EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197043 (Gene tree)
Gene ID: 309
Gene Symbol: ANXA6
Alias: ANX6
Full Name: annexin A6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 57,177 bases
Position: chr5:151,100,706-151,157,882
Accession: 544
RBP type: non-canonical RBP
Summary: Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000522664	ANXA6-213	451	-	ENSP00000431086	91 (aa)	-	H0YC77
ENST00000520054	ANXA6-209	487	-	-	- (aa)	-	-
ENST00000521749	ANXA6-212	880	-	ENSP00000430429	150 (aa)	-	E5RK63
ENST00000521512	ANXA6-211	1793	-	ENSP00000430420	460 (aa)	-	E5RK69
ENST00000523714	ANXA6-215	2451	-	ENSP00000430517	641 (aa)	-	P08133
ENST00000520378	ANXA6-210	1119	-	-	- (aa)	-	-
ENST00000517677	ANXA6-204	795	-	ENSP00000430826	129 (aa)	-	E5RI05
ENST00000523164	ANXA6-214	923	-	ENSP00000431078	110 (aa)	-	E5RJR0
ENST00000517486	ANXA6-203	562	-	ENSP00000428916	156 (aa)	-	E5RFF0
ENST00000517757	ANXA6-206	553	-	ENSP00000430572	129 (aa)	-	E5RJF5
ENST00000354546	ANXA6-201	2593	XM_005268432	ENSP00000346550	673 (aa)	-	P08133
ENST00000377751	ANXA6-202	1430	-	ENSP00000366980	330 (aa)	-	E7EMC6
ENST00000519644	ANXA6-208	728	-	ENSP00000430663	95 (aa)	-	E5RIU8
ENST00000517707	ANXA6-205	603	-	-	- (aa)	-	-
ENST00000519610	ANXA6-207	899	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000197043's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000197043	Platelet Function Tests	1.4291000E-005	-
ENSG00000197043	Platelet Function Tests	1.3802100E-005	-
ENSG00000197043	Platelet Function Tests	1.2186200E-005	-
ENSG00000197043	Cryptoxanthins	3.9490000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000197043	rs17728578	5	151138507	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197043's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197043	ANXA6	100	94.852	ENSMUSG00000018340	Anxa6	100	94.354	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001755	neural crest cell migration	21873635.	IBA	Process
GO:0001778	plasma membrane repair	21873635.	IBA	Process
GO:0001786	phosphatidylserine binding	21873635.	IBA	Function
GO:0003418	growth plate cartilage chondrocyte differentiation	21873635.	IBA	Process
GO:0005262	calcium channel activity	21873635.	IBA	Function
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	15576473.	IPI	Function
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005525	GTP binding	16605264.	IMP	Function
GO:0005544	calcium-dependent phospholipid binding	21873635.	IBA	Function
GO:0005544	calcium-dependent phospholipid binding	2138016.	IDA	Function
GO:0005739	mitochondrion	-	IEA	Component
GO:0005765	lysosomal membrane	23360953.	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	21873635.	IBA	Component
GO:0006937	regulation of muscle contraction	21873635.	IBA	Process
GO:0008201	heparin binding	21873635.	IBA	Function
GO:0008289	lipid binding	16605264.	IMP	Function
GO:0015276	ligand-gated ion channel activity	21873635.	IBA	Function
GO:0015276	ligand-gated ion channel activity	16605264.	IMP	Function
GO:0015485	cholesterol binding	21873635.	IBA	Function
GO:0015485	cholesterol binding	23360953.	IDA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0019899	enzyme binding	21873635.	IBA	Function
GO:0031214	biomineral tissue development	21873635.	IBA	Process
GO:0031902	late endosome membrane	23360953.	IDA	Component
GO:0034220	ion transmembrane transport	16605264.	IMP	Process
GO:0035374	chondroitin sulfate binding	21873635.	IBA	Function
GO:0038023	signaling receptor activity	21873635.	IBA	Function
GO:0042470	melanosome	-	IEA	Component
GO:0042803	protein homodimerization activity	21873635.	IBA	Function
GO:0042803	protein homodimerization activity	16605264.	IMP	Function
GO:0044877	protein-containing complex binding	21873635.	IBA	Function
GO:0048306	calcium-dependent protein binding	21873635.	IBA	Function
GO:0048306	calcium-dependent protein binding	15226301.	IPI	Function
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0051015	actin filament binding	21873635.	IBA	Function
GO:0051260	protein homooligomerization	21873635.	IBA	Process
GO:0051260	protein homooligomerization	16605264.	IMP	Process
GO:0051283	negative regulation of sequestering of calcium ion	21873635.	IBA	Process
GO:0051560	mitochondrial calcium ion homeostasis	21873635.	IBA	Process
GO:0062023	collagen-containing extracellular matrix	25037231.28344315.28675934.	HDA	Component
GO:0062023	collagen-containing extracellular matrix	28327460.	HDA	Component
GO:0070062	extracellular exosome	19056867.20458337.21362503.23533145.	HDA	Component
GO:0070509	calcium ion import	21873635.	IBA	Process
GO:0070588	calcium ion transmembrane transport	-	IEA	Process
GO:0097190	apoptotic signaling pathway	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27701147	Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness.	J Clin Invest	2016 Nov 1	Leca J	doi: 10.1172/JCI87734
24354805	Reduced annexin A6 expression promotes the degradation of activated epidermal growth factor receptor and sensitizes invasive breast cancer cells to EGFR-targeted tyrosine kinase inhibitors.	Mol Cancer	2013 Dec 19	Koumangoye RB	doi: 10.1186/1476-4598-12-167.
21185831	Annexin A6 contributes to the invasiveness of breast carcinoma cells by influencing the organization and localization of functional focal adhesions.	Exp Cell Res	2011 Apr 1	Sakwe AM	doi: 10.1016/j.yexcr.2010.12.008

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr5	151136300	Frame_Shift_Del	novel	*D149Tfs23**	0.47
BLCA	chr5	151103605	Missense_Mutation	NA	E643K	0.29
BLCA	chr5	151132533	Missense_Mutation	NA	E227K	0.26
BLCA	chr5	151136259	Silent	novel	L162L	0.19
BLCA	chr5	151132543	Silent	novel	G223G	0.31
BLCA	chr5	151133103	Missense_Mutation	novel	L211V	0.53
BLCA	chr5	151147897	Missense_Mutation	novel	A2V	0.2
BLCA	chr5	151147898	Missense_Mutation	novel	A2S	0.2
BRCA	chr5	151103646	Missense_Mutation	rs772576227	R629H	0.15
BRCA	chr5	151103654	Missense_Mutation	NA	M626I	0.33
BRCA	chr5	151123003	Missense_Mutation	rs748009214	E383K	0.36
BRCA	chr5	151124307	Missense_Mutation	novel	R373W	0.04
BRCA	chr5	151129483	Missense_Mutation	rs763713710	R281H	0.1
BRCA	chr5	151101406	3'UTR	novel		0.08
BRCA	chr5	151109787	Silent	novel	I550I	0.09
BRCA	chr5	151129420	Missense_Mutation	NA	Y302C	0.24
CESC	chr5	151122958	Missense_Mutation	novel	R398W	0.42
CESC	chr5	151122936	Frame_Shift_Del	novel	*F405Sfs9**	0.14
CESC	chr5	151139424	Missense_Mutation	novel	D45N	0.2
CESC	chr5	151137283	Silent	novel	L119L	0.43
CHOL	chr5	151105278	Silent	novel	L602L	0.37
COAD	chr5	151129488	Silent	NA	V279V	0.36
COAD	chr5	151123011	Missense_Mutation	NA	G380E	0.22
COAD	chr5	151122954	Missense_Mutation	NA	Q399R	0.1
COAD	chr5	151132538	Missense_Mutation	NA	P225Q	0.21
COAD	chr5	151136304	Silent	rs181203511	I147I	0.35
COAD	chr5	151132485	Silent	NA	L243L	0.2
COAD	chr5	151131248	Missense_Mutation	NA	L260I	0.34
COAD	chr5	151105276	Missense_Mutation	NA	F603Y	0.13
COAD	chr5	151110645	Splice_Site	NA	X525_splice	0.05
COAD	chr5	151122943	Nonsense_Mutation	NA	Q403*	0.43
COAD	chr5	151117758	Splice_Region	NA	T506T	0.1
COAD	chr5	151139409	Missense_Mutation	rs758088547	R50W	0.28
COAD	chr5	151133118	Missense_Mutation	NA	R206C	0.22
COAD	chr5	151101336	3'UTR	novel		0.38
COAD	chr5	151105264	Missense_Mutation	NA	K607T	0.34
COAD	chr5	151147920	5'UTR	novel		0.33
COAD	chr5	151123003	Missense_Mutation	rs748009214	E383K	0.51
COAD	chr5	151147900	Translation_Start_Site	NA	M1?	0.24
COAD	chr5	151139426	Missense_Mutation	novel	L44Q	0.05
COAD	chr5	151117818	Missense_Mutation	NA	E486D	0.31
COAD	chr5	151101446	3'UTR	novel		0.42
GBM	chr5	151119351	Frame_Shift_Del	novel	*A463Pfs27**	0.12
GBM	chr5	151132528	Silent	NA	A228A	0.33
HNSC	chr5	151119383	Missense_Mutation	novel	G452A	0.07
HNSC	chr5	151132520	Missense_Mutation	rs370325414	R231Q	0.22
HNSC	chr5	151132520	Missense_Mutation	rs370325414	R231Q	0.35
HNSC	chr5	151117833	Nonsense_Mutation	novel	Y481*	0.28
HNSC	chr5	151122979	Missense_Mutation	novel	T391A	0.22
KIRC	chr5	151140171	Missense_Mutation	NA	T31A	0.25
KIRC	chr5	151105302	Frame_Shift_Ins	novel	*Q595Sfs25**	0.05
KIRC	chr5	151105303	Frame_Shift_Ins	novel	*V594Dfs23**	0.05
KIRC	chr5	151140230	Missense_Mutation	rs200516508	R11Q	0.14
LGG	chr5	151108548	Missense_Mutation	novel	F563L	0.38
LGG	chr5	151108493	Missense_Mutation	novel	E581G	0.42
LGG	chr5	151134454	Silent	rs752269503	S173S	0.4
LGG	chr5	151103605	Frame_Shift_Ins	novel	*E643Rfs21**	0.13
LGG	chr5	151103606	Silent	novel	I642I	0.13
LIHC	chr5	151137257	Missense_Mutation	novel	H128R	0.38
LIHC	chr5	151103685	Frame_Shift_Del	novel	*G616Afs7**	0.41
LUAD	chr5	151122214	Missense_Mutation	NA	R427K	0.18
LUAD	chr5	151103661	Missense_Mutation	NA	R624T	0.47
LUAD	chr5	151122953	Missense_Mutation	novel	Q399H	0.15
LUAD	chr5	151128201	Missense_Mutation	novel	K319N	0.61
LUAD	chr5	151129498	Missense_Mutation	novel	R276P	0.43
LUAD	chr5	151129448	Missense_Mutation	novel	F293I	0.26
LUAD	chr5	151103589	Missense_Mutation	NA	S648F	0.15
LUSC	chr5	151117181	Splice_Site	NA	X507_splice	0.28
LUSC	chr5	151134483	Missense_Mutation	NA	G164R	0.3
LUSC	chr5	151105266	Missense_Mutation	NA	D606E	0.39
LUSC	chr5	151134483	Missense_Mutation	NA	G164R	0.26
LUSC	chr5	151139365	Silent	NA	S64S	0.15
LUSC	chr5	151108479	Missense_Mutation	rs201027048	V586I	0.04
LUSC	chr5	151123012	Splice_Site	NA	X380_splice	0.49
LUSC	chr5	151139371	Nonsense_Mutation	novel	Y62*	0.14
OV	chr5	151122195	Missense_Mutation	novel	M433I	0.18
OV	chr5	151122196	Frame_Shift_Ins	novel	*M433Tfs8**	0.17
OV	chr5	151139420	Frame_Shift_Ins	novel	*I46Sfs10**	0.07
OV	chr5	151131283	Missense_Mutation	novel	C248Y	0.05
OV	chr5	151139368	Silent	rs369346632	K63K	0.19
PAAD	chr5	151117825	Missense_Mutation	novel	S484F	0.2
PAAD	chr5	151119347	Missense_Mutation	NA	T464I	0.2
PRAD	chr5	151124286	Missense_Mutation	novel	G380W	0.08
READ	chr5	151105268	Missense_Mutation	rs771610573	D606N	0.34
READ	chr5	151105290	Missense_Mutation	NA	K598N	0.11
READ	chr5	151110633	Missense_Mutation	novel	E528D	0.14
SARC	chr5	151108454	Splice_Site	novel	X594_splice	0.17
SARC	chr5	151101268	3'UTR	novel		0.5
SKCM	chr5	151109813	Missense_Mutation	NA	S542A	0.11
SKCM	chr5	151108460	Missense_Mutation	NA	A592V	0.37
SKCM	chr5	151108518	Missense_Mutation	rs368344684	D573N	0.25
SKCM	chr5	151139365	Silent	NA	S64S	0.19
SKCM	chr5	151132567	Silent	rs376092227	F215F	0.16
SKCM	chr5	151140223	Silent	novel	S13S	0.08
SKCM	chr5	151140160	Silent	NA	K34K	0.23
SKCM	chr5	151105252	Missense_Mutation	novel	S611F	0.52
SKCM	chr5	151132529	Missense_Mutation	NA	A228V	0.48
SKCM	chr5	151122939	Missense_Mutation	NA	T404I	0.96
SKCM	chr5	151122238	Missense_Mutation	novel	S419F	0.26
STAD	chr5	151147884	Missense_Mutation	novel	Q6H	0.25
STAD	chr5	151122946	Missense_Mutation	rs762451507	R402W	0.15
STAD	chr5	151136316	Missense_Mutation	novel	E143D	0.17
STAD	chr5	151126414	Silent	NA	V348V	0.14
STAD	chr5	151105267	Missense_Mutation	NA	D606G	0.08
STAD	chr5	151109766	Silent	rs751215230	P557P	0.27
STAD	chr5	151129516	Missense_Mutation	rs374143469	R270Q	0.53
UCEC	chr5	151105249	Missense_Mutation	rs753583716	M612T	0.43
UCEC	chr5	151117758	Splice_Region	rs377149334	T506T	0.49
UCEC	chr5	151122973	Missense_Mutation	NA	R393C	0.53
UCEC	chr5	151117768	Missense_Mutation	NA	S503Y	0.38
UCEC	chr5	151128216	Missense_Mutation	NA	K314N	0.31
UCEC	chr5	151124312	Missense_Mutation	novel	A371V	0.38
UCEC	chr5	151101305	3'UTR	novel		0.44
UCEC	chr5	151139409	Missense_Mutation	rs758088547	R50W	0.26
UCEC	chr5	151140180	Missense_Mutation	NA	A28T	0.2
UCEC	chr5	151133154	Missense_Mutation	NA	T194A	0.29
UCEC	chr5	151124351	Missense_Mutation	rs545945295	R358H	0.4
UCEC	chr5	151132537	Silent	rs373984263	P225P	0.46
UCEC	chr5	151132567	Silent	rs376092227	F215F	0.32
UCEC	chr5	151137286	Silent	novel	I118I	0.29
UCEC	chr5	151101352	3'UTR	novel		0.41
UCEC	chr5	151101336	3'UTR	novel		0.69
UCEC	chr5	151133178	Missense_Mutation	rs371950946	E186K	0.33
UCEC	chr5	151133117	Missense_Mutation	rs759582371	R206H	0.56
UCEC	chr5	151122231	Silent	novel	I421I	0.43
UCEC	chr5	151133128	Silent	NA	I202I	0.29
UCEC	chr5	151101496	Silent	rs769574021	S658S	0.45
UCEC	chr5	151124318	Missense_Mutation	novel	A369V	0.31
UCEC	chr5	151109766	Silent	rs751215230	P557P	0.2
UCEC	chr5	151132567	Silent	rs376092227	F215F	0.29
UCEC	chr5	151101495	Missense_Mutation	rs747761940	G659R	0.46
UCEC	chr5	151137238	Silent	novel	Y134Y	0.43
UCEC	chr5	151136326	Missense_Mutation	rs781123987	R140Q	0.32
UCEC	chr5	151101465	Missense_Mutation	NA	C669R	0.41
UCEC	chr5	151109797	Missense_Mutation	novel	F547S	0.18
UCEC	chr5	151129456	Missense_Mutation	novel	R290Q	0.27
UCEC	chr5	151105271	Missense_Mutation	NA	A605T	0.23
UCEC	chr5	151117780	Missense_Mutation	NA	R499K	0.12
UCEC	chr5	151136301	Silent	rs775504114	G148G	0.33
UCEC	chr5	151132479	Missense_Mutation	rs199837151	V245I	0.06
UCEC	chr5	151108511	Missense_Mutation	novel	E575V	0.05
UCEC	chr5	151133139	Frame_Shift_Ins	novel	*F199Ifs36**	0.02
UCEC	chr5	151133103	Missense_Mutation	novel	L211I	0.06
UCEC	chr5	151147905	5'UTR	novel		0.04
UCEC	chr5	151117802	Missense_Mutation	novel	D492Y	0.2
UCEC	chr5	151122176	Missense_Mutation	rs540689618	D440N	0.25
UCEC	chr5	151108505	Missense_Mutation	NA	T577I	0.24
UCEC	chr5	151122983	Silent	novel	I389I	0.29
UCEC	chr5	151133118	Missense_Mutation	NA	R206C	0.55
UCEC	chr5	151139380	Silent	novel	C59C	0.4
UCEC	chr5	151124345	Missense_Mutation	novel	A360V	0.41
UCS	chr5	151132520	Missense_Mutation	rs370325414	R231P	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	AMP	0.1042	0.069756
KIRP	DEL	0.0382	0.11554
LAML	DEL	0.0838	1.2971e-07
LUSC	DEL	0.6208	0.002071
MESO	DEL	0.1379	0.20184
PRAD	AMP	0.0244	0.16448
SKCM	DEL	0.297	2.2081e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0078	Kaplan-Meier Survival Analysis
PRAD	0.039	Kaplan-Meier Survival Analysis
LUSC	0.04	Kaplan-Meier Survival Analysis
KIRP	0.012	Kaplan-Meier Survival Analysis
PAAD	0.0013	Kaplan-Meier Survival Analysis
BLCA	0.00053	Kaplan-Meier Survival Analysis
LGG	0.00049	Kaplan-Meier Survival Analysis
LUAD	0.0098	Kaplan-Meier Survival Analysis
OV	0.021	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742