EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000197885 (Gene tree)
Gene ID: 28512
Gene Symbol: NKIRAS1
Alias: KBRAS1|kappaB-Ras1
Full Name: NFKB inhibitor interacting Ras like 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 54,932 bases
Position: chr3:23,891,660-23,946,591
Accession: 17899
RBP type: canonical RBP
Summary: NKIRAS1 (NFKB Inhibitor Interacting Ras Like 1) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000396063	MMR_HSR1	PF01926.23	0.00053	1	1
ENSP00000406543	MMR_HSR1	PF01926.23	0.00053	1	1
ENSP00000415225	MMR_HSR1	PF01926.23	0.00053	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000421515	NKIRAS1-205	2018	-	ENSP00000392307	192 (aa)	-	Q9NYS0
ENST00000388759	NKIRAS1-201	2335	XM_005265076	ENSP00000373411	192 (aa)	XP_005265133	Q9NYS0
ENST00000415901	NKIRAS1-203	1644	-	ENSP00000415225	192 (aa)	-	G5E9P3
ENST00000437230	NKIRAS1-207	1898	-	ENSP00000406543	192 (aa)	-	G5E9P3
ENST00000416026	NKIRAS1-204	795	XM_005265077	ENSP00000394214	192 (aa)	XP_005265134	Q9NYS0
ENST00000412028	NKIRAS1-202	1605	-	ENSP00000396063	192 (aa)	-	G5E9P3
ENST00000425478	NKIRAS1-206	2014	XM_005265078	ENSP00000400385	192 (aa)	XP_005265135	Q9NYS0
ENST00000443659	NKIRAS1-208	2391	XM_024453460	ENSP00000393785	192 (aa)	XP_024309228	Q9NYS0
ENST00000614374	NKIRAS1-209	1612	-	ENSP00000483749	192 (aa)	-	Q9NYS0

Gene Model

Click here to download ENSG00000197885's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000197885	rs11129127	3	23901915	A	Intelligence (MTAG)	29326435	[0.011-0.023] unit decrease	0.016971255	EFO_0004337
ENSG00000197885	rs2001209	3	23921155	A	Intelligence (MTAG)	29326435	[0.019-0.032] unit increase	0.025788903	EFO_0004337
ENSG00000197885	rs1133926	3	23920271	A	Intelligence (MTAG)	29326435	[0.018-0.033] unit increase	0.025928907	EFO_0004337
ENSG00000197885	rs34476593	3	23902108	A	Intelligence (MTAG)	29326435	[0.018-0.033] unit decrease	0.025630234	EFO_0004337
ENSG00000197885	rs9862416	3	23946351	A	Educational attainment (MTAG)	30038396	[0.0064-0.0118] unit increase	0.0091	EFO_0004784
ENSG00000197885	rs7633520	3	23924934	T	Cognitive performance (MTAG)	30038396	[0.017-0.027] unit decrease	0.0217	EFO_0008354
ENSG00000197885	rs7633520	3	23924934	T	General cognitive ability	29844566	z-score decrease	7.43	EFO_0004337
ENSG00000197885	rs9836970	3	23908348	A	General cognitive ability	29844566	z-score decrease	6.856	EFO_0004337
ENSG00000197885	rs2885034	3	23891683	T	Intelligence	29942086	z-score decrease	5.742	EFO_0004337
ENSG00000197885	rs9815334	3	23904095	A	Intelligence	29942086	z-score decrease	7.107	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000197885's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000197885	NKIRAS1	99	72.251	ENSAPOG00000015479	nkiras1	99	72.251	Acanthochromis_polyacanthus
ENSG00000197885	NKIRAS1	99	73.822	ENSACIG00000009013	nkiras1	99	73.822	Amphilophus_citrinellus
ENSG00000197885	NKIRAS1	99	72.251	ENSAOCG00000013851	nkiras1	99	72.251	Amphiprion_ocellaris
ENSG00000197885	NKIRAS1	99	72.251	ENSAPEG00000007208	nkiras1	99	72.251	Amphiprion_percula
ENSG00000197885	NKIRAS1	99	73.822	ENSATEG00000008688	nkiras1	99	73.822	Anabas_testudineus
ENSG00000197885	NKIRAS1	100	80.208	ENSAPLG00000005623	NKIRAS1	100	80.208	Anas_platyrhynchos
ENSG00000197885	NKIRAS1	98	73.545	ENSACAG00000011317	NKIRAS1	99	73.545	Anolis_carolinensis
ENSG00000197885	NKIRAS1	99	72.775	ENSACLG00000017866	nkiras1	99	72.775	Astatotilapia_calliptera
ENSG00000197885	NKIRAS1	99	72.632	ENSAMXG00000029699	nkiras1	95	72.632	Astyanax_mexicanus
ENSG00000197885	NKIRAS1	100	97.917	ENSTSYG00000033666	NKIRAS1	100	97.917	Carlito_syrichta
ENSG00000197885	NKIRAS1	100	79.688	ENSCPBG00000022583	NKIRAS1	100	79.688	Chrysemys_picta_bellii
ENSG00000197885	NKIRAS1	99	74.869	ENSCSEG00000010391	nkiras1	99	74.869	Cynoglossus_semilaevis
ENSG00000197885	NKIRAS1	59	77.876	ENSCVAG00000012277	nkiras1	94	77.876	Cyprinodon_variegatus
ENSG00000197885	NKIRAS1	99	73.298	ENSDARG00000099527	nkiras1	99	73.298	Danio_rerio
ENSG00000197885	NKIRAS1	100	97.396	ENSEEUG00000011729	NKIRAS1	100	97.396	Erinaceus_europaeus
ENSG00000197885	NKIRAS1	99	73.298	ENSELUG00000009864	nkiras1	99	73.298	Esox_lucius
ENSG00000197885	NKIRAS1	100	81.250	ENSFALG00000009213	NKIRAS1	100	81.250	Ficedula_albicollis
ENSG00000197885	NKIRAS1	99	71.728	ENSFHEG00000018971	nkiras1	99	71.728	Fundulus_heteroclitus
ENSG00000197885	NKIRAS1	97	75.806	ENSGMOG00000006878	nkiras1	100	75.806	Gadus_morhua
ENSG00000197885	NKIRAS1	100	78.646	ENSGALG00000011289	NKIRAS1	100	78.646	Gallus_gallus
ENSG00000197885	NKIRAS1	99	71.728	ENSGAFG00000002436	nkiras1	64	71.728	Gambusia_affinis
ENSG00000197885	NKIRAS1	98	73.016	ENSGACG00000007951	nkiras1	99	73.016	Gasterosteus_aculeatus
ENSG00000197885	NKIRAS1	100	78.646	ENSGAGG00000001505	NKIRAS1	100	78.646	Gopherus_agassizii
ENSG00000197885	NKIRAS1	99	72.775	ENSHBUG00000018030	nkiras1	83	72.775	Haplochromis_burtoni
ENSG00000197885	NKIRAS1	99	73.822	ENSIPUG00000011718	nkiras1	99	73.822	Ictalurus_punctatus
ENSG00000197885	NKIRAS1	99	71.728	ENSKMAG00000000680	nkiras1	99	71.728	Kryptolebias_marmoratus
ENSG00000197885	NKIRAS1	99	72.251	ENSLBEG00000027387	nkiras1	99	72.251	Labrus_bergylta
ENSG00000197885	NKIRAS1	100	78.125	ENSLACG00000001664	NKIRAS1	100	78.125	Latimeria_chalumnae
ENSG00000197885	NKIRAS1	97	74.332	ENSLOCG00000006787	nkiras1	99	74.332	Lepisosteus_oculatus
ENSG00000197885	NKIRAS1	100	98.438	ENSLAFG00000004153	NKIRAS1	100	98.438	Loxodonta_africana
ENSG00000197885	NKIRAS1	99	72.775	ENSMAMG00000001902	nkiras1	99	72.775	Mastacembelus_armatus
ENSG00000197885	NKIRAS1	99	72.775	ENSMZEG00005017026	nkiras1	99	72.775	Maylandia_zebra
ENSG00000197885	NKIRAS1	100	78.646	ENSMGAG00000011005	NKIRAS1	100	78.646	Meleagris_gallopavo
ENSG00000197885	NKIRAS1	99	73.298	ENSMMOG00000014301	nkiras1	99	73.298	Mola_mola
ENSG00000197885	NKIRAS1	100	79.167	ENSMODG00000014879	NKIRAS1	100	79.167	Monodelphis_domestica
ENSG00000197885	NKIRAS1	99	72.251	ENSMALG00000004765	nkiras1	99	72.251	Monopterus_albus
ENSG00000197885	NKIRAS1	100	95.312	MGP_CAROLIEiJ_G0018974	Nkiras1	100	95.312	Mus_caroli
ENSG00000197885	NKIRAS1	100	95.312	ENSMUSG00000021772	Nkiras1	100	95.312	Mus_musculus
ENSG00000197885	NKIRAS1	100	95.312	MGP_PahariEiJ_G0029988	Nkiras1	100	95.312	Mus_pahari
ENSG00000197885	NKIRAS1	100	95.312	MGP_SPRETEiJ_G0019850	Nkiras1	100	95.312	Mus_spretus
ENSG00000197885	NKIRAS1	100	96.875	ENSNGAG00000022329	Nkiras1	100	96.875	Nannospalax_galili
ENSG00000197885	NKIRAS1	99	73.822	ENSNBRG00000006552	nkiras1	99	73.822	Neolamprologus_brichardi
ENSG00000197885	NKIRAS1	100	79.688	ENSMEUG00000014521	NKIRAS1	100	79.688	Notamacropus_eugenii
ENSG00000197885	NKIRAS1	99	73.822	ENSONIG00000010304	nkiras1	99	73.822	Oreochromis_niloticus
ENSG00000197885	NKIRAS1	59	92.035	ENSOANG00000031520	-	53	92.035	Ornithorhynchus_anatinus
ENSG00000197885	NKIRAS1	100	89.202	ENSPTIG00000019470	NKIRAS1	100	89.202	Panthera_tigris_altaica
ENSG00000197885	NKIRAS1	99	74.869	ENSPKIG00000009837	nkiras1	87	74.869	Paramormyrops_kingsleyae
ENSG00000197885	NKIRAS1	100	80.208	ENSPSIG00000008675	NKIRAS1	100	80.208	Pelodiscus_sinensis
ENSG00000197885	NKIRAS1	99	75.916	ENSPMGG00000003616	nkiras1	99	75.916	Periophthalmus_magnuspinnatus
ENSG00000197885	NKIRAS1	100	98.438	ENSPEMG00000015836	Nkiras1	100	98.438	Peromyscus_maniculatus_bairdii
ENSG00000197885	NKIRAS1	100	81.250	ENSPCIG00000026106	NKIRAS1	100	81.250	Phascolarctos_cinereus
ENSG00000197885	NKIRAS1	99	72.251	ENSPFOG00000005763	nkiras1	99	72.251	Poecilia_formosa
ENSG00000197885	NKIRAS1	99	72.775	ENSPLAG00000006192	nkiras1	99	72.775	Poecilia_latipinna
ENSG00000197885	NKIRAS1	99	72.251	ENSPMEG00000021056	nkiras1	99	72.251	Poecilia_mexicana
ENSG00000197885	NKIRAS1	99	72.251	ENSPREG00000013742	nkiras1	99	72.251	Poecilia_reticulata
ENSG00000197885	NKIRAS1	72	97.842	ENSPVAG00000001772	NKIRAS1	100	97.842	Pteropus_vampyrus
ENSG00000197885	NKIRAS1	99	72.775	ENSPNYG00000000881	nkiras1	99	72.775	Pundamilia_nyererei
ENSG00000197885	NKIRAS1	99	74.346	ENSPNAG00000010179	nkiras1	99	74.346	Pygocentrus_nattereri
ENSG00000197885	NKIRAS1	100	96.354	ENSRNOG00000008565	Nkiras1	100	96.354	Rattus_norvegicus
ENSG00000197885	NKIRAS1	100	98.958	ENSRBIG00000027456	NKIRAS1	100	98.958	Rhinopithecus_bieti
ENSG00000197885	NKIRAS1	100	98.958	ENSRROG00000032388	NKIRAS1	100	98.958	Rhinopithecus_roxellana
ENSG00000197885	NKIRAS1	100	84.375	ENSSHAG00000000958	NKIRAS1	100	84.375	Sarcophilus_harrisii
ENSG00000197885	NKIRAS1	99	73.822	ENSSMAG00000020198	nkiras1	99	73.822	Scophthalmus_maximus
ENSG00000197885	NKIRAS1	99	74.869	ENSSDUG00000011555	nkiras1	99	74.869	Seriola_dumerili
ENSG00000197885	NKIRAS1	99	74.869	ENSSLDG00000020730	nkiras1	99	74.869	Seriola_lalandi_dorsalis
ENSG00000197885	NKIRAS1	100	78.125	ENSSPUG00000010820	NKIRAS1	100	78.125	Sphenodon_punctatus
ENSG00000197885	NKIRAS1	99	73.822	ENSSPAG00000018593	nkiras1	99	73.822	Stegastes_partitus
ENSG00000197885	NKIRAS1	100	98.438	ENSSSCG00000024296	NKIRAS1	100	98.438	Sus_scrofa
ENSG00000197885	NKIRAS1	99	72.251	ENSTRUG00000008939	nkiras1	99	72.251	Takifugu_rubripes
ENSG00000197885	NKIRAS1	99	74.346	ENSTNIG00000009798	nkiras1	99	74.346	Tetraodon_nigroviridis
ENSG00000197885	NKIRAS1	76	76.712	ENSXETG00000003868	nkiras1	100	76.712	Xenopus_tropicalis
ENSG00000197885	NKIRAS1	99	72.251	ENSXCOG00000003137	nkiras1	99	72.251	Xiphophorus_couchianus
ENSG00000197885	NKIRAS1	99	71.728	ENSXMAG00000017139	nkiras1	99	71.728	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	10657303.	NAS	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005575	cellular_component	-	ND	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0007249	I-kappaB kinase/NF-kappaB signaling	10657303.	NAS	Process
GO:0016020	membrane	-	IEA	Component