EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000196961 (Gene tree)
Gene ID: 160
Gene Symbol: AP2A1
Alias: CLAPA1|ADTAA
Full Name: adaptor related protein complex 2 subunit alpha 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 40,191 bases
Position: chr19:49,766,923-49,807,113
Accession: 561
RBP type: non-canonical RBP
Summary: This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17880279	Regulation of clathrin-dependent endocytosis by diacylglycerol kinase delta: importance of kinase activity and binding to AP2alpha.	Biochem J	2008 Jan 15	Kawasaki T	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000594838	AP2A1-204	611	-	-	- (aa)	-	-
ENST00000354293	AP2A1-201	3388	XM_011526557	ENSP00000346246	955 (aa)	XP_011524859	O95782
ENST00000600466	AP2A1-207	2903	-	-	- (aa)	-	-
ENST00000597774	AP2A1-205	2196	-	ENSP00000472492	57 (aa)	-	M0R2D9
ENST00000600199	AP2A1-206	2381	-	-	- (aa)	-	-
ENST00000601356	AP2A1-208	2238	-	-	- (aa)	-	-
ENST00000359032	AP2A1-202	3286	XM_011526556	ENSP00000351926	977 (aa)	XP_011524858	O95782
ENST00000593788	AP2A1-203	611	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000196961's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG
hsa04721	Synaptic vesicle cycle	KEGG
hsa04961	Endocrine and other factor-regulated calcium reabsorption	KEGG
hsa05016	Huntington disease	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000196961	rs76403112	19	49796608	T	Self-reported math ability (MTAG)	30038396	[0.0087-0.0185] unit increase	0.0136	EFO_0004875
ENSG00000196961	rs7251251	19	49790893	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196961's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000196961	AP2A1	100	98.364	ENSMUSG00000060279	Ap2a1	100	98.364	Mus_musculus
ENSG00000196961	AP2A1	98	92.857	ENSMUSG00000002957	Ap2a2	95	96.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	16262731.19116314.	IPI	Function
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006886	intracellular protein transport	12036598.	NAS	Process
GO:0006895	Golgi to endosome transport	12036598.	NAS	Process
GO:0006897	endocytosis	12036598.	NAS	Process
GO:0008022	protein C-terminus binding	-	IEA	Function
GO:0010976	positive regulation of neuron projection development	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016323	basolateral plasma membrane	-	IEA	Component
GO:0016324	apical plasma membrane	-	IEA	Component
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0019901	protein kinase binding	-	ISS	Function
GO:0030122	AP-2 adaptor complex	12036598.	NAS	Component
GO:0030122	AP-2 adaptor complex	12121421.	TAS	Component
GO:0030130	clathrin coat of trans-Golgi network vesicle	12036598.	NAS	Component
GO:0030666	endocytic vesicle membrane	-	TAS	Component
GO:0030669	clathrin-coated endocytic vesicle membrane	-	TAS	Component
GO:0032433	filopodium tip	-	IEA	Component
GO:0032802	low-density lipoprotein particle receptor catabolic process	-	TAS	Process
GO:0034383	low-density lipoprotein particle clearance	-	TAS	Process
GO:0035615	clathrin adaptor activity	12121421.	TAS	Function
GO:0036020	endolysosome membrane	-	TAS	Component
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0045334	clathrin-coated endocytic vesicle	25898166.	NAS	Component
GO:0048013	ephrin receptor signaling pathway	-	TAS	Process
GO:0048260	positive regulation of receptor-mediated endocytosis	-	IEA	Process
GO:0050690	regulation of defense response to virus by virus	-	TAS	Process
GO:0050750	low-density lipoprotein particle receptor binding	26005850.	IPI	Function
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061024	membrane organization	-	TAS	Process
GO:0072583	clathrin-dependent endocytosis	12121421.	TAS	Process
GO:1900126	negative regulation of hyaluronan biosynthetic process	24251095.	IDA	Process
GO:1900126	negative regulation of hyaluronan biosynthetic process	23509262.	IMP	Process