EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197694 (Gene tree)
Gene ID: 6709
Gene Symbol: SPTAN1
Alias: N
Full Name: spectrin alpha, non-erythrocytic 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 81,108 bases
Position: chr9:128,552,558-128,633,665
Accession: 11273
RBP type: non-canonical RBP
Summary: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000628867	SPTAN1-215	579	-	-	- (aa)	-	-
ENST00000636939	SPTAN1-233	100	-	-	- (aa)	-	-
ENST00000631315	SPTAN1-226	581	-	-	- (aa)	-	-
ENST00000631121	SPTAN1-225	438	-	-	- (aa)	-	-
ENST00000637032	SPTAN1-234	152	-	ENSP00000490109	51 (aa)	-	A0A1B0GUH3
ENST00000627441	SPTAN1-212	585	-	ENSP00000486547	153 (aa)	-	A0A0D9SFF6
ENST00000472211	SPTAN1-205	272	-	-	- (aa)	-	-
ENST00000629047	SPTAN1-216	401	-	-	- (aa)	-	-
ENST00000625980	SPTAN1-211	1713	-	-	- (aa)	-	-
ENST00000635853	SPTAN1-228	5870	-	-	- (aa)	-	-
ENST00000636010	SPTAN1-229	1472	-	-	- (aa)	-	-
ENST00000628614	SPTAN1-214	993	-	-	- (aa)	-	-
ENST00000637820	SPTAN1-236	100	-	ENSP00000490179	25 (aa)	-	A0A1B0GUN2
ENST00000461855	SPTAN1-204	857	-	-	- (aa)	-	-
ENST00000629089	SPTAN1-217	1546	-	-	- (aa)	-	-
ENST00000637867	SPTAN1-237	100	-	ENSP00000490890	12 (aa)	-	A0A1B0GWE2
ENST00000637903	SPTAN1-238	574	-	ENSP00000490332	103 (aa)	-	A0A1B0GV13
ENST00000627809	SPTAN1-213	342	-	-	- (aa)	-	-
ENST00000358161	SPTAN1-201	7794	XM_006717253	ENSP00000350882	2452 (aa)	XP_006717316	Q13813
ENST00000497216	SPTAN1-209	351	-	-	- (aa)	-	-
ENST00000636257	SPTAN1-230	100	-	ENSP00000490229	12 (aa)	-	A0A1B0GWE2
ENST00000629137	SPTAN1-218	479	-	-	- (aa)	-	-
ENST00000630804	SPTAN1-222	7812	XM_006717252	ENSP00000486308	2457 (aa)	XP_006717315	A0A0D9SF54
ENST00000630147	SPTAN1-220	785	-	-	- (aa)	-	-
ENST00000636337	SPTAN1-231	100	-	ENSP00000490740	11 (aa)	-	A0A1B0GW19
ENST00000637434	SPTAN1-235	1496	-	-	- (aa)	-	-
ENST00000372739	SPTAN1-203	7868	XM_006717248	ENSP00000361824	2477 (aa)	XP_006717311	Q13813
ENST00000630866	SPTAN1-223	7498	XM_006717245	ENSP00000487444	2498 (aa)	XP_006717308	A0A0D9SGF6
ENST00000636483	SPTAN1-232	100	-	ENSP00000489629	22 (aa)	-	A0A1B0GTB7
ENST00000475367	SPTAN1-206	2237	-	-	- (aa)	-	-
ENST00000476825	SPTAN1-207	635	-	-	- (aa)	-	-
ENST00000372731	SPTAN1-202	7889	XM_006717249	ENSP00000361816	2472 (aa)	XP_006717312	Q13813
ENST00000630981	SPTAN1-224	416	-	ENSP00000486605	68 (aa)	-	A0A0D9SFH4
ENST00000491712	SPTAN1-208	714	-	-	- (aa)	-	-
ENST00000625282	SPTAN1-210	4102	-	-	- (aa)	-	-
ENST00000630763	SPTAN1-221	1503	-	-	- (aa)	-	-
ENST00000629378	SPTAN1-219	585	-	-	- (aa)	-	-
ENST00000635806	SPTAN1-227	193	-	ENSP00000489647	28 (aa)	-	A0A1B0GTD1

Gene Model

Click here to download ENSG00000197694's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04210	Apoptosis	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197694's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197694	SPTAN1	100	100.000	ENSMUSG00000057738	Sptan1	100	98.426	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	-	TAS	Process
GO:0003779	actin binding	-	IEA	Function
GO:0005200	structural constituent of cytoskeleton	2307671.	TAS	Function
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005515	protein binding	12571280.12820899.15328537.16336193.19102630.20706999.30021884.	IPI	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0007010	cytoskeleton organization	-	IEA	Process
GO:0007411	axon guidance	-	TAS	Process
GO:0008091	spectrin	2307671.	TAS	Component
GO:0015630	microtubule cytoskeleton	-	IDA	Component
GO:0016020	membrane	2307671.	TAS	Component
GO:0035580	specific granule lumen	-	TAS	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051693	actin filament capping	-	IEA	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:1903561	extracellular vesicle	24769233.	HDA	Component
GO:1904724	tertiary granule lumen	-	TAS	Component