EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197114 (Gene tree)
Gene ID: 84619
Gene Symbol: ZGPAT
Alias: dJ583P15.3|MGC44880|FLJ14972|ZC3HDC9|ZC3H9|GPATC6|GPATCH6|ZIP|KIAA1847
Full Name: zinc finger CCCH-type and G-patch domain containing
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 28,701 bases
Position: chr20:63,707,442-63,736,142
Accession: 15948
RBP type: canonical RBP
Summary: (Zinc Finger CCCH-Type And G-Patch Domain Containing) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and sequence-specific DNA binding. An important paralog of this gene is ENSG00000273154.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000349634	G-patch	PF01585.23	2.2e-11	1	1
ENSP00000348242	G-patch	PF01585.23	2.2e-11	1	1
ENSP00000358984	G-patch	PF01585.23	2.2e-11	1	1
ENSP00000391176	G-patch	PF01585.23	2.2e-11	1	1
ENSP00000332013	G-patch	PF01585.23	2.4e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28878014	Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.	J Biol Chem	2017 Nov 3	Chen Z	doi: 10.1074/jbc.M117.797357

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000431125	ZGPAT-205	427	-	ENSP00000403966	97 (aa)	-	X6RGY1
ENST00000478385	ZGPAT-210	935	-	-	- (aa)	-	-
ENST00000484569	ZGPAT-211	749	-	-	- (aa)	-	-
ENST00000448100	ZGPAT-206	1881	-	ENSP00000391176	511 (aa)	-	Q8N5A5
ENST00000472711	ZGPAT-208	787	-	-	- (aa)	-	-
ENST00000477340	ZGPAT-209	2831	-	-	- (aa)	-	-
ENST00000468235	ZGPAT-207	594	-	-	- (aa)	-	-
ENST00000357119	ZGPAT-203	1896	-	ENSP00000349634	502 (aa)	-	Q8N5A5
ENST00000328969	ZGPAT-201	1945	-	ENSP00000332013	531 (aa)	-	Q8N5A5
ENST00000355969	ZGPAT-202	1871	-	ENSP00000348242	511 (aa)	-	Q8N5A5
ENST00000369967	ZGPAT-204	1890	-	ENSP00000358984	511 (aa)	-	Q8N5A5

Gene Model

Click here to download ENSG00000197114's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000197114	Body Height	3.3110000E-006	-
ENSG00000197114	Inflammatory Bowel Diseases	1E-23	23128233
ENSG00000197114	Prostatic Neoplasms	4E-16	23535732
ENSG00000197114	Inflammatory Bowel Diseases	9E-15	18758464
ENSG00000197114	Colitis, Ulcerative	1E-8	26192919
ENSG00000197114	Crohn Disease	8E-17	26192919
ENSG00000197114	Crohn Disease	3E-15	21102463
ENSG00000197114	Forced Expiratory Volume	4E-13	28166213

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000197114	rs4809330	20	63718234	G	Crohn's disease	21102463	[1.06-1.18]	1.12	EFO_0000384
ENSG00000197114	rs6062509	20	63731211	A	Prostate cancer	23535732	[1.09-1.16]	1.12	EFO_0001663
ENSG00000197114	rs6062504	20	63717555	G	Ulcerative colitis	26192919		1.0814869	EFO_0000729
ENSG00000197114	rs6062504	20	63717555	A	Crohn's disease	26192919		1.1168494	EFO_0000384
ENSG00000197114	rs62217798	20	63715837	T	Blood protein levels	29875488	[0.16-0.28] unit decrease	0.22	EFO_0007937
ENSG00000197114	rs72448466	20	63732289	?	Lung function (FEV1)	28166213	[0.022-0.038] unit decrease	0.03	EFO_0004314
ENSG00000197114	rs2315008	20	63712604	G	Inflammatory bowel disease	18758464	[1.05-1.76]	1.36	EFO_0003767
ENSG00000197114	rs6062504	20	63717555	G	Inflammatory bowel disease	23128233	[1.071-1.139]	1.104	EFO_0003767
ENSG00000197114	rs6062498	20	63707707	G	Age of smoking initiation (MTAG)	30643251	[0.0069-0.013] unit decrease	0.00993772	EFO_0005670
ENSG00000197114	rs3761123	20	63711116	A	Smoking cessation (MTAG)	30643251	[0.0091-0.0156] unit increase	0.0123519	EFO_0004319
ENSG00000197114	rs6062509	20	63731211	T	Prostate cancer	29892016	[1.06-1.10]	1.08	EFO_0001663
ENSG00000197114	rs2315008	20	63712604	T	C-reactive protein levels	30388399	[0.015-0.031] unit decrease	0.023	EFO_0004458

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197114's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197114	ZGPAT	100	52.975	ENSAPOG00000001732	zgpat	100	52.453	Acanthochromis_polyacanthus
ENSG00000197114	ZGPAT	100	79.497	ENSAMEG00000001752	-	100	78.530	Ailuropoda_melanoleuca
ENSG00000197114	ZGPAT	100	51.515	ENSACIG00000015939	zgpat	100	51.124	Amphilophus_citrinellus
ENSG00000197114	ZGPAT	100	52.281	ENSAOCG00000014437	zgpat	100	51.880	Amphiprion_ocellaris
ENSG00000197114	ZGPAT	100	52.281	ENSAPEG00000006555	zgpat	100	52.068	Amphiprion_percula
ENSG00000197114	ZGPAT	100	52.134	ENSATEG00000003346	zgpat	100	50.919	Anabas_testudineus
ENSG00000197114	ZGPAT	100	64.232	ENSAPLG00000014707	-	100	64.193	Anas_platyrhynchos
ENSG00000197114	ZGPAT	91	61.992	ENSACAG00000012278	-	100	61.323	Anolis_carolinensis
ENSG00000197114	ZGPAT	100	92.188	ENSANAG00000035708	ZGPAT	100	92.773	Aotus_nancymaae
ENSG00000197114	ZGPAT	100	51.970	ENSACLG00000013778	zgpat	100	53.084	Astatotilapia_calliptera
ENSG00000197114	ZGPAT	100	46.904	ENSAMXG00000018583	zgpat	100	48.037	Astyanax_mexicanus
ENSG00000197114	ZGPAT	100	79.806	ENSBTAG00000007498	ZGPAT	100	78.641	Bos_taurus
ENSG00000197114	ZGPAT	100	90.310	ENSCJAG00000010398	ZGPAT	100	90.891	Callithrix_jacchus
ENSG00000197114	ZGPAT	99	76.641	ENSCAFG00000013056	ZGPAT	99	75.670	Canis_familiaris
ENSG00000197114	ZGPAT	100	76.482	ENSCAFG00020001956	-	100	75.717	Canis_lupus_dingo
ENSG00000197114	ZGPAT	100	80.000	ENSCHIG00000026209	-	100	78.835	Capra_hircus
ENSG00000197114	ZGPAT	96	81.363	ENSTSYG00000000795	ZGPAT	97	81.000	Carlito_syrichta
ENSG00000197114	ZGPAT	54	85.417	ENSCAPG00000009466	-	100	85.417	Cavia_aperea
ENSG00000197114	ZGPAT	100	79.537	ENSCPOG00000014427	ZGPAT	100	79.651	Cavia_porcellus
ENSG00000197114	ZGPAT	100	92.383	ENSCCAG00000035441	ZGPAT	100	92.773	Cebus_capucinus
ENSG00000197114	ZGPAT	100	97.065	ENSCATG00000034076	ZGPAT	100	97.065	Cercocebus_atys
ENSG00000197114	ZGPAT	100	82.171	ENSCLAG00000004087	ZGPAT	100	81.589	Chinchilla_lanigera
ENSG00000197114	ZGPAT	100	95.669	ENSCSAG00000016628	ZGPAT	100	95.669	Chlorocebus_sabaeus
ENSG00000197114	ZGPAT	66	68.246	ENSCHOG00000013646	-	84	68.246	Choloepus_hoffmanni
ENSG00000197114	ZGPAT	100	64.312	ENSCPBG00000014736	-	99	62.862	Chrysemys_picta_bellii
ENSG00000197114	ZGPAT	100	97.260	ENSCANG00000041082	ZGPAT	100	97.260	Colobus_angolensis_palliatus
ENSG00000197114	ZGPAT	100	79.183	ENSCGRG00001011442	Zgpat	100	79.961	Cricetulus_griseus_chok1gshd
ENSG00000197114	ZGPAT	98	74.737	ENSCGRG00000014321	Zgpat	100	71.790	Cricetulus_griseus_crigri
ENSG00000197114	ZGPAT	100	48.529	ENSCSEG00000002301	zgpat	100	49.341	Cynoglossus_semilaevis
ENSG00000197114	ZGPAT	100	52.363	ENSCVAG00000007255	zgpat	100	53.131	Cyprinodon_variegatus
ENSG00000197114	ZGPAT	100	49.529	ENSDARG00000027403	zgpat	100	49.905	Danio_rerio
ENSG00000197114	ZGPAT	100	79.457	ENSDNOG00000025874	-	100	78.876	Dasypus_novemcinctus
ENSG00000197114	ZGPAT	95	77.732	ENSDORG00000001360	Zgpat	100	77.347	Dipodomys_ordii
ENSG00000197114	ZGPAT	93	40.038	ENSEBUG00000009006	ZGPAT	99	39.847	Eptatretus_burgeri
ENSG00000197114	ZGPAT	100	71.374	ENSEASG00005023159	-	100	71.947	Equus_asinus_asinus
ENSG00000197114	ZGPAT	100	74.659	ENSECAG00000019674	-	100	74.464	Equus_caballus
ENSG00000197114	ZGPAT	100	50.560	ENSELUG00000003733	zgpat	100	49.067	Esox_lucius
ENSG00000197114	ZGPAT	100	78.447	ENSFCAG00000001173	-	100	77.670	Felis_catus
ENSG00000197114	ZGPAT	100	62.681	ENSFALG00000005924	-	100	64.457	Ficedula_albicollis
ENSG00000197114	ZGPAT	100	80.000	ENSFDAG00000002974	ZGPAT	100	79.806	Fukomys_damarensis
ENSG00000197114	ZGPAT	100	51.296	ENSFHEG00000009966	zgpat	100	53.383	Fundulus_heteroclitus
ENSG00000197114	ZGPAT	100	63.291	ENSGALG00000006092	-	100	61.939	Gallus_gallus
ENSG00000197114	ZGPAT	100	49.907	ENSGAFG00000020149	zgpat	100	50.657	Gambusia_affinis
ENSG00000197114	ZGPAT	100	51.119	ENSGACG00000004662	zgpat	100	50.375	Gasterosteus_aculeatus
ENSG00000197114	ZGPAT	100	63.755	ENSGAGG00000019510	-	99	62.319	Gopherus_agassizii
ENSG00000197114	ZGPAT	100	99.247	ENSGGOG00000004801	ZGPAT	100	99.247	Gorilla_gorilla
ENSG00000197114	ZGPAT	100	51.128	ENSHBUG00000010362	zgpat	100	52.897	Haplochromis_burtoni
ENSG00000197114	ZGPAT	100	77.863	ENSHGLG00000014870	ZGPAT	100	77.863	Heterocephalus_glaber_female
ENSG00000197114	ZGPAT	100	80.312	ENSHGLG00100003927	ZGPAT	100	80.312	Heterocephalus_glaber_male
ENSG00000197114	ZGPAT	100	51.631	ENSHCOG00000004674	zgpat	100	52.023	Hippocampus_comes
ENSG00000197114	ZGPAT	100	49.060	ENSIPUG00000012890	zgpat	100	49.719	Ictalurus_punctatus
ENSG00000197114	ZGPAT	95	77.710	ENSSTOG00000011986	ZGPAT	100	77.710	Ictidomys_tridecemlineatus
ENSG00000197114	ZGPAT	97	76.596	ENSJJAG00000008007	-	100	72.957	Jaculus_jaculus
ENSG00000197114	ZGPAT	100	80.934	ENSJJAG00000018714	-	100	80.739	Jaculus_jaculus
ENSG00000197114	ZGPAT	100	51.210	ENSKMAG00000006523	zgpat	100	51.402	Kryptolebias_marmoratus
ENSG00000197114	ZGPAT	100	50.844	ENSLBEG00000016259	zgpat	100	51.589	Labrus_bergylta
ENSG00000197114	ZGPAT	100	56.204	ENSLACG00000002661	zgpat	100	57.328	Latimeria_chalumnae
ENSG00000197114	ZGPAT	100	56.629	ENSLOCG00000001659	zgpat	100	56.818	Lepisosteus_oculatus
ENSG00000197114	ZGPAT	100	97.652	ENSMFAG00000001467	ZGPAT	100	97.652	Macaca_fascicularis
ENSG00000197114	ZGPAT	100	97.456	ENSMMUG00000000171	ZGPAT	100	97.456	Macaca_mulatta
ENSG00000197114	ZGPAT	100	97.456	ENSMNEG00000019568	ZGPAT	100	97.456	Macaca_nemestrina
ENSG00000197114	ZGPAT	100	97.847	ENSMLEG00000035416	ZGPAT	100	97.847	Mandrillus_leucophaeus
ENSG00000197114	ZGPAT	100	51.210	ENSMAMG00000008266	zgpat	100	50.652	Mastacembelus_armatus
ENSG00000197114	ZGPAT	100	52.841	ENSMZEG00005021620	zgpat	100	52.642	Maylandia_zebra
ENSG00000197114	ZGPAT	100	63.196	ENSMGAG00000006823	-	100	60.946	Meleagris_gallopavo
ENSG00000197114	ZGPAT	100	79.142	ENSMAUG00000017248	Zgpat	100	80.117	Mesocricetus_auratus
ENSG00000197114	ZGPAT	100	86.240	ENSMICG00000033269	ZGPAT	100	86.047	Microcebus_murinus
ENSG00000197114	ZGPAT	100	78.988	ENSMOCG00000001324	Zgpat	100	79.767	Microtus_ochrogaster
ENSG00000197114	ZGPAT	100	51.248	ENSMMOG00000014951	zgpat	100	51.577	Mola_mola
ENSG00000197114	ZGPAT	92	67.223	ENSMODG00000017016	-	88	67.015	Monodelphis_domestica
ENSG00000197114	ZGPAT	100	49.231	ENSMALG00000006584	zgpat	100	48.399	Monopterus_albus
ENSG00000197114	ZGPAT	100	79.264	MGP_CAROLIEiJ_G0024806	Zgpat	100	79.845	Mus_caroli
ENSG00000197114	ZGPAT	100	79.727	ENSMUSG00000027582	Zgpat	100	79.922	Mus_musculus
ENSG00000197114	ZGPAT	100	79.029	MGP_PahariEiJ_G0026254	Zgpat	100	79.612	Mus_pahari
ENSG00000197114	ZGPAT	100	80.078	MGP_SPRETEiJ_G0025732	Zgpat	100	80.078	Mus_spretus
ENSG00000197114	ZGPAT	100	77.079	ENSMLUG00000005264	-	100	76.895	Myotis_lucifugus
ENSG00000197114	ZGPAT	100	51.887	ENSNBRG00000021521	zgpat	100	52.247	Neolamprologus_brichardi
ENSG00000197114	ZGPAT	99	96.875	ENSNLEG00000010146	ZGPAT	100	94.727	Nomascus_leucogenys
ENSG00000197114	ZGPAT	95	63.043	ENSMEUG00000011946	-	100	58.036	Notamacropus_eugenii
ENSG00000197114	ZGPAT	62	73.375	ENSOPRG00000002115	-	100	74.613	Ochotona_princeps
ENSG00000197114	ZGPAT	100	81.287	ENSODEG00000006562	ZGPAT	100	80.897	Octodon_degus
ENSG00000197114	ZGPAT	100	51.673	ENSONIG00000009365	zgpat	100	52.593	Oreochromis_niloticus
ENSG00000197114	ZGPAT	100	69.011	ENSOANG00000004932	-	100	69.434	Ornithorhynchus_anatinus
ENSG00000197114	ZGPAT	64	76.106	ENSOCUG00000008687	-	100	76.991	Oryctolagus_cuniculus
ENSG00000197114	ZGPAT	100	51.894	ENSORLG00000000880	zgpat	100	52.919	Oryzias_latipes
ENSG00000197114	ZGPAT	100	52.083	ENSORLG00020004339	zgpat	100	53.107	Oryzias_latipes_hni
ENSG00000197114	ZGPAT	100	51.894	ENSORLG00015018532	zgpat	100	52.919	Oryzias_latipes_hsok
ENSG00000197114	ZGPAT	100	54.771	ENSOMEG00000014655	zgpat	100	52.256	Oryzias_melastigma
ENSG00000197114	ZGPAT	100	81.346	ENSOGAG00000034509	ZGPAT	100	80.577	Otolemur_garnettii
ENSG00000197114	ZGPAT	98	78.947	ENSOARG00000010128	ZGPAT	100	73.675	Ovis_aries
ENSG00000197114	ZGPAT	100	99.435	ENSPPAG00000027831	ZGPAT	100	99.435	Pan_paniscus
ENSG00000197114	ZGPAT	100	78.835	ENSPPRG00000024151	-	100	77.670	Panthera_pardus
ENSG00000197114	ZGPAT	100	78.835	ENSPTIG00000020325	-	100	77.670	Panthera_tigris_altaica
ENSG00000197114	ZGPAT	100	99.435	ENSPTRG00000013750	ZGPAT	100	99.435	Pan_troglodytes
ENSG00000197114	ZGPAT	100	94.915	ENSPANG00000005904	ZGPAT	100	94.915	Papio_anubis
ENSG00000197114	ZGPAT	100	52.214	ENSPKIG00000012056	zgpat	100	53.061	Paramormyrops_kingsleyae
ENSG00000197114	ZGPAT	100	63.720	ENSPSIG00000015801	-	100	63.129	Pelodiscus_sinensis
ENSG00000197114	ZGPAT	100	51.803	ENSPMGG00000014856	zgpat	100	51.423	Periophthalmus_magnuspinnatus
ENSG00000197114	ZGPAT	100	80.312	ENSPEMG00000015676	Zgpat	100	80.312	Peromyscus_maniculatus_bairdii
ENSG00000197114	ZGPAT	100	67.816	ENSPCIG00000017922	-	100	67.625	Phascolarctos_cinereus
ENSG00000197114	ZGPAT	100	52.174	ENSPFOG00000010326	zgpat	100	53.612	Poecilia_formosa
ENSG00000197114	ZGPAT	100	52.273	ENSPLAG00000002135	zgpat	100	53.802	Poecilia_latipinna
ENSG00000197114	ZGPAT	100	51.789	ENSPMEG00000019064	zgpat	100	53.612	Poecilia_mexicana
ENSG00000197114	ZGPAT	100	51.515	ENSPREG00000010919	zgpat	100	52.652	Poecilia_reticulata
ENSG00000197114	ZGPAT	100	97.847	ENSPPYG00000011246	ZGPAT	100	97.847	Pongo_abelii
ENSG00000197114	ZGPAT	70	71.154	ENSPCAG00000001883	-	99	72.055	Procavia_capensis
ENSG00000197114	ZGPAT	100	86.127	ENSPCOG00000012369	ZGPAT	100	86.127	Propithecus_coquereli
ENSG00000197114	ZGPAT	100	73.981	ENSPVAG00000013489	-	100	74.175	Pteropus_vampyrus
ENSG00000197114	ZGPAT	100	52.601	ENSPNYG00000013216	zgpat	100	52.975	Pundamilia_nyererei
ENSG00000197114	ZGPAT	100	48.204	ENSPNAG00000012769	zgpat	100	48.771	Pygocentrus_nattereri
ENSG00000197114	ZGPAT	100	78.752	ENSRNOG00000014235	Zgpat	100	78.752	Rattus_norvegicus
ENSG00000197114	ZGPAT	100	97.260	ENSRBIG00000034134	ZGPAT	100	97.260	Rhinopithecus_bieti
ENSG00000197114	ZGPAT	100	97.652	ENSRROG00000039084	ZGPAT	100	97.652	Rhinopithecus_roxellana
ENSG00000197114	ZGPAT	100	91.211	ENSSBOG00000028752	ZGPAT	100	91.211	Saimiri_boliviensis_boliviensis
ENSG00000197114	ZGPAT	100	66.667	ENSSHAG00000017828	-	100	66.475	Sarcophilus_harrisii
ENSG00000197114	ZGPAT	100	50.730	ENSSFOG00015000739	zgpat	100	50.275	Scleropages_formosus
ENSG00000197114	ZGPAT	100	49.907	ENSSMAG00000006646	zgpat	100	50.466	Scophthalmus_maximus
ENSG00000197114	ZGPAT	100	50.093	ENSSDUG00000014684	zgpat	100	50.369	Seriola_dumerili
ENSG00000197114	ZGPAT	100	49.630	ENSSLDG00000019446	zgpat	100	51.124	Seriola_lalandi_dorsalis
ENSG00000197114	ZGPAT	100	62.523	ENSSPUG00000018516	-	100	62.976	Sphenodon_punctatus
ENSG00000197114	ZGPAT	100	52.319	ENSSPAG00000022473	zgpat	100	52.799	Stegastes_partitus
ENSG00000197114	ZGPAT	100	78.641	ENSSSCG00000036595	-	100	78.641	Sus_scrofa
ENSG00000197114	ZGPAT	100	67.495	ENSTGUG00000007115	-	100	67.304	Taeniopygia_guttata
ENSG00000197114	ZGPAT	100	52.150	ENSTRUG00000010488	zgpat	100	51.407	Takifugu_rubripes
ENSG00000197114	ZGPAT	100	51.679	ENSTNIG00000004165	zgpat	100	50.933	Tetraodon_nigroviridis
ENSG00000197114	ZGPAT	98	83.158	ENSTTRG00000012223	-	71	79.564	Tursiops_truncatus
ENSG00000197114	ZGPAT	100	80.388	ENSUAMG00000009298	-	100	79.417	Ursus_americanus
ENSG00000197114	ZGPAT	100	80.702	ENSUMAG00000022033	-	100	80.312	Ursus_maritimus
ENSG00000197114	ZGPAT	100	75.146	ENSVVUG00000015014	-	100	74.854	Vulpes_vulpes
ENSG00000197114	ZGPAT	100	53.220	ENSXMAG00000004759	zgpat	100	53.220	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	19644445.	IDA	Process
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	19644445.	IDA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	19644445.	IDA	Function
GO:0003700	DNA-binding transcription factor activity	21873635.	IBA	Function
GO:0003700	DNA-binding transcription factor activity	19644445.	IDA	Function
GO:0005515	protein binding	19644445.21516116.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	19644445.	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	19644445.	IDA	Process
GO:0043565	sequence-specific DNA binding	19644445.	IDA	Function
GO:0045892	negative regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0045892	negative regulation of transcription, DNA-templated	19644445.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function