EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197102 (Gene tree)
Gene ID: 1778
Gene Symbol: DYNC1H1
Alias: Dnchc1|HL-3|p22|DHC1|CMT2O|DNECL|DNCL|DNCH1
Full Name: dynein cytoplasmic 1 heavy chain 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 91,934 bases
Position: chr14:101,964,510-102,056,443
Accession: 2961
RBP type: non-canonical RBP
Summary: Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000643684	DYNC1H1-219	7596	-	-	- (aa)	-	-
ENST00000647119	DYNC1H1-237	513	-	-	- (aa)	-	-
ENST00000555800	DYNC1H1-207	476	-	-	- (aa)	-	-
ENST00000645978	DYNC1H1-235	1675	-	ENSP00000495356	355 (aa)	-	A0A2R8Y6I5
ENST00000642882	DYNC1H1-213	2111	-	-	- (aa)	-	-
ENST00000645085	DYNC1H1-231	2397	-	-	- (aa)	-	-
ENST00000556791	DYNC1H1-211	539	-	-	- (aa)	-	-
ENST00000555102	DYNC1H1-205	561	-	-	- (aa)	-	-
ENST00000646418	DYNC1H1-236	2170	-	-	- (aa)	-	-
ENST00000555062	DYNC1H1-204	1374	-	-	- (aa)	-	-
ENST00000556139	DYNC1H1-208	818	-	-	- (aa)	-	-
ENST00000645114	DYNC1H1-232	1376	-	ENSP00000495884	421 (aa)	-	A0A2R8YGC7
ENST00000643958	DYNC1H1-224	1768	-	-	- (aa)	-	-
ENST00000643829	DYNC1H1-223	4050	-	-	- (aa)	-	-
ENST00000642716	DYNC1H1-212	1315	-	-	- (aa)	-	-
ENST00000644239	DYNC1H1-226	2163	-	-	- (aa)	-	-
ENST00000645039	DYNC1H1-230	6217	-	ENSP00000495220	1400 (aa)	-	A0A2R8Y6H2
ENST00000644794	DYNC1H1-227	4842	-	-	- (aa)	-	-
ENST00000647470	DYNC1H1-242	346	-	-	- (aa)	-	-
ENST00000554854	DYNC1H1-203	721	-	-	- (aa)	-	-
ENST00000647366	DYNC1H1-241	7322	-	-	- (aa)	-	-
ENST00000643729	DYNC1H1-221	2863	-	-	- (aa)	-	-
ENST00000647204	DYNC1H1-239	3610	-	ENSP00000494189	1076 (aa)	-	A0A2R8Y542
ENST00000647307	DYNC1H1-240	4416	-	-	- (aa)	-	-
ENST00000360184	DYNC1H1-201	20003	-	ENSP00000348965	4646 (aa)	-	Q14204
ENST00000647143	DYNC1H1-238	2554	-	-	- (aa)	-	-
ENST00000556229	DYNC1H1-209	582	-	-	- (aa)	-	-
ENST00000643764	DYNC1H1-222	3314	-	-	- (aa)	-	-
ENST00000645149	DYNC1H1-233	6050	-	ENSP00000495944	1942 (aa)	-	A0A2R8Y706
ENST00000643591	DYNC1H1-218	2950	-	-	- (aa)	-	-
ENST00000555204	DYNC1H1-206	357	-	-	- (aa)	-	-
ENST00000553423	DYNC1H1-202	1130	-	ENSP00000450674	309 (aa)	-	H0YJ21
ENST00000643508	DYNC1H1-216	5817	-	ENSP00000495528	1686 (aa)	-	A0A2R8YFZ7
ENST00000644888	DYNC1H1-229	968	-	-	- (aa)	-	-
ENST00000643565	DYNC1H1-217	3159	-	-	- (aa)	-	-
ENST00000643722	DYNC1H1-220	4102	-	-	- (aa)	-	-
ENST00000645697	DYNC1H1-234	3547	-	-	- (aa)	-	-
ENST00000556499	DYNC1H1-210	1409	-	-	- (aa)	-	-
ENST00000643279	DYNC1H1-214	2845	-	-	- (aa)	-	-
ENST00000644881	DYNC1H1-228	4786	-	ENSP00000495022	1476 (aa)	-	A0A2R8Y5T0
ENST00000644206	DYNC1H1-225	1919	-	-	- (aa)	-	-
ENST00000643437	DYNC1H1-215	4773	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000197102's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04145	Phagosome	KEGG
hsa04962	Vasopressin-regulated water reabsorption	KEGG
hsa05132	Salmonella infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000197102	Blood Pressure	2.7300000E-005	-
ENSG00000197102	Child Development Disorders, Pervasive	1.7676400E-005	-
ENSG00000197102	Lithium	3.4747400E-005	-
ENSG00000197102	Menopause	3E-6	19448619

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000197102	rs4906172	14	101988596	?	Menopause (age at onset)	19448619	[0.21-0.51] years decrease	0.36	EFO_0004704

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197102's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197102	DYNC1H1	99	77.527	FBgn0261797	Dhc64C	99	71.909	Drosophila_melanogaster
ENSG00000197102	DYNC1H1	100	99.161	ENSMUSG00000018707	Dync1h1	100	99.161	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	17043677.17500595.17548833.21163940.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005813	centrosome	21399614.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005868	cytoplasmic dynein complex	21873635.	IBA	Component
GO:0005868	cytoplasmic dynein complex	21723285.25272277.	IDA	Component
GO:0005868	cytoplasmic dynein complex	8666668.	NAS	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0007018	microtubule-based movement	21873635.	IBA	Process
GO:0007052	mitotic spindle organization	8227145.	NAS	Process
GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed	21873635.	IBA	Function
GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed	21723285.	IDA	Function
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0030175	filopodium	-	IEA	Component
GO:0030286	dynein complex	21873635.	IBA	Component
GO:0031122	cytoplasmic microtubule organization	21873635.	IBA	Process
GO:0032388	positive regulation of intracellular transport	27462074.	IMP	Process
GO:0033962	cytoplasmic mRNA processing body assembly	-	ISS	Process
GO:0034063	stress granule assembly	-	ISS	Process
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045503	dynein light chain binding	21873635.	IBA	Function
GO:0045505	dynein intermediate chain binding	21873635.	IBA	Function
GO:0051293	establishment of spindle localization	23027904.	IMP	Process
GO:0051301	cell division	-	IEA	Process
GO:0051959	dynein light intermediate chain binding	21873635.	IBA	Function
GO:0051959	dynein light intermediate chain binding	25272277.	IPI	Function
GO:0060236	regulation of mitotic spindle organization	23027904.	IMP	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.21362503.23533145.	HDA	Component
GO:0072382	minus-end-directed vesicle transport along microtubule	21873635.	IBA	Process
GO:0090235	regulation of metaphase plate congression	27462074.	IMP	Process
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process
GO:0120162	positive regulation of cold-induced thermogenesis	20887786.	ISS	Process
GO:1905832	positive regulation of spindle assembly	27462074.	IMP	Process