EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197594 (Gene tree)
Gene ID: 5167
Gene Symbol: ENPP1
Alias: PC-1|PCA1|NPPS|M6S1|PDNP1
Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 87,140 bases
Position: chr6:131,808,016-131,895,155
Accession: 3356
RBP type: canonical RBP
Summary: This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000354238	Endonuclease_NS	PF01223.23	1.7e-09	1	1
ENSP00000498074	Endonuclease_NS	PF01223.23	1.7e-09	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19083193	The role of HSP70 on ENPP1 expression and insulin-receptor activation.	J Mol Med (Berl)	2009 Feb	Marucci A	doi: 10.1007/s00109-008-0429-9

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000459624	ENPP1-202	1633	-	-	- (aa)	-	-
ENST00000650437	ENPP1-208	2090	-	ENSP00000497981	68 (aa)	-	-
ENST00000647893	ENPP1-205	7438	-	ENSP00000498074	925 (aa)	-	UPI00001303F0
ENST00000486853	ENPP1-203	732	-	-	- (aa)	-	-
ENST00000650147	ENPP1-207	2146	-	ENSP00000497519	110 (aa)	-	-
ENST00000513998	ENPP1-204	3107	-	ENSP00000422424	378 (aa)	-	E9PE72
ENST00000650507	ENPP1-209	412	-	ENSP00000497375	56 (aa)	-	-
ENST00000647981	ENPP1-206	981	-	-	- (aa)	-	-
ENST00000360971	ENPP1-201	7442	-	ENSP00000354238	925 (aa)	-	P22413

Gene Model

Click here to download ENSG00000197594's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00230	Purine metabolism	KEGG
hsa00240	Pyrimidine metabolism	KEGG
hsa00500	Starch and sucrose metabolism	KEGG
hsa00740	Riboflavin metabolism	KEGG
hsa00760	Nicotinate and nicotinamide metabolism	KEGG
hsa00770	Pantothenate and CoA biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000197594	Heart Failure	9.3515330E-004	-
ENSG00000197594	Neutrophils	3.6200000E-005	-
ENSG00000197594	Fetal Hemoglobin	2.6300000E-005	20018918
ENSG00000197594	Platelet Function Tests	7.5800000E-007	-
ENSG00000197594	Transforming Growth Factor beta	3.5380000E-005	-
ENSG00000197594	C-Reactive Protein	3E-6	23251661

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197594's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197594	ENPP1	92	87.135	ENSAMEG00000010477	ENPP1	100	87.135	Ailuropoda_melanoleuca
ENSG00000197594	ENPP1	83	44.898	ENSACIG00000012031	-	94	44.898	Amphilophus_citrinellus
ENSG00000197594	ENPP1	54	41.016	ENSACIG00000013841	enpp1	99	41.016	Amphilophus_citrinellus
ENSG00000197594	ENPP1	88	50.673	ENSAOCG00000009328	-	98	49.592	Amphiprion_ocellaris
ENSG00000197594	ENPP1	83	50.904	ENSAPEG00000010146	-	93	50.904	Amphiprion_percula
ENSG00000197594	ENPP1	88	50.971	ENSATEG00000014039	-	98	50.117	Anabas_testudineus
ENSG00000197594	ENPP1	54	42.353	ENSATEG00000016939	enpp1	99	42.353	Anabas_testudineus
ENSG00000197594	ENPP1	92	66.084	ENSAPLG00000009457	ENPP1	100	66.084	Anas_platyrhynchos
ENSG00000197594	ENPP1	97	63.234	ENSACAG00000001235	ENPP1	99	63.234	Anolis_carolinensis
ENSG00000197594	ENPP1	97	96.437	ENSANAG00000022013	ENPP1	100	96.449	Aotus_nancymaae
ENSG00000197594	ENPP1	80	52.949	ENSACLG00000023811	enpp1	92	53.091	Astatotilapia_calliptera
ENSG00000197594	ENPP1	88	49.878	ENSACLG00000012456	-	96	49.878	Astatotilapia_calliptera
ENSG00000197594	ENPP1	91	42.638	ENSAMXG00000017732	-	99	42.638	Astyanax_mexicanus
ENSG00000197594	ENPP1	100	87.027	ENSBTAG00000021830	ENPP1	100	87.027	Bos_taurus
ENSG00000197594	ENPP1	100	96.108	ENSCJAG00000003010	ENPP1	100	96.108	Callithrix_jacchus
ENSG00000197594	ENPP1	99	86.761	ENSCAFG00000000001	ENPP1	99	87.182	Canis_familiaris
ENSG00000197594	ENPP1	99	86.324	ENSCAFG00020012520	ENPP1	97	89.984	Canis_lupus_dingo
ENSG00000197594	ENPP1	91	93.964	ENSTSYG00000008531	ENPP1	91	93.964	Carlito_syrichta
ENSG00000197594	ENPP1	97	79.041	ENSCPOG00000015236	ENPP1	99	79.041	Cavia_porcellus
ENSG00000197594	ENPP1	100	96.216	ENSCCAG00000021746	ENPP1	100	96.216	Cebus_capucinus
ENSG00000197594	ENPP1	100	97.946	ENSCATG00000033828	ENPP1	100	97.946	Cercocebus_atys
ENSG00000197594	ENPP1	93	81.618	ENSCLAG00000010425	ENPP1	100	80.299	Chinchilla_lanigera
ENSG00000197594	ENPP1	87	65.019	ENSCHOG00000003028	ENPP1	100	65.019	Choloepus_hoffmanni
ENSG00000197594	ENPP1	99	64.224	ENSCPBG00000017802	ENPP1	98	65.590	Chrysemys_picta_bellii
ENSG00000197594	ENPP1	94	98.272	ENSCANG00000017218	ENPP1	100	98.272	Colobus_angolensis_palliatus
ENSG00000197594	ENPP1	100	76.757	ENSCGRG00001000175	Enpp1	98	77.741	Cricetulus_griseus_chok1gshd
ENSG00000197594	ENPP1	100	76.757	ENSCGRG00000008073	Enpp1	98	77.741	Cricetulus_griseus_crigri
ENSG00000197594	ENPP1	88	47.222	ENSCSEG00000018458	-	99	47.038	Cynoglossus_semilaevis
ENSG00000197594	ENPP1	53	43.114	ENSCVAG00000002535	-	98	43.114	Cyprinodon_variegatus
ENSG00000197594	ENPP1	97	87.791	ENSDNOG00000035737	ENPP1	98	87.762	Dasypus_novemcinctus
ENSG00000197594	ENPP1	100	86.054	ENSDORG00000008721	Enpp1	99	87.168	Dipodomys_ordii
ENSG00000197594	ENPP1	91	78.431	ENSETEG00000010961	ENPP1	98	68.653	Echinops_telfairi
ENSG00000197594	ENPP1	56	42.447	ENSEBUG00000015544	-	100	42.447	Eptatretus_burgeri
ENSG00000197594	ENPP1	98	85.967	ENSEASG00005009938	ENPP1	100	86.827	Equus_asinus_asinus
ENSG00000197594	ENPP1	98	86.519	ENSECAG00000013035	ENPP1	87	86.519	Equus_caballus
ENSG00000197594	ENPP1	96	79.121	ENSEEUG00000006944	ENPP1	83	81.015	Erinaceus_europaeus
ENSG00000197594	ENPP1	88	49.268	ENSELUG00000017901	-	97	48.296	Esox_lucius
ENSG00000197594	ENPP1	77	52.089	ENSELUG00000013530	enpp1	88	52.089	Esox_lucius
ENSG00000197594	ENPP1	98	86.364	ENSFCAG00000029427	ENPP1	98	86.409	Felis_catus
ENSG00000197594	ENPP1	90	73.607	ENSFALG00000011753	ENPP1	99	65.781	Ficedula_albicollis
ENSG00000197594	ENPP1	93	81.882	ENSFDAG00000014619	ENPP1	99	81.692	Fukomys_damarensis
ENSG00000197594	ENPP1	54	38.370	ENSFHEG00000022910	enpp1	99	38.370	Fundulus_heteroclitus
ENSG00000197594	ENPP1	83	49.483	ENSFHEG00000012807	-	93	49.483	Fundulus_heteroclitus
ENSG00000197594	ENPP1	78	52.132	ENSGAFG00000000602	enpp1	86	52.132	Gambusia_affinis
ENSG00000197594	ENPP1	83	49.354	ENSGAFG00000001944	-	93	49.354	Gambusia_affinis
ENSG00000197594	ENPP1	88	50.914	ENSGACG00000009662	-	99	50.852	Gasterosteus_aculeatus
ENSG00000197594	ENPP1	74	52.080	ENSGACG00000010030	enpp1	99	52.080	Gasterosteus_aculeatus
ENSG00000197594	ENPP1	96	64.452	ENSGAGG00000020186	ENPP1	100	66.433	Gopherus_agassizii
ENSG00000197594	ENPP1	97	98.996	ENSGGOG00000011164	ENPP1	100	98.996	Gorilla_gorilla
ENSG00000197594	ENPP1	80	53.083	ENSHBUG00000017900	enpp1	92	53.226	Haplochromis_burtoni
ENSG00000197594	ENPP1	98	82.198	ENSHGLG00000018978	ENPP1	98	83.540	Heterocephalus_glaber_female
ENSG00000197594	ENPP1	91	83.492	ENSHGLG00100017294	ENPP1	96	83.492	Heterocephalus_glaber_male
ENSG00000197594	ENPP1	91	52.872	ENSIPUG00000004957	enpp1	95	52.872	Ictalurus_punctatus
ENSG00000197594	ENPP1	96	85.294	ENSJJAG00000020325	Enpp1	99	85.231	Jaculus_jaculus
ENSG00000197594	ENPP1	83	49.612	ENSKMAG00000007820	-	97	49.612	Kryptolebias_marmoratus
ENSG00000197594	ENPP1	80	51.867	ENSLBEG00000009898	enpp1	92	51.867	Labrus_bergylta
ENSG00000197594	ENPP1	88	50.363	ENSLBEG00000026248	-	98	49.766	Labrus_bergylta
ENSG00000197594	ENPP1	91	56.089	ENSLACG00000002139	ENPP1	100	56.089	Latimeria_chalumnae
ENSG00000197594	ENPP1	85	54.109	ENSLOCG00000016378	enpp1	99	50.685	Lepisosteus_oculatus
ENSG00000197594	ENPP1	88	48.492	ENSLOCG00000009125	-	96	47.841	Lepisosteus_oculatus
ENSG00000197594	ENPP1	91	88.284	ENSLAFG00000010741	ENPP1	100	88.284	Loxodonta_africana
ENSG00000197594	ENPP1	100	98.486	ENSMFAG00000036178	ENPP1	100	98.486	Macaca_fascicularis
ENSG00000197594	ENPP1	100	98.270	ENSMMUG00000014151	ENPP1	100	98.270	Macaca_mulatta
ENSG00000197594	ENPP1	97	95.185	ENSMNEG00000027631	ENPP1	99	94.260	Macaca_nemestrina
ENSG00000197594	ENPP1	91	98.107	ENSMLEG00000031178	ENPP1	100	98.107	Mandrillus_leucophaeus
ENSG00000197594	ENPP1	54	42.254	ENSMAMG00000004963	enpp1	99	42.254	Mastacembelus_armatus
ENSG00000197594	ENPP1	92	49.826	ENSMAMG00000020053	-	99	49.826	Mastacembelus_armatus
ENSG00000197594	ENPP1	88	49.756	ENSMZEG00005027061	-	96	49.756	Maylandia_zebra
ENSG00000197594	ENPP1	80	52.759	ENSMZEG00005001195	enpp1	92	52.759	Maylandia_zebra
ENSG00000197594	ENPP1	91	66.903	ENSMGAG00000013148	ENPP1	99	66.903	Meleagris_gallopavo
ENSG00000197594	ENPP1	99	77.875	ENSMAUG00000018561	Enpp1	99	78.170	Mesocricetus_auratus
ENSG00000197594	ENPP1	100	89.622	ENSMICG00000002958	ENPP1	100	89.622	Microcebus_murinus
ENSG00000197594	ENPP1	99	77.024	ENSMOCG00000014029	Enpp1	99	77.203	Microtus_ochrogaster
ENSG00000197594	ENPP1	86	47.596	ENSMMOG00000016250	-	96	47.080	Mola_mola
ENSG00000197594	ENPP1	100	76.483	ENSMODG00000017564	ENPP1	99	77.288	Monodelphis_domestica
ENSG00000197594	ENPP1	88	51.160	ENSMALG00000016153	-	98	50.234	Monopterus_albus
ENSG00000197594	ENPP1	100	78.595	MGP_CAROLIEiJ_G0015189	Enpp1	99	79.603	Mus_caroli
ENSG00000197594	ENPP1	100	78.811	ENSMUSG00000037370	Enpp1	99	79.713	Mus_musculus
ENSG00000197594	ENPP1	100	78.486	MGP_PahariEiJ_G0023811	Enpp1	99	79.383	Mus_pahari
ENSG00000197594	ENPP1	100	79.027	MGP_SPRETEiJ_G0015998	Enpp1	96	86.164	Mus_spretus
ENSG00000197594	ENPP1	91	83.353	ENSMPUG00000014674	ENPP1	100	83.353	Mustela_putorius_furo
ENSG00000197594	ENPP1	98	85.936	ENSMLUG00000016838	ENPP1	98	85.982	Myotis_lucifugus
ENSG00000197594	ENPP1	88	46.455	ENSNBRG00000023296	-	96	46.699	Neolamprologus_brichardi
ENSG00000197594	ENPP1	93	95.099	ENSNLEG00000014508	ENPP1	100	95.099	Nomascus_leucogenys
ENSG00000197594	ENPP1	78	87.952	ENSMEUG00000015321	-	77	87.952	Notamacropus_eugenii
ENSG00000197594	ENPP1	91	84.314	ENSOPRG00000017133	ENPP1	97	81.390	Ochotona_princeps
ENSG00000197594	ENPP1	79	52.086	ENSONIG00000005988	enpp1	99	52.086	Oreochromis_niloticus
ENSG00000197594	ENPP1	88	51.095	ENSONIG00000007202	-	96	51.152	Oreochromis_niloticus
ENSG00000197594	ENPP1	91	89.349	ENSOCUG00000014455	ENPP1	100	89.349	Oryctolagus_cuniculus
ENSG00000197594	ENPP1	88	49.577	ENSORLG00000000744	-	98	49.063	Oryzias_latipes
ENSG00000197594	ENPP1	88	49.698	ENSORLG00020013759	-	98	49.180	Oryzias_latipes_hni
ENSG00000197594	ENPP1	88	49.577	ENSORLG00015006829	-	98	49.063	Oryzias_latipes_hsok
ENSG00000197594	ENPP1	91	86.036	ENSOGAG00000014125	ENPP1	100	86.036	Otolemur_garnettii
ENSG00000197594	ENPP1	89	87.089	ENSOARG00000014188	ENPP1	100	87.089	Ovis_aries
ENSG00000197594	ENPP1	99	96.409	ENSPPAG00000031536	ENPP1	100	99.198	Pan_paniscus
ENSG00000197594	ENPP1	98	86.585	ENSPPRG00000023788	ENPP1	100	86.162	Panthera_pardus
ENSG00000197594	ENPP1	91	86.864	ENSPTIG00000007796	ENPP1	98	82.139	Panthera_tigris_altaica
ENSG00000197594	ENPP1	100	99.351	ENSPTRG00000018603	ENPP1	100	99.351	Pan_troglodytes
ENSG00000197594	ENPP1	100	98.054	ENSPANG00000021190	ENPP1	100	98.054	Papio_anubis
ENSG00000197594	ENPP1	72	57.194	ENSPKIG00000024511	-	92	50.093	Paramormyrops_kingsleyae
ENSG00000197594	ENPP1	80	50.604	ENSPKIG00000021026	enpp1	86	50.604	Paramormyrops_kingsleyae
ENSG00000197594	ENPP1	90	73.529	ENSPSIG00000006021	ENPP1	99	66.445	Pelodiscus_sinensis
ENSG00000197594	ENPP1	100	78.378	ENSPEMG00000023126	Enpp1	99	79.360	Peromyscus_maniculatus_bairdii
ENSG00000197594	ENPP1	96	80.274	ENSPCIG00000010328	ENPP1	95	77.379	Phascolarctos_cinereus
ENSG00000197594	ENPP1	80	52.005	ENSPFOG00000018956	enpp1	89	52.005	Poecilia_formosa
ENSG00000197594	ENPP1	87	48.276	ENSPFOG00000001997	-	99	48.291	Poecilia_formosa
ENSG00000197594	ENPP1	87	46.402	ENSPLAG00000009992	-	98	46.402	Poecilia_latipinna
ENSG00000197594	ENPP1	72	50.975	ENSPMEG00000005061	-	94	51.124	Poecilia_mexicana
ENSG00000197594	ENPP1	87	46.230	ENSPMEG00000020899	-	99	46.363	Poecilia_mexicana
ENSG00000197594	ENPP1	83	48.837	ENSPREG00000021481	-	93	48.837	Poecilia_reticulata
ENSG00000197594	ENPP1	80	51.613	ENSPREG00000008053	enpp1	90	51.613	Poecilia_reticulata
ENSG00000197594	ENPP1	100	98.054	ENSPPYG00000017010	ENPP1	100	98.054	Pongo_abelii
ENSG00000197594	ENPP1	86	79.167	ENSPCAG00000000736	ENPP1	98	66.924	Procavia_capensis
ENSG00000197594	ENPP1	100	90.811	ENSPCOG00000022684	ENPP1	100	90.811	Propithecus_coquereli
ENSG00000197594	ENPP1	97	85.588	ENSPVAG00000015527	ENPP1	99	85.588	Pteropus_vampyrus
ENSG00000197594	ENPP1	88	48.234	ENSPNYG00000023705	-	95	54.312	Pundamilia_nyererei
ENSG00000197594	ENPP1	80	52.941	ENSPNYG00000023212	enpp1	92	53.217	Pundamilia_nyererei
ENSG00000197594	ENPP1	91	48.946	ENSPNAG00000013193	-	97	48.946	Pygocentrus_nattereri
ENSG00000197594	ENPP1	94	80.298	ENSRNOG00000013994	Enpp1	100	80.298	Rattus_norvegicus
ENSG00000197594	ENPP1	99	96.760	ENSRBIG00000043798	ENPP1	99	96.760	Rhinopithecus_bieti
ENSG00000197594	ENPP1	97	98.436	ENSRROG00000034709	ENPP1	100	98.436	Rhinopithecus_roxellana
ENSG00000197594	ENPP1	91	96.213	ENSSBOG00000020891	ENPP1	100	96.213	Saimiri_boliviensis_boliviensis
ENSG00000197594	ENPP1	92	71.379	ENSSHAG00000010375	-	100	71.495	Sarcophilus_harrisii
ENSG00000197594	ENPP1	79	50.678	ENSSFOG00015007214	enpp1	99	47.566	Scleropages_formosus
ENSG00000197594	ENPP1	88	49.265	ENSSFOG00015000567	-	96	49.265	Scleropages_formosus
ENSG00000197594	ENPP1	88	51.285	ENSSMAG00000013625	-	97	51.285	Scophthalmus_maximus
ENSG00000197594	ENPP1	87	50.923	ENSSDUG00000013142	-	95	55.405	Seriola_dumerili
ENSG00000197594	ENPP1	88	51.285	ENSSLDG00000019675	-	98	50.058	Seriola_lalandi_dorsalis
ENSG00000197594	ENPP1	96	83.014	ENSSARG00000008794	ENPP1	99	78.060	Sorex_araneus
ENSG00000197594	ENPP1	88	49.332	ENSSPAG00000022568	-	95	49.332	Stegastes_partitus
ENSG00000197594	ENPP1	100	89.081	ENSSSCG00000004193	ENPP1	100	91.217	Sus_scrofa
ENSG00000197594	ENPP1	94	65.486	ENSTGUG00000011628	ENPP1	100	65.486	Taeniopygia_guttata
ENSG00000197594	ENPP1	99	88.420	ENSTTRG00000009907	ENPP1	99	88.420	Tursiops_truncatus
ENSG00000197594	ENPP1	91	85.799	ENSUAMG00000007109	ENPP1	99	85.799	Ursus_americanus
ENSG00000197594	ENPP1	91	86.509	ENSUMAG00000024441	ENPP1	99	86.509	Ursus_maritimus
ENSG00000197594	ENPP1	91	84.142	ENSVPAG00000005659	ENPP1	100	84.142	Vicugna_pacos
ENSG00000197594	ENPP1	91	87.574	ENSVVUG00000002928	ENPP1	98	82.637	Vulpes_vulpes
ENSG00000197594	ENPP1	88	58.717	ENSXETG00000030043	ENPP1	99	58.717	Xenopus_tropicalis
ENSG00000197594	ENPP1	78	52.538	ENSXMAG00000017408	enpp1	90	52.538	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004527	exonuclease activity	22285541.	IDA	Function
GO:0004528	phosphodiesterase I activity	21873635.	IBA	Function
GO:0004528	phosphodiesterase I activity	27467858.	IDA	Function
GO:0004528	phosphodiesterase I activity	-	ISS	Function
GO:0004551	nucleotide diphosphatase activity	21873635.	IBA	Function
GO:0004551	nucleotide diphosphatase activity	12746903.	IDA	Function
GO:0005044	scavenger receptor activity	-	IEA	Function
GO:0005158	insulin receptor binding	7830796.	IDA	Function
GO:0005509	calcium ion binding	-	ISS	Function
GO:0005515	protein binding	11289049.	IPI	Function
GO:0005524	ATP binding	7830796.	IDA	Function
GO:0005615	extracellular space	11159191.	IDA	Component
GO:0005765	lysosomal membrane	17897319.	HDA	Component
GO:0005886	plasma membrane	10513816.27467858.	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005887	integral component of plasma membrane	-	ISS	Component
GO:0006091	generation of precursor metabolites and energy	12746903.	IDA	Process
GO:0006771	riboflavin metabolic process	-	TAS	Process
GO:0006796	phosphate-containing compound metabolic process	10513816.11159191.	IDA	Process
GO:0006898	receptor-mediated endocytosis	-	IEA	Process
GO:0006955	immune response	-	IEA	Process
GO:0008270	zinc ion binding	-	ISS	Function
GO:0009143	nucleoside triphosphate catabolic process	21873635.	IBA	Process
GO:0009143	nucleoside triphosphate catabolic process	10513816.	IDA	Process
GO:0009986	cell surface	21873635.	IBA	Component
GO:0009986	cell surface	10513816.	IDA	Component
GO:0016021	integral component of membrane	-	ISS	Component
GO:0016323	basolateral plasma membrane	9553761.	NAS	Component
GO:0030247	polysaccharide binding	-	IEA	Function
GO:0030308	negative regulation of cell growth	17849011.	IDA	Process
GO:0030500	regulation of bone mineralization	21873635.	IBA	Process
GO:0030500	regulation of bone mineralization	10513816.	IC	Process
GO:0030505	inorganic diphosphate transport	21873635.	IBA	Process
GO:0030505	inorganic diphosphate transport	10513816.	IDA	Process
GO:0030643	cellular phosphate ion homeostasis	11159191.	IDA	Process
GO:0030730	sequestering of triglyceride	17849011.	IDA	Process
GO:0031214	biomineral tissue development	-	IEA	Process
GO:0031953	negative regulation of protein autophosphorylation	11289049.	IDA	Process
GO:0032869	cellular response to insulin stimulus	7830796.17849011.	IDA	Process
GO:0035529	NADH pyrophosphatase activity	-	IEA	Function
GO:0042803	protein homodimerization activity	7830796.	IDA	Function
GO:0045599	negative regulation of fat cell differentiation	21873635.	IBA	Process
GO:0045599	negative regulation of fat cell differentiation	17849011.	IDA	Process
GO:0045719	negative regulation of glycogen biosynthetic process	11289049.	IDA	Process
GO:0046034	ATP metabolic process	21873635.	IBA	Process
GO:0046034	ATP metabolic process	-	ISS	Process
GO:0046325	negative regulation of glucose import	17849011.	IDA	Process
GO:0046627	negative regulation of insulin receptor signaling pathway	7830796.17849011.	IDA	Process
GO:0047429	nucleoside-triphosphate diphosphatase activity	7830796.10513816.11159191.	IDA	Function
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process	7830796.	IDA	Process
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding	7830796.	IC	Function
GO:0090305	nucleic acid phosphodiester bond hydrolysis	22285541.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25344812	Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.	Nat Chem Biol	2014 Dec	Li L	doi: 10.1038/nchembio.1661
21195542	The expression of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP1) is correlated with astrocytic tumor grade.	Clin Neurol Neurosurg	2011 Apr	Aerts I	doi: 10.1016/j.clineuro.2010.11.018
25231727	EphA3, induced by PC-1/PrLZ, contributes to the malignant progression of prostate cancer.	Oncol Rep	2014 Dec	Wu R	doi: 10.3892/or.2014.3482
23861746	Enpp1: a potential facilitator of breast cancer bone metastasis.	PLoS One	2013 Jul 5	Lau WM	doi: 10.1371/journal.pone.0066752
23433854	Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: influence of Gleason score, treatment and bone metastasis.	Biomed Pharmacother	2013 Apr	Battisti V	doi: 10.1016/j.biopha.2012.12.004
22826605	PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis.	Cancer Res	2012 Sep 15	Yamato I	doi: 10.1158/0008-5472.CAN-12-0328

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	131882455	Silent	rs376128399	Y737Y	0.58
BLCA	chr6	131886699	Missense_Mutation	NA	R861K	0.26	Endonuclease_NS
BLCA	chr6	131890360	Missense_Mutation	rs764466020	S876L	0.7
BLCA	chr6	131880019	Silent	NA	Y695Y	0.17
BLCA	chr6	131877070	Missense_Mutation	rs763005831	T601M	0.38
BLCA	chr6	131868091	Missense_Mutation	novel	H413R	0.1
BLCA	chr6	131869451	Missense_Mutation	rs765071179	R456Q	0.36
BLCA	chr6	131869481	Missense_Mutation	novel	Y466C	0.85
BRCA	chr6	131875839	Missense_Mutation	rs750660271	I567V	0.41
BRCA	chr6	131886650	Missense_Mutation	NA	P845S	0.21	Endonuclease_NS
BRCA	chr6	131890721	3'UTR	novel		0.4
BRCA	chr6	131879879	Splice_Site	NA	X649_splice	0.73
BRCA	chr6	131884970	Missense_Mutation	NA	Y784C	0.12	Endonuclease_NS
BRCA	chr6	131874305	Missense_Mutation	NA	H535N	0.2
BRCA	chr6	131851241	Frame_Shift_Ins	novel	*I178Pfs15**	0.04
BRCA	chr6	131886588	Missense_Mutation	NA	E824A	0.32	Endonuclease_NS
CESC	chr6	131850031	Missense_Mutation	NA	N119D	0.34
CESC	chr6	131886605	Missense_Mutation	NA	H830Y	0.45	Endonuclease_NS
CESC	chr6	131872926	Missense_Mutation	rs373044722	R481W	0.51
CESC	chr6	131877098	Silent	novel	P610P	0.36
CESC	chr6	131886648	Missense_Mutation	rs202179867	T844M	0.38	Endonuclease_NS
CESC	chr6	131890437	Missense_Mutation	novel	Q902E	0.31
CESC	chr6	131851188	Silent	NA	L159L	0.42
COAD	chr6	131858688	Frame_Shift_Del	rs759257042	*N247Tfs2**	0.13
COAD	chr6	131847790	Silent	novel	C85C	0.33
COAD	chr6	131869418	Missense_Mutation	rs771292916	K445T	0.36
COAD	chr6	131890564	3'UTR	novel		0.42
COAD	chr6	131861608	Missense_Mutation	NA	A310V	0.16
COAD	chr6	131877206	Intron	novel		0.12
COAD	chr6	131879890	Silent	NA	I652I	0.55
COAD	chr6	131872069	Splice_Site	novel	X469_splice	0.3
COAD	chr6	131882352	Missense_Mutation	novel	F703S	0.09	Endonuclease_NS
COAD	chr6	131883728	Missense_Mutation	NA	E755D	0.2	Endonuclease_NS
COAD	chr6	131886660	Missense_Mutation	NA	C848Y	0.26	Endonuclease_NS
COAD	chr6	131873012	Silent	novel	P509P	0.28
COAD	chr6	131890467	Missense_Mutation	NA	L912V	0.36
COAD	chr6	131884998	Silent	rs755592935	V793V	0.16
COAD	chr6	131890444	Missense_Mutation	NA	R904I	0.16
COAD	chr6	131858704	Missense_Mutation	NA	V251A	0.32
COAD	chr6	131874328	In_Frame_Ins	novel	S542_N543insL	0.13
COAD	chr6	131874330	Missense_Mutation	novel	N543I	0.07
COAD	chr6	131877024	Missense_Mutation	NA	G586R	0.29
ESCA	chr6	131869411	Missense_Mutation	rs768378653	D443Y	0.11
ESCA	chr6	131851190	Missense_Mutation	novel	T160N	0.28
ESCA	chr6	131879912	Missense_Mutation	novel	G660R	0.3
GBM	chr6	131877301	Intron	novel		0.18
GBM	chr6	131852225	Missense_Mutation	novel	C203R	0.23
GBM	chr6	131852226	Missense_Mutation	novel	C203Y	0.23
GBM	chr6	131877301	Intron	novel		0.17
GBM	chr6	131890554	3'UTR	rs771559519		0.36
GBM	chr6	131877301	Intron	novel		0.17
GBM	chr6	131890606	3'UTR	novel		0.14
GBM	chr6	131879957	Missense_Mutation	novel	S675T	0.08	Endonuclease_NS
HNSC	chr6	131882456	Missense_Mutation	novel	G738R	0.39	Endonuclease_NS
HNSC	chr6	131885062	Nonsense_Mutation	novel	Q815*	0.29	Endonuclease_NS
HNSC	chr6	131873010	Missense_Mutation	novel	P509T	0.09
HNSC	chr6	131882471	Missense_Mutation	novel	P743T	0.13	Endonuclease_NS
HNSC	chr6	131851196	Missense_Mutation	novel	S162I	0.36
HNSC	chr6	131879930	Nonsense_Mutation	novel	Q666*	0.09
HNSC	chr6	131879905	Missense_Mutation	novel	L657F	0.45
HNSC	chr6	131885036	Missense_Mutation	novel	R806P	0.17	Endonuclease_NS
HNSC	chr6	131860416	Silent	rs369580462	I275I	0.25
HNSC	chr6	131874286	Silent	novel	K528K	0.2
HNSC	chr6	131877160	Missense_Mutation	rs773654100	S631L	0.17
HNSC	chr6	131883756	Missense_Mutation	novel	M765L	0.17	Endonuclease_NS
KIRC	chr6	131864548	Missense_Mutation	novel	W356C	0.24
KIRP	chr6	131858668	Frame_Shift_Del	novel	*K240Nfs9**	0.29
KIRP	chr6	131850067	Missense_Mutation	NA	N131H	0.3
KIRP	chr6	131884967	Missense_Mutation	NA	K783T	0.38	Endonuclease_NS
KIRP	chr6	131890371	Frame_Shift_Del	novel	*E880Nfs3**	0.29
KIRP	chr6	131890372	Missense_Mutation	novel	E880V	0.29
KIRP	chr6	131877262	Intron	novel		0.41
LAML	chr6	131826194	Intron	NA		0.32
LAML	chr6	131868031	Missense_Mutation	novel	L393W	0.17
LGG	chr6	131872978	Missense_Mutation	rs762558218	R498H	0.39
LGG	chr6	131877070	Missense_Mutation	rs763005831	T601M	0.53
LGG	chr6	131890345	Missense_Mutation	novel	G871V	0.11
LGG	chr6	131854993	Missense_Mutation	rs147798392	G229S	0.04
LIHC	chr6	131868048	Missense_Mutation	novel	M399L	0.25
LUAD	chr6	131861623	Missense_Mutation	novel	L315H	0.1
LUAD	chr6	131874332	Missense_Mutation	novel	M544V	0.42
LUAD	chr6	131890453	Missense_Mutation	NA	P907L	0.33
LUAD	chr6	131882457	Missense_Mutation	NA	G738E	0.25	Endonuclease_NS
LUAD	chr6	131868086	Missense_Mutation	NA	N411K	0.55
LUAD	chr6	131852174	Splice_Site	NA	X186_splice	0.58
LUAD	chr6	131860491	Missense_Mutation	novel	W300C	0.25
LUAD	chr6	131877098	Silent	novel	P610P	0.19
LUAD	chr6	131890398	Missense_Mutation	NA	I889V	0.11
LUAD	chr6	131852232	Missense_Mutation	NA	A205V	0.2
LUAD	chr6	131847847	Missense_Mutation	NA	E104D	0.14
LUAD	chr6	131868060	Missense_Mutation	NA	L403V	0.33
LUAD	chr6	131890427	Silent	novel	L898L	0.16
LUAD	chr6	131869451	Missense_Mutation	NA	R456L	0.2
LUAD	chr6	131890344	Missense_Mutation	NA	G871W	0.26
LUAD	chr6	131882358	Missense_Mutation	rs138032713	T705M	0.12	Endonuclease_NS
LUAD	chr6	131886672	Missense_Mutation	rs772387213	D852V	0.29	Endonuclease_NS
LUAD	chr6	131874313	Silent	novel	S537S	0.48
LUAD	chr6	131850093	Silent	novel	T139T	0.28
LUSC	chr6	131864878	Nonsense_Mutation	novel	Y368*	0.18
LUSC	chr6	131850041	Missense_Mutation	novel	C122F	0.16
LUSC	chr6	131850043	Missense_Mutation	novel	D123H	0.2
LUSC	chr6	131877210	Intron	novel		0.23
LUSC	chr6	131875824	Missense_Mutation	novel	D562N	0.06
LUSC	chr6	131860485	Silent	novel	P298P	0.25
LUSC	chr6	131883729	Missense_Mutation	NA	A756S	0.16	Endonuclease_NS
LUSC	chr6	131850049	Missense_Mutation	rs201280142	A125T	0.24
LUSC	chr6	131847821	Missense_Mutation	novel	G96W	0.52
LUSC	chr6	131877030	Missense_Mutation	novel	H588Y	0.13
LUSC	chr6	131858748	Splice_Site	rs753851892	X265_splice	0.27
LUSC	chr6	131847837	Missense_Mutation	NA	C101F	0.35
LUSC	chr6	131851205	Missense_Mutation	NA	A165D	0.21
LUSC	chr6	131884981	Missense_Mutation	novel	R788G	0.36	Endonuclease_NS
LUSC	chr6	131890452	Missense_Mutation	novel	P907S	0.25
LUSC	chr6	131890396	Frame_Shift_Del	novel	*I889Sfs24**	0.17
LUSC	chr6	131858688	Missense_Mutation	rs774807507	K246E	0.2
LUSC	chr6	131858712	Missense_Mutation	NA	T254A	0.21
LUSC	chr6	131885009	Missense_Mutation	novel	P797L	0.41	Endonuclease_NS
LUSC	chr6	131877011	Silent	novel	P581P	0.37
LUSC	chr6	131877012	Missense_Mutation	NA	A582S	0.36
LUSC	chr6	131868032	Missense_Mutation	NA	L393F	0.2
LUSC	chr6	131886567	Missense_Mutation	novel	R817T	0.2	Endonuclease_NS
LUSC	chr6	131884988	Missense_Mutation	novel	G790V	0.38	Endonuclease_NS
LUSC	chr6	131855002	Missense_Mutation	NA	L232F	0.34
LUSC	chr6	131850094	Missense_Mutation	NA	C140S	0.25
LUSC	chr6	131890560	3'UTR	novel		0.17
LUSC	chr6	131873017	Missense_Mutation	novel	T511I	0.24
OV	chr6	131890449	Missense_Mutation	NA	E906Q	0.35
OV	chr6	131877301	Intron	novel		0.23
OV	chr6	131850007	Missense_Mutation	NA	R111C	0.28
OV	chr6	131827124	Intron	NA		0.24
OV	chr6	131890660	3'UTR	novel		0.15
OV	chr6	131877301	Intron	novel		0.5
OV	chr6	131847786	Missense_Mutation	novel	V84A	0.1
OV	chr6	131828357	Intron	NA		0.73
OV	chr6	131879905	Silent	novel	L657L	0.14
OV	chr6	131850007	Missense_Mutation	NA	R111C	0.25
OV	chr6	131868117	Missense_Mutation	novel	S422P	0.05
PRAD	chr6	131886717	Missense_Mutation	novel	S867I	0.06
PRAD	chr6	131874317	Missense_Mutation	NA	N539D	0.34
PRAD	chr6	131882455	Silent	rs376128399	Y737Y	0.15
READ	chr6	131878541	Splice_Site	NA	X632_splice	0.26
READ	chr6	131886718	Silent	NA	S867S	0.18
READ	chr6	131858747	Splice_Region	rs764173846	T265T	0.43
READ	chr6	131879886	Missense_Mutation	novel	I651S	0.17
SARC	chr6	131864564	Missense_Mutation	novel	D362N	0.25
SKCM	chr6	131875778	Splice_Region	novel	A546A	0.35
SKCM	chr6	131886610	Silent	NA	F831F	0.5
SKCM	chr6	131886702	Missense_Mutation	NA	T862I	0.51	Endonuclease_NS
SKCM	chr6	131868028	Missense_Mutation	NA	A392V	0.3
SKCM	chr6	131860387	Missense_Mutation	NA	G266R	0.34
SKCM	chr6	131875842	Missense_Mutation	NA	E568K	0.23
SKCM	chr6	131860435	Missense_Mutation	novel	P282S	0.43
SKCM	chr6	131886662	Missense_Mutation	NA	E849K	0.41	Endonuclease_NS
SKCM	chr6	131877202	Intron	novel		0.82
SKCM	chr6	131880016	Silent	NA	S694S	0.4
SKCM	chr6	131890546	3'UTR	novel		0.13
SKCM	chr6	131860496	Missense_Mutation	novel	K302R	0.23
SKCM	chr6	131890444	Missense_Mutation	NA	R904K	0.41
SKCM	chr6	131868111	Missense_Mutation	novel	L420F	0.49
SKCM	chr6	131850004	Missense_Mutation	rs372420217	G110S	0.55
SKCM	chr6	131852234	Missense_Mutation	novel	G206R	0.46
SKCM	chr6	131872091	Missense_Mutation	rs776045926	R476Q	0.34
SKCM	chr6	131849997	Silent	NA	S107S	0.45
SKCM	chr6	131854996	Missense_Mutation	novel	G230R	0.51
SKCM	chr6	131877156	Missense_Mutation	NA	P630S	0.35
SKCM	chr6	131860417	Missense_Mutation	rs143771474	D276N	0.75
SKCM	chr6	131883771	Nonsense_Mutation	NA	Q770*	0.33	Endonuclease_NS
SKCM	chr6	131883702	Frame_Shift_Del	novel	*N748Ffs7**	0.38	Endonuclease_NS
SKCM	chr6	131880003	Missense_Mutation	NA	P690L	0.08	Endonuclease_NS
SKCM	chr6	131847826	Silent	NA	L97L	0.69
SKCM	chr6	131886577	Silent	NA	I820I	0.92
SKCM	chr6	131879958	Missense_Mutation	NA	S675F	0.35	Endonuclease_NS
SKCM	chr6	131855002	Missense_Mutation	NA	L232F	0.07
SKCM	chr6	131852179	Silent	NA	E187E	0.38
SKCM	chr6	131882409	Missense_Mutation	novel	P722L	0.43	Endonuclease_NS
SKCM	chr6	131877051	Silent	novel	L595L	0.12
STAD	chr6	131872975	Missense_Mutation	NA	K497T	0.42
STAD	chr6	131861701	Missense_Mutation	novel	N341S	0.18
STAD	chr6	131858715	Missense_Mutation	NA	K255Q	0.29
STAD	chr6	131864529	Missense_Mutation	NA	I350S	0.24
STAD	chr6	131858704	Missense_Mutation	NA	V251A	0.28
STAD	chr6	131883748	Missense_Mutation	NA	I762T	0.29	Endonuclease_NS
STAD	chr6	131877095	Frame_Shift_Del	novel	*L611Wfs34**	0.34
STAD	chr6	131877169	Splice_Region	novel		0.23
THCA	chr6	131850000	Nonsense_Mutation	NA	C108*	0.12
THCA	chr6	131890465	Frame_Shift_Ins	novel	*L912Yfs4**	0.07
THCA	chr6	131850055	Missense_Mutation	NA	V127I	0.1
UCEC	chr6	131883703	Missense_Mutation	NA	K747T	0.32	Endonuclease_NS
UCEC	chr6	131884964	Missense_Mutation	rs375822204	R782Q	0.24	Endonuclease_NS
UCEC	chr6	131872091	Missense_Mutation	rs776045926	R476Q	0.33
UCEC	chr6	131858743	Missense_Mutation	novel	V264A	0.07
UCEC	chr6	131847795	Missense_Mutation	novel	L87S	0.47
UCEC	chr6	131877160	Missense_Mutation	rs773654100	S631L	0.47
UCEC	chr6	131879886	Missense_Mutation	novel	I651N	0.38
UCEC	chr6	131855016	Silent	novel	S236S	0.09
UCEC	chr6	131890568	3'UTR	novel		0.36
UCEC	chr6	131874277	Silent	novel	S525S	0.38
UCEC	chr6	131884998	Silent	rs755592935	V793V	0.55
UCEC	chr6	131861670	Missense_Mutation	rs543043974	G331R	0.41
UCEC	chr6	131880008	Missense_Mutation	novel	W692R	0.14	Endonuclease_NS
UCEC	chr6	131860473	Missense_Mutation	novel	E294D	0.32
UCEC	chr6	131876995	Nonsense_Mutation	novel	L576*	0.53
UCEC	chr6	131884964	Missense_Mutation	rs375822204	R782Q	0.37	Endonuclease_NS
UCEC	chr6	131890449	Nonsense_Mutation	novel	E906*	0.17
UCEC	chr6	131877079	Missense_Mutation	novel	H604P	0.07
UCEC	chr6	131873052	Splice_Site	novel	X522_splice	0.39
UCEC	chr6	131877061	Missense_Mutation	novel	P598H	0.25
UCEC	chr6	131854935	Silent	rs774561788	T209T	0.25
UCEC	chr6	131875855	Missense_Mutation	novel	L572S	0.41
UCEC	chr6	131882353	Missense_Mutation	novel	F703L	0.14	Endonuclease_NS
UCEC	chr6	131869400	Missense_Mutation	novel	K439T	0.55
UCEC	chr6	131886610	Missense_Mutation	NA	F831L	0.33	Endonuclease_NS
UCEC	chr6	131874322	Silent	novel	V540V	0.06
UCEC	chr6	131877001	Missense_Mutation	novel	N578T	0.38
UCEC	chr6	131883693	Splice_Site	novel	X744_splice	0.43
UCEC	chr6	131872083	Silent	novel	G473G	0.23
UCEC	chr6	131875862	Splice_Region	novel	C574C	0.33
UCEC	chr6	131884962	Silent	novel	L781L	0.39
UCEC	chr6	131886634	Missense_Mutation	novel	K839N	0.21	Endonuclease_NS
UCEC	chr6	131850038	Missense_Mutation	novel	R121H	0.4
UCEC	chr6	131877081	Missense_Mutation	novel	P605S	0.33
UCEC	chr6	131877176	Intron	novel		0.33
UCEC	chr6	131890503	Missense_Mutation	novel	E924K	0.67
UCEC	chr6	131875829	Silent	novel	T563T	0.17
UCEC	chr6	131882455	Silent	rs376128399	Y737Y	0.43
UCEC	chr6	131886697	Silent	novel	H860H	0.32
UCEC	chr6	131874282	Missense_Mutation	NA	R527M	0.36
UCEC	chr6	131877139	Missense_Mutation	rs775258307	L624P	0.2
UCEC	chr6	131861692	Missense_Mutation	NA	K338T	0.48
UCEC	chr6	131869450	Nonsense_Mutation	NA	R456*	0.52
UCEC	chr6	131847833	Missense_Mutation	NA	S100C	0.11
UCEC	chr6	131890564	3'UTR	novel		0.41
UCEC	chr6	131877013	Missense_Mutation	novel	A582D	0.52
UCEC	chr6	131886686	Missense_Mutation	novel	I857V	0.28	Endonuclease_NS
UCEC	chr6	131886686	Missense_Mutation	novel	I857V	0.47	Endonuclease_NS
UCEC	chr6	131875813	Missense_Mutation	NA	G558D	0.2
UCEC	chr6	131884997	Missense_Mutation	NA	V793D	0.25	Endonuclease_NS
UCEC	chr6	131877312	Intron	novel		0.59
UCEC	chr6	131808261	Missense_Mutation	novel	K76E	0.47
UCEC	chr6	131877254	Intron	novel		0.43
UCS	chr6	131850016	Missense_Mutation	novel	E114K	0.55

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.25	0.00052595
GBM	DEL	0.2357	1.056e-05
KIRC	DEL	0.2405	7.439e-11
LGG	DEL	0.1423	0.0054594
MESO	DEL	0.4138	0.05642
PAAD	DEL	0.3587	0.11274
SKCM	DEL	0.5368	1.5442e-06
THYM	DEL	0.1301	0.10691

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.035	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.0043	Kaplan-Meier Survival Analysis
SKCM	0.038	Kaplan-Meier Survival Analysis
KIRP	0.049	Kaplan-Meier Survival Analysis
BLCA	0.0019	Kaplan-Meier Survival Analysis
KICH	0.015	Kaplan-Meier Survival Analysis
UCEC	0.028	Kaplan-Meier Survival Analysis
CHOL	0.022	Kaplan-Meier Survival Analysis
LUAD	0.00069	Kaplan-Meier Survival Analysis
UVM	0.00044	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742