EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000197386 (Gene tree)
Gene ID: 3064
Gene Symbol: HTT
Alias: IT15|HD
Full Name: huntingtin
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 202,539 bases
Position: chr4:3,041,422-3,243,960
Accession: 4851
RBP type: non-canonical RBP
Summary: Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range of trinucleotide repeats (9-35) has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000513326	HTT-211	373	-	-	- (aa)	-	-
ENST00000510626	HTT-208	14438	-	-	- (aa)	-	-
ENST00000649900	HTT-218	587	-	-	- (aa)	-	-
ENST00000513806	HTT-213	432	-	-	- (aa)	-	-
ENST00000650588	HTT-219	503	-	ENSP00000497844	75 (aa)	-	-
ENST00000509751	HTT-207	723	-	-	- (aa)	-	-
ENST00000649131	HTT-217	289	-	ENSP00000497424	97 (aa)	-	-
ENST00000649009	HTT-216	195	-	ENSP00000497967	65 (aa)	-	-
ENST00000506137	HTT-203	781	-	-	- (aa)	-	-
ENST00000509618	HTT-206	429	-	ENSP00000425743	112 (aa)	-	H0YA07
ENST00000509043	HTT-205	380	-	-	- (aa)	-	-
ENST00000512068	HTT-209	401	-	-	- (aa)	-	-
ENST00000648150	HTT-215	331	-	-	- (aa)	-	-
ENST00000355072	HTT-201	13475	-	ENSP00000347184	3142 (aa)	-	P42858
ENST00000647962	HTT-214	1324	-	-	- (aa)	-	-
ENST00000508321	HTT-204	386	-	-	- (aa)	-	-
ENST00000502820	HTT-202	524	-	ENSP00000498059	175 (aa)	-	-
ENST00000512909	HTT-210	611	-	-	- (aa)	-	-
ENST00000650595	HTT-220	390	-	ENSP00000497994	75 (aa)	-	-
ENST00000513639	HTT-212	259	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000197386's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05016	Huntington disease	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000197386	Prostatic Neoplasms	6.2460000E-005	18264096
ENSG00000197386	Cholesterol, HDL	8.7540000E-005	-
ENSG00000197386	Platelet Function Tests	1.2864800E-005	-
ENSG00000197386	Eyebrows	1E-22	27182965
ENSG00000197386	Sulfates	3E-7	27412988
ENSG00000197386	Longevity	2E-6	27015805

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000197386	rs362272	4	3233253	?	Serum sulfate level	27412988	NR unit decrease	0.02	EFO_0007864
ENSG00000197386	rs6828882	4	3164469	?	Monobrow	27182965	[0.071-0.048] unit decrease	0.059	EFO_0007906
ENSG00000197386	rs55962025	4	3110382	?	Parental longevity (mother's age at death)	27015805	[0.015-0.036] unit decrease	0.02542	EFO_0007796
ENSG00000197386	rs363096	4	3178294	T	Educational attainment (MTAG)	30038396	[0.01-0.016] unit decrease	0.013	EFO_0004784
ENSG00000197386	rs113928896	4	3138682	T	Highest math class taken (MTAG)	30038396	[0.01-0.02] unit increase	0.015	EFO_0004875
ENSG00000197386	rs149109767	4	3228684	AGAG	Hepatocyte growth factor levels	27989323	[0.084-0.213] SD units decrease	0.1483	EFO_0006903
ENSG00000197386	rs76778080	4	3114605	T	Itch intensity from mosquito bite adjusted by bite size	28199695	[0.094-0.242] unit increase	0.167963	EFO_0008377\|EFO_0008378
ENSG00000197386	rs362307	4	3240118	?	General cognitive ability	29844566	z-score decrease	5.016	EFO_0004337
ENSG00000197386	rs362307	4	3240118	T	Worry too long after an embarrassing experience	29500382	z score decrease	6.13	EFO_0009589
ENSG00000197386	rs363096	4	3178294	T	Educational attainment (years of education)	30038396	[0.012-0.017] unit decrease	0.0143	EFO_0004784
ENSG00000197386	rs362307	4	3240118	T	Educational attainment (years of education)	30038396	[0.017-0.028] unit decrease	0.0226	EFO_0004784
ENSG00000197386	rs363096	4	3178294	?	Educational attainment (years of education)	30595370			EFO_0004784
ENSG00000197386	rs362307	4	3240118	T	Automobile speeding propensity	30643258	[0.024-0.04] unit decrease	0.03203624	EFO_0008579
ENSG00000197386	rs55962025	4	3110382	?	Waist-hip ratio	30595370			EFO_0004343
ENSG00000197386	rs6855981	4	3146549	?	White blood cell count	30595370			EFO_0004308
ENSG00000197386	rs7685686	4	3205415	A	Depression	30718901	[1.013-1.022]	1.017	EFO_0003761

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197386's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000132	establishment of mitotic spindle orientation	20696378.	IMP	Process
GO:0002039	p53 binding	10823891.	IPI	Function
GO:0005515	protein binding	7477378.9285789.9668110.9798945.10823891.12873381.15383276.15603740.15654337.16115810.17161366.17500595.17548833.17947297.18192679.18615096.19240112.19498170.20417604.20515468.22119730.22835334.23275563.23303669.24705354.25686248.26198635.28445460.29466333.	IPI	Function
GO:0005522	profilin binding	18573880.	IPI	Function
GO:0005634	nucleus	12783847.15654337.17704510.	IDA	Component
GO:0005634	nucleus	17947297.	IMP	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	7748555.15064418.15654337.	IDA	Component
GO:0005737	cytoplasm	17947297.	IMP	Component
GO:0005770	late endosome	17704510.	IDA	Component
GO:0005776	autophagosome	17704510.	IDA	Component
GO:0005783	endoplasmic reticulum	17704510.	IDA	Component
GO:0005794	Golgi apparatus	15837803.	IDA	Component
GO:0005814	centriole	21985783.	IDA	Component
GO:0005829	cytosol	20515468.	IDA	Component
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	20515468.	IMP	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0007030	Golgi organization	20515468.	IMP	Process
GO:0016234	inclusion body	17947297.	IMP	Component
GO:0019900	kinase binding	25686248.	IPI	Function
GO:0030424	axon	7748555.	IDA	Component
GO:0030425	dendrite	7748555.	IDA	Component
GO:0030659	cytoplasmic vesicle membrane	7748555.	IDA	Component
GO:0031072	heat shock protein binding	21909508.	IPI	Function
GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	12873381.	IDA	Process
GO:0031648	protein destabilization	17947297.	IMP	Process
GO:0032991	protein-containing complex	18922795.	IDA	Component
GO:0032991	protein-containing complex	17947297.	IMP	Component
GO:0034452	dynactin binding	18922795.	IPI	Function
GO:0042297	vocal learning	26436900.	IMP	Process
GO:0042802	identical protein binding	19487684.22119730.23275563.25848931.	IPI	Function
GO:0043065	positive regulation of apoptotic process	17947297.	IDA	Process
GO:0043666	regulation of phosphoprotein phosphatase activity	21562226.	IMP	Process
GO:0044325	ion channel binding	12873381.	IDA	Function
GO:0045505	dynein intermediate chain binding	20515468.	IDA	Function
GO:0045724	positive regulation of cilium assembly	21985783.	IMP	Process
GO:0047496	vesicle transport along microtubule	20515468.	IMP	Process
GO:0048471	perinuclear region of cytoplasm	17947297.	IMP	Component
GO:0048471	perinuclear region of cytoplasm	-	ISS	Component
GO:0048487	beta-tubulin binding	11870213.	IDA	Function
GO:0099523	presynaptic cytosol	7748555.	IDA	Component
GO:0099524	postsynaptic cytosol	7748555.	IDA	Component
GO:1903599	positive regulation of autophagy of mitochondrion	25686248.	IMP	Process
GO:1904504	positive regulation of lipophagy	25686248.	IMP	Process
GO:1905289	regulation of CAMKK-AMPK signaling cascade	21768291.	IMP	Process
GO:1905337	positive regulation of aggrephagy	25686248.	IMP	Process
GO:2000479	regulation of cAMP-dependent protein kinase activity	21768291.	IMP	Process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	19240112.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26293574	Unraveling the Role of Huntingtin in Breast Cancer Metastasis.	J Natl Cancer Inst	2015 Aug 20	Thion MS	doi: 10.1093/jnci/djv208
21454471	Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation.	J Biol Chem	2011 Jul 15	Zucchelli S	doi: 10.1074/jbc.M110.187591
26980106	CAG repeat size in Huntingtin alleles is associated with cancer prognosis.	Eur J Hum Genet	2016 Aug	Thion MS	doi: 10.1038/ejhg.2016.13

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr4	3135951	Missense_Mutation	novel	A894V	0.29
ACC	chr4	3238954	Missense_Mutation	novel	S3064F	0.46
BLCA	chr4	3240007	Missense_Mutation	NA	Y3126C	0.25
BLCA	chr4	3206558	Silent	novel	L1927L	0.48
BLCA	chr4	3173024	Silent	novel	G1353G	0.48
BLCA	chr4	3211987	Missense_Mutation	novel	G2158D	0.06
BLCA	chr4	3212603	Missense_Mutation	rs375059996	R2223Q	0.07
BLCA	chr4	3235762	Silent	NA	L2923L	0.23
BLCA	chr4	3116182	Silent	novel	V329V	0.15
BLCA	chr4	3235348	Missense_Mutation	NA	E2841Q	0.06
BLCA	chr4	3148049	Missense_Mutation	novel	E1114K	0.16
BLCA	chr4	3206831	Nonsense_Mutation	novel	Q1975*	0.07
BLCA	chr4	3209904	Silent	novel	V2123V	0.47
BLCA	chr4	3206561	Silent	NA	I1928I	0.16
BLCA	chr4	3180613	Missense_Mutation	NA	V1571L	0.49
BLCA	chr4	3238601	Missense_Mutation	rs377159286	V3016M	0.58
BLCA	chr4	3180577	Missense_Mutation	NA	D1559N	0.15
BLCA	chr4	3206571	Missense_Mutation	NA	H1932Y	0.09
BLCA	chr4	3228624	Missense_Mutation	novel	H2620N	0.26
BLCA	chr4	3233303	Silent	novel	L2802L	0.2
BLCA	chr4	3211997	Silent	NA	K2161K	0.2
BLCA	chr4	3235656	Missense_Mutation	rs374836871	S2888C	0.12
BLCA	chr4	3235576	Silent	novel	V2861V	0.21
BLCA	chr4	3146892	Missense_Mutation	novel	P1080Q	0.23
BLCA	chr4	3206854	Silent	NA	L1982L	0.52
BLCA	chr4	3146900	Missense_Mutation	novel	L1083V	0.03
BLCA	chr4	3146904	Nonsense_Mutation	novel	S1084*	0.07
BLCA	chr4	3130031	Silent	novel	F617F	0.21
BRCA	chr4	3220267	Missense_Mutation	novel	K2443T	0.24
BRCA	chr4	3224089	Missense_Mutation	novel	Q2575E	0.07
BRCA	chr4	3204147	Missense_Mutation	NA	V1906A	0.23
BRCA	chr4	3177352	Silent	NA	L1476L	0.29
BRCA	chr4	3115374	Missense_Mutation	novel	S273L	0.31
BRCA	chr4	3214107	In_Frame_Del	novel	Y2309del	0.27
BRCA	chr4	3154303	Missense_Mutation	NA	P1170R	0.16
BRCA	chr4	3241480	3'UTR	novel		0.2
BRCA	chr4	3215127	Missense_Mutation	NA	E2324K	0.32
BRCA	chr4	3174739	Missense_Mutation	NA	Q1395H	0.14
BRCA	chr4	3222410	Missense_Mutation	NA	E2465K	0.12
BRCA	chr4	3146858	Missense_Mutation	rs41264725	M1069V	0.15
BRCA	chr4	3208810	Missense_Mutation	novel	L2064V	0.14
BRCA	chr4	3222392	Missense_Mutation	novel	T2459A	0.15
BRCA	chr4	3121359	Silent	novel	G400G	0.23
BRCA	chr4	3131322	Missense_Mutation	NA	D675N	0.23
BRCA	chr4	3233330	Silent	NA	L2811L	0.53
BRCA	chr4	3189021	Missense_Mutation	NA	E1766K	0.3
BRCA	chr4	3235583	Missense_Mutation	NA	S2864P	0.3
BRCA	chr4	3188988	Missense_Mutation	rs758872041	I1755V	0.2
BRCA	chr4	3160377	Silent	NA	L1283L	0.17
BRCA	chr4	3182431	Missense_Mutation	rs776464028	Q1609H	0.04
BRCA	chr4	3233252	Silent	rs200390355	G2785G	0.38
BRCA	chr4	3212020	Missense_Mutation	novel	R2169P	0.08
BRCA	chr4	3146880	Nonsense_Mutation	NA	S1076*	0.18
BRCA	chr4	3132650	Silent	NA	L775L	0.45
CESC	chr4	3127433	Silent	novel	G524G	0.17
CESC	chr4	3107337	Missense_Mutation	NA	E221K	0.29
CESC	chr4	3180577	Missense_Mutation	NA	D1559N	0.24
CESC	chr4	3217944	Missense_Mutation	novel	P2412S	0.09
CESC	chr4	3178419	Missense_Mutation	novel	A1529T	0.05
CESC	chr4	3222450	Missense_Mutation	novel	Q2478R	0.16
CESC	chr4	3134416	Missense_Mutation	NA	L837V	0.27
CESC	chr4	3074829	Missense_Mutation	novel	A2S	0.24
CESC	chr4	3131356	Missense_Mutation	rs758062108	R686H	0.31
CESC	chr4	3236233	Missense_Mutation	rs779386355	R2957Q	0.32
CESC	chr4	3187769	Missense_Mutation	rs775722498	P1703L	0.29
CESC	chr4	3217863	Missense_Mutation	novel	P2385S	0.12
CESC	chr4	3189072	Silent	novel	L1783L	0.65
CESC	chr4	3212010	Missense_Mutation	NA	E2166K	0.35
CESC	chr4	3240521	3'UTR	novel		0.38
CESC	chr4	3243269	3'UTR	novel		0.28
CESC	chr4	3148132	Silent	novel	L1141L	0.38
CESC	chr4	3187718	Missense_Mutation	NA	Q1686P	0.65
CESC	chr4	3074819	5'UTR	novel		0.57
CESC	chr4	3115355	Missense_Mutation	rs747789499	R267W	0.51
CESC	chr4	3199779	Missense_Mutation	novel	D1806N	0.38
COAD	chr4	3214052	Missense_Mutation	NA	G2290V	0.23
COAD	chr4	3238550	Missense_Mutation	rs752320329	G2999R	0.34
COAD	chr4	3206611	Missense_Mutation	NA	R1945Q	0.28
COAD	chr4	3131372	Silent	rs374740113	S691S	0.4
COAD	chr4	3238549	Silent	rs767267961	I2998I	0.34
COAD	chr4	3220182	Missense_Mutation	rs759626383	V2415M	0.21
COAD	chr4	3127293	Silent	NA	L478L	0.32
COAD	chr4	3130348	Silent	NA	R637R	0.15
COAD	chr4	3206878	Silent	rs748994859	T1990T	0.23
COAD	chr4	3105378	Missense_Mutation	rs780520733	R184C	0.33
COAD	chr4	3172978	Missense_Mutation	rs752386077	S1338L	0.39
COAD	chr4	3239913	Missense_Mutation	novel	A3095T	0.31
COAD	chr4	3220274	Silent	novel	V2445V	0.44
COAD	chr4	3154341	Nonsense_Mutation	NA	R1183*	0.32
COAD	chr4	3174788	Missense_Mutation	rs754826573	R1412C	0.38
COAD	chr4	3239915	Silent	NA	A3095A	0.27
COAD	chr4	3217877	Silent	rs528326466	T2389T	0.31
COAD	chr4	3212643	Frame_Shift_Del	NA	*H2238Ffs6**	0.28
COAD	chr4	3208881	Silent	rs200512822	H2087H	0.42
COAD	chr4	3238964	Silent	novel	P3067P	0.24
COAD	chr4	3238894	Missense_Mutation	NA	T3044M	0.45
COAD	chr4	3217917	Missense_Mutation	NA	P2403A	0.29
COAD	chr4	3228888	Missense_Mutation	rs377091390	R2663Q	0.32
COAD	chr4	3238597	Silent	rs373377741	T3014T	0.41
COAD	chr4	3238510	Silent	rs374515950	D2985D	0.29
COAD	chr4	3212610	Silent	novel	L2225L	0.47
COAD	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.14
COAD	chr4	3103870	Missense_Mutation	NA	K172T	0.3
COAD	chr4	3127559	Silent	rs756855367	T566T	0.44
COAD	chr4	3132569	Silent	NA	Q748Q	0.32
COAD	chr4	3182358	Missense_Mutation	NA	L1585S	0.41
COAD	chr4	3186647	Missense_Mutation	NA	E1639D	0.43
COAD	chr4	3229982	Silent	rs754534599	D2735D	0.47
COAD	chr4	3127479	Missense_Mutation	rs747431001	V540I	0.45
COAD	chr4	3154316	Frame_Shift_Del	NA	*P1176Lfs3**	0.18
COAD	chr4	3235281	Splice_Region	novel		0.39
COAD	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.2
COAD	chr4	3127442	Missense_Mutation	NA	E527D	0.35
COAD	chr4	3129944	Missense_Mutation	novel	N588K	0.34
COAD	chr4	3160286	Missense_Mutation	NA	T1253M	0.07
COAD	chr4	3212565	Splice_Region	NA	G2210G	0.35
COAD	chr4	3148149	Missense_Mutation	novel	K1147T	0.21
COAD	chr4	3174983	Missense_Mutation	novel	L1428R	0.09
COAD	chr4	3115411	Silent	rs751408145	Q285Q	0.22
COAD	chr4	3187836	Missense_Mutation	NA	E1725D	0.38
COAD	chr4	3174968	Missense_Mutation	rs777708796	R1423H	0.34
COAD	chr4	3131293	Missense_Mutation	rs556061424	R665H	0.19
COAD	chr4	3174789	Missense_Mutation	rs201053245	R1412H	0.18
COAD	chr4	3228915	Missense_Mutation	rs202216456	S2672L	0.4
COAD	chr4	3099308	Missense_Mutation	NA	A128T	0.17
COAD	chr4	3180544	Missense_Mutation	rs770827394	D1548N	0.19
COAD	chr4	3175085	Missense_Mutation	novel	Y1462F	0.21
COAD	chr4	3131660	Silent	NA	V707V	0.4
COAD	chr4	3206604	Missense_Mutation	rs201639415	V1943I	0.24
COAD	chr4	3174955	Missense_Mutation	rs375899948	H1419N	0.1
COAD	chr4	3217944	Frame_Shift_Del	NA	*P2413Hfs44**	0.6
DLBC	chr4	3127560	Missense_Mutation	NA	E567K	0.41
DLBC	chr4	3182453	Missense_Mutation	novel	M1617V	0.32
ESCA	chr4	3131385	Missense_Mutation	novel	G696R	0.15
ESCA	chr4	3238952	Frame_Shift_Del	novel	*S3064Pfs25**	0.54
ESCA	chr4	3240508	3'UTR	novel		0.42
ESCA	chr4	3206656	Missense_Mutation	rs762436871	R1960H	0.38
ESCA	chr4	3229992	Missense_Mutation	rs772607321	A2739T	0.52
ESCA	chr4	3107340	In_Frame_Del	novel	S223_E226del	0.27
ESCA	chr4	3157188	Missense_Mutation	rs376975573	A1248T	0.26
ESCA	chr4	3132597	Missense_Mutation	novel	D758N	0.21
ESCA	chr4	3243084	3'UTR	novel		0.13
ESCA	chr4	3154326	Frame_Shift_Ins	novel	*S1179Kfs27**	0.13
GBM	chr4	3116224	Silent	novel	K343K	0.07
GBM	chr4	3116121	Missense_Mutation	novel	L309Q	0.05
GBM	chr4	3207344	Missense_Mutation	rs181217572	G2047R	0.41
GBM	chr4	3175045	Silent	novel	L1449L	0.09
GBM	chr4	3131390	Silent	novel	G697G	0.33
GBM	chr4	3172339	Missense_Mutation	novel	G1295E	0.28
GBM	chr4	3235652	Frame_Shift_Del	novel	*L2887Sfs16**	0.06
GBM	chr4	3116129	Missense_Mutation	novel	L312I	0.2
GBM	chr4	3172362	Nonsense_Mutation	NA	R1303*	0.27
GBM	chr4	3206897	Silent	novel	L1997L	0.23
GBM	chr4	3236162	Silent	novel	V2933V	0.21
GBM	chr4	3127406	Silent	novel	C515C	0.3
GBM	chr4	3175013	Missense_Mutation	novel	T1438N	0.08
GBM	chr4	3148100	Missense_Mutation	novel	D1131Y	0.1
GBM	chr4	3186629	Silent	novel	V1633V	0.09
GBM	chr4	3199769	Silent	novel	L1802L	0.11
GBM	chr4	3239967	Missense_Mutation	novel	Q3113E	0.15
GBM	chr4	3172351	Missense_Mutation	novel	S1299C	0.15
GBM	chr4	3175059	Silent	novel	A1453A	0.24
GBM	chr4	3229949	Silent	novel	L2724L	0.07
GBM	chr4	3223482	Frame_Shift_Del	novel	*V2516Gfs9**	0.06
GBM	chr4	3236157	Nonsense_Mutation	novel	K2932*	0.07
GBM	chr4	3220244	Silent	novel	I2435I	0.19
HNSC	chr4	3224068	Missense_Mutation	novel	I2568V	0.22
HNSC	chr4	3238892	Silent	novel	F3043F	0.29
HNSC	chr4	3233207	Silent	rs369914566	T2770T	0.27
HNSC	chr4	3238953	Missense_Mutation	novel	S3064P	0.23
HNSC	chr4	3129944	Missense_Mutation	novel	N588K	0.06
HNSC	chr4	3129945	Missense_Mutation	novel	Q589E	0.06
HNSC	chr4	3099346	Silent	novel	E140E	0.08
HNSC	chr4	3180565	Missense_Mutation	novel	T1555A	0.18
HNSC	chr4	3115345	Silent	novel	S263S	0.55
HNSC	chr4	3132719	Splice_Region	novel	T798T	0.3
HNSC	chr4	3099375	Missense_Mutation	NA	C150Y	0.15
HNSC	chr4	3199852	Missense_Mutation	novel	P1830L	0.13
HNSC	chr4	3154316	Frame_Shift_Del	NA	*P1176Lfs3**	0.36
HNSC	chr4	3136310	Missense_Mutation	rs369875192	A928T	0.09
HNSC	chr4	3187781	Missense_Mutation	novel	S1707F	0.08
HNSC	chr4	3187782	Silent	novel	S1707S	0.08
HNSC	chr4	3103865	Silent	novel	L170L	0.15
HNSC	chr4	3127373	Silent	novel	T504T	0.41
HNSC	chr4	3180544	Missense_Mutation	rs770827394	D1548N	0.23
HNSC	chr4	3217901	Silent	novel	I2397I	0.26
HNSC	chr4	3228977	Missense_Mutation	rs767514232	P2693S	0.32
KICH	chr4	3105404	Silent	novel	E192E	0.32
KIRC	chr4	3115421	Frame_Shift_Del	novel	*S289Mfs4**	0.31
KIRC	chr4	3206835	Missense_Mutation	NA	C1976F	0.14
KIRC	chr4	3206528	Silent	NA	T1917T	0.2
KIRC	chr4	3131752	Frame_Shift_Del	novel	*L739Pfs14**	0.1
KIRC	chr4	3136285	Silent	NA	E919E	0.3
KIRP	chr4	3229007	Missense_Mutation	NA	S2703P	0.39
KIRP	chr4	3160330	Missense_Mutation	rs779780620	R1268C	0.38
KIRP	chr4	3199835	Silent	NA	S1824S	0.07
KIRP	chr4	3228887	Silent	novel	R2663R	0.31
LGG	chr4	3224121	Silent	rs779366537	P2585P	0.04
LGG	chr4	3238918	Missense_Mutation	novel	A3052D	0.16
LGG	chr4	3172319	Splice_Site	novel	X1289_splice	0.09
LGG	chr4	3186720	Splice_Site	novel	X1663_splice	0.37
LGG	chr4	3235365	Silent	rs759383537	D2846D	0.38
LGG	chr4	3212695	Missense_Mutation	novel	V2254M	0.18
LIHC	chr4	3239872	Missense_Mutation	novel	G3081A	0.43
LIHC	chr4	3129960	Nonsense_Mutation	novel	Q594*	0.52
LIHC	chr4	3207291	Frame_Shift_Ins	novel	*Q2030Pfs43**	0.31
LIHC	chr4	3207292	Silent	novel	A2029A	0.3
LIHC	chr4	3127497	Missense_Mutation	rs781353727	M546V	0.47
LIHC	chr4	3206533	Missense_Mutation	novel	L1919R	0.33
LIHC	chr4	3187869	Silent	NA	P1736P	0.72
LIHC	chr4	3224122	Missense_Mutation	NA	A2586S	0.4
LIHC	chr4	3177382	Missense_Mutation	NA	Q1486H	0.19
LIHC	chr4	3239885	Missense_Mutation	novel	Q3085H	0.19
LIHC	chr4	3189081	Missense_Mutation	NA	I1786V	0.4
LIHC	chr4	3238515	Missense_Mutation	NA	F2987Y	0.09
LIHC	chr4	3235699	Silent	NA	L2902L	0.49
LIHC	chr4	3235734	Missense_Mutation	NA	R2914L	0.07
LIHC	chr4	3121280	Missense_Mutation	NA	T374N	0.4
LIHC	chr4	3222398	Missense_Mutation	rs764639811	R2461C	0.37
LIHC	chr4	3160379	Missense_Mutation	novel	Q1284R	0.25
LIHC	chr4	3228634	Missense_Mutation	NA	W2623L	0.49
LIHC	chr4	3240057	Nonstop_Mutation	NA	3143Rext8	0.55
LIHC	chr4	3228731	Silent	novel	S2655S	0.12
LUAD	chr4	3105371	Silent	novel	R181R	0.12
LUAD	chr4	3228995	Missense_Mutation	novel	E2699K	0.25
LUAD	chr4	3172971	Missense_Mutation	NA	S1336C	0.57
LUAD	chr4	3154340	Silent	novel	R1182R	0.36
LUAD	chr4	3220179	Splice_Region	novel		0.1
LUAD	chr4	3212107	Missense_Mutation	rs777249004	P2198L	0.35
LUAD	chr4	3199883	Silent	NA	L1840L	0.28
LUAD	chr4	3127588	Missense_Mutation	NA	S576L	0.1
LUAD	chr4	3233327	Silent	NA	L2810L	0.35
LUAD	chr4	3127382	Silent	rs201861325	A507A	0.36
LUAD	chr4	3175063	Silent	NA	L1455L	0.26
LUAD	chr4	3146872	Silent	novel	L1073L	0.35
LUAD	chr4	3230030	Silent	rs2229985	A2751A	0.3
LUAD	chr4	3235348	Missense_Mutation	NA	E2841Q	0.11
LUAD	chr4	3225668	Silent	novel	L2591L	0.22
LUAD	chr4	3154306	Missense_Mutation	novel	S1171C	0.27
LUAD	chr4	3182354	Missense_Mutation	novel	V1584L	0.13
LUAD	chr4	3115356	Missense_Mutation	novel	R267Q	0.07
LUAD	chr4	3173106	Missense_Mutation	novel	A1381T	0.17
LUAD	chr4	3225705	Missense_Mutation	novel	E2604K	0.16
LUAD	chr4	3132874	Missense_Mutation	NA	S819C	0.31
LUAD	chr4	3177352	Missense_Mutation	NA	L1476F	0.31
LUAD	chr4	3174945	Splice_Site	novel	X1416_splice	0.13
LUAD	chr4	3238906	Missense_Mutation	NA	P3048L	0.32
LUAD	chr4	3199870	Nonsense_Mutation	novel	W1836*	0.38
LUAD	chr4	3187860	Missense_Mutation	novel	K1733N	0.13
LUAD	chr4	3135910	Silent	NA	V880V	0.09
LUAD	chr4	3154355	Silent	NA	E1187E	0.29
LUAD	chr4	3220272	Missense_Mutation	NA	V2445I	0.21
LUSC	chr4	3130352	Missense_Mutation	novel	P639S	0.61
LUSC	chr4	3238950	Missense_Mutation	NA	A3063P	0.24
LUSC	chr4	3224018	Missense_Mutation	novel	R2551T	0.25
LUSC	chr4	3115365	Missense_Mutation	NA	A270V	0.07
LUSC	chr4	3086947	Frame_Shift_Del	novel	*E91Dfs10**	0.26
LUSC	chr4	3228737	Silent	NA	V2657V	0.18
LUSC	chr4	3229990	Missense_Mutation	novel	L2738P	0.24
LUSC	chr4	3238538	Missense_Mutation	NA	N2995H	0.32
LUSC	chr4	3130370	Missense_Mutation	novel	D645Y	0.26
LUSC	chr4	3131371	Missense_Mutation	rs779467594	S691L	0.19
LUSC	chr4	3187843	Missense_Mutation	NA	E1728K	0.1
LUSC	chr4	3186668	Silent	NA	L1646L	0.24
LUSC	chr4	3186669	Missense_Mutation	NA	R1647C	0.24
LUSC	chr4	3122931	Frame_Shift_Del	novel	*K440Rfs14**	0.18
LUSC	chr4	3222404	Missense_Mutation	novel	Q2463E	0.34
LUSC	chr4	3134524	Missense_Mutation	novel	A873T	0.48
LUSC	chr4	3206499	Missense_Mutation	NA	Q1908E	0.2
LUSC	chr4	3233309	Silent	rs71608259	P2804P	0.13
LUSC	chr4	3225700	Missense_Mutation	novel	N2602S	0.3
LUSC	chr4	3206865	Missense_Mutation	novel	G1986E	0.47
LUSC	chr4	3187772	Missense_Mutation	NA	Y1704C	0.2
LUSC	chr4	3208905	Silent	novel	P2095P	0.2
LUSC	chr4	3238816	Splice_Site	novel	X3019_splice	0.18
MESO	chr4	3127588	Nonsense_Mutation	novel	S576*	0.14
MESO	chr4	3116241	In_Frame_Del	novel	S350del	0.64
OV	chr4	3180588	Silent	NA	K1562K	0.06
OV	chr4	3212603	Missense_Mutation	rs375059996	R2223Q	0.07
OV	chr4	3235373	Missense_Mutation	rs144891713	P2849L	0.18
OV	chr4	3187669	Nonsense_Mutation	novel	Q1670*	0.04
OV	chr4	3214128	Silent	novel	L2315L	0.14
OV	chr4	3220197	Missense_Mutation	NA	W2420R	0.09
OV	chr4	3182402	Missense_Mutation	novel	E1600Q	0.36
OV	chr4	3230022	Missense_Mutation	novel	A2749P	0.09
OV	chr4	3212016	Missense_Mutation	novel	A2168T	0.27
OV	chr4	3229963	Missense_Mutation	novel	R2729M	0.19
OV	chr4	3208838	In_Frame_Ins	novel	P2073_S2074insAVHRN	0.07
OV	chr4	3206627	Silent	rs201305332	S1950S	0.24
OV	chr4	3217843	Missense_Mutation	novel	H2378P	0.13
OV	chr4	3175045	Silent	novel	L1449L	0.06
OV	chr4	3186653	Silent	NA	L1641L	0.11
OV	chr4	3127529	Silent	NA	S556S	0.22
OV	chr4	3175075	Missense_Mutation	novel	R1459G	0.21
OV	chr4	3182387	Missense_Mutation	novel	C1595S	0.18
OV	chr4	3204014	Missense_Mutation	novel	S1862C	0.05
OV	chr4	3220225	Missense_Mutation	novel	G2429D	0.07
PAAD	chr4	3131776	Splice_Site	novel	X746_splice	0.19
PAAD	chr4	3140649	Missense_Mutation	novel	I980L	0.17
PAAD	chr4	3142869	Missense_Mutation	novel	T1017A	0.17
PAAD	chr4	3238903	Missense_Mutation	novel	A3047V	0.24
PCPG	chr4	3235635	Missense_Mutation	novel	G2881V	0.31
PRAD	chr4	3233249	Silent	rs751199242	H2784H	0.24
PRAD	chr4	3233285	Silent	rs769866904	D2796D	0.13
PRAD	chr4	3132832	Missense_Mutation	rs140979048	A805V	0.43
PRAD	chr4	3175108	Splice_Site	NA	X1469_splice	0.07
PRAD	chr4	3204101	Missense_Mutation	novel	R1891G	0.36
PRAD	chr4	3132832	Missense_Mutation	rs140979048	A805V	0.34
PRAD	chr4	3208882	Missense_Mutation	NA	V2088M	0.17
READ	chr4	3206924	Missense_Mutation	rs777338986	R2006C	0.18
READ	chr4	3148095	Missense_Mutation	NA	L1129P	0.16
READ	chr4	3206637	Missense_Mutation	novel	I1954V	0.13
READ	chr4	3086946	Nonsense_Mutation	NA	E91*	0.44
READ	chr4	3175011	Silent	rs771433441	T1437T	0.48
READ	chr4	3180544	Missense_Mutation	rs770827394	D1548N	0.09
READ	chr4	3186701	Silent	rs199866794	F1657F	0.06
READ	chr4	3212691	Silent	rs369632008	F2252F	0.2
READ	chr4	3238949	Silent	rs756339121	S3062S	0.29
SARC	chr4	3223449	Missense_Mutation	novel	A2505G	0.15
SARC	chr4	3213993	Silent	rs370817761	P2270P	0.27
SARC	chr4	3240691	3'UTR	rs142037345		0.41
SARC	chr4	3236245	Frame_Shift_Del	novel	*F2962Lfs23**	0.87
SARC	chr4	3235745	Missense_Mutation	novel	A2918P	0.22
SARC	chr4	3136230	Nonsense_Mutation	novel	L901*	0.12
SARC	chr4	3186665	Silent	NA	S1645S	0.33
SKCM	chr4	3225703	Missense_Mutation	novel	P2603L	0.28
SKCM	chr4	3225704	Silent	rs570565498	P2603P	0.3
SKCM	chr4	3214065	Silent	novel	V2294V	0.38
SKCM	chr4	3214066	Missense_Mutation	novel	V2295I	0.36
SKCM	chr4	3121380	Silent	NA	A407A	0.25
SKCM	chr4	3131371	Missense_Mutation	rs779467594	S691L	0.38
SKCM	chr4	3121407	Silent	NA	R416R	0.18
SKCM	chr4	3240020	Silent	novel	L3130L	0.3
SKCM	chr4	3235603	Silent	NA	T2870T	0.44
SKCM	chr4	3132866	Silent	NA	K816K	0.2
SKCM	chr4	3134443	Missense_Mutation	NA	G846R	0.22
SKCM	chr4	3238464	Missense_Mutation	novel	P2970L	0.35
SKCM	chr4	3233227	Missense_Mutation	novel	P2777L	0.42
SKCM	chr4	3233228	Silent	novel	P2777P	0.42
SKCM	chr4	3199848	Missense_Mutation	novel	H1829Y	0.63
SKCM	chr4	3220213	Missense_Mutation	novel	G2425E	0.07
SKCM	chr4	3099323	Silent	NA	L133L	0.1
SKCM	chr4	3172344	Silent	NA	L1297L	0.08
SKCM	chr4	3173009	Silent	NA	S1348S	0.27
SKCM	chr4	3178415	Silent	NA	I1527I	0.2
SKCM	chr4	3186665	Silent	NA	S1645S	0.27
SKCM	chr4	3228913	Frame_Shift_Del	novel	*S2672Rfs25**	0.31
SKCM	chr4	3173020	Missense_Mutation	NA	P1352L	0.93
SKCM	chr4	3187695	Silent	NA	A1678A	0.93
SKCM	chr4	3187786	Missense_Mutation	novel	T1709A	0.44
SKCM	chr4	3127321	Missense_Mutation	NA	P487L	0.33
SKCM	chr4	3212691	Silent	rs369632008	F2252F	0.52
SKCM	chr4	3229972	Missense_Mutation	NA	P2732L	0.58
SKCM	chr4	3224101	Missense_Mutation	novel	P2579S	0.32
SKCM	chr4	3173005	Missense_Mutation	NA	S1347F	0.5
SKCM	chr4	3211992	Nonsense_Mutation	novel	Q2160*	0.2
SKCM	chr4	3145197	Missense_Mutation	NA	V1038I	0.32
SKCM	chr4	3228705	Missense_Mutation	NA	P2647S	0.24
SKCM	chr4	3186665	Silent	NA	S1645S	0.36
SKCM	chr4	3146841	Missense_Mutation	NA	T1063I	0.18
SKCM	chr4	3208790	Missense_Mutation	novel	S2057F	0.49
SKCM	chr4	3208791	Silent	novel	S2057S	0.49
SKCM	chr4	3172335	Silent	NA	L1294L	0.41
SKCM	chr4	3233348	Silent	NA	I2817I	0.45
SKCM	chr4	3187766	Missense_Mutation	NA	S1702F	0.49
SKCM	chr4	3199835	Silent	NA	S1824S	0.32
SKCM	chr4	3238879	Missense_Mutation	NA	S3039F	0.24
SKCM	chr4	3132618	Nonsense_Mutation	NA	R765*	0.25
SKCM	chr4	3099290	Nonsense_Mutation	NA	Q122*	0.51
SKCM	chr4	3146892	Missense_Mutation	NA	P1080L	0.15
SKCM	chr4	3235608	Missense_Mutation	NA	S2872F	0.1
SKCM	chr4	3224054	Missense_Mutation	NA	S2563L	0.51
SKCM	chr4	3240003	Missense_Mutation	NA	P3125S	0.28
SKCM	chr4	3148032	Missense_Mutation	NA	S1108L	0.48
SKCM	chr4	3116092	Silent	rs776923517	L299L	0.08
SKCM	chr4	3127462	Missense_Mutation	NA	S534F	0.11
SKCM	chr4	3222428	Missense_Mutation	NA	L2471F	0.06
SKCM	chr4	3212063	Silent	NA	L2183L	0.51
SKCM	chr4	3212659	Missense_Mutation	NA	P2242S	0.25
SKCM	chr4	3206911	Silent	NA	F2001F	0.39
SKCM	chr4	3099314	Missense_Mutation	NA	E130K	0.51
SKCM	chr4	3157117	Missense_Mutation	NA	S1224F	0.31
SKCM	chr4	3189039	Missense_Mutation	novel	Y1772D	0.44
SKCM	chr4	3214008	Silent	rs780305834	L2275L	0.33
SKCM	chr4	3212021	Frame_Shift_Del	novel	*E2170Rfs2**	0.47
SKCM	chr4	3208888	Missense_Mutation	NA	L2090V	0.47
SKCM	chr4	3228629	Silent	NA	S2621S	0.42
SKCM	chr4	3154408	Missense_Mutation	novel	E1205V	0.08
SKCM	chr4	3206569	Missense_Mutation	NA	S1931F	0.32
SKCM	chr4	3208791	Silent	novel	S2057S	0.13
SKCM	chr4	3223543	Silent	rs775119502	L2536L	0.17
SKCM	chr4	3125593	Missense_Mutation	NA	E456K	0.65
SKCM	chr4	3187682	Missense_Mutation	rs753577443	S1674L	0.43
SKCM	chr4	3238588	Silent	NA	F3011F	0.6
SKCM	chr4	3208790	Missense_Mutation	novel	S2057F	0.43
SKCM	chr4	3208791	Silent	novel	S2057S	0.43
SKCM	chr4	3107292	Silent	NA	L206L	0.18
SKCM	chr4	3217919	Silent	rs376323222	P2403P	0.74
SKCM	chr4	3127448	Silent	NA	I529I	0.25
SKCM	chr4	3175045	Missense_Mutation	novel	L1449V	0.16
SKCM	chr4	3229008	Missense_Mutation	NA	S2703F	0.39
STAD	chr4	3105370	Missense_Mutation	NA	R181Q	0.38
STAD	chr4	3208808	Missense_Mutation	novel	R2063L	0.35
STAD	chr4	3135904	Splice_Region	novel	R878R	0.5
STAD	chr4	3140617	Missense_Mutation	rs759239953	T969M	0.52
STAD	chr4	3222476	Missense_Mutation	novel	S2487C	0.21
STAD	chr4	3217917	Missense_Mutation	NA	P2403A	0.14
STAD	chr4	3157116	Missense_Mutation	NA	S1224T	0.1
STAD	chr4	3214134	Splice_Region	rs376635317	A2317A	0.12
STAD	chr4	3188985	Missense_Mutation	NA	D1754H	0.11
STAD	chr4	3217913	Silent	NA	R2401R	0.13
STAD	chr4	3225708	Frame_Shift_Ins	novel	*E2606Gfs62**	0.42
STAD	chr4	3086946	Nonsense_Mutation	NA	E91*	0.28
STAD	chr4	3136299	Missense_Mutation	NA	R924Q	0.34
STAD	chr4	3182417	Nonsense_Mutation	NA	R1605*	0.36
STAD	chr4	3199752	Missense_Mutation	NA	A1797T	0.35
STAD	chr4	3208807	Missense_Mutation	rs746044552	R2063C	0.26
STAD	chr4	3214135	Frame_Shift_Ins	novel	*A2319Cfs10**	0.13
STAD	chr4	3180635	Missense_Mutation	NA	L1578P	0.17
STAD	chr4	3146877	Missense_Mutation	NA	S1075L	0.09
STAD	chr4	3131355	Missense_Mutation	rs745573312	R686C	0.23
STAD	chr4	3214110	Silent	novel	Y2309Y	0.21
STAD	chr4	3132833	Silent	rs760077091	A805A	0.24
STAD	chr4	3238970	Silent	rs745832191	V3069V	0.43
STAD	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.28
STAD	chr4	3132887	Silent	NA	C823C	0.27
STAD	chr4	3213958	Missense_Mutation	NA	A2259S	0.2
STAD	chr4	3206554	Missense_Mutation	NA	D1926G	0.27
STAD	chr4	3188952	Frame_Shift_Del	novel	L1744*	0.15
STAD	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.47
STAD	chr4	3211947	Silent	novel	L2145L	0.39
STAD	chr4	3225745	Splice_Site	novel	X2616_splice	0.3
STAD	chr4	3235729	Silent	rs369845532	P2912P	0.33
STAD	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.38
STAD	chr4	3187682	Missense_Mutation	rs753577443	S1674L	0.5
STAD	chr4	3199901	Silent	NA	T1846T	0.28
STAD	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.15
STAD	chr4	3235750	Frame_Shift_Del	novel	*G2920Afs2**	0.36
STAD	chr4	3180588	Missense_Mutation	NA	K1562N	0.1
STAD	chr4	3233177	Silent	rs529410176	A2760A	0.24
STAD	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.13
STAD	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.18
STAD	chr4	3212664	Silent	NA	P2243P	0.1
STAD	chr4	3121389	Silent	novel	E410E	0.44
STAD	chr4	3222458	Missense_Mutation	NA	V2481M	0.16
STAD	chr4	3157075	Missense_Mutation	NA	S1210Y	0.3
STAD	chr4	3107309	Silent	rs750956107	P211P	0.2
STAD	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.18
STAD	chr4	3188981	Missense_Mutation	NA	L1752F	0.23
STAD	chr4	3217912	Missense_Mutation	NA	R2401H	0.25
STAD	chr4	3228728	Silent	rs369624996	T2654T	0.18
STAD	chr4	3148036	Nonsense_Mutation	novel	W1109*	0.17
TGCT	chr4	3235734	Missense_Mutation	NA	R2914L	0.19
UCEC	chr4	3178325	Silent	NA	I1497I	0.32
UCEC	chr4	3206517	Missense_Mutation	rs763949259	E1914K	0.27
UCEC	chr4	3233348	Silent	NA	I2817I	0.44
UCEC	chr4	3103837	Missense_Mutation	novel	S161C	0.35
UCEC	chr4	3103860	Missense_Mutation	NA	E169K	0.3
UCEC	chr4	3154342	Missense_Mutation	NA	R1183Q	0.21
UCEC	chr4	3131299	Missense_Mutation	novel	K667R	0.34
UCEC	chr4	3134503	Missense_Mutation	NA	T866A	0.34
UCEC	chr4	3182353	Splice_Site	novel	X1584_splice	0.15
UCEC	chr4	3206872	Silent	novel	V1988V	0.1
UCEC	chr4	3099273	Splice_Site	NA	X116_splice	0.29
UCEC	chr4	3134467	Silent	novel	L854L	0.29
UCEC	chr4	3136309	Silent	rs188101620	A927A	0.31
UCEC	chr4	3142866	Missense_Mutation	novel	S1016P	0.45
UCEC	chr4	3160308	Silent	rs753867386	T1260T	0.48
UCEC	chr4	3187682	Missense_Mutation	rs753577443	S1674L	0.32
UCEC	chr4	3235734	Missense_Mutation	NA	R2914L	0.41
UCEC	chr4	3208798	Missense_Mutation	NA	D2060N	0.43
UCEC	chr4	3236244	Missense_Mutation	novel	L2961I	0.11
UCEC	chr4	3131293	Missense_Mutation	rs556061424	R665H	0.32
UCEC	chr4	3235721	Missense_Mutation	novel	H2910N	0.41
UCEC	chr4	3136247	Missense_Mutation	novel	V907M	0.48
UCEC	chr4	3180592	Missense_Mutation	novel	L1564I	0.34
UCEC	chr4	3154393	Missense_Mutation	novel	P1200L	0.14
UCEC	chr4	3223994	Missense_Mutation	novel	F2543C	0.26
UCEC	chr4	3129977	Missense_Mutation	NA	Q599H	0.33
UCEC	chr4	3131640	Missense_Mutation	novel	L701M	0.15
UCEC	chr4	3132866	Missense_Mutation	novel	K816N	0.07
UCEC	chr4	3172373	Missense_Mutation	rs374335589	M1306I	0.28
UCEC	chr4	3125612	Missense_Mutation	NA	S462N	0.28
UCEC	chr4	3103860	Missense_Mutation	NA	E169K	0.11
UCEC	chr4	3160346	Missense_Mutation	NA	V1273A	0.09
UCEC	chr4	3175007	Missense_Mutation	NA	Y1436C	0.25
UCEC	chr4	3208807	Missense_Mutation	rs746044552	R2063C	0.29
UCEC	chr4	3225680	Missense_Mutation	novel	E2595D	0.15
UCEC	chr4	3148127	Nonsense_Mutation	novel	Q1140*	0.23
UCEC	chr4	3199834	Missense_Mutation	novel	S1824F	0.24
UCEC	chr4	3217796	Missense_Mutation	novel	M2362I	0.17
UCEC	chr4	3228727	Missense_Mutation	rs375426084	T2654M	0.38
UCEC	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.38
UCEC	chr4	3154387	Missense_Mutation	NA	L1198S	0.5
UCEC	chr4	3241248	3'UTR	novel		0.4
UCEC	chr4	3160361	Missense_Mutation	novel	L1278P	0.32
UCEC	chr4	3148149	Missense_Mutation	novel	K1147T	0.41
UCEC	chr4	3160350	Silent	novel	L1274L	0.46
UCEC	chr4	3175010	Missense_Mutation	rs760144960	T1437M	0.55
UCEC	chr4	3188976	Missense_Mutation	novel	L1751I	0.47
UCEC	chr4	3206529	Missense_Mutation	novel	W1918R	0.33
UCEC	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.36
UCEC	chr4	3129975	Nonsense_Mutation	novel	Q599*	0.35
UCEC	chr4	3212664	Silent	NA	P2243P	0.31
UCEC	chr4	3239966	Silent	rs763102180	F3112F	0.19
UCEC	chr4	3240141	3'UTR	novel		0.44
UCEC	chr4	3121399	Nonsense_Mutation	NA	R414*	0.34
UCEC	chr4	3182417	Nonsense_Mutation	NA	R1605*	0.75
UCEC	chr4	3099375	Missense_Mutation	NA	C150Y	0.33
UCEC	chr4	3116093	Missense_Mutation	rs113106141	V300I	0.35
UCEC	chr4	3148020	Missense_Mutation	NA	S1104Y	0.47
UCEC	chr4	3186619	Missense_Mutation	novel	A1630V	0.4
UCEC	chr4	3115430	Missense_Mutation	novel	L292I	0.58
UCEC	chr4	3220274	Silent	novel	V2445V	0.6
UCEC	chr4	3208870	Missense_Mutation	rs780493120	G2084R	0.33
UCEC	chr4	3182427	Missense_Mutation	NA	R1608Q	0.11
UCEC	chr4	3131390	Frame_Shift_Del	NA	*N699Mfs9**	0.16
UCEC	chr4	3154384	Missense_Mutation	rs767004706	P1197L	0.53
UCEC	chr4	3134416	Missense_Mutation	novel	L837F	0.49
UCEC	chr4	3206556	Missense_Mutation	novel	L1927M	0.47
UCEC	chr4	3107395	Missense_Mutation	novel	G240D	0.35
UCEC	chr4	3132633	Missense_Mutation	rs371462947	I770V	0.4
UCEC	chr4	3208896	Silent	novel	T2092T	0.31
UCEC	chr4	3238512	Missense_Mutation	novel	D2986V	0.29
UCEC	chr4	3223417	Missense_Mutation	novel	E2494D	0.07
UCEC	chr4	3225701	Frame_Shift_Del	novel	*E2604Sfs7**	0.18
UCEC	chr4	3239959	Missense_Mutation	novel	R3110M	0.28
UCEC	chr4	3189043	Nonsense_Mutation	novel	C1773delins*	0.02
UCEC	chr4	3154338	Nonsense_Mutation	novel	R1182*	0.16
UCEC	chr4	3206655	Missense_Mutation	NA	R1960C	0.14
UCEC	chr4	3235334	Missense_Mutation	rs757464347	A2836V	0.4
UCEC	chr4	3172995	Missense_Mutation	rs200657357	R1344C	0.3
UCEC	chr4	3189038	Missense_Mutation	NA	F1771L	0.42
UCEC	chr4	3212692	Missense_Mutation	rs374360323	V2253M	0.1
UCEC	chr4	3223440	Missense_Mutation	NA	A2502V	0.51
UCEC	chr4	3238965	Missense_Mutation	novel	W3068R	0.35
UCEC	chr4	3243298	3'UTR	novel		0.3
UCEC	chr4	3235339	Missense_Mutation	novel	Y2838H	0.6
UCEC	chr4	3116135	Missense_Mutation	rs756912473	V314M	0.35
UCEC	chr4	3122894	Frame_Shift_Del	novel	*G428Vfs18**	0.32
UCEC	chr4	3127575	Missense_Mutation	novel	A572T	0.25
UCEC	chr4	3186670	Missense_Mutation	novel	R1647H	0.31
UCEC	chr4	3116251	Silent	novel	E352E	0.34
UCEC	chr4	3129939	Missense_Mutation	novel	D587N	0.56
UCEC	chr4	3131752	Missense_Mutation	novel	P738H	0.24
UCEC	chr4	3172362	Nonsense_Mutation	NA	R1303*	0.51
UCEC	chr4	3233330	Silent	novel	L2811L	0.44
UCEC	chr4	3235666	Silent	rs781175874	L2891L	0.35
UCEC	chr4	3230000	Silent	novel	Y2741Y	0.34
UCEC	chr4	3172362	Nonsense_Mutation	NA	R1303*	0.24
UCEC	chr4	3233286	Missense_Mutation	NA	D2797N	0.33
UCEC	chr4	3233219	Silent	NA	S2774S	0.28
UCEC	chr4	3228677	Silent	rs768674350	D2637D	0.51
UCEC	chr4	3099323	Missense_Mutation	novel	L133M	0.2
UCEC	chr4	3209827	Missense_Mutation	novel	D2098N	0.15
UCEC	chr4	3115417	Missense_Mutation	novel	F287L	0.29
UCEC	chr4	3240856	3'UTR	rs372664017		0.19
UCEC	chr4	3121281	Silent	rs765073592	T374T	0.33
UCEC	chr4	3199936	Missense_Mutation	rs377136202	P1858L	0.17
UCEC	chr4	3132597	Missense_Mutation	novel	D758N	0.62
UCEC	chr4	3099331	Silent	rs368590997	C135C	0.12
UCEC	chr4	3187770	Silent	rs760738948	P1703P	0.06
UCEC	chr4	3206892	Missense_Mutation	NA	R1995M	0.47
UCEC	chr4	3154368	Nonsense_Mutation	novel	E1192*	0.43
UCEC	chr4	3186708	Missense_Mutation	novel	P1660T	0.3
UCEC	chr4	3236197	Frame_Shift_Del	novel	*D2947Tfs5**	0.25
UCEC	chr4	3130024	Missense_Mutation	novel	E615G	0.11
UCEC	chr4	3146799	Missense_Mutation	novel	V1049A	0.44
UCEC	chr4	3160381	Missense_Mutation	novel	D1285N	0.35
UCEC	chr4	3236233	Missense_Mutation	rs779386355	R2957Q	0.39
UCEC	chr4	3136325	Missense_Mutation	novel	R933W	0.04
UCEC	chr4	3188955	Missense_Mutation	NA	L1744I	0.46
UCEC	chr4	3228642	Missense_Mutation	rs757552793	N2626D	0.27
UCEC	chr4	3125557	Missense_Mutation	rs779703721	L444F	0.19
UCEC	chr4	3182427	Missense_Mutation	NA	R1608Q	0.44
UCEC	chr4	3212101	Missense_Mutation	NA	A2196V	0.32
UCEC	chr4	3127550	Missense_Mutation	novel	Q563H	0.27
UCEC	chr4	3129933	Missense_Mutation	rs764859997	G585S	0.3
UCEC	chr4	3140523	Silent	novel	L938L	0.27
UCEC	chr4	3174968	Missense_Mutation	rs777708796	R1423H	0.23
UCEC	chr4	3199925	Silent	novel	V1854V	0.19
UCEC	chr4	3204057	Missense_Mutation	novel	E1876A	0.26
UCEC	chr4	3223440	Missense_Mutation	NA	A2502V	0.21
UCEC	chr4	3121257	Silent	rs760722683	Q366Q	0.35
UCEC	chr4	3235289	Missense_Mutation	novel	V2821A	0.29
UCEC	chr4	3127475	Silent	novel	S538S	0.05
UCEC	chr4	3148067	Missense_Mutation	NA	T1120A	0.25
UCEC	chr4	3099371	Missense_Mutation	novel	E149K	0.36
UCEC	chr4	3206877	Missense_Mutation	rs772994297	T1990M	0.37
UCEC	chr4	3217947	Missense_Mutation	novel	P2413S	0.44
UCEC	chr4	3142791	Missense_Mutation	novel	P991S	0.45
UCEC	chr4	3174729	Missense_Mutation	novel	D1392G	0.35
UCEC	chr4	3182417	Nonsense_Mutation	NA	R1605*	0.45
UCEC	chr4	3206564	Missense_Mutation	novel	S1929R	0.28
UCEC	chr4	3229982	Silent	rs754534599	D2735D	0.35
UCEC	chr4	3240128	3'UTR	novel		0.23
UCEC	chr4	3239891	Silent	novel	D3087D	0.5
UCS	chr4	3224120	Missense_Mutation	novel	P2585L	0.24
UCS	chr4	3230041	Missense_Mutation	novel	M2755R	0.06
UVM	chr4	3121326	Silent	rs759711755	P389P	0.5

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.3661	0.12975
COAD	DEL	0.2616	0.14844
HNSC	DEL	0.3391	0.00046209
LIHC	DEL	0.1946	0.14149
LUAD	DEL	0.1453	0.16034
SKCM	DEL	0.1717	0.09333
UCEC	DEL	0.141	0.013734

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.015	Kaplan-Meier Survival Analysis
MESO	0.018	Kaplan-Meier Survival Analysis
HNSC	0.0013	Kaplan-Meier Survival Analysis
LUSC	0.0092	Kaplan-Meier Survival Analysis
ESCA	0.011	Kaplan-Meier Survival Analysis
KIRP	0.00045	Kaplan-Meier Survival Analysis
COAD	0.029	Kaplan-Meier Survival Analysis
PAAD	0.011	Kaplan-Meier Survival Analysis
LIHC	0.021	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742