EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000198015 (Gene tree)
Gene ID: 28977
Gene Symbol: MRPL42
Alias: MRPS32|MRP-L31|RPML31|PTD007|HSPC204|MRPL31
Full Name: mitochondrial ribosomal protein L42
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 48,726 bases
Position: chr12:93,467,488-93,516,213
Accession: 14493
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000447547	MRP-S32	PF10210.9	6.9e-41	1	1
ENSP00000449884	MRP-S32	PF10210.9	6.9e-41	1	1
ENSP00000376836	MRP-S32	PF10210.9	1.4e-38	1	1
ENSP00000473798	MRP-S32	PF10210.9	4.8e-36	1	1
ENSP00000473958	MRP-S32	PF10210.9	8.7e-36	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000549982	MRPL42-206	15582	-	ENSP00000449884	142 (aa)	-	Q9Y6G3
ENST00000549561	MRPL42-205	775	-	ENSP00000449392	142 (aa)	-	Q9Y6G3
ENST00000552326	MRPL42-209	567	-	-	- (aa)	-	-
ENST00000548545	MRPL42-204	692	-	ENSP00000473958	128 (aa)	-	S4R360
ENST00000551396	MRPL42-207	725	-	ENSP00000449886	53 (aa)	-	F8VVR0
ENST00000393128	MRPL42-202	1983	-	ENSP00000376836	139 (aa)	-	J3KPP0
ENST00000358678	MRPL42-201	2105	-	ENSP00000351506	51 (aa)	-	J3KP21
ENST00000547098	MRPL42-203	701	-	ENSP00000473798	155 (aa)	-	S4R2Z7
ENST00000552938	MRPL42-210	999	-	-	- (aa)	-	-
ENST00000552217	MRPL42-208	920	-	ENSP00000447547	142 (aa)	-	Q9Y6G3

Gene Model

Click here to download ENSG00000198015's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198015	Child Development Disorders, Pervasive	4.9777200E-005	-
ENSG00000198015	Lipids	4E-7	25246029
ENSG00000198015	Obesity	4E-7	25246029

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198015	rs10161215	12	93494763	?	Peanut allergy (maternal genetic effects)	29489655			EFO_0007017\|EFO_0005939
ENSG00000198015	rs10431427	12	93489363	?	Platelet count	29403010	[0.017-0.036] unit increase novel	0.02646	EFO_0004309

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198015's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198015	MRPL42	82	90.476	ENSAMEG00000009832	MRPL42	83	90.476	Ailuropoda_melanoleuca
ENSG00000198015	MRPL42	69	67.347	ENSACIG00000017826	mrpl42	71	67.347	Amphilophus_citrinellus
ENSG00000198015	MRPL42	97	65.468	ENSAPLG00000015057	MRPL42	97	65.468	Anas_platyrhynchos
ENSG00000198015	MRPL42	100	92.188	ENSANAG00000036935	-	100	92.086	Aotus_nancymaae
ENSG00000198015	MRPL42	100	73.381	ENSANAG00000036083	-	100	73.381	Aotus_nancymaae
ENSG00000198015	MRPL42	99	85.827	ENSANAG00000033101	-	94	77.632	Aotus_nancymaae
ENSG00000198015	MRPL42	100	87.500	ENSANAG00000000692	-	92	86.822	Aotus_nancymaae
ENSG00000198015	MRPL42	100	88.281	ENSBTAG00000002708	MRPL42	100	88.281	Bos_taurus
ENSG00000198015	MRPL42	75	73.585	ENSBTAG00000052971	-	97	73.585	Bos_taurus
ENSG00000198015	MRPL42	100	93.750	ENSCJAG00000046971	MRPL42	100	93.662	Callithrix_jacchus
ENSG00000198015	MRPL42	60	75.000	ENSCAFG00000030257	-	93	75.000	Canis_familiaris
ENSG00000198015	MRPL42	70	87.129	ENSCAFG00020022967	-	89	87.129	Canis_lupus_dingo
ENSG00000198015	MRPL42	57	86.301	ENSCAFG00020016271	-	97	86.301	Canis_lupus_dingo
ENSG00000198015	MRPL42	100	88.281	ENSCHIG00000014921	MRPL42	100	88.281	Capra_hircus
ENSG00000198015	MRPL42	66	89.362	ENSTSYG00000032810	-	86	89.362	Carlito_syrichta
ENSG00000198015	MRPL42	100	90.625	ENSTSYG00000006370	-	100	89.437	Carlito_syrichta
ENSG00000198015	MRPL42	100	85.938	ENSTSYG00000036466	-	98	78.000	Carlito_syrichta
ENSG00000198015	MRPL42	100	66.197	ENSCAPG00000015105	-	100	66.197	Cavia_aperea
ENSG00000198015	MRPL42	84	84.034	ENSCAPG00000016985	-	89	84.034	Cavia_aperea
ENSG00000198015	MRPL42	100	66.901	ENSCPOG00000008943	-	100	66.901	Cavia_porcellus
ENSG00000198015	MRPL42	96	82.353	ENSCPOG00000030015	-	98	81.560	Cavia_porcellus
ENSG00000198015	MRPL42	100	72.656	ENSCCAG00000029290	-	93	67.763	Cebus_capucinus
ENSG00000198015	MRPL42	100	92.969	ENSCCAG00000031179	-	100	92.958	Cebus_capucinus
ENSG00000198015	MRPL42	99	87.402	ENSCCAG00000032203	-	91	79.605	Cebus_capucinus
ENSG00000198015	MRPL42	100	96.875	ENSCATG00000037616	MRPL42	100	95.775	Cercocebus_atys
ENSG00000198015	MRPL42	100	83.594	ENSCLAG00000005421	MRPL42	100	82.394	Chinchilla_lanigera
ENSG00000198015	MRPL42	100	96.875	ENSCSAG00000003706	MRPL42	100	95.775	Chlorocebus_sabaeus
ENSG00000198015	MRPL42	83	48.305	ENSCHOG00000007010	-	100	48.305	Choloepus_hoffmanni
ENSG00000198015	MRPL42	100	66.892	ENSCPBG00000001581	MRPL42	100	66.892	Chrysemys_picta_bellii
ENSG00000198015	MRPL42	100	97.656	ENSCANG00000033457	MRPL42	100	97.183	Colobus_angolensis_palliatus
ENSG00000198015	MRPL42	100	77.465	ENSCGRG00001012694	-	99	77.465	Cricetulus_griseus_chok1gshd
ENSG00000198015	MRPL42	99	68.613	ENSCGRG00001003813	-	99	68.613	Cricetulus_griseus_chok1gshd
ENSG00000198015	MRPL42	99	78.571	ENSCGRG00000003801	Mrpl42	99	78.571	Cricetulus_griseus_crigri
ENSG00000198015	MRPL42	100	85.156	ENSDNOG00000032710	-	100	84.507	Dasypus_novemcinctus
ENSG00000198015	MRPL42	100	86.719	ENSDNOG00000049701	-	100	82.270	Dasypus_novemcinctus
ENSG00000198015	MRPL42	99	86.429	ENSDORG00000015571	Mrpl42	99	86.429	Dipodomys_ordii
ENSG00000198015	MRPL42	87	59.677	ENSETEG00000014745	-	92	59.677	Echinops_telfairi
ENSG00000198015	MRPL42	100	90.625	ENSEASG00005019361	MRPL42	100	89.437	Equus_asinus_asinus
ENSG00000198015	MRPL42	100	89.062	ENSECAG00000026888	MRPL42	100	88.028	Equus_caballus
ENSG00000198015	MRPL42	99	70.079	ENSFCAG00000036356	-	97	62.338	Felis_catus
ENSG00000198015	MRPL42	100	89.062	ENSFCAG00000037907	-	100	87.324	Felis_catus
ENSG00000198015	MRPL42	86	85.455	ENSFCAG00000040567	-	100	83.871	Felis_catus
ENSG00000198015	MRPL42	99	67.376	ENSFALG00000010717	MRPL42	95	67.376	Ficedula_albicollis
ENSG00000198015	MRPL42	99	84.252	ENSFDAG00000018129	MRPL42	100	83.099	Fukomys_damarensis
ENSG00000198015	MRPL42	87	69.919	ENSGALG00000011293	MRPL42	84	69.919	Gallus_gallus
ENSG00000198015	MRPL42	100	67.568	ENSGAGG00000010125	MRPL42	100	67.568	Gopherus_agassizii
ENSG00000198015	MRPL42	100	100.000	ENSGGOG00000022760	MRPL42	100	100.000	Gorilla_gorilla
ENSG00000198015	MRPL42	95	87.705	ENSHGLG00000007399	-	99	83.582	Heterocephalus_glaber_female
ENSG00000198015	MRPL42	96	83.740	ENSHGLG00000008248	-	100	83.740	Heterocephalus_glaber_female
ENSG00000198015	MRPL42	98	86.508	ENSHGLG00100018317	-	89	86.508	Heterocephalus_glaber_male
ENSG00000198015	MRPL42	95	83.471	ENSHGLG00100013257	-	98	83.471	Heterocephalus_glaber_male
ENSG00000198015	MRPL42	100	85.938	ENSSTOG00000026544	MRPL42	100	85.915	Ictidomys_tridecemlineatus
ENSG00000198015	MRPL42	87	66.667	ENSLACG00000006919	MRPL42	84	66.667	Latimeria_chalumnae
ENSG00000198015	MRPL42	84	85.714	ENSLAFG00000013779	MRPL42	85	85.714	Loxodonta_africana
ENSG00000198015	MRPL42	100	96.875	ENSMFAG00000032330	MRPL42	100	95.775	Macaca_fascicularis
ENSG00000198015	MRPL42	100	96.875	ENSMMUG00000016805	MRPL42	100	95.683	Macaca_mulatta
ENSG00000198015	MRPL42	100	96.875	ENSMNEG00000028853	MRPL42	100	95.775	Macaca_nemestrina
ENSG00000198015	MRPL42	100	97.656	ENSMLEG00000038104	MRPL42	100	96.479	Mandrillus_leucophaeus
ENSG00000198015	MRPL42	87	69.919	ENSMGAG00000011346	MRPL42	84	69.919	Meleagris_gallopavo
ENSG00000198015	MRPL42	99	64.286	ENSMAUG00000018130	-	99	64.286	Mesocricetus_auratus
ENSG00000198015	MRPL42	99	72.857	ENSMAUG00000010057	-	99	72.857	Mesocricetus_auratus
ENSG00000198015	MRPL42	100	87.500	ENSMICG00000032596	-	100	86.620	Microcebus_murinus
ENSG00000198015	MRPL42	68	85.417	ENSMICG00000028094	-	88	86.905	Microcebus_murinus
ENSG00000198015	MRPL42	100	85.938	ENSMICG00000035189	-	100	78.146	Microcebus_murinus
ENSG00000198015	MRPL42	69	82.653	ENSMICG00000045594	-	99	82.653	Microcebus_murinus
ENSG00000198015	MRPL42	98	88.000	ENSMICG00000036541	-	94	85.149	Microcebus_murinus
ENSG00000198015	MRPL42	99	75.000	ENSMOCG00000004616	-	99	75.000	Microtus_ochrogaster
ENSG00000198015	MRPL42	99	78.571	ENSMOCG00000013541	-	99	78.571	Microtus_ochrogaster
ENSG00000198015	MRPL42	99	75.887	MGP_CAROLIEiJ_G0015750	Mrpl42	99	75.887	Mus_caroli
ENSG00000198015	MRPL42	99	75.887	ENSMUSG00000062981	Mrpl42	99	75.887	Mus_musculus
ENSG00000198015	MRPL42	100	82.031	ENSMLUG00000023702	-	100	80.282	Myotis_lucifugus
ENSG00000198015	MRPL42	100	82.812	ENSMLUG00000029623	-	100	80.986	Myotis_lucifugus
ENSG00000198015	MRPL42	100	84.375	ENSMLUG00000025058	-	99	82.143	Myotis_lucifugus
ENSG00000198015	MRPL42	100	86.719	ENSNGAG00000000717	Mrpl42	100	86.719	Nannospalax_galili
ENSG00000198015	MRPL42	100	100.000	ENSNLEG00000005699	MRPL42	100	100.000	Nomascus_leucogenys
ENSG00000198015	MRPL42	100	78.169	ENSOPRG00000010967	MRPL42	100	78.169	Ochotona_princeps
ENSG00000198015	MRPL42	99	73.239	ENSODEG00000016452	-	99	74.648	Octodon_degus
ENSG00000198015	MRPL42	83	84.034	ENSODEG00000008681	-	100	84.034	Octodon_degus
ENSG00000198015	MRPL42	100	76.224	ENSODEG00000012689	-	100	77.622	Octodon_degus
ENSG00000198015	MRPL42	100	91.406	ENSOCUG00000010928	MRPL42	100	86.620	Oryctolagus_cuniculus
ENSG00000198015	MRPL42	100	79.688	ENSOGAG00000024156	-	100	78.169	Otolemur_garnettii
ENSG00000198015	MRPL42	100	79.688	ENSOGAG00000034004	-	100	78.873	Otolemur_garnettii
ENSG00000198015	MRPL42	100	81.250	ENSOGAG00000027617	-	100	80.420	Otolemur_garnettii
ENSG00000198015	MRPL42	100	85.156	ENSOGAG00000025686	-	100	84.507	Otolemur_garnettii
ENSG00000198015	MRPL42	100	86.719	ENSOGAG00000025600	-	100	85.915	Otolemur_garnettii
ENSG00000198015	MRPL42	100	79.688	ENSOGAG00000026395	-	100	77.465	Otolemur_garnettii
ENSG00000198015	MRPL42	99	77.305	ENSOGAG00000030438	-	100	77.305	Otolemur_garnettii
ENSG00000198015	MRPL42	100	89.062	ENSOARG00000015849	MRPL42	100	89.062	Ovis_aries
ENSG00000198015	MRPL42	100	98.710	ENSPPAG00000038254	MRPL42	100	98.710	Pan_paniscus
ENSG00000198015	MRPL42	86	87.273	ENSPPRG00000017935	-	100	83.871	Panthera_pardus
ENSG00000198015	MRPL42	100	87.500	ENSPPRG00000015755	-	100	85.915	Panthera_pardus
ENSG00000198015	MRPL42	99	69.291	ENSPPRG00000006533	-	98	61.290	Panthera_pardus
ENSG00000198015	MRPL42	100	89.062	ENSPPRG00000013218	-	100	87.324	Panthera_pardus
ENSG00000198015	MRPL42	80	85.437	ENSPTIG00000009717	-	95	82.051	Panthera_tigris_altaica
ENSG00000198015	MRPL42	100	88.281	ENSPTIG00000009394	-	100	87.324	Panthera_tigris_altaica
ENSG00000198015	MRPL42	100	89.062	ENSPTIG00000019099	-	100	87.324	Panthera_tigris_altaica
ENSG00000198015	MRPL42	100	98.710	ENSPTRG00000022791	MRPL42	100	98.710	Pan_troglodytes
ENSG00000198015	MRPL42	100	85.256	ENSPANG00000030179	MRPL42	100	85.256	Papio_anubis
ENSG00000198015	MRPL42	100	64.189	ENSPSIG00000010745	MRPL42	100	64.189	Pelodiscus_sinensis
ENSG00000198015	MRPL42	99	77.143	ENSPEMG00000020562	-	99	77.778	Peromyscus_maniculatus_bairdii
ENSG00000198015	MRPL42	100	64.925	ENSPCIG00000001472	-	77	64.865	Phascolarctos_cinereus
ENSG00000198015	MRPL42	100	98.592	ENSPPYG00000004833	MRPL42	100	98.592	Pongo_abelii
ENSG00000198015	MRPL42	83	84.746	ENSPCAG00000003791	MRPL42	100	84.746	Procavia_capensis
ENSG00000198015	MRPL42	98	82.400	ENSPCOG00000025008	-	100	79.137	Propithecus_coquereli
ENSG00000198015	MRPL42	99	88.976	ENSPCOG00000014986	-	99	85.507	Propithecus_coquereli
ENSG00000198015	MRPL42	100	68.310	ENSPCOG00000018896	-	100	68.310	Propithecus_coquereli
ENSG00000198015	MRPL42	64	67.073	ENSPVAG00000013736	-	69	67.073	Pteropus_vampyrus
ENSG00000198015	MRPL42	98	71.429	ENSRNOG00000021867	AABR07009508.1	98	71.429	Rattus_norvegicus
ENSG00000198015	MRPL42	99	77.143	ENSRNOG00000042740	Mrpl42	99	77.143	Rattus_norvegicus
ENSG00000198015	MRPL42	100	78.710	ENSRBIG00000044361	-	100	78.710	Rhinopithecus_bieti
ENSG00000198015	MRPL42	100	95.312	ENSRBIG00000011046	-	100	95.070	Rhinopithecus_bieti
ENSG00000198015	MRPL42	100	97.656	ENSRROG00000033949	MRPL42	100	97.183	Rhinopithecus_roxellana
ENSG00000198015	MRPL42	83	69.492	ENSSBOG00000025086	-	100	69.492	Saimiri_boliviensis_boliviensis
ENSG00000198015	MRPL42	100	89.437	ENSSBOG00000009656	-	100	89.437	Saimiri_boliviensis_boliviensis
ENSG00000198015	MRPL42	66	87.234	ENSSBOG00000027483	-	82	87.234	Saimiri_boliviensis_boliviensis
ENSG00000198015	MRPL42	84	63.333	ENSSFOG00015006975	mrpl42	82	63.333	Scleropages_formosus
ENSG00000198015	MRPL42	100	62.585	ENSSPUG00000015009	-	99	62.585	Sphenodon_punctatus
ENSG00000198015	MRPL42	71	67.033	ENSSPAG00000013637	mrpl42	71	67.033	Stegastes_partitus
ENSG00000198015	MRPL42	61	79.070	ENSSSCG00000035613	-	80	79.070	Sus_scrofa
ENSG00000198015	MRPL42	100	89.062	ENSSSCG00000030478	-	100	87.324	Sus_scrofa
ENSG00000198015	MRPL42	69	59.375	ENSSSCG00000034693	-	84	59.375	Sus_scrofa
ENSG00000198015	MRPL42	99	63.768	ENSSSCG00000036897	-	99	63.768	Sus_scrofa
ENSG00000198015	MRPL42	83	73.729	ENSTGUG00000008272	MRPL42	100	73.729	Taeniopygia_guttata
ENSG00000198015	MRPL42	72	59.783	ENSTNIG00000018478	mrpl42	70	59.783	Tetraodon_nigroviridis
ENSG00000198015	MRPL42	87	86.179	ENSTTRG00000003312	MRPL42	92	86.179	Tursiops_truncatus
ENSG00000198015	MRPL42	63	76.543	ENSUAMG00000019831	-	86	75.610	Ursus_americanus
ENSG00000198015	MRPL42	100	89.844	ENSUAMG00000025405	-	100	88.028	Ursus_americanus
ENSG00000198015	MRPL42	90	77.586	ENSUMAG00000014643	-	77	76.423	Ursus_maritimus
ENSG00000198015	MRPL42	100	89.844	ENSUMAG00000003107	-	100	89.922	Ursus_maritimus
ENSG00000198015	MRPL42	81	91.346	ENSVPAG00000007658	MRPL42	100	88.983	Vicugna_pacos
ENSG00000198015	MRPL42	59	85.526	ENSVVUG00000002834	-	94	85.526	Vulpes_vulpes
ENSG00000198015	MRPL42	100	87.500	ENSVVUG00000011842	-	100	85.915	Vulpes_vulpes
ENSG00000198015	MRPL42	59	88.000	ENSVVUG00000007253	-	96	88.000	Vulpes_vulpes
ENSG00000198015	MRPL42	95	52.632	ENSXMAG00000004057	mrpl42	94	52.632	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003735	structural constituent of ribosome	11279123.	NAS	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0005763	mitochondrial small ribosomal subunit	11279123.	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006412	translation	11279123.	NAS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process