EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197345 (Gene tree)
Gene ID: 219927
Gene Symbol: MRPL21
Alias: N
Full Name: mitochondrial ribosomal protein L21
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 12,564 bases
Position: chr11:68,891,272-68,903,835
Accession: 14479
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000389400	Ribosomal_L21p	PF00829.21	1.7e-22	1	1
ENSP00000354580	Ribosomal_L21p	PF00829.21	6.3e-22	1	1
ENSP00000457859	Ribosomal_L21p	PF00829.21	2.9e-18	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000541279	MRPL21-205	764	-	ENSP00000442243	150 (aa)	-	F5H7V8
ENST00000536637	MRPL21-203	557	-	-	- (aa)	-	-
ENST00000565125	MRPL21-207	2283	-	ENSP00000456520	49 (aa)	-	F5H4R5
ENST00000362034	MRPL21-201	683	XM_005273823	ENSP00000354580	205 (aa)	XP_005273880	Q7Z2W9
ENST00000541265	MRPL21-204	555	-	ENSP00000445009	49 (aa)	-	F5H4R5
ENST00000544567	MRPL21-206	654	-	ENSP00000438837	36 (aa)	-	F5H3L0
ENST00000567045	MRPL21-208	932	-	ENSP00000457859	195 (aa)	-	H3BUY0
ENST00000450904	MRPL21-202	662	-	ENSP00000389400	120 (aa)	-	Q7Z2W9

Gene Model

Click here to download ENSG00000197345's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197345's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197345	MRPL21	94	72.566	ENSAPOG00000009928	mrpl21	79	65.806	Acanthochromis_polyacanthus
ENSG00000197345	MRPL21	98	82.906	ENSAMEG00000008591	MRPL21	99	78.846	Ailuropoda_melanoleuca
ENSG00000197345	MRPL21	94	74.336	ENSACIG00000012089	MRPL21	95	60.541	Amphilophus_citrinellus
ENSG00000197345	MRPL21	94	73.451	ENSAOCG00000012726	MRPL21	79	65.605	Amphiprion_ocellaris
ENSG00000197345	MRPL21	94	73.451	ENSAPEG00000005507	MRPL21	79	65.806	Amphiprion_percula
ENSG00000197345	MRPL21	94	71.681	ENSATEG00000021329	mrpl21	97	57.073	Anabas_testudineus
ENSG00000197345	MRPL21	99	74.790	ENSAPLG00000003685	MRPL21	96	71.930	Anas_platyrhynchos
ENSG00000197345	MRPL21	99	79.832	ENSACAG00000013770	MRPL21	96	67.016	Anolis_carolinensis
ENSG00000197345	MRPL21	99	94.118	ENSANAG00000020754	MRPL21	98	89.706	Aotus_nancymaae
ENSG00000197345	MRPL21	94	73.451	ENSACLG00000016665	-	79	66.452	Astatotilapia_calliptera
ENSG00000197345	MRPL21	100	70.833	ENSAMXG00000036794	mrpl21	86	64.458	Astyanax_mexicanus
ENSG00000197345	MRPL21	99	84.034	ENSBTAG00000004348	MRPL21	54	82.353	Bos_taurus
ENSG00000197345	MRPL21	88	43.810	WBGene00023422	mrpl-21	89	35.443	Caenorhabditis_elegans
ENSG00000197345	MRPL21	99	93.277	ENSCJAG00000015881	MRPL21	99	91.176	Callithrix_jacchus
ENSG00000197345	MRPL21	83	86.869	ENSCAFG00000031492	MRPL21	70	88.889	Canis_familiaris
ENSG00000197345	MRPL21	99	84.874	ENSCHIG00000020757	MRPL21	98	82.353	Capra_hircus
ENSG00000197345	MRPL21	99	80.672	ENSTSYG00000002850	MRPL21	99	77.941	Carlito_syrichta
ENSG00000197345	MRPL21	99	84.034	ENSCAPG00000014147	MRPL21	99	83.908	Cavia_aperea
ENSG00000197345	MRPL21	99	84.034	ENSCPOG00000038509	MRPL21	97	81.281	Cavia_porcellus
ENSG00000197345	MRPL21	99	82.353	ENSCCAG00000023999	MRPL21	99	82.353	Cebus_capucinus
ENSG00000197345	MRPL21	99	97.479	ENSCATG00000041171	MRPL21	98	94.608	Cercocebus_atys
ENSG00000197345	MRPL21	99	83.193	ENSCLAG00000016038	MRPL21	98	80.392	Chinchilla_lanigera
ENSG00000197345	MRPL21	99	96.639	ENSCSAG00000009065	MRPL21	98	93.627	Chlorocebus_sabaeus
ENSG00000197345	MRPL21	100	84.667	ENSCHOG00000002067	MRPL21	100	80.976	Choloepus_hoffmanni
ENSG00000197345	MRPL21	67	77.228	ENSCPBG00000026901	-	68	76.636	Chrysemys_picta_bellii
ENSG00000197345	MRPL21	99	81.513	ENSCPBG00000008807	-	99	80.435	Chrysemys_picta_bellii
ENSG00000197345	MRPL21	98	47.458	ENSCING00000022513	-	99	48.361	Ciona_intestinalis
ENSG00000197345	MRPL21	97	53.448	ENSCSAVG00000007364	-	84	39.423	Ciona_savignyi
ENSG00000197345	MRPL21	99	95.798	ENSCANG00000043723	MRPL21	99	92.157	Colobus_angolensis_palliatus
ENSG00000197345	MRPL21	100	85.833	ENSCGRG00001024565	Mrpl21	98	82.927	Cricetulus_griseus_chok1gshd
ENSG00000197345	MRPL21	100	85.833	ENSCGRG00000007332	Mrpl21	98	82.927	Cricetulus_griseus_crigri
ENSG00000197345	MRPL21	98	68.067	ENSCSEG00000020721	MRPL21	96	57.527	Cynoglossus_semilaevis
ENSG00000197345	MRPL21	94	69.912	ENSCVAG00000014089	mrpl21	86	60.241	Cyprinodon_variegatus
ENSG00000197345	MRPL21	99	72.269	ENSDARG00000003846	mrpl21	99	56.938	Danio_rerio
ENSG00000197345	MRPL21	100	83.333	ENSDNOG00000002330	-	71	80.000	Dasypus_novemcinctus
ENSG00000197345	MRPL21	100	81.667	ENSDORG00000025967	Mrpl21	99	81.034	Dipodomys_ordii
ENSG00000197345	MRPL21	93	45.946	FBgn0036853	mRpL21	61	42.276	Drosophila_melanogaster
ENSG00000197345	MRPL21	99	68.067	ENSEBUG00000008024	mrpl21	98	57.812	Eptatretus_burgeri
ENSG00000197345	MRPL21	99	86.555	ENSEASG00005007733	-	50	81.863	Equus_asinus_asinus
ENSG00000197345	MRPL21	94	76.106	ENSELUG00000023223	mrpl21	80	64.286	Esox_lucius
ENSG00000197345	MRPL21	99	84.034	ENSFCAG00000005779	MRPL21	98	80.882	Felis_catus
ENSG00000197345	MRPL21	99	71.429	ENSFALG00000011677	MRPL21	83	70.056	Ficedula_albicollis
ENSG00000197345	MRPL21	99	79.866	ENSFDAG00000015353	MRPL21	86	79.866	Fukomys_damarensis
ENSG00000197345	MRPL21	93	69.369	ENSFHEG00000003319	mrpl21	81	61.677	Fundulus_heteroclitus
ENSG00000197345	MRPL21	67	65.000	ENSGMOG00000010935	-	74	61.261	Gadus_morhua
ENSG00000197345	MRPL21	99	75.630	ENSGALG00000004362	MRPL21	94	72.472	Gallus_gallus
ENSG00000197345	MRPL21	93	70.270	ENSGAFG00000018076	mrpl21	79	63.871	Gambusia_affinis
ENSG00000197345	MRPL21	94	71.681	ENSGACG00000019780	-	75	66.013	Gasterosteus_aculeatus
ENSG00000197345	MRPL21	100	80.000	ENSGAGG00000020313	MRPL21	73	79.355	Gopherus_agassizii
ENSG00000197345	MRPL21	100	98.333	ENSGGOG00000012124	MRPL21	98	98.049	Gorilla_gorilla
ENSG00000197345	MRPL21	94	74.336	ENSHBUG00000006577	-	79	67.097	Haplochromis_burtoni
ENSG00000197345	MRPL21	99	85.714	ENSHGLG00000007657	MRPL21	94	83.673	Heterocephalus_glaber_female
ENSG00000197345	MRPL21	99	85.714	ENSHGLG00100008966	MRPL21	99	85.057	Heterocephalus_glaber_male
ENSG00000197345	MRPL21	99	66.387	ENSHCOG00000001927	-	85	62.195	Hippocampus_comes
ENSG00000197345	MRPL21	96	70.435	ENSIPUG00000017862	MRPL21	86	62.963	Ictalurus_punctatus
ENSG00000197345	MRPL21	100	85.000	ENSSTOG00000032759	MRPL21	100	82.286	Ictidomys_tridecemlineatus
ENSG00000197345	MRPL21	100	83.333	ENSJJAG00000018455	Mrpl21	98	81.373	Jaculus_jaculus
ENSG00000197345	MRPL21	94	67.257	ENSKMAG00000020148	mrpl21	79	62.581	Kryptolebias_marmoratus
ENSG00000197345	MRPL21	94	69.912	ENSLBEG00000001294	MRPL21	80	64.516	Labrus_bergylta
ENSG00000197345	MRPL21	100	73.333	ENSLACG00000018790	MRPL21	99	64.390	Latimeria_chalumnae
ENSG00000197345	MRPL21	99	72.269	ENSLOCG00000001501	mrpl21	91	63.830	Lepisosteus_oculatus
ENSG00000197345	MRPL21	99	82.353	ENSLAFG00000003336	MRPL21	98	78.922	Loxodonta_africana
ENSG00000197345	MRPL21	100	92.667	ENSMFAG00000043823	MRPL21	92	93.605	Macaca_fascicularis
ENSG00000197345	MRPL21	100	89.796	ENSMMUG00000010124	MRPL21	96	88.235	Macaca_mulatta
ENSG00000197345	MRPL21	99	96.639	ENSMNEG00000036906	MRPL21	98	94.118	Macaca_nemestrina
ENSG00000197345	MRPL21	99	96.639	ENSMLEG00000044097	MRPL21	99	94.118	Mandrillus_leucophaeus
ENSG00000197345	MRPL21	95	72.807	ENSMAMG00000001083	MRPL21	83	57.868	Mastacembelus_armatus
ENSG00000197345	MRPL21	94	73.451	ENSMZEG00005005496	-	79	66.452	Maylandia_zebra
ENSG00000197345	MRPL21	99	73.950	ENSMGAG00000002814	MRPL21	99	75.325	Meleagris_gallopavo
ENSG00000197345	MRPL21	100	85.833	ENSMAUG00000018243	Mrpl21	98	82.927	Mesocricetus_auratus
ENSG00000197345	MRPL21	100	83.333	ENSMICG00000046580	MRPL21	98	82.439	Microcebus_murinus
ENSG00000197345	MRPL21	100	86.667	ENSMOCG00000002555	Mrpl21	98	82.927	Microtus_ochrogaster
ENSG00000197345	MRPL21	93	75.000	ENSMMOG00000000053	-	91	61.236	Mola_mola
ENSG00000197345	MRPL21	99	78.151	ENSMODG00000004013	MRPL21	81	70.000	Monodelphis_domestica
ENSG00000197345	MRPL21	92	74.545	ENSMALG00000021416	mrpl21	69	74.545	Monopterus_albus
ENSG00000197345	MRPL21	100	84.167	MGP_CAROLIEiJ_G0022464	Mrpl21	98	81.463	Mus_caroli
ENSG00000197345	MRPL21	100	83.333	ENSMUSG00000024829	Mrpl21	98	80.976	Mus_musculus
ENSG00000197345	MRPL21	100	86.667	MGP_PahariEiJ_G0013961	-	98	83.415	Mus_pahari
ENSG00000197345	MRPL21	98	85.470	ENSMPUG00000004430	MRPL21	85	84.091	Mustela_putorius_furo
ENSG00000197345	MRPL21	99	84.874	ENSMLUG00000017397	MRPL21	94	84.091	Myotis_lucifugus
ENSG00000197345	MRPL21	100	82.000	ENSNGAG00000023813	Mrpl21	100	79.512	Nannospalax_galili
ENSG00000197345	MRPL21	84	70.297	ENSNBRG00000004248	mrpl21	58	70.297	Neolamprologus_brichardi
ENSG00000197345	MRPL21	100	98.049	ENSNLEG00000006605	MRPL21	98	98.049	Nomascus_leucogenys
ENSG00000197345	MRPL21	73	80.460	ENSMEUG00000012464	-	90	74.590	Notamacropus_eugenii
ENSG00000197345	MRPL21	93	72.143	ENSOPRG00000011828	MRPL21	99	65.347	Ochotona_princeps
ENSG00000197345	MRPL21	99	82.353	ENSODEG00000017369	MRPL21	97	79.803	Octodon_degus
ENSG00000197345	MRPL21	94	74.336	ENSONIG00000020699	MRPL21	79	67.742	Oreochromis_niloticus
ENSG00000197345	MRPL21	61	69.231	ENSOANG00000006870	-	92	69.231	Ornithorhynchus_anatinus
ENSG00000197345	MRPL21	98	70.339	ENSORLG00000000120	MRPL21	80	64.744	Oryzias_latipes
ENSG00000197345	MRPL21	98	70.339	ENSORLG00020020197	-	75	62.651	Oryzias_latipes_hni
ENSG00000197345	MRPL21	98	70.339	ENSORLG00015020425	MRPL21	76	65.584	Oryzias_latipes_hsok
ENSG00000197345	MRPL21	94	70.796	ENSOMEG00000014420	MRPL21	79	63.694	Oryzias_melastigma
ENSG00000197345	MRPL21	99	76.033	ENSOARG00000016869	MRPL21	99	78.652	Ovis_aries
ENSG00000197345	MRPL21	100	100.000	ENSPPAG00000038393	MRPL21	100	98.315	Pan_paniscus
ENSG00000197345	MRPL21	100	83.333	ENSPPRG00000024109	MRPL21	99	80.392	Panthera_pardus
ENSG00000197345	MRPL21	97	81.034	ENSPTIG00000000955	MRPL21	99	81.633	Panthera_tigris_altaica
ENSG00000197345	MRPL21	100	100.000	ENSPTRG00000003988	MRPL21	100	96.923	Pan_troglodytes
ENSG00000197345	MRPL21	99	96.639	ENSPANG00000018811	MRPL21	99	94.118	Papio_anubis
ENSG00000197345	MRPL21	99	69.748	ENSPKIG00000012297	mrpl21	79	63.314	Paramormyrops_kingsleyae
ENSG00000197345	MRPL21	99	78.151	ENSPSIG00000015523	MRPL21	83	77.922	Pelodiscus_sinensis
ENSG00000197345	MRPL21	98	67.227	ENSPMGG00000000115	-	91	58.889	Periophthalmus_magnuspinnatus
ENSG00000197345	MRPL21	100	85.833	ENSPEMG00000015425	Mrpl21	98	84.390	Peromyscus_maniculatus_bairdii
ENSG00000197345	MRPL21	98	67.797	ENSPMAG00000008611	mrpl21	98	66.225	Petromyzon_marinus
ENSG00000197345	MRPL21	94	70.796	ENSPFOG00000020119	mrpl21	78	64.516	Poecilia_formosa
ENSG00000197345	MRPL21	94	70.796	ENSPLAG00000013159	mrpl21	76	64.516	Poecilia_latipinna
ENSG00000197345	MRPL21	94	69.912	ENSPMEG00000016468	mrpl21	76	63.871	Poecilia_mexicana
ENSG00000197345	MRPL21	94	69.912	ENSPREG00000021810	mrpl21	79	63.871	Poecilia_reticulata
ENSG00000197345	MRPL21	100	97.500	ENSPPYG00000002966	-	65	97.073	Pongo_abelii
ENSG00000197345	MRPL21	99	80.672	ENSPCAG00000003449	MRPL21	99	75.490	Procavia_capensis
ENSG00000197345	MRPL21	100	80.000	ENSPCOG00000015404	MRPL21	95	83.333	Propithecus_coquereli
ENSG00000197345	MRPL21	99	84.874	ENSPVAG00000006772	MRPL21	72	84.921	Pteropus_vampyrus
ENSG00000197345	MRPL21	94	74.336	ENSPNYG00000023486	-	79	67.097	Pundamilia_nyererei
ENSG00000197345	MRPL21	99	71.429	ENSPNAG00000003269	mrpl21	73	67.308	Pygocentrus_nattereri
ENSG00000197345	MRPL21	100	83.333	ENSRNOG00000013845	Mrpl21	98	80.976	Rattus_norvegicus
ENSG00000197345	MRPL21	99	97.479	ENSRBIG00000044044	MRPL21	98	94.608	Rhinopithecus_bieti
ENSG00000197345	MRPL21	99	97.479	ENSRROG00000025365	MRPL21	98	94.118	Rhinopithecus_roxellana
ENSG00000197345	MRPL21	99	95.798	ENSSBOG00000021429	MRPL21	98	91.667	Saimiri_boliviensis_boliviensis
ENSG00000197345	MRPL21	99	78.151	ENSSHAG00000000978	MRPL21	99	75.325	Sarcophilus_harrisii
ENSG00000197345	MRPL21	97	70.690	ENSSFOG00015019282	mrpl21	62	68.874	Scleropages_formosus
ENSG00000197345	MRPL21	94	69.912	ENSSMAG00000020855	mrpl21	78	65.161	Scophthalmus_maximus
ENSG00000197345	MRPL21	98	71.186	ENSSDUG00000001524	-	99	57.073	Seriola_dumerili
ENSG00000197345	MRPL21	98	71.186	ENSSLDG00000014690	-	99	57.214	Seriola_lalandi_dorsalis
ENSG00000197345	MRPL21	99	73.109	ENSSPUG00000008781	MRPL21	99	64.706	Sphenodon_punctatus
ENSG00000197345	MRPL21	98	69.492	ENSSPAG00000010420	MRPL21	80	65.806	Stegastes_partitus
ENSG00000197345	MRPL21	99	83.193	ENSSSCG00000012879	MRPL21	98	77.451	Sus_scrofa
ENSG00000197345	MRPL21	99	73.950	ENSTGUG00000006693	MRPL21	99	74.675	Taeniopygia_guttata
ENSG00000197345	MRPL21	94	67.257	ENSTRUG00000006299	-	81	61.111	Takifugu_rubripes
ENSG00000197345	MRPL21	94	68.142	ENSTNIG00000006295	-	93	54.787	Tetraodon_nigroviridis
ENSG00000197345	MRPL21	97	76.552	ENSTBEG00000017030	MRPL21	92	77.778	Tupaia_belangeri
ENSG00000197345	MRPL21	95	80.986	ENSTTRG00000013635	MRPL21	99	66.176	Tursiops_truncatus
ENSG00000197345	MRPL21	99	84.874	ENSUMAG00000018330	MRPL21	96	84.091	Ursus_maritimus
ENSG00000197345	MRPL21	99	73.109	ENSXETG00000019978	mrpl21	94	68.452	Xenopus_tropicalis
ENSG00000197345	MRPL21	94	69.912	ENSXCOG00000011393	mrpl21	77	63.226	Xiphophorus_couchianus
ENSG00000197345	MRPL21	94	69.027	ENSXMAG00000020294	mrpl21	76	62.581	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process