREG00000009361	dapk2b	82	74.375	Poecilia_reticulata
ENSG00000196730	DAPK1	98	80.541	ENSPREG00000013588	-	61	84.058	Poecilia_reticulata
ENSG00000196730	DAPK1	98	76.757	ENSPPYG00000006543	DAPK2	98	68.169	Pongo_abelii
ENSG00000196730	DAPK1	100	99.161	ENSPPYG00000019346	DAPK1	100	99.161	Pongo_abelii
ENSG00000196730	DAPK1	98	98.919	ENSPCAG00000005202	DAPK1	93	91.513	Procavia_capensis
ENSG00000196730	DAPK1	100	96.923	ENSPCOG00000015755	DAPK1	100	96.923	Propithecus_coquereli
ENSG00000196730	DAPK1	98	76.757	ENSPCOG00000015063	DAPK2	89	72.561	Propithecus_coquereli
ENSG00000196730	DAPK1	87	99.390	ENSPVAG00000011341	DAPK1	91	96.819	Pteropus_vampyrus
ENSG00000196730	DAPK1	98	76.757	ENSPVAG00000016867	DAPK2	95	66.479	Pteropus_vampyrus
ENSG00000196730	DAPK1	93	80.571	ENSPNYG00000003754	dapk1	99	69.716	Pundamilia_nyererei
ENSG00000196730	DAPK1	99	80.749	ENSPNYG00000008207	-	91	80.749	Pundamilia_nyererei
ENSG00000196730	DAPK1	99	78.961	ENSPNAG00000014365	dapk1	95	77.820	Pygocentrus_nattereri
ENSG00000196730	DAPK1	98	81.081	ENSPNAG00000010482	-	63	80.220	Pygocentrus_nattereri
ENSG00000196730	DAPK1	98	77.297	ENSPNAG00000013223	dapk2b	94	71.250	Pygocentrus_nattereri
ENSG00000196730	DAPK1	98	98.378	ENSRNOG00000018198	Dapk1	100	95.035	Rattus_norvegicus
ENSG00000196730	DAPK1	98	75.135	ENSRNOG00000017332	Dapk2	91	71.299	Rattus_norvegicus
ENSG00000196730	DAPK1	98	76.757	ENSRBIG00000029819	DAPK2	95	69.014	Rhinopithecus_bieti
ENSG00000196730	DAPK1	98	76.757	ENSRROG00000029585	DAPK2	95	69.014	Rhinopithecus_roxellana
ENSG00000196730	DAPK1	100	99.286	ENSRROG00000043192	DAPK1	100	99.286	Rhinopithecus_roxellana
ENSG00000196730	DAPK1	100	99.107	ENSSBOG00000027113	DAPK1	100	99.107	Saimiri_boliviensis_boliviensis
ENSG00000196730	DAPK1	98	76.757	ENSSBOG00000018728	DAPK2	89	72.866	Saimiri_boliviensis_boliviensis
ENSG00000196730	DAPK1	98	75.135	ENSSHAG00000018240	DAPK2	90	71.341	Sarcophilus_harrisii
ENSG00000196730	DAPK1	98	89.189	ENSSFOG00015015059	dapk1	100	77.964	Scleropages_formosus
ENSG00000196730	DAPK1	98	82.703	ENSSFOG00015019739	-	100	71.299	Scleropages_formosus
ENSG00000196730	DAPK1	89	82.635	ENSSMAG00000013330	dapk1	97	74.043	Scophthalmus_maximus
ENSG00000196730	DAPK1	98	76.216	ENSSMAG00000015584	dapk2b	88	73.750	Scophthalmus_maximus
ENSG00000196730	DAPK1	98	76.216	ENSSDUG00000008929	dapk2b	87	74.837	Seriola_dumerili
ENSG00000196730	DAPK1	98	83.243	ENSSDUG00000020113	dapk1	96	77.200	Seriola_dumerili
ENSG00000196730	DAPK1	96	77.222	ENSSLDG00000024401	dapk2b	86	67.722	Seriola_lalandi_dorsalis
ENSG00000196730	DAPK1	98	77.226	ENSSLDG00000025280	dapk1	98	71.858	Seriola_lalandi_dorsalis
ENSG00000196730	DAPK1	98	97.297	ENSSARG00000002847	DAPK1	78	95.000	Sorex_araneus
ENSG00000196730	DAPK1	98	75.676	ENSSPUG00000014936	DAPK2	77	73.171	Sphenodon_punctatus
ENSG00000196730	DAPK1	98	76.216	ENSSPAG00000017851	dapk2b	95	69.075	Stegastes_partitus
ENSG00000196730	DAPK1	98	82.162	ENSSPAG00000005994	dapk1	96	77.076	Stegastes_partitus
ENSG00000196730	DAPK1	98	98.919	ENSSSCG00000010949	DAPK1	100	96.805	Sus_scrofa
ENSG00000196730	DAPK1	98	92.973	ENSTGUG00000000606	-	99	90.805	Taeniopygia_guttata
ENSG00000196730	DAPK1	98	74.595	ENSTGUG00000003221	DAPK2	90	72.615	Taeniopygia_guttata
ENSG00000196730	DAPK1	98	84.324	ENSTRUG00000015844	dapk1	95	76.828	Takifugu_rubripes
ENSG00000196730	DAPK1	98	73.514	ENSTRUG00000012994	dapk2b	94	67.449	Takifugu_rubripes
ENSG00000196730	DAPK1	98	73.514	ENSTNIG00000008407	dapk2b	87	70.938	Tetraodon_nigroviridis
ENSG00000196730	DAPK1	98	81.622	ENSTNIG00000015634	dapk1	100	72.149	Tetraodon_nigroviridis
ENSG00000196730	DAPK1	98	99.459	ENSTBEG00000015766	DAPK1	95	94.781	Tupaia_belangeri
ENSG00000196730	DAPK1	98	99.459	ENSTTRG00000012855	DAPK1	100	96.224	Tursiops_truncatus
ENSG00000196730	DAPK1	98	76.757	ENSTTRG00000011301	DAPK2	89	73.171	Tursiops_truncatus
ENSG00000196730	DAPK1	98	76.216	ENSUMAG00000012690	DAPK2	91	69.014	Ursus_maritimus
ENSG00000196730	DAPK1	98	80.000	ENSUMAG00000007459	-	59	80.435	Ursus_maritimus
ENSG00000196730	DAPK1	99	99.465	ENSUMAG00000007670	DAPK1	100	94.545	Ursus_maritimus
ENSG00000196730	DAPK1	98	76.216	ENSVVUG00000013611	DAPK2	95	68.820	Vulpes_vulpes
ENSG00000196730	DAPK1	98	99.459	ENSVVUG00000022391	DAPK1	100	95.455	Vulpes_vulpes
ENSG00000196730	DAPK1	98	92.391	ENSXETG00000017571	dapk1	100	86.313	Xenopus_tropicalis
ENSG00000196730	DAPK1	98	72.432	ENSXETG00000009747	dapk2	89	70.497	Xenopus_tropicalis
ENSG00000196730	DAPK1	87	76.829	ENSXCOG00000020035	dapk2b	94	68.615	Xiphophorus_couchianus
ENSG00000196730	DAPK1	89	80.838	ENSXCOG00000018726	-	59	84.496	Xiphophorus_couchianus
ENSG00000196730	DAPK1	98	76.216	ENSXMAG00000003350	dapk2b	88	73.438	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004672	protein kinase activity	7828849.12730201.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	16756490.	TAS	Function
GO:0004683	calmodulin-dependent protein kinase activity	10629061.	IDA	Function
GO:0005515	protein binding	15616583.16132846.19180116.19712061.20103772.20389280.21725354.25241761.25852190.27068745.29513927.	IPI	Function
GO:0005516	calmodulin binding	10629061.	IDA	Function
GO:0005524	ATP binding	21873635.	IBA	Function
GO:0005524	ATP binding	10629061.	IDA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	12730201.	IDA	Component
GO:0005886	plasma membrane	12730201.	IDA	Component
GO:0006468	protein phosphorylation	10629061.	IDA	Process
GO:0006468	protein phosphorylation	16756490.	TAS	Process
GO:0006915	apoptotic process	7828849.	IGI	Process
GO:0006915	apoptotic process	10629061.	IMP	Process
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	-	IEA	Process
GO:0010506	regulation of autophagy	16756490.	TAS	Process
GO:0010508	positive regulation of autophagy	22095288.	IMP	Process
GO:0015629	actin cytoskeleton	10629061.	IDA	Component
GO:0017075	syntaxin-1 binding	12730201.	IPI	Function
GO:0017148	negative regulation of translation	18995835.	IDA	Process
GO:0035556	intracellular signal transduction	10629061.	IDA	Process
GO:0042802	identical protein binding	19180116.19712061.21738225.	IPI	Function
GO:0042981	regulation of apoptotic process	16756490.	TAS	Process
GO:0043066	negative regulation of apoptotic process	-	IEA	Process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	16132846.	IDA	Process
GO:0046777	protein autophosphorylation	10629061.12730201.	IDA	Process
GO:0046777	protein autophosphorylation	16756490.	TAS	Process
GO:0071346	cellular response to interferon-gamma	18995835.	IDA	Process
GO:0071447	cellular response to hydroperoxide	22095288.	IMP	Process
GO:0097190	apoptotic signaling pathway	7828849.	IMP	Process
GO:2000310	regulation of NMDA receptor activity	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28231808	ITIH5 mediates epigenetic reprogramming of breast cancer cells.	Mol Cancer	2017 Feb 23	Rose M	doi: 10.1186/s12943-017-0610-2.
23804521	Promoter hypermethylation of CDKN2A, MGMT, MLH1, and DAPK genes in laryngeal squamous cell carcinoma and their associations with clinical profiles of the patients.	Head Neck	2014 Aug	Pierini S	doi: 10.1002/hed.23413
26405175	DAPK loss in colon cancer tumor buds: implications for migration capacity of disseminating tumor cells.	Oncotarget	2015 Nov 3	Ivanovska J	doi: 10.18632/oncotarget.4908.
17209433	[Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer].	Mol Biol (Mosk)	2006 Nov-Dec	Mashkova TD	-
20682398	Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer.	Cancer Genet Cytogenet	2010 Sep	Pehlivan S	doi: 10.1016/j.cancergencyto.2010.05.019.
19628771	RETRACTED: Identification of phosphorylated p38 as a novel DAPK-interacting partner during TNFalpha-induced apoptosis in colorectal tumor cells.	Am J Pathol	2009 Aug	Bajbouj K	doi: 10.2353/ajpath.2009.080853
24337450	Suppression of VEGF expression through interruption of the HIF1α and Akt signaling cascade modulates the antiangiogenic activity of DAPK in ovarian carcinoma cells.	Oncol Rep	2014 Feb	Park ST	doi: 10.3892/or.2013.2928
26267895	DAPK1 Promoter Methylation and Cervical Cancer Risk: A Systematic Review and a Meta-Analysis.	PLoS One	2015 Aug 12	Agodi A	doi: 10.1371/journal.pone.0135078
22136354	Alterations in promoter methylation status of tumor suppressor HIC1, SFRP2, and DAPK1 genes in prostate carcinomas.	DNA Cell Biol	2012 May	Kilinc D	doi: 10.1089/dna.2011.1431
25496179	Aberrant methylation and expression of DAPk1 in human hypopharyngeal squamous cell carcinoma.	Acta Otolaryngol	2015 Jan	Wei DM	doi: 10.3109/00016489.2014.956335.
23275143	Prognostic significance of epigenetic inactivation of p16, p15, MGMT and DAPK genes in follicular lymphoma.	Med Oncol	2013 Mar	Krajnovic M	doi: 10.1007/s12032-012-0441-3
26406950	DAPK promoter methylation status correlates with tumor metastasis and poor prognosis in patients with non-small cell lung cancer.	Cancer Biomark	2015	Zhang J	doi: 10.3233/CBM-150501.
21922274	Methylation of the APAF-1 and DAPK-1 promoter region correlates with progression of renal cell carcinoma in North Indian population.	Tumour Biol	2012 Apr	Ahmad ST	doi: 10.1007/s13277-011-0235-9
15492995	Death-associated protein kinase (DAP kinase) alteration in soft tissue leiomyosarcoma: Promoter methylation or homozygous deletion is associated with a loss of DAP kinase expression.	Hum Pathol	2004 Oct	Kawaguchi K	-
27286455	Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.	Oncotarget	2016 Jul 12	Bai J	doi: 10.18632/oncotarget.9866.
29775889	LncRNA MIR22HG negatively regulates miR-141-3p to enhance DAPK1 expression and inhibits endometrial carcinoma cells proliferation.	Biomed Pharmacother	2018 Aug	Cui Z	doi: 10.1016/j.biopha.2018.05.046
21302620	Promoter methylation of p16, Runx3, DAPK and CHFR genes is frequent in gastric carcinoma.	Tumori	2010 Sep-Oct	Hu SL	-
26075823	Death-associated protein kinase 1 promotes growth of p53-mutant cancers.	J Clin Invest	2015 Jul 1	Zhao J	doi: 10.1172/JCI70805
21159370	Hypermethylated DAPK in serum DNA of women with uterine leiomyoma is a biomarker not restricted to cancer.	Gynecol Oncol	2011 Apr	Hafner N	doi: 10.1016/j.ygyno.2010.11.018
27907054	DAPK Promoter Methylation and Bladder Cancer Risk: A Systematic Review and Meta-Analysis.	PLoS One	2016 Dec 1	Dai L	doi: 10.1371/journal.pone.0167228
28388658	The prognostic significance of DAPK1 in bladder cancer.	PLoS One	2017 Apr 7	Xie JY	doi: 10.1371/journal.pone.0175290
19778817	[Reversion transcriptional expression of DAPK in bladder cancer T24 cells 5-aza-2'-deoxycytidine].	Nan Fang Yi Ke Da Xue Xue Bao	2009 Sep	Xu NR	-
20704749	Combined effects of cigarette smoking, gene polymorphisms and methylations of tumor suppressor genes on non small cell lung cancer: a hospital-based case-control study in China.	BMC Cancer	2010 Aug 12	Jin Y	doi: 10.1186/1471-2407-10-422.
15809761	Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer.	Oncol Rep	2005 May	Chan AW	-
20811724	Death-associated protein kinase is essential for the survival of various types of uterine cancer cells.	Int J Oncol	2010 Oct	Tanaka T	-
21965790	An evaluation of prognostic value of death-associated protein kinase 1 in breast cancer.	Anticancer Res	2011 Oct	Chou SE	-
19795445	PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage I and II nonsmall cell lung cancer patients.	Int J Cancer	2010 Apr 1	Buckingham L	doi: 10.1002/ijc.24896.
21287504	[Relationship between promoter methylation of p16, DAPK and RAR beta genes and the clinical data of non-small cell lung cancer].	Zhonghua Yi Xue Yi Chuan Xue Za Zhi	2011 Feb	Zhang CY	doi: 10.3760/cma.j.issn.1003-9406.2011.01.006.
25268905	Association between DAPK1 promoter methylation and cervical cancer: a meta-analysis.	PLoS One	2014 Sep 30	Xiong J	doi: 10.1371/journal.pone.0107272
23245584	Unexpected close surgical margin in resected buccal cancer: very close margin and DAPK promoter hypermethylation predict poor clinical outcomes.	Oral Oncol	2013 Apr	Lin HY	doi: 10.1016/j.oraloncology.2012.11.005
19878310	Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer.	FEBS J	2010 Jan	Michie AM	doi: 10.1111/j.1742-4658.2009.07414.x
17868341	Analysis of human papillomavirus and Epstein-Barr virus infection and aberrant death-associated protein kinase methylation in high-grade squamous intraepithelial lesions.	Int J Gynecol Cancer	2008 Jul-Aug	Lattario F	-
22160140	Sodium butyrate-induced DAPK-mediated apoptosis in human gastric cancer cells.	Oncol Rep	2012 Apr	Shin H	doi: 10.3892/or.2011.1585
18799028	[Promoter methylation of DAPK gene in cervical carcinoma].	Ai Zheng	2008 Sep	Zhao XL	-
20360646	[Value of promoter methylation of RASSF1A, p16, and DAPK genes in induced sputum in diagnosing lung cancers].	Zhong Nan Da Xue Xue Bao Yi Xue Ban	2010 Mar	Peng Z	doi: 10.3969/j.issn.1672-7347.2010.03.010.
25848215	Clinical significance of DAPK promoter hypermethylation in lung cancer: a meta-analysis.	Drug Des Devel Ther	2015 Mar 24	Li Y	doi: 10.2147/DDDT.S78012
22490852	[Death-associated protein kinase promoter (DAPK) hypermethylation in uterine cervical cancer and intraepithelial neoplasia in Uyghur nationality women].	Zhonghua Zhong Liu Za Zhi	2012 Jan	Niyazi M	-
19521987	Down-regulation of the transcriptional mediator subunit Med1 contributes to the loss of expression of metastasis-associated dapk1 in human cancers and cancer cells.	Int J Cancer	2009 Oct 1	Gade P	doi: 10.1002/ijc.24493.
18425396	Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer.	Oncol Rep	2008 May	Leung RC	-
24314662	Methylation of human papillomavirus 16, 18, 31, and 45 L2 and L1 genes and the cellular DAPK gene: Considerations for use as biomarkers of the progression of cervical neoplasia.	Virology	2014 Jan 5	Kalantari M	doi: 10.1016/j.virol.2013.10.032
21152877	Methylation of BNIP3 and DAPK indicates lower response to chemotherapy and poor prognosis in gastric cancer.	Oncol Rep	2011 Feb	Sugita H	doi: 10.3892/or.2010.1085
19506903	RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China.	J Cancer Res Clin Oncol	2009 Dec	Lin Q	doi: 10.1007/s00432-009-0614-4
21979297	Epigenetic regulation of death-associated protein kinase expression in primary gastric cancers from Chinese patients.	Eur J Cancer Prev	2012 May	Ye M	doi: 10.1097/CEJ.0b013e32834c9caa.
19917631	Dual promoter regulation of death-associated protein kinase gene leads to differentially silenced transcripts by methylation in cancer.	Carcinogenesis	2009 Dec	Pulling LC	doi: 10.1093/carcin/bgp276.
28934284	Correlation of DAPK1 methylation and the risk of gastrointestinal cancer: A systematic review and meta-analysis.	PLoS One	2017 Sep 21	Yuan W	doi: 10.1371/journal.pone.0184959
28429233	Role of Methylation in the Regulation of Apoptosis Genes APAF1, DAPK1, and BCL2 in Breast Cancer.	Bull Exp Biol Med	2017 Apr	Loginov VI	doi: 10.1007/s10517-017-3716-z
29480000	Promoter Methylation of BRCA1, DAPK1 and RASSF1A is Associated with Increased Mortality among Indian Women with Breast Cancer	Asian Pac J Cancer Prev	2018 Feb 26	Yadav P	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr9	87706239	Silent	rs193150601	A1056A	0.05
ACC	chr9	87703142	Silent	novel	V995V	0.36
BLCA	chr9	87650065	Missense_Mutation	rs776122467	D525N	0.29
BLCA	chr9	87642008	Missense_Mutation	novel	A290T	0.19
BLCA	chr9	87658044	Silent	novel	L614L	0.31
BLCA	chr9	87647333	Missense_Mutation	novel	A420V	0.09
BLCA	chr9	87650098	Missense_Mutation	novel	D536H	0.13
BLCA	chr9	87668669	Nonsense_Mutation	novel	R666*	0.45
BLCA	chr9	87647394	Silent	NA	V440V	0.27
BLCA	chr9	87639661	Missense_Mutation	novel	V189L	0.72
BLCA	chr9	87637998	Missense_Mutation	NA	E114K	0.38	RIO1
BLCA	chr9	87706184	Missense_Mutation	rs768648374	R1038H	0.37
BLCA	chr9	87650139	Intron	novel		0.21
BLCA	chr9	87647365	Missense_Mutation	NA	L431V	0.16
BLCA	chr9	87668641	Missense_Mutation	NA	E656D	0.23
BLCA	chr9	87703103	Silent	novel	P982P	0.3
BLCA	chr9	87658050	Missense_Mutation	novel	L616F	0.83
BLCA	chr9	87681492	Missense_Mutation	NA	G697E	0.51
BLCA	chr9	87647350	Missense_Mutation	novel	D426H	0.29
BRCA	chr9	87697087	Frame_Shift_Ins	novel	*P832Lfs10**	0.06
BRCA	chr9	87697088	Missense_Mutation	novel	P832R	0.05
BRCA	chr9	87499033	5'UTR	novel		0.25
BRCA	chr9	87637952	Silent	NA	G98G	0.25
BRCA	chr9	87707245	Missense_Mutation	NA	L1392M	0.23
BRCA	chr9	87686614	Missense_Mutation	rs748331719	M763T	0.33
BRCA	chr9	87605164	Silent	NA	L91L	0.15
BRCA	chr9	87697084	Missense_Mutation	NA	D831N	0.19
BRCA	chr9	87643385	Missense_Mutation	NA	R310C	0.11
BRCA	chr9	87605011	Silent	rs374777068	A40A	0.18
BRCA	chr9	87706999	Missense_Mutation	rs371992448	R1310W	0.57
BRCA	chr9	87640410	Missense_Mutation	novel	A248T	0.79
CESC	chr9	87681448	Silent	novel	Q682Q	0.29
CESC	chr9	87698730	Nonsense_Mutation	novel	R896*	0.23
CESC	chr9	87686600	Silent	NA	V758V	0.21
CESC	chr9	87706460	Missense_Mutation	NA	R1130H	0.2
CESC	chr9	87605123	Missense_Mutation	novel	T78A	0.08	RIO1
CESC	chr9	87640389	Missense_Mutation	novel	F241V	0.37
CESC	chr9	87681490	Silent	rs770475590	S696S	0.37
CESC	chr9	87706252	Missense_Mutation	rs371272256	R1061W	0.47
CESC	chr9	87707062	Missense_Mutation	novel	A1331T	0.3
CESC	chr9	87708586	3'UTR	novel		0.26
CESC	chr9	87605151	Missense_Mutation	rs760156331	T87M	0.38	RIO1
CESC	chr9	87703109	Silent	novel	Q984Q	0.17
CESC	chr9	87649927	Missense_Mutation	novel	E479Q	0.46
CHOL	chr9	87639437	Missense_Mutation	rs369801129	D169E	0.15
CHOL	chr9	87640425	Missense_Mutation	novel	R253G	0.45
COAD	chr9	87642008	Missense_Mutation	novel	A290P	0.58
COAD	chr9	87640371	Missense_Mutation	rs548113187	E235K	0.42
COAD	chr9	87706164	Silent	rs371818389	D1031D	0.34
COAD	chr9	87706887	Frame_Shift_Del	NA	*Y1275Tfs31**	0.41
COAD	chr9	87649992	Silent	rs765826018	A500A	0.43
COAD	chr9	87650175	Intron	novel		0.06
COAD	chr9	87650065	Missense_Mutation	rs776122467	D525N	0.29
COAD	chr9	87650085	Silent	rs773562327	A531A	0.27
COAD	chr9	87651529	Splice_Region	rs371746705	D543D	0.06
COAD	chr9	87706489	Missense_Mutation	novel	F1140L	0.22
COAD	chr9	87668670	Missense_Mutation	rs369031259	R666Q	0.35
COAD	chr9	87681485	Missense_Mutation	novel	H695Y	0.32
COAD	chr9	87681561	Missense_Mutation	NA	R720Q	0.49
COAD	chr9	87639391	Missense_Mutation	novel	K154T	0.26
COAD	chr9	87706935	Silent	rs201377316	H1288H	0.22
COAD	chr9	87650242	Intron	novel		0.18
COAD	chr9	87649936	Silent	NA	L482L	0.43
COAD	chr9	87637984	Frame_Shift_Ins	novel	*E109Dfs4**	0.03	RIO1
COAD	chr9	87605064	Missense_Mutation	rs375169492	R58H	0.28	RIO1
COAD	chr9	87706412	Missense_Mutation	rs375598719	R1114H	0.4
COAD	chr9	87681500	Frame_Shift_Del	NA	*T701Pfs4**	0.23
COAD	chr9	87706435	Missense_Mutation	novel	E1122K	0.04
COAD	chr9	87650034	Silent	novel	P514P	0.17
COAD	chr9	87703207	Missense_Mutation	novel	S1017N	0.28
COAD	chr9	87707517	3'UTR	novel		0.67
COAD	chr9	87642047	Frame_Shift_Del	novel	*K304Nfs8**	0.27
COAD	chr9	87605065	Silent	rs200958656	R58R	0.24
COAD	chr9	87706918	Missense_Mutation	NA	M1283V	0.28
COAD	chr9	87650326	Intron	novel		0.29
COAD	chr9	87681601	Silent	novel	P733P	0.22
COAD	chr9	87706434	Silent	rs769931498	D1121D	0.32
COAD	chr9	87686592	Missense_Mutation	novel	V756M	0.33
COAD	chr9	87707298	Missense_Mutation	novel	E1409D	0.3
COAD	chr9	87605048	Missense_Mutation	rs774238093	R53W	0.37	RIO1
COAD	chr9	87649972	Missense_Mutation	NA	A494T	0.38
COAD	chr9	87700136	Missense_Mutation	novel	I924F	0.07
COAD	chr9	87700220	Nonsense_Mutation	rs749723265	R952*	0.07
COAD	chr9	87642047	Frame_Shift_Del	novel	*K304Nfs8**	0.19
COAD	chr9	87650017	Silent	novel	R509R	0.2
COAD	chr9	87604983	Missense_Mutation	rs777469310	R31H	0.29
COAD	chr9	87648827	Missense_Mutation	novel	D459A	0.21
COAD	chr9	87700200	Missense_Mutation	rs748494486	R945Q	0.11
COAD	chr9	87651607	Silent	rs755628476	F569F	0.29
COAD	chr9	87706560	Silent	rs768494372	G1163G	0.19
COAD	chr9	87706749	Silent	rs202069940	T1226T	0.1
COAD	chr9	87651530	Missense_Mutation	rs200262418	G544R	0.27
COAD	chr9	87706324	Missense_Mutation	NA	L1085I	0.31
COAD	chr9	87640308	Missense_Mutation	rs749825789	A214T	0.21
COAD	chr9	87647349	Silent	rs55637131	V425V	0.19
COAD	chr9	87706846	Missense_Mutation	rs771500801	R1259W	0.26
COAD	chr9	87697031	Missense_Mutation	novel	E813A	0.03
COAD	chr9	87697032	Silent	novel	E813E	0.02
COAD	chr9	87498974	5'UTR	novel		0.15
COAD	chr9	87686678	Silent	rs750748509	P784P	0.21
COAD	chr9	87706560	Silent	rs768494372	G1163G	0.19
DLBC	chr9	87604992	Missense_Mutation	novel	S34I	0.31
ESCA	chr9	87706412	Missense_Mutation	rs375598719	R1114H	0.2
ESCA	chr9	87697059	Silent	novel	C822C	0.05
ESCA	chr9	87706266	Silent	novel	T1065T	0.25
ESCA	chr9	87707150	Missense_Mutation	novel	A1360V	0.14
ESCA	chr9	87681600	Missense_Mutation	novel	P733H	0.57
ESCA	chr9	87637956	Missense_Mutation	novel	E100K	0.61	RIO1
ESCA	chr9	87706886	Frame_Shift_Ins	rs779681511	*Y1275Vfs64**	0.42
ESCA	chr9	87707071	Missense_Mutation	novel	L1334V	0.16
GBM	chr9	87605167	Silent	NA	I92I	0.44
GBM	chr9	87707216	Missense_Mutation	novel	E1382A	0.1
GBM	chr9	87650145	Intron	novel		0.1
GBM	chr9	87645954	Silent	novel	V357V	0.04
GBM	chr9	87499100	Missense_Mutation	novel	N8S	0.64
GBM	chr9	87604965	Missense_Mutation	rs775973031	A25V	0.21
GBM	chr9	87651561	Missense_Mutation	novel	R554Q	0.24
GBM	chr9	87658084	Missense_Mutation	rs202110666	R627Q	0.22
GBM	chr9	87668670	Missense_Mutation	rs369031259	R666Q	0.18
GBM	chr9	87697015	Missense_Mutation	rs761206401	D808N	0.23
GBM	chr9	87706472	Missense_Mutation	novel	V1134A	0.09
GBM	chr9	87645914	Missense_Mutation	novel	V344A	0.14
GBM	chr9	87706472	Missense_Mutation	novel	V1134A	0.77
GBM	chr9	87637982	Missense_Mutation	novel	K108N	0.13	RIO1
GBM	chr9	87643462	Silent	novel	D335D	0.27
GBM	chr9	87648677	Intron	novel		0.33
GBM	chr9	87703217	Missense_Mutation	novel	E1020D	0.14
HNSC	chr9	87649953	Nonsense_Mutation	novel	W487*	0.29
HNSC	chr9	87707015	Missense_Mutation	rs368364961	R1315H	0.39
HNSC	chr9	87698735	Silent	novel	P897P	0.08
HNSC	chr9	87706749	Silent	rs202069940	T1226T	0.22
HNSC	chr9	87707028	Silent	rs200815823	P1319P	0.07
HNSC	chr9	87703076	Silent	rs570648177	L973L	0.2
HNSC	chr9	87707134	Missense_Mutation	novel	P1355S	0.32
HNSC	chr9	87499081	Missense_Mutation	novel	T2A	0.36
HNSC	chr9	87681437	Nonsense_Mutation	NA	R679*	0.19
HNSC	chr9	87637950	Missense_Mutation	novel	G98C	0.19	RIO1
HNSC	chr9	87706460	Missense_Mutation	NA	R1130H	0.08
HNSC	chr9	87706423	Missense_Mutation	novel	D1118N	0.27
HNSC	chr9	87658044	Silent	novel	L614L	0.27
HNSC	chr9	87681448	Missense_Mutation	novel	Q682H	0.15
KIRC	chr9	87638011	Frame_Shift_Del	novel	*F119Tfs4**	0.1	RIO1
KIRC	chr9	87697048	Missense_Mutation	NA	V819L	0.52
KIRC	chr9	87681438	Missense_Mutation	rs745756807	R679Q	0.13
KIRC	chr9	87706737	Silent	NA	V1222V	0.14
KIRC	chr9	87640382	Silent	NA	D238D	0.32
KIRP	chr9	87697199	Missense_Mutation	novel	P869R	0.47
KIRP	chr9	87639374	Missense_Mutation	NA	L148F	0.16	RIO1
KIRP	chr9	87706906	Missense_Mutation	NA	F1279V	0.73
LGG	chr9	87686645	Missense_Mutation	NA	M773I	0.47
LGG	chr9	87668669	Nonsense_Mutation	novel	R666*	0.08
LGG	chr9	87698678	Silent	rs372000773	N878N	0.24
LGG	chr9	87700192	Missense_Mutation	novel	K942N	0.29
LGG	chr9	87638029	Missense_Mutation	novel	L124H	0.09	RIO1
LIHC	chr9	87703073	Silent	rs370713535	T972T	0.39
LIHC	chr9	87604973	Frame_Shift_Del	novel	*K28Rfs29**	0.39
LIHC	chr9	87605065	Silent	rs200958656	R58R	0.49
LIHC	chr9	87703121	Silent	NA	L988L	0.3
LIHC	chr9	87681606	Missense_Mutation	novel	P735L	0.3
LIHC	chr9	87658055	Silent	rs777677048	A617A	0.33
LUAD	chr9	87648779	Splice_Site	NA	X444_splice	0.22
LUAD	chr9	87706580	Missense_Mutation	novel	W1170L	0.18
LUAD	chr9	87707113	Missense_Mutation	NA	G1348W	0.76
LUAD	chr9	87605131	Silent	rs36207429	H80H	0.26
LUAD	chr9	87706720	Missense_Mutation	novel	S1217R	0.11
LUAD	chr9	87700115	Splice_Site	novel	X917_splice	0.19
LUAD	chr9	87697105	In_Frame_Ins	novel	V838delinsEI	0.06
LUAD	chr9	87697106	Nonsense_Mutation	novel	*V838_V839insTQG**	0.06
LUAD	chr9	87706165	Frame_Shift_Del	novel	*V1032Cfs64**	0.19
LUAD	chr9	87640308	Missense_Mutation	NA	A214P	0.27
LUAD	chr9	87640805	Missense_Mutation	NA	K262N	0.38
LUAD	chr9	87706580	Missense_Mutation	novel	W1170S	0.14
LUAD	chr9	87706204	Missense_Mutation	NA	L1045M	0.11
LUAD	chr9	87706222	Missense_Mutation	rs368803870	V1051M	0.09
LUAD	chr9	87706239	Silent	rs193150601	A1056A	0.27
LUAD	chr9	87698661	Missense_Mutation	novel	G873C	0.25
LUAD	chr9	87706654	Missense_Mutation	NA	E1195Q	0.13
LUAD	chr9	87648866	Missense_Mutation	novel	N472T	0.27
LUAD	chr9	87707427	3'UTR	novel		0.29
LUSC	chr9	87639482	Splice_Region	novel	V184V	0.13
LUSC	chr9	87707340	Silent	novel	S1423S	0.22
LUSC	chr9	87706887	Frame_Shift_Del	NA	*Y1275Tfs31**	0.58
LUSC	chr9	87697198	Missense_Mutation	novel	P869S	0.23
LUSC	chr9	87706455	Silent	rs116652186	G1128G	0.28
LUSC	chr9	87700150	Silent	rs529643379	L928L	0.15
LUSC	chr9	87686698	Missense_Mutation	novel	Q791L	0.57
LUSC	chr9	87686703	Missense_Mutation	novel	T793S	0.33
LUSC	chr9	87698747	Silent	NA	E901E	0.36
LUSC	chr9	87707074	Missense_Mutation	novel	G1335C	0.28
LUSC	chr9	87605012	Missense_Mutation	novel	A41S	0.29	RIO1
LUSC	chr9	87650242	Intron	novel		0.5
LUSC	chr9	87706525	Silent	rs756576358	L1152L	0.61
LUSC	chr9	87639377	Missense_Mutation	novel	D149E	0.35	RIO1
LUSC	chr9	87651630	Missense_Mutation	novel	G577D	0.44
LUSC	chr9	87681563	Missense_Mutation	NA	P721S	0.3
LUSC	chr9	87647305	Missense_Mutation	NA	G411C	0.35
LUSC	chr9	87697164	Silent	NA	L857L	0.16
LUSC	chr9	87698691	Missense_Mutation	novel	V883F	0.1
OV	chr9	87638076	Missense_Mutation	novel	L140I	0.2	RIO1
OV	chr9	87650119	Splice_Site	novel	X542_splice	0.09
OV	chr9	87707195	Missense_Mutation	novel	T1375I	0.14
OV	chr9	87707293	Missense_Mutation	novel	Q1408E	0.11
OV	chr9	87700157	Missense_Mutation	novel	L931M	0.28
OV	chr9	87697085	Missense_Mutation	novel	D831A	0.13
OV	chr9	87697086	In_Frame_Ins	novel	D831_P832insLKSWASSEL	0.13
OV	chr9	87706991	Missense_Mutation	novel	L1307P	0.07
OV	chr9	87707254	Missense_Mutation	novel	A1395P	0.13
OV	chr9	87648710	Intron	novel		0.09
OV	chr9	87707225	Missense_Mutation	novel	R1385H	0.52
OV	chr9	87707459	3'UTR	novel		0.21
OV	chr9	87707460	3'UTR	novel		0.19
OV	chr9	87697076	Missense_Mutation	novel	A828V	0.04
PAAD	chr9	87605051	Missense_Mutation	novel	R54W	0.17	RIO1
PAAD	chr9	87643385	Missense_Mutation	NA	R310C	0.13
PRAD	chr9	87646521	Missense_Mutation	NA	L398V	0.21
PRAD	chr9	87647374	Missense_Mutation	novel	N434D	0.28
PRAD	chr9	87637970	Silent	NA	F104F	0.08
PRAD	chr9	87604983	Missense_Mutation	rs777469310	R31H	0.4
PRAD	chr9	87706709	Missense_Mutation	novel	D1213G	0.44
PRAD	chr9	87681617	Nonsense_Mutation	NA	K739*	0.24
READ	chr9	87706911	Silent	novel	S1280S	0.21
READ	chr9	87605131	Silent	rs36207429	H80H	0.17
READ	chr9	87686627	Silent	rs371530974	P767P	0.35
READ	chr9	87646537	Missense_Mutation	NA	S403L	0.28
READ	chr9	87707115	Silent	novel	G1348G	0.41
READ	chr9	87700199	Nonsense_Mutation	NA	R945*	0.38
READ	chr9	87639483	Missense_Mutation	rs761997264	A185T	0.53
READ	chr9	87647363	Missense_Mutation	NA	F430Y	0.16
READ	chr9	87706471	Missense_Mutation	novel	V1134L	0.23
SARC	chr9	87668597	Missense_Mutation	novel	D642N	0.3
SARC	chr9	87638064	Missense_Mutation	NA	A136T	0.22	RIO1
SARC	chr9	87706253	Missense_Mutation	novel	R1061Q	0.24
SKCM	chr9	87686640	Missense_Mutation	rs374989008	G772R	0.78
SKCM	chr9	87706265	Missense_Mutation	novel	T1065I	0.16
SKCM	chr9	87639469	Missense_Mutation	NA	T180I	0.19
SKCM	chr9	87706203	Silent	NA	V1044V	0.18
SKCM	chr9	87707176	Missense_Mutation	novel	P1369S	0.71
SKCM	chr9	87706887	Frame_Shift_Del	NA	*Y1275Tfs31**	0.44
SKCM	chr9	87707130	Silent	rs373446864	F1353F	0.51
SKCM	chr9	87697170	Silent	rs376600898	F859F	0.97
SKCM	chr9	87605104	Silent	novel	I71I	0.61
SKCM	chr9	87706605	Silent	NA	N1178N	0.63
SKCM	chr9	87698770	Missense_Mutation	NA	S909L	0.59
SKCM	chr9	87703117	Missense_Mutation	NA	S987L	0.08
SKCM	chr9	87605052	Missense_Mutation	rs767507074	R54Q	0.54	RIO1
SKCM	chr9	87605053	Silent	novel	R54R	0.52
SKCM	chr9	87605161	Silent	rs376105560	I90I	0.17
SKCM	chr9	87707357	Missense_Mutation	novel	S1429F	0.36
SKCM	chr9	87707169	Silent	rs774013763	T1366T	0.42
SKCM	chr9	87697046	Missense_Mutation	NA	P818L	0.09
STAD	chr9	87686658	Missense_Mutation	NA	V778L	0.24
STAD	chr9	87649931	Frame_Shift_Del	novel	*L482Cfs23**	0.13
STAD	chr9	87650030	Missense_Mutation	rs778729228	T513M	0.14
STAD	chr9	87706887	Frame_Shift_Del	NA	*Y1275Tfs31**	0.42
STAD	chr9	87650009	In_Frame_Del	novel	K507_L515del	0.13
STAD	chr9	87706815	Silent	NA	P1248P	0.24
STAD	chr9	87706222	Missense_Mutation	rs368803870	V1051M	0.31
STAD	chr9	87707015	Missense_Mutation	rs368364961	R1315H	0.17
STAD	chr9	87707291	Missense_Mutation	NA	G1407D	0.13
STAD	chr9	87703040	Silent	NA	P961P	0.22
STAD	chr9	87706471	Missense_Mutation	novel	V1134M	0.22
STAD	chr9	87668608	Silent	rs773785893	T645T	0.31
STAD	chr9	87648796	Missense_Mutation	NA	L449I	0.21
STAD	chr9	87706887	Frame_Shift_Del	NA	*Y1275Tfs31**	0.28
STAD	chr9	87650013	Missense_Mutation	NA	K507N	0.48
STAD	chr9	87698771	Silent	rs371785798	S909S	0.36
STAD	chr9	87706887	Frame_Shift_Del	NA	*Y1275Tfs31**	0.34
STAD	chr9	87697196	Frame_Shift_Del	novel	*E868Dfs3**	0.53
STAD	chr9	87648629	Intron	novel		0.67
STAD	chr9	87668622	Missense_Mutation	novel	A650V	0.06
STAD	chr9	87698781	Missense_Mutation	novel	E913Q	0.26
STAD	chr9	87706887	Frame_Shift_Del	NA	*Y1275Tfs31**	0.31
STAD	chr9	87639355	Missense_Mutation	NA	P142H	0.31	RIO1
STAD	chr9	87700164	Missense_Mutation	NA	A933V	0.21
STAD	chr9	87637988	Frame_Shift_Del	novel	*L111Nfs2**	0.27	RIO1
STAD	chr9	87651646	Missense_Mutation	NA	H582Q	0.26
STAD	chr9	87647335	Missense_Mutation	novel	R421W	0.43
STAD	chr9	87706464	Silent	rs765353398	I1131I	0.11
STAD	chr9	87639453	Frame_Shift_Del	novel	*N176Tfs13**	0.08
STAD	chr9	87706525	Missense_Mutation	novel	L1152M	0.33
STAD	chr9	87640403	Silent	NA	S245S	0.33
THCA	chr9	87681437	Nonsense_Mutation	NA	R679*	0.45
THYM	chr9	87708505	3'UTR	novel		0.08
THYM	chr9	87605043	Missense_Mutation	novel	S51F	0.24	RIO1
UCEC	chr9	87708576	3'UTR	novel		0.12
UCEC	chr9	87681490	Silent	rs770475590	S696S	0.38
UCEC	chr9	87604987	Missense_Mutation	NA	E32D	0.34
UCEC	chr9	87651611	Missense_Mutation	rs199940257	D571N	0.29
UCEC	chr9	87706842	Missense_Mutation	NA	F1257L	0.28
UCEC	chr9	87639478	Missense_Mutation	NA	F183C	0.36
UCEC	chr9	87700200	Missense_Mutation	rs748494486	R945Q	0.34
UCEC	chr9	87707235	Silent	rs747472606	A1388A	0.45
UCEC	chr9	87605049	Missense_Mutation	rs759575186	R53Q	0.17	RIO1
UCEC	chr9	87645922	Missense_Mutation	novel	A347S	0.31
UCEC	chr9	87681490	Silent	rs770475590	S696S	0.52
UCEC	chr9	87707061	Silent	NA	L1330L	0.54
UCEC	chr9	87698660	Silent	rs770623157	F872F	0.41
UCEC	chr9	87706179	Frame_Shift_Del	novel	*R1038Afs58**	0.43
UCEC	chr9	87706887	Frame_Shift_Del	NA	*Y1275Tfs31**	0.56
UCEC	chr9	87708593	3'UTR	rs200951613		0.31
UCEC	chr9	87648802	Missense_Mutation	rs759240509	V451M	0.42
UCEC	chr9	87706812	Silent	NA	E1247E	0.5
UCEC	chr9	87707088	Silent	rs772323488	L1339L	0.43
UCEC	chr9	87700200	Missense_Mutation	rs748494486	R945Q	0.42
UCEC	chr9	87649937	Missense_Mutation	novel	L482P	0.49
UCEC	chr9	87707196	Silent	novel	T1375T	0.46
UCEC	chr9	87646537	Missense_Mutation	NA	S403L	0.37
UCEC	chr9	87686619	Missense_Mutation	novel	F765L	0.32
UCEC	chr9	87707274	Silent	novel	I1401I	0.16
UCEC	chr9	87650242	Intron	novel		0.5
UCEC	chr9	87637955	Silent	rs747691896	G99G	0.26
UCEC	chr9	87643407	Missense_Mutation	NA	R317I	0.13
UCEC	chr9	87707015	Missense_Mutation	rs368364961	R1315H	0.36
UCEC	chr9	87638063	Silent	rs757517692	I135I	0.28
UCEC	chr9	87706734	Silent	rs759128375	N1221N	0.29
UCEC	chr9	87650057	Missense_Mutation	rs746514916	G522D	0.44
UCEC	chr9	87698788	Missense_Mutation	novel	R915M	0.31
UCEC	chr9	87706560	Silent	rs768494372	G1163G	0.47
UCEC	chr9	87658064	Silent	rs775422906	N620N	0.31
UCEC	chr9	87651615	Missense_Mutation	novel	Y572C	0.1
UCEC	chr9	87708600	3'UTR	novel		0.39
UCEC	chr9	87706281	Silent	NA	Q1070Q	0.3
UCEC	chr9	87681628	Splice_Site	novel	X742_splice	0.06
UCEC	chr9	87698708	Silent	rs199931949	H888H	0.4
UCEC	chr9	87651561	Missense_Mutation	novel	R554Q	0.26
UCEC	chr9	87708205	3'UTR	novel		0.28
UCEC	chr9	87604983	Missense_Mutation	rs777469310	R31H	0.64
UCEC	chr9	87707711	3'UTR	novel		0.44
UCEC	chr9	87707960	3'UTR	rs766605071		0.43
UCEC	chr9	87605026	Missense_Mutation	novel	K45N	0.16	RIO1
UCEC	chr9	87708500	3'UTR	novel		0.21
UCEC	chr9	87681557	Missense_Mutation	rs757064991	R719C	0.56
UCEC	chr9	87706506	Silent	novel	F1145F	0.41
UCEC	chr9	87708592	3'UTR	novel		0.46
UCEC	chr9	87642046	Frame_Shift_Ins	NA	*W305Mfs23**	0.32
UCEC	chr9	87648801	Silent	rs375721291	H450H	0.47
UCEC	chr9	87706613	Missense_Mutation	NA	A1181V	0.42
UCEC	chr9	87697105	Nonsense_Mutation	novel	*V838Efs5**	0.04
UCEC	chr9	87638028	Missense_Mutation	NA	L124F	0.32	RIO1
UCEC	chr9	87640416	Missense_Mutation	NA	D250Y	0.39
UCEC	chr9	87648852	Silent	rs777004845	F467F	0.13
UCEC	chr9	87648667	Intron	novel		0.36
UCEC	chr9	87650103	Silent	novel	L537L	0.18
UCEC	chr9	87640428	Silent	NA	R254R	0.23
UCEC	chr9	87648802	Missense_Mutation	rs759240509	V451M	0.21
UCEC	chr9	87686666	Silent	rs545837227	P780P	0.47
UCEC	chr9	87637958	Silent	novel	E100E	0.16
UCEC	chr9	87658035	Nonsense_Mutation	NA	R611*	0.41
UCEC	chr9	87639383	Missense_Mutation	novel	N151K	0.48	RIO1
UCEC	chr9	87708576	3'UTR	novel		0.21
UCEC	chr9	87499122	Silent	novel	T15T	0.36
UCEC	chr9	87639482	Splice_Region	rs776970342	V184V	0.26
UCEC	chr9	87706299	Silent	rs753318665	S1076S	0.34
UCEC	chr9	87697153	Missense_Mutation	novel	I854L	0.45
UCEC	chr9	87706345	Missense_Mutation	rs199730400	A1092T	0.45
UCEC	chr9	87706464	Silent	rs765353398	I1131I	0.41
UCEC	chr9	87708378	3'UTR	novel		0.27
UCEC	chr9	87706515	Silent	rs748723486	V1148V	0.3
UCEC	chr9	87681563	Missense_Mutation	NA	P721S	0.16
UCEC	chr9	87700205	Missense_Mutation	rs770473562	H947N	0.3
UCEC	chr9	87707219	Missense_Mutation	NA	L1383P	0.24
UCEC	chr9	87700200	Missense_Mutation	rs748494486	R945Q	0.12
UCEC	chr9	87707062	Missense_Mutation	novel	A1331T	0.56
UCEC	chr9	87499052	5'UTR	novel		0.15
UCEC	chr9	87686695	Missense_Mutation	novel	D790G	0.24
UCEC	chr9	87499123	Missense_Mutation	rs759598995	G16R	0.23
UCEC	chr9	87707157	Silent	rs768819316	L1362L	0.22
UCEC	chr9	87708505	3'UTR	novel		0.27
UCEC	chr9	87604982	Missense_Mutation	rs755737290	R31C	0.44
UCEC	chr9	87700220	Nonsense_Mutation	rs749723265	R952*	0.31
UCEC	chr9	87697092	Silent	NA	T833T	0.4
UCEC	chr9	87658032	Missense_Mutation	novel	G610R	0.36
UCEC	chr9	87708626	3'UTR	novel		0.2
UCEC	chr9	87706345	Missense_Mutation	rs199730400	A1092T	0.5
UCEC	chr9	87643385	Missense_Mutation	NA	R310C	0.35
UCEC	chr9	87707309	Missense_Mutation	rs763698491	S1413L	0.55
UCEC	chr9	87700200	Missense_Mutation	rs748494486	R945Q	0.24
UCEC	chr9	87647307	Splice_Region	rs777844307	G411G	0.38
UCEC	chr9	87650181	Intron	novel		0.21
UCEC	chr9	87640847	Missense_Mutation	novel	K276N	0.23
UCEC	chr9	87643456	Missense_Mutation	novel	S333R	0.18
UCEC	chr9	87645923	Missense_Mutation	novel	A347V	0.19
UCEC	chr9	87646540	Missense_Mutation	novel	R404I	0.19
UCEC	chr9	87681438	Missense_Mutation	rs745756807	R679Q	0.16
UCEC	chr9	87697195	Missense_Mutation	novel	E868K	0.11
UCEC	chr9	87707235	Silent	rs747472606	A1388A	0.45
UCEC	chr9	87658117	Missense_Mutation	novel	A638V	0.36
UCEC	chr9	87650002	Missense_Mutation	rs372895478	V504M	0.46
UCEC	chr9	87681544	Frame_Shift_Ins	novel	*R717Qfs23**	0.1
UCEC	chr9	87681626	Missense_Mutation	novel	V742F	0.13
UCEC	chr9	87706299	Silent	rs753318665	S1076S	0.09
UCEC	chr9	87703139	Silent	novel	D994D	0.44
UCEC	chr9	87668669	Nonsense_Mutation	novel	R666*	0.52
UCEC	chr9	87681613	Silent	novel	A737A	0.48
UCEC	chr9	87639483	Missense_Mutation	rs761997264	A185T	0.35
UCEC	chr9	87700169	Missense_Mutation	novel	A935T	0.09
UCEC	chr9	87645946	Missense_Mutation	novel	D355N	0.43
UVM	chr9	87605063	Missense_Mutation	rs753510016	R58C	0.4	RIO1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.4722	0.067545
LAML	DEL	0.0209	0.24147
PCPG	DEL	0.0617	0.13351
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0244	0.022012
UCEC	DEL	0.2245	0.027215
UCS	DEL	0.5714	0.089783

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0068	Kaplan-Meier Survival Analysis
KIRC	0.00018	Kaplan-Meier Survival Analysis
SKCM	0.046	Kaplan-Meier Survival Analysis
PRAD	0.02	Kaplan-Meier Survival Analysis
COAD	0.0018	Kaplan-Meier Survival Analysis
BLCA	0.0087	Kaplan-Meier Survival Analysis
LAML	0.019	Kaplan-Meier Survival Analysis
KICH	0.042	Kaplan-Meier Survival Analysis
LGG	0.0056	Kaplan-Meier Survival Analysis
CHOL	0.038	Kaplan-Meier Survival Analysis
LUAD	0.043	Kaplan-Meier Survival Analysis
OV	0.007	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742