EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000197321 (Gene tree)
Gene ID: 6840
Gene Symbol: SVIL
Alias: N
Full Name: supervillin
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 279,598 bases
Position: chr10:29,457,338-29,736,935
Accession: 11480
RBP type: non-canonical RBP
Summary: This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000464984	SVIL-206	645	-	-	- (aa)	-	-
ENST00000375398	SVIL-202	8201	XM_024448141	ENSP00000364547	2182 (aa)	XP_024303909	O95425
ENST00000483758	SVIL-210	262	-	-	- (aa)	-	-
ENST00000491872	SVIL-212	454	-	-	- (aa)	-	-
ENST00000490031	SVIL-211	190	-	-	- (aa)	-	-
ENST00000482607	SVIL-209	368	-	-	- (aa)	-	-
ENST00000355867	SVIL-201	7586	XM_005252570	ENSP00000348128	2214 (aa)	XP_005252627	O95425
ENST00000464726	SVIL-205	287	-	-	- (aa)	-	-
ENST00000465422	SVIL-207	196	-	-	- (aa)	-	-
ENST00000375400	SVIL-203	6729	XM_024448147	ENSP00000364549	1788 (aa)	XP_024303915	O95425
ENST00000474106	SVIL-208	622	-	-	- (aa)	-	-
ENST00000632315	SVIL-213	2889	-	ENSP00000488171	963 (aa)	-	A0A0J9YWY6
ENST00000460007	SVIL-204	779	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000197321's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000197321	Body Mass Index	7.27829925104861E-5	17903300
ENSG00000197321	Receptors, Tumor Necrosis Factor, Type II	6.9790165024076E-5	17903293
ENSG00000197321	Body Height	6.7970000E-005	-
ENSG00000197321	Body Height	7.7690000E-005	-
ENSG00000197321	Body Height	3.6160000E-005	-
ENSG00000197321	Diabetes Mellitus	6.5410000E-009	-
ENSG00000197321	Diabetes Mellitus	6.5410000E-009	-
ENSG00000197321	Diabetes Mellitus	1.4120000E-006	-
ENSG00000197321	Diabetes Mellitus	7.1750000E-006	-
ENSG00000197321	Cell Adhesion Molecules	1.6030000E-006	-
ENSG00000197321	Cholesterol, LDL	6.6870000E-005	-
ENSG00000197321	Cholesterol, LDL	7.6280000E-005	-
ENSG00000197321	Cholesterol	1.1450000E-005	-
ENSG00000197321	Cholesterol	1.0780000E-005	-
ENSG00000197321	Warfarin	4.7540000E-005	-
ENSG00000197321	Blood Platelets	4E-8	22550155
ENSG00000197321	Thrombosis	4E-8	22550155
ENSG00000197321	Multiple Sclerosis	8E-6	19010793

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000197321	rs7070678	10	29523673	?	Platelet thrombus formation	22550155	[0.0044-0.0092] unit decrease	0.006807	EFO_0004985\|EFO_0007615
ENSG00000197321	rs1927457	10	29719734	?	Normalized brain volume	19010793	[NR]		EFO_0003885
ENSG00000197321	rs12775980	10	29570927	A	Bone fracture in osteoporosis	28580392	[1.61-2.79] unit increase	2.12	EFO_0003931\|EFO_0003882
ENSG00000197321	rs11007604	10	29469586	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000197321	rs7098831	10	29728119	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197321's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002102	podosome	-	IEA	Component
GO:0005515	protein binding	18639526.	IPI	Function
GO:0005634	nucleus	12711699.	IDA	Component
GO:0005737	cytoplasm	12711699.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	12711699.	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0007010	cytoskeleton organization	-	IEA	Process
GO:0007519	skeletal muscle tissue development	12711699.	IMP	Process
GO:0015629	actin cytoskeleton	-	IDA	Component
GO:0015629	actin cytoskeleton	9867483.	NAS	Component
GO:0030496	midbody	-	ISS	Component
GO:0032154	cleavage furrow	-	ISS	Component
GO:0032467	positive regulation of cytokinesis	-	ISS	Process
GO:0036449	microtubule minus-end	-	ISS	Component
GO:0043034	costamere	12711699.	IDA	Component
GO:0051015	actin filament binding	12711699.	IDA	Function
GO:0071437	invadopodium	-	IEA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23382381	Supervillin-mediated suppression of p53 protein enhances cell survival.	J Biol Chem	2013 Mar 15	Fang Z	doi: 10.1074/jbc.M112.416842

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr10	29529724	Nonsense_Mutation	novel	E743*	0.4
BLCA	chr10	29524501	Nonsense_Mutation	novel	Q853*	0.39
BLCA	chr10	29487296	Missense_Mutation	NA	R1451T	0.27
BLCA	chr10	29532550	Missense_Mutation	NA	N606I	0.24
BLCA	chr10	29488692	Silent	NA	S1419S	0.33
BLCA	chr10	29532687	Missense_Mutation	novel	L560F	0.19
BLCA	chr10	29523722	Silent	novel	E964E	0.06
BLCA	chr10	29532845	Missense_Mutation	novel	E508K	0.15
BLCA	chr10	29524673	Missense_Mutation	novel	Q795H	0.2
BLCA	chr10	29532035	Missense_Mutation	NA	P659H	0.12
BLCA	chr10	29458250	Silent	NA	F2214F	0.06
BLCA	chr10	29473971	Missense_Mutation	novel	G1799E	0.14
BLCA	chr10	29531280	Nonsense_Mutation	NA	S673*	0.16
BLCA	chr10	29532934	Missense_Mutation	novel	G478V	0.29
BLCA	chr10	29471236	Missense_Mutation	NA	V1846D	0.59
BLCA	chr10	29458487	Missense_Mutation	novel	E2169Q	0.47
BLCA	chr10	29551206	Missense_Mutation	novel	S73F	0.27
BLCA	chr10	29533128	Silent	rs77837604	D413D	0.32
BLCA	chr10	29488689	Frame_Shift_Del	novel	*N1420Kfs9**	0.15
BLCA	chr10	29532653	Missense_Mutation	novel	E572Q	0.48
BLCA	chr10	29550942	Missense_Mutation	novel	R161K	0.17
BLCA	chr10	29529823	Nonsense_Mutation	novel	E710*	0.48
BLCA	chr10	29523569	Silent	rs573451026	P1015P	0.42
BLCA	chr10	29545061	Intron	NA		0.23
BLCA	chr10	29523861	Missense_Mutation	rs745851162	S918L	0.14
BLCA	chr10	29535997	Nonsense_Mutation	rs773614292	W300*	0.37
BLCA	chr10	29532725	Silent	novel	L548L	0.07
BLCA	chr10	29527033	Missense_Mutation	novel	S757C	0.24
BLCA	chr10	29523572	Silent	novel	E1014E	0.17
BLCA	chr10	29524511	Frame_Shift_Del	novel	*S834Kfs25**	0.1
BLCA	chr10	29532072	Missense_Mutation	novel	E647Q	0.3
BLCA	chr10	29458448	Missense_Mutation	rs147020336	D2182N	0.1
BLCA	chr10	29522440	Missense_Mutation	NA	S1120L	0.53
BLCA	chr10	29524629	Missense_Mutation	rs747601597	S810F	0.18
BLCA	chr10	29532026	Missense_Mutation	novel	S662L	0.19
BLCA	chr10	29523610	Missense_Mutation	novel	E1002Q	0.19
BLCA	chr10	29463505	Silent	NA	L2088L	0.23
BRCA	chr10	29527008	Silent	rs376791749	A765A	0.17
BRCA	chr10	29550851	Silent	rs200054252	D191D	0.39
BRCA	chr10	29550659	Missense_Mutation	novel	Q255H	0.06
BRCA	chr10	29522604	Missense_Mutation	novel	Q1065H	0.2
BRCA	chr10	29523930	Missense_Mutation	rs777510006	R895H	0.84
BRCA	chr10	29524666	Missense_Mutation	novel	E798K	0.3
BRCA	chr10	29550741	Missense_Mutation	NA	S228L	0.25
BRCA	chr10	29524507	Nonsense_Mutation	NA	Q851*	0.4
BRCA	chr10	29490873	Missense_Mutation	novel	E1389G	0.05
BRCA	chr10	29473950	Missense_Mutation	novel	A1806G	0.32
BRCA	chr10	29533319	Missense_Mutation	NA	D350H	0.16
BRCA	chr10	29463574	Silent	novel	E2065E	0.27
BRCA	chr10	29470349	Missense_Mutation	NA	L1924M	0.2
BRCA	chr10	29457813	3'Flank	novel		0.25
BRCA	chr10	29524512	Missense_Mutation	NA	R849H	0.2
BRCA	chr10	29486450	Missense_Mutation	NA	K1531N	0.23
BRCA	chr10	29471244	Splice_Site	novel	X1844_splice	0.29
BRCA	chr10	29458553	Missense_Mutation	NA	D2147H	0.14
BRCA	chr10	29486465	Missense_Mutation	novel	H1526Q	0.09
BRCA	chr10	29523861	Missense_Mutation	rs745851162	S918L	0.09
BRCA	chr10	29524675	Missense_Mutation	novel	Q795K	0.33
BRCA	chr10	29512786	Silent	rs200568811	A1155A	0.42
BRCA	chr10	29550659	Missense_Mutation	novel	Q255H	0.08
BRCA	chr10	29523991	Missense_Mutation	rs371981407	V875M	0.25
CESC	chr10	29458571	Missense_Mutation	novel	Q2141E	0.09
CESC	chr10	29532157	Silent	NA	E618E	0.44
CESC	chr10	29484818	Missense_Mutation	novel	D1598V	0.22
CESC	chr10	29473931	Silent	novel	V1812V	0.24
CESC	chr10	29554822	Missense_Mutation	rs780503821	R41G	0.42
CESC	chr10	29545070	Intron	NA		0.16
CESC	chr10	29554784	Splice_Region	rs540544541	I53I	0.17
CESC	chr10	29524535	Silent	rs139994927	T841T	0.09
CESC	chr10	29522464	Missense_Mutation	rs745770769	P1112L	0.33
CESC	chr10	29533418	Nonsense_Mutation	novel	R317*	0.43
CESC	chr10	29550694	Missense_Mutation	novel	R244W	0.42
CESC	chr10	29554861	Nonsense_Mutation	novel	G28*	0.87
CESC	chr10	29530609	Missense_Mutation	NA	R702G	0.37
CESC	chr10	29480687	Missense_Mutation	rs762707894	D1743H	0.24
CESC	chr10	29533380	Missense_Mutation	NA	Q329H	0.1
CESC	chr10	29457782	3'Flank	novel		0.1
CESC	chr10	29532753	Silent	NA	S538S	0.18
COAD	chr10	29473929	Missense_Mutation	novel	Y1813C	0.1
COAD	chr10	29493243	Silent	rs376322653	F1330F	0.4
COAD	chr10	29462311	Missense_Mutation	novel	E2123A	0.22
COAD	chr10	29471186	Frame_Shift_Ins	rs775832874	*M1863Dfs18**	0.28
COAD	chr10	29551113	Missense_Mutation	NA	R104I	0.31
COAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.4
COAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.43
COAD	chr10	29458229	3'UTR	novel		0.45
COAD	chr10	29532088	Silent	novel	R641R	0.08
COAD	chr10	29495160	Missense_Mutation	novel	I1229T	0.13
COAD	chr10	29554845	Missense_Mutation	NA	R33H	0.27
COAD	chr10	29524691	Silent	NA	K789K	0.14
COAD	chr10	29487167	Missense_Mutation	rs753738627	A1494V	0.34
COAD	chr10	29499154	Missense_Mutation	rs767673427	S1209L	0.38
COAD	chr10	29533232	Missense_Mutation	NA	L379I	0.33
COAD	chr10	29532101	Missense_Mutation	rs202239155	R637Q	0.26
COAD	chr10	29532089	Missense_Mutation	rs376203305	R641H	0.31
COAD	chr10	29533401	Silent	rs758838524	L322L	0.48
COAD	chr10	29529713	Silent	rs757805709	I746I	0.31
COAD	chr10	29523524	Silent	novel	D1030D	0.46
COAD	chr10	29473911	Missense_Mutation	rs746309637	R1819Q	0.22
COAD	chr10	29480434	Intron	novel		0.29
COAD	chr10	29532754	Missense_Mutation	rs140127802	S538L	0.3
COAD	chr10	29473934	Silent	rs770649851	C1811C	0.24
COAD	chr10	29480418	Intron	novel		0.49
COAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.2
COAD	chr10	29550851	Silent	rs200054252	D191D	0.3
COAD	chr10	29487341	Intron	novel		0.39
COAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.29
COAD	chr10	29465728	Silent	rs764013430	A2000A	0.35
COAD	chr10	29473934	Silent	rs770649851	C1811C	0.35
COAD	chr10	29491013	Silent	rs774857966	T1342T	0.25
COAD	chr10	29532699	Silent	novel	Q556Q	0.37
COAD	chr10	29533363	Missense_Mutation	rs754274252	A335V	0.34
COAD	chr10	29532117	Missense_Mutation	rs201516624	R632W	0.22
COAD	chr10	29470460	Missense_Mutation	rs749173358	R1887C	0.37
COAD	chr10	29533272	Silent	NA	R365R	0.29
COAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.51
COAD	chr10	29490933	Missense_Mutation	rs184191419	A1369V	0.26
COAD	chr10	29527038	Silent	rs139725472	S755S	0.14
COAD	chr10	29545072	Intron	novel		0.06
COAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.5
COAD	chr10	29533260	Silent	novel	Q369Q	0.26
COAD	chr10	29522464	Missense_Mutation	rs745770769	P1112L	0.43
COAD	chr10	29551187	Silent	novel	T79T	0.28
COAD	chr10	29462394	Frame_Shift_Ins	rs765540249	*N2095Kfs36**	0.25
COAD	chr10	29522534	Missense_Mutation	novel	S1089P	0.36
COAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.44
COAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.34
COAD	chr10	29463521	Missense_Mutation	NA	A2083V	0.13
COAD	chr10	29481659	Missense_Mutation	novel	F1675L	0.2
COAD	chr10	29555074	5'UTR	novel		0.13
COAD	chr10	29465605	Silent	NA	A2041A	0.27
COAD	chr10	29487240	Missense_Mutation	rs370827091	D1470N	0.29
COAD	chr10	29480751	Silent	rs751165855	T1721T	0.38
COAD	chr10	29533082	Nonsense_Mutation	NA	E429*	0.38
COAD	chr10	29458437	Silent	rs761584860	F2185F	0.27
COAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.26
COAD	chr10	29494995	Missense_Mutation	rs778604932	E1254K	0.14
COAD	chr10	29473948	Missense_Mutation	rs140359734	G1807S	0.56
COAD	chr10	29458138	3'UTR	novel		0.5
COAD	chr10	29550797	Silent	novel	Q209Q	0.12
COAD	chr10	29550799	Frame_Shift_Del	novel	*Q209Rfs10**	0.09
COAD	chr10	29533237	Missense_Mutation	NA	A377V	0.41
COAD	chr10	29536060	Missense_Mutation	NA	K279N	0.33
COAD	chr10	29487385	Intron	novel		0.31
COAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.38
COAD	chr10	29550852	Missense_Mutation	novel	D191G	0.13
DLBC	chr10	29462312	Missense_Mutation	novel	E2123Q	0.24
ESCA	chr10	29458217	3'UTR	novel		0.47
ESCA	chr10	29457862	3'Flank	novel		0.3
ESCA	chr10	29480433	Intron	rs768128912		0.35
ESCA	chr10	29484764	Missense_Mutation	novel	R1616Q	0.17
ESCA	chr10	29550930	Missense_Mutation	novel	S165F	0.13
ESCA	chr10	29532007	Silent	rs781483012	S668S	0.24
ESCA	chr10	29532972	Silent	novel	V465V	0.24
ESCA	chr10	29487363	Intron	rs372964266		0.35
GBM	chr10	29523560	Missense_Mutation	novel	F1018L	0.21
GBM	chr10	29533143	Silent	rs763326997	T408T	0.32
GBM	chr10	29487345	Intron	novel		0.13
GBM	chr10	29532849	Silent	novel	P506P	0.52
GBM	chr10	29533121	Missense_Mutation	novel	D416H	0.38
GBM	chr10	29487381	Intron	rs573490315		0.41
GBM	chr10	29488641	Silent	rs186064356	S1436S	0.15
GBM	chr10	29523817	Missense_Mutation	novel	P933S	0.43
GBM	chr10	29523718	Missense_Mutation	novel	Y966D	0.11
GBM	chr10	29473933	Missense_Mutation	rs762726751	V1812I	0.77
GBM	chr10	29522553	Silent	novel	S1082S	0.29
GBM	chr10	29480674	Missense_Mutation	novel	F1747S	0.08
GBM	chr10	29533225	Missense_Mutation	rs372993830	T381M	0.68
GBM	chr10	29458222	3'UTR	novel		0.13
GBM	chr10	29495110	Missense_Mutation	rs552158750	V1246I	0.66
GBM	chr10	29462402	Splice_Site	NA	X2093_splice	0.58
GBM	chr10	29463547	Missense_Mutation	novel	I2074M	0.25
GBM	chr10	29458148	3'UTR	novel		0.21
GBM	chr10	29499243	Missense_Mutation	novel	E1179D	0.12
GBM	chr10	29487345	Intron	novel		0.82
HNSC	chr10	29462304	Frame_Shift_Ins	novel	*E2126Rfs5**	0.15
HNSC	chr10	29533008	Missense_Mutation	novel	K453N	0.43
HNSC	chr10	29533180	Missense_Mutation	rs142485178	S396L	0.23
HNSC	chr10	29545089	Intron	rs376672879		0.28
HNSC	chr10	29533064	Missense_Mutation	novel	E435K	0.52
HNSC	chr10	29533197	Missense_Mutation	novel	E390D	0.26
HNSC	chr10	29473877	Silent	novel	A1830A	0.2
HNSC	chr10	29536053	Missense_Mutation	novel	H282D	0.16
HNSC	chr10	29473940	Missense_Mutation	novel	E1809D	0.24
HNSC	chr10	29487154	Intron	novel		0.32
HNSC	chr10	29523547	Missense_Mutation	novel	M1023V	0.17
HNSC	chr10	29462309	Missense_Mutation	novel	H2124Y	0.26
HNSC	chr10	29512764	Nonsense_Mutation	novel	Q1163*	0.24
HNSC	chr10	29487326	Intron	novel		0.35
HNSC	chr10	29473877	Silent	rs139597633	A1830A	0.48
HNSC	chr10	29532866	Missense_Mutation	rs772337197	Q501E	0.19
HNSC	chr10	29487223	Silent	rs770598355	L1475L	0.12
HNSC	chr10	29458309	Missense_Mutation	novel	E2195K	0.38
HNSC	chr10	29487167	Missense_Mutation	rs753738627	A1494V	0.16
KICH	chr10	29470341	Silent	rs201300228	H1926H	0.14
KIRC	chr10	29462341	Frame_Shift_Del	novel	*L2113Dfs17**	0.07
KIRC	chr10	29463569	Missense_Mutation	NA	K2067R	0.33
KIRC	chr10	29480623	Missense_Mutation	NA	Y1764C	0.51
KIRC	chr10	29473868	In_Frame_Del	novel	L1831_T1833del	0.21
KIRC	chr10	29527053	Missense_Mutation	NA	E750D	0.27
KIRP	chr10	29480571	Silent	rs773565742	Y1781Y	0.45
KIRP	chr10	29471186	Missense_Mutation	novel	M1863V	0.27
KIRP	chr10	29602338	Intron	novel		0.32
KIRP	chr10	29532761	Frame_Shift_Del	novel	*E536Kfs25**	0.29
KIRP	chr10	29467815	Missense_Mutation	novel	E1968D	0.41
LAML	chr10	29494974	Silent	novel	L1261L	0.04
LGG	chr10	29522519	Missense_Mutation	NA	E1094Q	0.12
LGG	chr10	29481587	Missense_Mutation	NA	H1699Q	0.34
LGG	chr10	29531258	Silent	rs748555767	V680V	0.25
LGG	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.56
LGG	chr10	29491008	Missense_Mutation	novel	S1344F	0.13
LGG	chr10	29481669	Missense_Mutation	rs369100650	T1672M	0.27
LGG	chr10	29522446	Missense_Mutation	rs761132947	L1118P	0.39
LGG	chr10	29529705	Missense_Mutation	rs146446036	T749I	0.19
LGG	chr10	29533421	Missense_Mutation	novel	A316P	0.25
LGG	chr10	29480519	Intron	novel		0.14
LIHC	chr10	29480545	Missense_Mutation	novel	S1790N	0.37
LIHC	chr10	29533421	Missense_Mutation	novel	A316T	0.16
LIHC	chr10	29523604	Missense_Mutation	rs374116755	A1004T	0.52
LIHC	chr10	29529792	Missense_Mutation	novel	N720T	0.44
LIHC	chr10	29529769	Missense_Mutation	rs757759541	R728C	0.19
LIHC	chr10	29493368	Missense_Mutation	novel	L1289F	0.33
LIHC	chr10	29533233	Silent	novel	K378K	0.1
LUAD	chr10	29458304	Nonsense_Mutation	novel	Y2196*	0.2
LUAD	chr10	29532637	Missense_Mutation	novel	K577R	0.22
LUAD	chr10	29524562	Silent	NA	A832A	0.36
LUAD	chr10	29532086	Missense_Mutation	NA	Y642C	0.55
LUAD	chr10	29495117	Silent	NA	T1243T	0.24
LUAD	chr10	29523574	Missense_Mutation	NA	E1014K	0.1
LUAD	chr10	29531274	Missense_Mutation	NA	S675L	0.13
LUAD	chr10	29486165	Missense_Mutation	rs770365610	R1567C	0.12
LUAD	chr10	29523725	Missense_Mutation	novel	M963I	0.16
LUAD	chr10	29532001	Splice_Site	rs754851303	X670_splice	0.27
LUAD	chr10	29523860	Silent	novel	S918S	0.14
LUAD	chr10	29530610	Silent	NA	F701F	0.26
LUAD	chr10	29491001	Frame_Shift_Del	novel	*E1347Sfs19**	0.18
LUAD	chr10	29493274	Missense_Mutation	NA	P1320L	0.25
LUAD	chr10	29484709	Silent	novel	E1634E	0.16
LUAD	chr10	29533340	Missense_Mutation	novel	Q343E	0.09
LUAD	chr10	29523888	Missense_Mutation	NA	Y909F	0.16
LUAD	chr10	29480667	Silent	novel	I1749I	0.05
LUAD	chr10	29495139	Missense_Mutation	NA	I1236S	0.16
LUAD	chr10	29488599	Splice_Site	novel	X1450_splice	0.56
LUAD	chr10	29530637	Silent	novel	L692L	0.1
LUAD	chr10	29473892	Silent	novel	E1825E	0.28
LUAD	chr10	29532101	Missense_Mutation	novel	R637L	0.15
LUAD	chr10	29527058	Splice_Site	novel	X749_splice	0.14
LUAD	chr10	29488682	Missense_Mutation	novel	L1423M	0.35
LUAD	chr10	29487305	Splice_Region	novel		0.11
LUAD	chr10	29532074	Missense_Mutation	novel	G646V	0.17
LUAD	chr10	29602262	Intron	novel		0.13
LUAD	chr10	29486553	Missense_Mutation	novel	S1497L	0.16
LUAD	chr10	29533182	Silent	novel	A395A	0.47
LUAD	chr10	29550958	Nonsense_Mutation	NA	Q156*	0.37
LUAD	chr10	29488642	Missense_Mutation	novel	S1436N	0.2
LUAD	chr10	29524550	Silent	NA	R836R	0.23
LUAD	chr10	29490917	Silent	NA	L1374L	0.11
LUAD	chr10	29551214	Missense_Mutation	NA	Q70H	0.2
LUSC	chr10	29529801	Missense_Mutation	rs145481818	R717H	0.15
LUSC	chr10	29465728	Silent	rs764013430	A2000A	0.08
LUSC	chr10	29523686	Nonsense_Mutation	NA	Y976*	0.11
LUSC	chr10	29480438	Intron	novel		0.31
LUSC	chr10	29487158	Splice_Region	novel		0.24
LUSC	chr10	29458317	Missense_Mutation	rs777862633	T2192M	0.22
LUSC	chr10	29487381	Intron	rs573490315		0.42
LUSC	chr10	29550913	Missense_Mutation	rs562741034	E171K	0.13
LUSC	chr10	29480452	Intron	novel		0.39
LUSC	chr10	29523855	Missense_Mutation	rs770589221	S920C	0.15
LUSC	chr10	29531268	Missense_Mutation	novel	T677R	0.14
LUSC	chr10	29527028	Missense_Mutation	NA	G759C	0.18
LUSC	chr10	29458316	Silent	rs550416170	T2192T	0.13
LUSC	chr10	29480547	Silent	novel	V1789V	0.26
LUSC	chr10	29481690	Missense_Mutation	novel	R1665K	0.2
LUSC	chr10	29484807	Missense_Mutation	novel	E1602K	0.16
LUSC	chr10	29532701	Nonsense_Mutation	novel	Q556*	0.19
LUSC	chr10	29523529	Missense_Mutation	NA	L1029V	0.45
LUSC	chr10	29555065	5'UTR	novel		0.43
LUSC	chr10	29470441	Missense_Mutation	NA	E1893G	0.27
LUSC	chr10	29524550	Silent	NA	R836R	0.14
LUSC	chr10	29550692	Silent	novel	R244R	0.17
LUSC	chr10	29480739	Silent	novel	T1725T	0.29
LUSC	chr10	29522467	Missense_Mutation	rs754799636	T1111M	0.08
LUSC	chr10	29533389	Silent	novel	S326S	0.27
LUSC	chr10	29524491	Missense_Mutation	novel	T856K	0.14
LUSC	chr10	29480553	Silent	novel	F1787F	0.12
OV	chr10	29481619	Missense_Mutation	novel	N1689Y	0.05
OV	chr10	29533152	Silent	novel	P405P	0.08
OV	chr10	29481610	Missense_Mutation	novel	N1692D	0.06
OV	chr10	29493326	Missense_Mutation	novel	D1303H	0.2
OV	chr10	29463536	Missense_Mutation	novel	S2078C	0.65
OV	chr10	29458493	Missense_Mutation	novel	L2167F	0.04
OV	chr10	29484777	Missense_Mutation	NA	T1612S	0.2
OV	chr10	29488756	Frame_Shift_Ins	novel	*M1398Nfs18**	0.04
OV	chr10	29487194	Missense_Mutation	NA	G1485E	0.33
OV	chr10	29487180	Missense_Mutation	rs148716000	V1490I	0.14
OV	chr10	29532080	Missense_Mutation	NA	S644F	0.24
OV	chr10	29533386	Silent	NA	V327V	0.28
OV	chr10	29551054	Missense_Mutation	NA	L124V	0.35
OV	chr10	29522587	Missense_Mutation	novel	G1071V	0.08
OV	chr10	29522505	Missense_Mutation	novel	K1098N	0.05
OV	chr10	29470463	Missense_Mutation	NA	V1886M	0.33
OV	chr10	29486492	Silent	rs377454947	Q1517Q	0.31
OV	chr10	29487264	Nonsense_Mutation	novel	R1462*	0.44
OV	chr10	29493242	Missense_Mutation	NA	D1331N	0.12
OV	chr10	29551075	Missense_Mutation	NA	A117S	0.12
OV	chr10	29484750	Nonsense_Mutation	novel	Q1621*	0.03
OV	chr10	29488671	Silent	NA	V1426V	0.43
PAAD	chr10	29533279	Missense_Mutation	novel	P363L	0.1
PAAD	chr10	29524513	Missense_Mutation	novel	R849S	0.04
PAAD	chr10	29465653	Silent	novel	P2025P	0.17
PAAD	chr10	29473949	Silent	rs760784110	A1806A	0.14
PAAD	chr10	29480667	Silent	novel	I1749I	0.18
PAAD	chr10	29487408	Intron	novel		0.08
PAAD	chr10	29490973	Missense_Mutation	novel	R1356C	0.15
PAAD	chr10	29602312	Intron	novel		0.26
PCPG	chr10	29551232	Missense_Mutation	novel	D64E	0.31
PRAD	chr10	29486132	Missense_Mutation	novel	D1578N	0.14
PRAD	chr10	29480434	Intron	novel		0.23
PRAD	chr10	29486444	Missense_Mutation	novel	F1533L	0.44
PRAD	chr10	29530631	Silent	rs778769331	V694V	0.11
READ	chr10	29512823	Missense_Mutation	novel	R1143I	0.13
READ	chr10	29493310	Missense_Mutation	NA	F1308S	0.22
READ	chr10	29493372	Silent	novel	T1287T	0.45
READ	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.26
READ	chr10	29493237	Silent	novel	V1332V	0.7
READ	chr10	29524637	Missense_Mutation	novel	E807D	0.07
READ	chr10	29550881	Silent	novel	E181E	0.1
READ	chr10	29458448	Missense_Mutation	rs147020336	D2182N	0.44
READ	chr10	29473881	Missense_Mutation	rs751498024	S1829L	0.5
READ	chr10	29493243	Silent	rs376322653	F1330F	0.39
READ	chr10	29523666	Missense_Mutation	novel	R983K	0.43
READ	chr10	29523831	Missense_Mutation	rs148261163	S928L	0.32
READ	chr10	29524022	Missense_Mutation	NA	Q864H	0.3
READ	chr10	29551098	Missense_Mutation	novel	K109T	0.39
READ	chr10	29463524	Missense_Mutation	novel	S2082T	0.5
READ	chr10	29458220	3'UTR	novel		0.14
READ	chr10	29486112	Silent	rs367859141	P1584P	0.39
READ	chr10	29522414	Nonsense_Mutation	novel	E1129*	0.14
READ	chr10	29554930	Nonsense_Mutation	NA	E5*	0.33
SARC	chr10	29532957	Frame_Shift_Del	novel	*S472Lfs11**	0.13
SARC	chr10	29550613	Missense_Mutation	novel	P271S	0.42
SARC	chr10	29532910	Missense_Mutation	novel	T486N	0.06
SKCM	chr10	29523610	Missense_Mutation	NA	E1002K	0.32
SKCM	chr10	29551103	Silent	NA	R107R	0.47
SKCM	chr10	29491000	Missense_Mutation	NA	E1347K	0.3
SKCM	chr10	29523574	Missense_Mutation	NA	E1014K	0.35
SKCM	chr10	29532125	Missense_Mutation	NA	G629D	0.06
SKCM	chr10	29550835	Missense_Mutation	novel	E197K	0.29
SKCM	chr10	29554877	Silent	rs759126952	L22L	0.3
SKCM	chr10	29493371	Missense_Mutation	NA	V1288M	0.3
SKCM	chr10	29532125	Missense_Mutation	NA	G629D	0.3
SKCM	chr10	29551210	Nonsense_Mutation	NA	R72*	0.33
SKCM	chr10	29602261	Intron	novel		0.18
SKCM	chr10	29545011	Intron	novel		0.45
SKCM	chr10	29486219	Missense_Mutation	NA	P1549S	0.8
SKCM	chr10	29550862	Missense_Mutation	NA	H188Y	0.21
SKCM	chr10	29484768	Nonsense_Mutation	NA	Q1615*	0.42
SKCM	chr10	29470280	Missense_Mutation	NA	E1947K	0.31
SKCM	chr10	29524551	Missense_Mutation	rs766015860	R836Q	0.32
SKCM	chr10	29532732	Silent	NA	T545T	0.18
SKCM	chr10	29532017	Missense_Mutation	novel	R665Q	0.39
SKCM	chr10	29481603	Missense_Mutation	novel	G1694E	0.46
SKCM	chr10	29529766	Missense_Mutation	rs536836258	R729C	0.38
SKCM	chr10	29523927	Missense_Mutation	NA	T896I	0.62
SKCM	chr10	29484787	Silent	NA	G1608G	0.48
SKCM	chr10	29524549	Missense_Mutation	NA	N837Y	0.17
SKCM	chr10	29524551	Missense_Mutation	rs766015860	R836Q	0.2
SKCM	chr10	29526994	Missense_Mutation	NA	P770L	0.33
SKCM	chr10	29551004	Silent	NA	R140R	0.33
SKCM	chr10	29480596	Missense_Mutation	novel	G1773E	0.6
SKCM	chr10	29473929	Missense_Mutation	novel	Y1813S	0.61
SKCM	chr10	29487310	Intron	rs778414783		0.36
SKCM	chr10	29522536	Missense_Mutation	novel	S1088F	0.39
SKCM	chr10	29487261	Missense_Mutation	NA	A1463P	0.23
SKCM	chr10	29523980	Silent	novel	S878S	0.38
SKCM	chr10	29481602	Silent	novel	G1694G	0.24
SKCM	chr10	29493377	Missense_Mutation	rs145704372	E1286K	0.57
SKCM	chr10	29458434	Splice_Region	NA	E2186E	0.42
STAD	chr10	29458584	Silent	NA	T2136T	0.41
STAD	chr10	29524628	Silent	NA	S810S	0.39
STAD	chr10	29550604	Nonsense_Mutation	NA	R274*	0.13
STAD	chr10	29524517	Silent	rs746176867	N847N	0.17
STAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.23
STAD	chr10	29473842	Frame_Shift_Ins	NA	*A1842Gfs39**	0.34
STAD	chr10	29532568	Missense_Mutation	rs761777087	A600V	0.17
STAD	chr10	29524679	Missense_Mutation	NA	K793N	0.26
STAD	chr10	29532089	Missense_Mutation	rs376203305	R641H	0.07
STAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.37
STAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.36
STAD	chr10	29532567	Silent	rs144823074	A600A	0.14
STAD	chr10	29488720	Missense_Mutation	rs750828170	A1410V	0.26
STAD	chr10	29532543	Silent	NA	C608C	0.18
STAD	chr10	29551108	Missense_Mutation	NA	A106T	0.3
STAD	chr10	29523577	Frame_Shift_Del	novel	*D1013Mfs11**	0.17
STAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.43
STAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.45
STAD	chr10	29493296	Missense_Mutation	rs141855067	R1313C	0.46
STAD	chr10	29550837	Missense_Mutation	NA	P196L	0.31
STAD	chr10	29524639	Nonsense_Mutation	NA	E807*	0.31
STAD	chr10	29532786	Silent	rs761155563	D527D	0.3
STAD	chr10	29465608	Silent	rs200107973	S2040S	0.43
STAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.44
STAD	chr10	29470355	Missense_Mutation	NA	I1922V	0.1
STAD	chr10	29499192	Missense_Mutation	NA	E1196D	0.12
STAD	chr10	29532705	Silent	NA	P554P	0.18
STAD	chr10	29481605	Silent	rs137968783	P1693P	0.35
STAD	chr10	29522433	Silent	NA	S1122S	0.35
STAD	chr10	29602288	Intron	novel		0.24
STAD	chr10	29550990	Missense_Mutation	NA	A145D	0.08
STAD	chr10	29470386	Silent	novel	S1911S	0.28
STAD	chr10	29480706	Nonsense_Mutation	NA	Y1736*	0.07
STAD	chr10	29458559	Missense_Mutation	rs759776112	V2145M	0.11
STAD	chr10	29486199	Silent	rs540861977	Y1555Y	0.33
STAD	chr10	29512765	Silent	novel	T1162T	0.29
STAD	chr10	29465607	Missense_Mutation	NA	A2041T	0.37
STAD	chr10	29488625	Missense_Mutation	NA	R1442G	0.23
STAD	chr10	29499233	Missense_Mutation	NA	T1183A	0.17
STAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.43
STAD	chr10	29480714	Missense_Mutation	rs777960352	R1734C	0.16
STAD	chr10	29532544	Missense_Mutation	NA	C608Y	0.16
STAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.33
STAD	chr10	29470318	Missense_Mutation	rs746667526	T1934M	0.14
STAD	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.28
THCA	chr10	29484809	Frame_Shift_Del	novel	*S1601Mfs13**	0.37
THCA	chr10	29480579	Missense_Mutation	NA	D1779Y	0.38
THCA	chr10	29465642	Missense_Mutation	NA	S2029I	0.26
UCEC	chr10	29481621	Missense_Mutation	rs745442275	S1688L	0.24
UCEC	chr10	29487218	Missense_Mutation	NA	P1477H	0.38
UCEC	chr10	29493302	Missense_Mutation	NA	F1311V	0.32
UCEC	chr10	29524639	Nonsense_Mutation	NA	E807*	0.33
UCEC	chr10	29532719	Missense_Mutation	novel	D550Y	0.04
UCEC	chr10	29508373	Intron	novel		0.41
UCEC	chr10	29493243	Silent	rs376322653	F1330F	0.25
UCEC	chr10	29563198	Splice_Region	novel		0.33
UCEC	chr10	29550710	Silent	novel	S238S	0.48
UCEC	chr10	29529804	Missense_Mutation	rs148902382	R716Q	0.11
UCEC	chr10	29524006	Missense_Mutation	novel	P870A	0.15
UCEC	chr10	29463546	Missense_Mutation	novel	R2075C	0.24
UCEC	chr10	29465602	Silent	novel	P2042P	0.44
UCEC	chr10	29499155	Missense_Mutation	novel	S1209P	0.37
UCEC	chr10	29524492	Missense_Mutation	novel	T856A	0.4
UCEC	chr10	29530606	Splice_Site	novel	X702_splice	0.58
UCEC	chr10	29533123	Missense_Mutation	NA	R415M	0.09
UCEC	chr10	29463544	Silent	novel	R2075R	0.38
UCEC	chr10	29480606	Missense_Mutation	NA	Q1770E	0.47
UCEC	chr10	29554784	Splice_Region	rs540544541	I53I	0.12
UCEC	chr10	29480392	Intron	novel		0.45
UCEC	chr10	29490848	Missense_Mutation	novel	K1397N	0.16
UCEC	chr10	29465616	Silent	novel	L2038L	0.19
UCEC	chr10	29458551	Silent	rs138190166	D2147D	0.43
UCEC	chr10	29467758	Silent	rs377129994	Y1987Y	0.43
UCEC	chr10	29470349	Missense_Mutation	NA	L1924M	0.5
UCEC	chr10	29470460	Missense_Mutation	rs749173358	R1887C	0.44
UCEC	chr10	29473934	Silent	rs770649851	C1811C	0.56
UCEC	chr10	29523674	Silent	novel	N980N	0.47
UCEC	chr10	29458446	Silent	rs766760077	D2182D	0.42
UCEC	chr10	29470363	Missense_Mutation	novel	K1919T	0.4
UCEC	chr10	29480598	Silent	novel	I1772I	0.38
UCEC	chr10	29488757	Splice_Site	novel	X1398_splice	0.36
UCEC	chr10	29550679	Missense_Mutation	rs373559551	A249T	0.4
UCEC	chr10	29529833	Missense_Mutation	novel	K706N	0.3
UCEC	chr10	29569310	Splice_Region	novel		0.29
UCEC	chr10	29499248	Nonsense_Mutation	NA	R1178*	0.39
UCEC	chr10	29457790	3'Flank	novel		0.22
UCEC	chr10	29481709	Missense_Mutation	rs746483403	D1659N	0.31
UCEC	chr10	29523861	Missense_Mutation	rs745851162	S918L	0.17
UCEC	chr10	29523669	Missense_Mutation	NA	A982V	0.25
UCEC	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.55
UCEC	chr10	29473869	Missense_Mutation	rs373607156	T1833M	0.12
UCEC	chr10	29484735	Missense_Mutation	novel	L1626V	0.07
UCEC	chr10	29487307	Splice_Region	rs752975682		0.27
UCEC	chr10	29458225	3'UTR	novel		0.2
UCEC	chr10	29522467	Missense_Mutation	rs754799636	T1111M	0.19
UCEC	chr10	29551084	Nonsense_Mutation	NA	R114*	0.2
UCEC	chr10	29533421	Missense_Mutation	novel	A316T	0.18
UCEC	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.4
UCEC	chr10	29490924	Missense_Mutation	NA	E1372G	0.16
UCEC	chr10	29550833	Silent	NA	E197E	0.54
UCEC	chr10	29522625	Silent	rs780637207	F1058F	0.52
UCEC	chr10	29486183	Nonsense_Mutation	novel	E1561*	0.11
UCEC	chr10	29522422	Missense_Mutation	novel	S1126Y	0.32
UCEC	chr10	29523694	Missense_Mutation	rs757847426	A974T	0.19
UCEC	chr10	29458242	3'UTR	novel		0.46
UCEC	chr10	29484679	Silent	novel	G1644G	0.31
UCEC	chr10	29488689	Silent	rs771991389	N1420N	0.13
UCEC	chr10	29524652	Silent	novel	L802L	0.2
UCEC	chr10	29532150	Missense_Mutation	novel	A621T	0.22
UCEC	chr10	29523987	Missense_Mutation	novel	N876S	0.53
UCEC	chr10	29532584	Missense_Mutation	rs763112940	A595T	0.39
UCEC	chr10	29533389	Silent	novel	S326S	0.38
UCEC	chr10	29550721	Nonsense_Mutation	novel	R235*	0.53
UCEC	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.66
UCEC	chr10	29470312	Missense_Mutation	novel	E1936G	0.3
UCEC	chr10	29532633	Silent	rs747151604	T578T	0.4
UCEC	chr10	29470463	Missense_Mutation	NA	V1886M	0.45
UCEC	chr10	29512809	Missense_Mutation	novel	R1148G	0.41
UCEC	chr10	29524513	Missense_Mutation	novel	R849G	0.34
UCEC	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.38
UCEC	chr10	29523846	Missense_Mutation	novel	R923I	0.24
UCEC	chr10	29524689	Missense_Mutation	novel	A790V	0.48
UCEC	chr10	29533375	Missense_Mutation	novel	R331I	0.52
UCEC	chr10	29494977	Nonsense_Mutation	novel	Q1260*	0.42
UCEC	chr10	29536016	Missense_Mutation	novel	T294I	0.3
UCEC	chr10	29545089	Intron	rs376672879		0.52
UCEC	chr10	29569273	5'UTR	rs564716546		0.27
UCEC	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.38
UCEC	chr10	29523569	Silent	rs573451026	P1015P	0.35
UCEC	chr10	29458461	Missense_Mutation	novel	E2177D	0.5
UCEC	chr10	29484678	Nonsense_Mutation	novel	E1645*	0.47
UCEC	chr10	29484798	Missense_Mutation	rs377161548	V1605I	0.45
UCEC	chr10	29551210	Nonsense_Mutation	NA	R72*	0.43
UCEC	chr10	29487510	Intron	novel		0.38
UCEC	chr10	29532591	Silent	novel	V592V	0.46
UCEC	chr10	29532808	In_Frame_Ins	novel	I519_Q520insPDTQSTSSPLVGRSEMVLYI	0.06
UCEC	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.47
UCEC	chr10	29512753	Silent	rs768560592	G1166G	0.38
UCEC	chr10	29467843	Missense_Mutation	NA	S1959N	0.16
UCEC	chr10	29470419	Silent	novel	A1900A	0.07
UCEC	chr10	29551155	Missense_Mutation	novel	S90L	0.38
UCEC	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.63
UCEC	chr10	29530659	Missense_Mutation	novel	K685R	0.52
UCEC	chr10	29532859	Missense_Mutation	rs143302930	P503L	0.37
UCEC	chr10	29532596	Missense_Mutation	novel	K591E	0.38
UCEC	chr10	29551083	Missense_Mutation	rs752184901	R114Q	0.36
UCEC	chr10	29457527	3'Flank	novel		0.09
UCEC	chr10	29457701	3'Flank	novel		0.45
UCEC	chr10	29480578	Missense_Mutation	novel	D1779G	0.22
UCEC	chr10	29524535	Silent	novel	T841T	0.57
UCEC	chr10	29532868	Missense_Mutation	NA	P500H	0.36
UCEC	chr10	29470317	Silent	rs762361927	T1934T	0.22
UCEC	chr10	29487206	Missense_Mutation	novel	F1481C	0.28
UCEC	chr10	29493271	Missense_Mutation	novel	R1321I	0.18
UCEC	chr10	29532736	Missense_Mutation	rs112187580	R544H	0.15
UCEC	chr10	29533039	Missense_Mutation	novel	V443G	0.16
UCEC	chr10	29533306	Missense_Mutation	novel	S354I	0.16
UCEC	chr10	29550604	Nonsense_Mutation	NA	R274*	0.44
UCEC	chr10	29480776	Missense_Mutation	rs143178190	T1713I	0.18
UCEC	chr10	29490950	Missense_Mutation	NA	N1363K	0.26
UCEC	chr10	29458122	3'UTR	novel		0.58
UCEC	chr10	29487473	Intron	novel		0.38
UCEC	chr10	29488616	Silent	novel	L1445L	0.43
UCEC	chr10	29493242	Missense_Mutation	NA	D1331N	0.35
UCEC	chr10	29493243	Silent	rs376322653	F1330F	0.38
UCEC	chr10	29533362	Silent	rs764204188	A335A	0.34
UCEC	chr10	29550741	Missense_Mutation	NA	S228L	0.5
UCEC	chr10	29470485	Splice_Site	novel	X1879_splice	0.21
UCEC	chr10	29487351	Intron	rs572368473		0.4
UCEC	chr10	29480507	Intron	novel		0.13
UCEC	chr10	29522559	Silent	novel	P1080P	0.27
UCEC	chr10	29457597	3'Flank	rs536239949		0.33
UCEC	chr10	29470308	Silent	novel	V1937V	0.46
UCEC	chr10	29486517	Missense_Mutation	novel	L1509R	0.53
UCEC	chr10	29493243	Silent	rs376322653	F1330F	0.64
UCEC	chr10	29490887	Silent	novel	N1384N	0.16
UCEC	chr10	29458524	Missense_Mutation	NA	I2156M	0.29
UCEC	chr10	29524609	Missense_Mutation	rs757553985	E817K	0.25
UCEC	chr10	29480688	Silent	rs748042633	H1742H	0.22
UCEC	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.33
UCEC	chr10	29462346	Missense_Mutation	novel	E2111D	0.12
UCEC	chr10	29536066	Nonsense_Mutation	novel	G278*	0.04
UCEC	chr10	29536067	Missense_Mutation	novel	T277I	0.02
UCEC	chr10	29490998	Missense_Mutation	NA	E1347D	0.28
UCEC	chr10	29467826	Nonsense_Mutation	novel	E1965*	0.5
UCEC	chr10	29487181	Silent	rs780225927	N1489N	0.18
UCEC	chr10	29480598	Silent	novel	I1772I	0.06
UCEC	chr10	29524536	Missense_Mutation	NA	T841K	0.06
UCEC	chr10	29494975	Silent	novel	Q1260Q	0.1
UCEC	chr10	29602328	Intron	novel		0.09
UCEC	chr10	29532914	Missense_Mutation	novel	V485F	0.32
UCEC	chr10	29458445	Missense_Mutation	rs758477266	E2183K	0.23
UCEC	chr10	29532980	Frame_Shift_Ins	NA	*G463Wfs11**	0.23
UCEC	chr10	29467858	Missense_Mutation	NA	G1954A	0.07
UCEC	chr10	29533294	Missense_Mutation	NA	G358D	0.09
UCEC	chr10	29480505	Intron	novel		0.53
UCEC	chr10	29493242	Missense_Mutation	NA	D1331N	0.44
UCEC	chr10	29465731	Silent	novel	F1999F	0.2
UCEC	chr10	29523481	Missense_Mutation	NA	N1045H	0.41
UCEC	chr10	29494996	Silent	novel	I1253I	0.46
UCEC	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.58
UCEC	chr10	29523916	Missense_Mutation	rs750778684	L900F	0.1
UCEC	chr10	29467810	Missense_Mutation	NA	S1970F	0.51
UCEC	chr10	29554900	Missense_Mutation	novel	E15Q	0.22
UCEC	chr10	29463538	Silent	novel	A2077A	0.22
UCEC	chr10	29465748	Missense_Mutation	novel	P1994S	0.35
UCEC	chr10	29473981	Missense_Mutation	novel	R1796C	0.41
UCEC	chr10	29480350	Intron	novel		0.24
UCEC	chr10	29481621	Missense_Mutation	rs745442275	S1688L	0.26
UCEC	chr10	29484751	Missense_Mutation	novel	F1620L	0.44
UCEC	chr10	29499180	Silent	novel	T1200T	0.24
UCEC	chr10	29523581	Silent	rs749838207	L1011L	0.43
UCEC	chr10	29524635	Missense_Mutation	novel	P808H	0.22
UCEC	chr10	29529750	Missense_Mutation	novel	S734Y	0.21
UCEC	chr10	29532144	Missense_Mutation	NA	G623R	0.44
UCEC	chr10	29533201	Missense_Mutation	novel	S389Y	0.23
UCEC	chr10	29551084	Nonsense_Mutation	NA	R114*	0.32
UCEC	chr10	29533220	Nonsense_Mutation	novel	E383*	0.44
UCEC	chr10	29536036	Silent	novel	Q287Q	0.57
UCEC	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.34
UCEC	chr10	29550943	Missense_Mutation	novel	R161G	0.62
UCEC	chr10	29458478	Missense_Mutation	novel	D2172N	0.12
UCEC	chr10	29487351	Intron	rs572368473		0.3
UCEC	chr10	29471187	Frame_Shift_Del	rs770033147	*M1863Wfs44**	0.5
UCEC	chr10	29524661	Silent	rs770586568	G799G	0.42
UCEC	chr10	29457783	3'Flank	novel		0.35
UCEC	chr10	29463514	Silent	novel	E2085E	0.23
UCEC	chr10	29533127	Missense_Mutation	rs149688596	G414R	0.32
UCEC	chr10	29462358	Silent	rs201435282	H2107H	0.45
UCEC	chr10	29470420	Missense_Mutation	novel	A1900V	0.35
UCEC	chr10	29473912	Missense_Mutation	rs768290693	R1819W	0.47
UCEC	chr10	29522602	Missense_Mutation	rs747349151	T1066M	0.3
UCS	chr10	29523658	Missense_Mutation	novel	D986Y	0.39
UCS	chr10	29533324	Missense_Mutation	novel	A348V	0.54
UCS	chr10	29554805	Silent	rs371700516	S46S	0.54
UCS	chr10	29458305	Missense_Mutation	novel	Y2196C	0.25
UCS	chr10	29480434	Intron	novel		0.5
UCS	chr10	29480628	Silent	rs769930737	F1762F	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1111	0.19593
BLCA	DEL	0.1397	0.16614
PAAD	DEL	0.1141	0.169
STAD	DEL	0.1066	0.13903

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00056	Kaplan-Meier Survival Analysis
STAD	0.007	Kaplan-Meier Survival Analysis
SARC	0.039	Kaplan-Meier Survival Analysis
MESO	0.0019	Kaplan-Meier Survival Analysis
SKCM	0.0063	Kaplan-Meier Survival Analysis
ESCA	0.031	Kaplan-Meier Survival Analysis
BLCA	0.00011	Kaplan-Meier Survival Analysis
LAML	0.0037	Kaplan-Meier Survival Analysis
UCEC	0.0068	Kaplan-Meier Survival Analysis
GBM	0.014	Kaplan-Meier Survival Analysis
LGG	0.009	Kaplan-Meier Survival Analysis
UVM	0.0049	Kaplan-Meier Survival Analysis
OV	0.0027	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742