EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000198265 (Gene tree)
Gene ID: 9931
Gene Symbol: HELZ
Alias: KIAA0054|HUMORF5|DHRC
Full Name: helicase with zinc finger
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 175,552 bases
Position: chr17:67,070,438-67,245,989
Accession: 16878
RBP type: canonical RBP
Summary: HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000351524	zf-CCCH	PF00642.24	5.2e-07	1	1
ENSP00000464512	zf-CCCH	PF00642.24	5.2e-07	1	1
ENSP00000464512	ResIII	PF04851.15	0.0002	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000579861	HELZ-205	583	-	ENSP00000462320	65 (aa)	-	J3KS59
ENST00000584641	HELZ-212	1101	-	-	- (aa)	-	-
ENST00000581159	HELZ-210	617	-	ENSP00000462763	103 (aa)	-	J3KT20
ENST00000580662	HELZ-208	758	-	-	- (aa)	-	-
ENST00000578783	HELZ-203	577	-	ENSP00000464354	193 (aa)	-	J3QRR8
ENST00000358691	HELZ-201	13810	XM_005257888	ENSP00000351524	1942 (aa)	XP_005257945	P42694
ENST00000580963	HELZ-209	520	-	-	- (aa)	-	-
ENST00000417253	HELZ-202	1872	-	ENSP00000411144	567 (aa)	-	A0A075B6R3
ENST00000578938	HELZ-204	660	-	-	- (aa)	-	-
ENST00000582864	HELZ-211	425	-	-	- (aa)	-	-
ENST00000580168	HELZ-207	6279	XM_006722214	ENSP00000464512	1943 (aa)	XP_006722277	J3QS41
ENST00000579953	HELZ-206	6365	-	ENSP00000463727	1163 (aa)	-	P42694

Gene Model

Click here to download ENSG00000198265's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198265	Body Mass Index	4.2951713158379E-5	17903300
ENSG00000198265	Body Mass Index	3.87179414731431E-5	17903300
ENSG00000198265	Body Mass Index	3.72348892492269E-5	17903300
ENSG00000198265	Body Mass Index	7.00841250222961E-5	17903300
ENSG00000198265	Body Weight	5.55400436901277E-5	17903300
ENSG00000198265	Body Weight	6.38799512153732E-5	17903300
ENSG00000198265	Insulin Resistance	8.28509725157023E-5	17903298

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198265	rs9914426	17	67130525	?	Putamen volume	29147026	[17.12-40.21] mm3 decrease	28.667	EFO_0006932

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198265's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198265	HELZ	96	76.367	ENSAPOG00000001626	helz	100	59.684	Acanthochromis_polyacanthus
ENSG00000198265	HELZ	100	96.825	ENSAMEG00000018396	HELZ	100	95.424	Ailuropoda_melanoleuca
ENSG00000198265	HELZ	100	62.694	ENSACIG00000006410	-	97	62.396	Amphilophus_citrinellus
ENSG00000198265	HELZ	97	74.848	ENSAOCG00000018131	helz	88	72.658	Amphiprion_ocellaris
ENSG00000198265	HELZ	100	61.750	ENSAPEG00000003806	-	99	61.614	Amphiprion_percula
ENSG00000198265	HELZ	96	77.531	ENSATEG00000007191	helz	100	59.550	Anabas_testudineus
ENSG00000198265	HELZ	97	91.873	ENSAPLG00000007762	HELZ	100	85.054	Anas_platyrhynchos
ENSG00000198265	HELZ	97	89.134	ENSACAG00000000206	HELZ	100	82.199	Anolis_carolinensis
ENSG00000198265	HELZ	100	100.000	ENSANAG00000037949	HELZ	100	98.661	Aotus_nancymaae
ENSG00000198265	HELZ	100	61.246	ENSACLG00000002206	-	99	61.231	Astatotilapia_calliptera
ENSG00000198265	HELZ	97	78.012	ENSAMXG00000020742	helz	100	62.065	Astyanax_mexicanus
ENSG00000198265	HELZ	100	96.923	ENSBTAG00000004746	HELZ	100	92.541	Bos_taurus
ENSG00000198265	HELZ	100	100.000	ENSCJAG00000032527	HELZ	100	98.610	Callithrix_jacchus
ENSG00000198265	HELZ	100	97.354	ENSCAFG00000011422	HELZ	100	95.525	Canis_familiaris
ENSG00000198265	HELZ	100	96.923	ENSCAFG00020026103	HELZ	100	94.810	Canis_lupus_dingo
ENSG00000198265	HELZ	100	95.385	ENSCHIG00000002760	HELZ	100	90.278	Capra_hircus
ENSG00000198265	HELZ	100	95.944	ENSTSYG00000009414	HELZ	94	95.547	Carlito_syrichta
ENSG00000198265	HELZ	99	72.917	ENSCAPG00000013940	HELZ	96	89.362	Cavia_aperea
ENSG00000198265	HELZ	100	96.923	ENSCPOG00000014911	HELZ	98	94.981	Cavia_porcellus
ENSG00000198265	HELZ	100	100.000	ENSCCAG00000025885	-	93	99.581	Cebus_capucinus
ENSG00000198265	HELZ	100	99.471	ENSCATG00000037268	HELZ	100	99.074	Cercocebus_atys
ENSG00000198265	HELZ	100	95.944	ENSCLAG00000004638	HELZ	100	93.567	Chinchilla_lanigera
ENSG00000198265	HELZ	100	100.000	ENSCSAG00000004152	HELZ	100	99.279	Chlorocebus_sabaeus
ENSG00000198265	HELZ	97	91.608	ENSCPBG00000009548	HELZ	100	85.663	Chrysemys_picta_bellii
ENSG00000198265	HELZ	100	100.000	ENSCANG00000029169	HELZ	99	98.784	Colobus_angolensis_palliatus
ENSG00000198265	HELZ	100	95.238	ENSCGRG00001015066	Helz	100	91.313	Cricetulus_griseus_chok1gshd
ENSG00000198265	HELZ	100	95.238	ENSCGRG00000012094	Helz	100	91.309	Cricetulus_griseus_crigri
ENSG00000198265	HELZ	97	74.341	ENSCSEG00000012232	helz	100	58.204	Cynoglossus_semilaevis
ENSG00000198265	HELZ	100	60.922	ENSCVAG00000000746	-	99	61.211	Cyprinodon_variegatus
ENSG00000198265	HELZ	97	77.065	ENSDARG00000030560	helz	74	71.306	Danio_rerio
ENSG00000198265	HELZ	100	98.462	ENSDNOG00000007899	HELZ	100	95.013	Dasypus_novemcinctus
ENSG00000198265	HELZ	100	96.649	ENSDORG00000027745	-	99	92.283	Dipodomys_ordii
ENSG00000198265	HELZ	86	97.103	ENSEASG00005015902	HELZ	96	97.103	Equus_asinus_asinus
ENSG00000198265	HELZ	100	98.462	ENSECAG00000010404	HELZ	100	94.961	Equus_caballus
ENSG00000198265	HELZ	53	97.980	ENSEEUG00000010327	-	55	97.980	Erinaceus_europaeus
ENSG00000198265	HELZ	96	75.445	ENSELUG00000014335	helz	100	60.261	Esox_lucius
ENSG00000198265	HELZ	100	96.923	ENSFCAG00000011711	HELZ	100	94.750	Felis_catus
ENSG00000198265	HELZ	97	91.519	ENSFALG00000002404	HELZ	100	84.548	Ficedula_albicollis
ENSG00000198265	HELZ	100	97.531	ENSFDAG00000008065	HELZ	100	95.214	Fukomys_damarensis
ENSG00000198265	HELZ	96	76.732	ENSFHEG00000016609	helz	95	68.883	Fundulus_heteroclitus
ENSG00000198265	HELZ	96	76.351	ENSGMOG00000009758	helz	96	69.817	Gadus_morhua
ENSG00000198265	HELZ	90	93.048	ENSGALG00000027152	HELZ	99	85.461	Gallus_gallus
ENSG00000198265	HELZ	100	61.986	ENSGAFG00000016137	-	100	61.513	Gambusia_affinis
ENSG00000198265	HELZ	96	75.351	ENSGACG00000018530	helz	92	70.346	Gasterosteus_aculeatus
ENSG00000198265	HELZ	75	85.092	ENSGAGG00000006506	-	98	86.239	Gopherus_agassizii
ENSG00000198265	HELZ	100	85.891	ENSGAGG00000022363	-	99	85.739	Gopherus_agassizii
ENSG00000198265	HELZ	100	100.000	ENSGGOG00000012312	HELZ	100	99.743	Gorilla_gorilla
ENSG00000198265	HELZ	96	77.128	ENSHBUG00000015322	helz	100	59.673	Haplochromis_burtoni
ENSG00000198265	HELZ	100	96.923	ENSHGLG00000000732	HELZ	100	97.245	Heterocephalus_glaber_female
ENSG00000198265	HELZ	100	96.923	ENSHGLG00100002144	HELZ	100	95.162	Heterocephalus_glaber_male
ENSG00000198265	HELZ	96	76.039	ENSHCOG00000019617	helz	100	58.616	Hippocampus_comes
ENSG00000198265	HELZ	97	78.032	ENSIPUG00000003010	helz	60	78.032	Ictalurus_punctatus
ENSG00000198265	HELZ	100	97.178	ENSSTOG00000007818	HELZ	100	95.214	Ictidomys_tridecemlineatus
ENSG00000198265	HELZ	100	93.827	ENSJJAG00000019941	Helz	100	90.170	Jaculus_jaculus
ENSG00000198265	HELZ	97	75.493	ENSKMAG00000017251	helz	100	58.609	Kryptolebias_marmoratus
ENSG00000198265	HELZ	100	61.831	ENSLBEG00000012585	-	97	60.000	Labrus_bergylta
ENSG00000198265	HELZ	97	80.756	ENSLACG00000010742	HELZ	100	71.894	Latimeria_chalumnae
ENSG00000198265	HELZ	97	80.990	ENSLOCG00000013617	helz	100	67.306	Lepisosteus_oculatus
ENSG00000198265	HELZ	98	96.875	ENSLAFG00000003860	HELZ	100	94.856	Loxodonta_africana
ENSG00000198265	HELZ	100	100.000	ENSMFAG00000045166	HELZ	100	99.279	Macaca_fascicularis
ENSG00000198265	HELZ	100	100.000	ENSMMUG00000002959	HELZ	100	99.279	Macaca_mulatta
ENSG00000198265	HELZ	100	100.000	ENSMNEG00000037121	HELZ	100	99.177	Macaca_nemestrina
ENSG00000198265	HELZ	100	100.000	ENSMLEG00000039575	HELZ	100	99.279	Mandrillus_leucophaeus
ENSG00000198265	HELZ	96	77.798	ENSMAMG00000016108	helz	97	62.548	Mastacembelus_armatus
ENSG00000198265	HELZ	96	77.128	ENSMZEG00005001957	helz	100	59.480	Maylandia_zebra
ENSG00000198265	HELZ	97	91.961	ENSMGAG00000007422	HELZ	100	84.694	Meleagris_gallopavo
ENSG00000198265	HELZ	98	94.092	ENSMAUG00000013803	Helz	100	90.316	Mesocricetus_auratus
ENSG00000198265	HELZ	100	98.462	ENSMICG00000013321	HELZ	100	97.221	Microcebus_murinus
ENSG00000198265	HELZ	100	95.414	ENSMOCG00000017691	-	93	95.270	Microtus_ochrogaster
ENSG00000198265	HELZ	100	61.821	ENSMMOG00000000459	-	98	60.992	Mola_mola
ENSG00000198265	HELZ	100	89.947	ENSMODG00000004034	HELZ	99	82.455	Monodelphis_domestica
ENSG00000198265	HELZ	100	94.004	MGP_CAROLIEiJ_G0017337	Helz	100	90.904	Mus_caroli
ENSG00000198265	HELZ	100	94.356	ENSMUSG00000020721	Helz	100	90.687	Mus_musculus
ENSG00000198265	HELZ	100	94.180	MGP_PahariEiJ_G0018467	Helz	100	91.109	Mus_pahari
ENSG00000198265	HELZ	100	94.180	MGP_SPRETEiJ_G0018181	Helz	100	91.461	Mus_spretus
ENSG00000198265	HELZ	100	97.002	ENSMPUG00000014672	HELZ	100	92.387	Mustela_putorius_furo
ENSG00000198265	HELZ	100	96.296	ENSMLUG00000000962	HELZ	100	94.293	Myotis_lucifugus
ENSG00000198265	HELZ	100	98.462	ENSNGAG00000023219	Helz	100	92.766	Nannospalax_galili
ENSG00000198265	HELZ	88	86.250	ENSNBRG00000003933	helz	74	84.709	Neolamprologus_brichardi
ENSG00000198265	HELZ	100	99.647	ENSNLEG00000000218	HELZ	100	99.331	Nomascus_leucogenys
ENSG00000198265	HELZ	100	95.062	ENSODEG00000007838	-	99	94.764	Octodon_degus
ENSG00000198265	HELZ	96	77.160	ENSONIG00000006486	helz	100	60.541	Oreochromis_niloticus
ENSG00000198265	HELZ	97	91.703	ENSOANG00000008056	HELZ	100	85.329	Ornithorhynchus_anatinus
ENSG00000198265	HELZ	97	92.948	ENSOCUG00000008856	HELZ	100	92.948	Oryctolagus_cuniculus
ENSG00000198265	HELZ	96	76.381	ENSORLG00000013894	helz	100	59.478	Oryzias_latipes
ENSG00000198265	HELZ	96	76.586	ENSORLG00020021251	helz	99	61.157	Oryzias_latipes_hni
ENSG00000198265	HELZ	96	76.377	ENSORLG00015022086	helz	100	58.690	Oryzias_latipes_hsok
ENSG00000198265	HELZ	96	76.732	ENSOMEG00000008739	helz	99	59.225	Oryzias_melastigma
ENSG00000198265	HELZ	100	97.354	ENSOGAG00000002482	HELZ	100	96.859	Otolemur_garnettii
ENSG00000198265	HELZ	100	95.385	ENSOARG00000015884	HELZ	100	90.231	Ovis_aries
ENSG00000198265	HELZ	100	100.000	ENSPPAG00000036899	HELZ	100	99.794	Pan_paniscus
ENSG00000198265	HELZ	100	96.923	ENSPPRG00000024752	HELZ	100	94.699	Panthera_pardus
ENSG00000198265	HELZ	100	96.923	ENSPTIG00000020571	HELZ	100	94.133	Panthera_tigris_altaica
ENSG00000198265	HELZ	100	100.000	ENSPTRG00000009562	HELZ	100	99.640	Pan_troglodytes
ENSG00000198265	HELZ	90	99.260	ENSPANG00000020569	HELZ	100	99.260	Papio_anubis
ENSG00000198265	HELZ	97	80.160	ENSPKIG00000006157	helz	100	64.318	Paramormyrops_kingsleyae
ENSG00000198265	HELZ	97	91.873	ENSPSIG00000005225	HELZ	100	85.383	Pelodiscus_sinensis
ENSG00000198265	HELZ	97	73.037	ENSPMGG00000002314	helz	88	71.253	Periophthalmus_magnuspinnatus
ENSG00000198265	HELZ	97	76.775	ENSPFOG00000013386	helz	100	60.099	Poecilia_formosa
ENSG00000198265	HELZ	96	77.067	ENSPLAG00000020664	helz	98	58.458	Poecilia_latipinna
ENSG00000198265	HELZ	96	77.067	ENSPMEG00000011144	helz	100	59.466	Poecilia_mexicana
ENSG00000198265	HELZ	96	76.848	ENSPREG00000000245	helz	100	58.790	Poecilia_reticulata
ENSG00000198265	HELZ	100	100.000	ENSPPYG00000008564	-	100	95.335	Pongo_abelii
ENSG00000198265	HELZ	100	96.923	ENSPCAG00000001731	HELZ	95	93.198	Procavia_capensis
ENSG00000198265	HELZ	100	96.923	ENSPCOG00000016213	HELZ	100	95.780	Propithecus_coquereli
ENSG00000198265	HELZ	96	77.216	ENSPNYG00000018395	helz	100	59.625	Pundamilia_nyererei
ENSG00000198265	HELZ	99	77.643	ENSPNAG00000016575	helz	72	72.819	Pygocentrus_nattereri
ENSG00000198265	HELZ	98	95.414	ENSRNOG00000003213	Helz	100	90.733	Rattus_norvegicus
ENSG00000198265	HELZ	100	100.000	ENSRBIG00000026299	HELZ	100	99.185	Rhinopithecus_bieti
ENSG00000198265	HELZ	100	100.000	ENSRROG00000038961	HELZ	100	99.228	Rhinopithecus_roxellana
ENSG00000198265	HELZ	100	100.000	ENSSBOG00000033082	HELZ	100	98.404	Saimiri_boliviensis_boliviensis
ENSG00000198265	HELZ	97	79.505	ENSSFOG00015005413	helz	100	64.282	Scleropages_formosus
ENSG00000198265	HELZ	96	76.554	ENSSMAG00000018328	helz	100	58.793	Scophthalmus_maximus
ENSG00000198265	HELZ	96	77.620	ENSSDUG00000011381	helz	100	59.697	Seriola_dumerili
ENSG00000198265	HELZ	96	77.620	ENSSLDG00000000611	helz	88	74.257	Seriola_lalandi_dorsalis
ENSG00000198265	HELZ	100	87.692	ENSSARG00000004508	HELZ	73	88.655	Sorex_araneus
ENSG00000198265	HELZ	97	90.724	ENSSPUG00000011226	HELZ	100	84.781	Sphenodon_punctatus
ENSG00000198265	HELZ	96	76.455	ENSSPAG00000012867	helz	100	58.462	Stegastes_partitus
ENSG00000198265	HELZ	100	97.354	ENSSSCG00000017272	HELZ	99	96.390	Sus_scrofa
ENSG00000198265	HELZ	97	91.784	ENSTGUG00000004401	HELZ	100	84.592	Taeniopygia_guttata
ENSG00000198265	HELZ	97	75.704	ENSTRUG00000000488	helz	99	60.158	Takifugu_rubripes
ENSG00000198265	HELZ	96	73.566	ENSTNIG00000014131	helz	100	58.974	Tetraodon_nigroviridis
ENSG00000198265	HELZ	88	97.586	ENSTBEG00000003140	HELZ	82	97.863	Tupaia_belangeri
ENSG00000198265	HELZ	100	96.923	ENSTTRG00000016778	HELZ	100	93.063	Tursiops_truncatus
ENSG00000198265	HELZ	100	97.002	ENSUAMG00000005560	HELZ	99	95.329	Ursus_americanus
ENSG00000198265	HELZ	100	95.385	ENSUMAG00000018753	HELZ	100	94.190	Ursus_maritimus
ENSG00000198265	HELZ	96	94.361	ENSVPAG00000001848	HELZ	100	94.146	Vicugna_pacos
ENSG00000198265	HELZ	100	97.178	ENSVVUG00000006563	HELZ	100	95.476	Vulpes_vulpes
ENSG00000198265	HELZ	97	84.629	ENSXETG00000015395	helz	100	74.936	Xenopus_tropicalis
ENSG00000198265	HELZ	100	62.176	ENSXCOG00000014875	-	100	62.149	Xiphophorus_couchianus
ENSG00000198265	HELZ	96	76.978	ENSXMAG00000006535	helz	100	58.680	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	24606901.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0035194	posttranscriptional gene silencing by RNA	21873635.	IBA	Process
GO:0043186	P granule	21873635.	IBA	Component
GO:0046872	metal ion binding	-	IEA	Function