EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197170 (Gene tree)
Gene ID: 5718
Gene Symbol: PSMD12
Alias: p55|Rpn5
Full Name: proteasome 26S subunit, non-ATPase 12
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 28,712 bases
Position: chr17:67,337,916-67,366,627
Accession: 9557
RBP type: non-canonical RBP
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000357146	PSMD12-202	2437	XM_024450843	ENSP00000349667	436 (aa)	XP_024306611	O00232
ENST00000577724	PSMD12-203	377	-	-	- (aa)	-	-
ENST00000581618	PSMD12-206	613	-	-	- (aa)	-	-
ENST00000584008	PSMD12-207	1752	-	ENSP00000462525	42 (aa)	-	J3KSK1
ENST00000578015	PSMD12-204	448	-	-	- (aa)	-	-
ENST00000356126	PSMD12-201	4406	XM_024450842	ENSP00000348442	456 (aa)	XP_024306610	O00232
ENST00000584289	PSMD12-208	1090	-	-	- (aa)	-	-
ENST00000579365	PSMD12-205	560	-	ENSP00000463017	38 (aa)	-	J3KTJ5

Gene Model

Click here to download ENSG00000197170's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03050	Proteasome	KEGG
hsa05169	Epstein-Barr virus infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000197170	Platelet Function Tests	3.2000000E-006	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197170's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197170	PSMD12	97	41.124	YDL147W	RPN5	98	41.124	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0000502	proteasome complex	17323924.	IDA	Component
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	Process
GO:0005576	extracellular region	-	TAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005838	proteasome regulatory particle	9426256.	TAS	Component
GO:0006521	regulation of cellular amino acid metabolic process	-	TAS	Process
GO:0008541	proteasome regulatory particle, lid subcomplex	21873635.	IBA	Component
GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0022624	proteasome accessory complex	-	ISS	Component
GO:0031145	anaphase-promoting complex-dependent catabolic process	-	TAS	Process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0031595	nuclear proteasome complex	21873635.	IBA	Component
GO:0033209	tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0038061	NIK/NF-kappaB signaling	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	-	TAS	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043488	regulation of mRNA stability	-	TAS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0060071	Wnt signaling pathway, planar cell polarity pathway	-	TAS	Process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-	TAS	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0070498	interleukin-1-mediated signaling pathway	-	TAS	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	-	TAS	Process
GO:1901990	regulation of mitotic cell cycle phase transition	-	TAS	Process
GO:1902036	regulation of hematopoietic stem cell differentiation	-	TAS	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component