EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000198522 (Gene tree)
Gene ID: 11321
Gene Symbol: GPN1
Alias: NTPBP|MBDIN|ATPBD1A|RPAP4|XAB1
Full Name: GPN-loop GTPase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 23,262 bases
Position: chr2:27,628,247-27,651,508
Accession: 17030
RBP type: canonical RBP
Summary: This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000476446	GTP_EFTU	PF00009.27	5.7e-07	1	1
ENSP00000264718	GTP_EFTU	PF00009.27	6.5e-07	1	1
ENSP00000484680	GTP_EFTU	PF00009.27	6.5e-07	1	1
ENSP00000398115	GTP_EFTU	PF00009.27	9.2e-06	1	1
ENSP00000424678	GTP_EFTU	PF00009.27	9.2e-06	1	1
ENSP00000476446	MMR_HSR1	PF01926.23	1.2e-05	1	1
ENSP00000264718	MMR_HSR1	PF01926.23	1.3e-05	1	1
ENSP00000484680	MMR_HSR1	PF01926.23	1.3e-05	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
8969509	Sequencing of a 65 kb region of the Bacillus subtilis genome containing the lic and cel loci, and creation of a 177 kb contig covering the gnt-sacXY region.	Microbiology	1996 Nov	Yoshida K	-
31293528	Gene Targets in Ocular Pathogenic Escherichia coli for Mitigation of Biofilm Formation to Overcome Antibiotic Resistance.	Front Microbiol	2019 Jun 21	Ranjith K	doi: 10.3389/fmicb.2019.01308

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000610189	GPN1-211	1778	-	ENSP00000476446	374 (aa)	-	Q9HCN4
ENST00000478484	GPN1-207	826	-	-	- (aa)	-	-
ENST00000461249	GPN1-206	969	-	-	- (aa)	-	-
ENST00000503738	GPN1-209	984	-	ENSP00000427269	279 (aa)	-	Q9HCN4
ENST00000436280	GPN1-204	577	-	ENSP00000395981	73 (aa)	-	F8WD09
ENST00000264718	GPN1-201	2496	-	ENSP00000264718	388 (aa)	-	Q9HCN4
ENST00000407583	GPN1-202	1395	-	ENSP00000384255	362 (aa)	-	Q9HCN4
ENST00000458167	GPN1-205	1618	-	ENSP00000412170	279 (aa)	-	Q9HCN4
ENST00000481754	GPN1-208	537	-	-	- (aa)	-	-
ENST00000515877	GPN1-210	1646	-	ENSP00000424678	295 (aa)	-	Q9HCN4
ENST00000616939	GPN1-212	1832	-	ENSP00000484680	388 (aa)	-	Q9HCN4
ENST00000424214	GPN1-203	1725	-	ENSP00000398115	295 (aa)	-	Q9HCN4

Gene Model

Click here to download ENSG00000198522's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198522	Triglycerides	1E-9	21386085
ENSG00000198522	Metabolic Syndrome X	1E-9	21386085
ENSG00000198522	Mouth Neoplasms	4E-8	27749845
ENSG00000198522	Periodontitis	8E-6	24024966

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198522	rs6547741	2	27633057	G	Oral cavity cancer	27749845	NR	1.1983223	EFO_0005570
ENSG00000198522	rs111571364	2	27636450	T	Periodontitis (CDC/AAP)	24024966	[2.01-5.97]	3.46	EFO_0000649
ENSG00000198522	rs3749147	2	27629051	C	Waist Circumference - Triglycerides (WC-TG)	21386085	[0.12-0.24] unit decrease	0.18	EFO_0004530\|EFO_0000195
ENSG00000198522	rs11692692	2	27638840	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000198522	rs2178197	2	27637684	G	Alcohol consumption (drinks per week)	30643251	[0.0059-0.0117] unit decrease	0.008781445	EFO_0007878

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198522's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198522	GPN1	100	96.610	ENSAMEG00000001201	GPN1	99	95.607	Ailuropoda_melanoleuca
ENSG00000198522	GPN1	100	75.593	ENSAPEG00000000050	gpn1	91	76.796	Amphiprion_percula
ENSG00000198522	GPN1	92	73.623	ENSAPEG00000000067	gpn1	86	72.156	Amphiprion_percula
ENSG00000198522	GPN1	100	78.041	ENSATEG00000015542	gpn1	96	77.657	Anabas_testudineus
ENSG00000198522	GPN1	100	80.405	ENSAPLG00000003530	GPN1	99	81.268	Anas_platyrhynchos
ENSG00000198522	GPN1	99	75.585	ENSACAG00000008974	GPN1	99	75.510	Anolis_carolinensis
ENSG00000198522	GPN1	100	97.288	ENSANAG00000024716	GPN1	100	96.134	Aotus_nancymaae
ENSG00000198522	GPN1	100	77.966	ENSACLG00000025644	gpn1	90	78.237	Astatotilapia_calliptera
ENSG00000198522	GPN1	100	78.041	ENSAMXG00000031098	gpn1	89	79.006	Astyanax_mexicanus
ENSG00000198522	GPN1	92	59.420	WBGene00001661	gop-2	83	55.082	Caenorhabditis_elegans
ENSG00000198522	GPN1	100	97.288	ENSCJAG00000046633	GPN1	99	96.382	Callithrix_jacchus
ENSG00000198522	GPN1	100	96.949	ENSCAFG00000005160	-	97	94.474	Canis_familiaris
ENSG00000198522	GPN1	73	97.059	ENSCAFG00000032406	-	95	97.059	Canis_familiaris
ENSG00000198522	GPN1	96	84.015	ENSCAFG00000024379	-	98	84.982	Canis_familiaris
ENSG00000198522	GPN1	100	96.610	ENSCAFG00020020326	-	100	94.920	Canis_lupus_dingo
ENSG00000198522	GPN1	100	96.271	ENSCAFG00020022034	-	99	94.681	Canis_lupus_dingo
ENSG00000198522	GPN1	100	87.797	ENSCHIG00000017789	-	100	87.701	Capra_hircus
ENSG00000198522	GPN1	100	94.237	ENSTSYG00000006604	GPN1	99	93.885	Carlito_syrichta
ENSG00000198522	GPN1	99	91.809	ENSCAPG00000015026	GPN1	90	91.809	Cavia_aperea
ENSG00000198522	GPN1	99	93.515	ENSCPOG00000004359	GPN1	100	91.421	Cavia_porcellus
ENSG00000198522	GPN1	100	97.966	ENSCCAG00000035409	GPN1	99	96.899	Cebus_capucinus
ENSG00000198522	GPN1	100	99.322	ENSCATG00000042260	GPN1	100	98.454	Cercocebus_atys
ENSG00000198522	GPN1	100	95.593	ENSCLAG00000008226	GPN1	98	93.989	Chinchilla_lanigera
ENSG00000198522	GPN1	100	98.983	ENSCSAG00000010222	GPN1	99	98.191	Chlorocebus_sabaeus
ENSG00000198522	GPN1	99	83.051	ENSCPBG00000009367	GPN1	96	82.920	Chrysemys_picta_bellii
ENSG00000198522	GPN1	74	70.909	ENSCING00000023847	-	86	68.248	Ciona_intestinalis
ENSG00000198522	GPN1	68	76.000	ENSCSAVG00000004925	-	95	65.614	Ciona_savignyi
ENSG00000198522	GPN1	100	98.644	ENSCANG00000031249	GPN1	100	98.644	Colobus_angolensis_palliatus
ENSG00000198522	GPN1	99	94.881	ENSCGRG00001017621	Gpn1	98	93.956	Cricetulus_griseus_chok1gshd
ENSG00000198522	GPN1	99	94.881	ENSCGRG00000003560	Gpn1	98	93.956	Cricetulus_griseus_crigri
ENSG00000198522	GPN1	97	70.877	ENSCSEG00000019468	gpn1	89	71.549	Cynoglossus_semilaevis
ENSG00000198522	GPN1	100	79.730	ENSDARG00000043928	gpn1	89	81.232	Danio_rerio
ENSG00000198522	GPN1	99	94.558	ENSDORG00000006558	Gpn1	97	93.699	Dipodomys_ordii
ENSG00000198522	GPN1	93	52.778	FBgn0040346	CG3704	65	60.956	Drosophila_melanogaster
ENSG00000198522	GPN1	100	96.949	ENSEASG00005009082	GPN1	100	95.989	Equus_asinus_asinus
ENSG00000198522	GPN1	100	89.153	ENSECAG00000009579	GPN1	100	90.107	Equus_caballus
ENSG00000198522	GPN1	100	94.915	ENSEEUG00000013421	GPN1	97	94.809	Erinaceus_europaeus
ENSG00000198522	GPN1	100	74.324	ENSELUG00000006293	gpn1	90	75.766	Esox_lucius
ENSG00000198522	GPN1	100	96.610	ENSFCAG00000030425	GPN1	100	96.610	Felis_catus
ENSG00000198522	GPN1	99	80.000	ENSFALG00000011331	GPN1	99	80.539	Ficedula_albicollis
ENSG00000198522	GPN1	99	93.878	ENSFDAG00000014526	GPN1	99	91.667	Fukomys_damarensis
ENSG00000198522	GPN1	99	75.768	ENSGMOG00000016174	gpn1	99	77.528	Gadus_morhua
ENSG00000198522	GPN1	100	80.743	ENSGALG00000016505	GPN1	99	80.769	Gallus_gallus
ENSG00000198522	GPN1	100	75.254	ENSGAFG00000016670	gpn1	76	76.667	Gambusia_affinis
ENSG00000198522	GPN1	100	75.333	ENSGACG00000017639	gpn1	96	81.040	Gasterosteus_aculeatus
ENSG00000198522	GPN1	99	83.390	ENSGAGG00000016449	GPN1	95	83.989	Gopherus_agassizii
ENSG00000198522	GPN1	100	100.000	ENSGGOG00000015285	GPN1	100	99.742	Gorilla_gorilla
ENSG00000198522	GPN1	100	78.305	ENSHBUG00000022933	gpn1	90	78.512	Haplochromis_burtoni
ENSG00000198522	GPN1	100	93.898	ENSHGLG00000010319	GPN1	98	92.077	Heterocephalus_glaber_female
ENSG00000198522	GPN1	100	93.898	ENSHGLG00100016905	GPN1	98	92.077	Heterocephalus_glaber_male
ENSG00000198522	GPN1	100	77.966	ENSIPUG00000011938	gpn1	92	77.507	Ictalurus_punctatus
ENSG00000198522	GPN1	99	95.563	ENSSTOG00000006379	-	97	94.722	Ictidomys_tridecemlineatus
ENSG00000198522	GPN1	100	73.559	ENSKMAG00000011063	gpn1	93	74.931	Kryptolebias_marmoratus
ENSG00000198522	GPN1	63	89.840	ENSLACG00000001268	GPN1	98	88.938	Latimeria_chalumnae
ENSG00000198522	GPN1	100	77.288	ENSLOCG00000015949	gpn1	90	78.116	Lepisosteus_oculatus
ENSG00000198522	GPN1	99	96.259	ENSLAFG00000011179	GPN1	98	95.616	Loxodonta_africana
ENSG00000198522	GPN1	100	99.322	ENSMFAG00000035863	GPN1	100	98.711	Macaca_fascicularis
ENSG00000198522	GPN1	100	99.322	ENSMMUG00000019745	GPN1	100	98.711	Macaca_mulatta
ENSG00000198522	GPN1	100	99.322	ENSMNEG00000027876	GPN1	100	98.711	Macaca_nemestrina
ENSG00000198522	GPN1	100	90.909	ENSMLEG00000031376	GPN1	100	90.722	Mandrillus_leucophaeus
ENSG00000198522	GPN1	100	77.966	ENSMZEG00005003265	gpn1	90	78.237	Maylandia_zebra
ENSG00000198522	GPN1	100	81.757	ENSMGAG00000014062	GPN1	99	82.748	Meleagris_gallopavo
ENSG00000198522	GPN1	99	93.515	ENSMAUG00000018225	Gpn1	99	92.473	Mesocricetus_auratus
ENSG00000198522	GPN1	100	96.271	ENSMICG00000042626	GPN1	98	95.902	Microcebus_murinus
ENSG00000198522	GPN1	99	93.174	ENSMOCG00000021769	Gpn1	98	92.582	Microtus_ochrogaster
ENSG00000198522	GPN1	100	76.667	ENSMMOG00000002005	gpn1	73	76.648	Mola_mola
ENSG00000198522	GPN1	100	87.500	ENSMODG00000015592	GPN1	97	87.397	Monodelphis_domestica
ENSG00000198522	GPN1	100	77.778	ENSMALG00000015121	gpn1	83	78.492	Monopterus_albus
ENSG00000198522	GPN1	99	93.174	MGP_CAROLIEiJ_G0027095	Gpn1	98	92.308	Mus_caroli
ENSG00000198522	GPN1	99	92.491	ENSMUSG00000064037	Gpn1	98	91.758	Mus_musculus
ENSG00000198522	GPN1	93	91.329	MGP_PahariEiJ_G0029286	Gpn1	94	92.012	Mus_pahari
ENSG00000198522	GPN1	99	91.809	MGP_SPRETEiJ_G0028091	Gpn1	98	91.209	Mus_spretus
ENSG00000198522	GPN1	99	95.222	ENSMLUG00000011928	GPN1	99	94.778	Myotis_lucifugus
ENSG00000198522	GPN1	100	100.000	ENSNLEG00000003945	GPN1	100	100.000	Nomascus_leucogenys
ENSG00000198522	GPN1	100	95.593	ENSOPRG00000013015	GPN1	100	95.187	Ochotona_princeps
ENSG00000198522	GPN1	100	93.898	ENSODEG00000007092	GPN1	100	92.246	Octodon_degus
ENSG00000198522	GPN1	100	78.716	ENSONIG00000003361	gpn1	90	78.992	Oreochromis_niloticus
ENSG00000198522	GPN1	100	77.288	ENSORLG00020015676	gpn1	92	75.000	Oryzias_latipes_hni
ENSG00000198522	GPN1	100	77.627	ENSORLG00015013049	gpn1	93	79.444	Oryzias_latipes_hsok
ENSG00000198522	GPN1	100	77.288	ENSOMEG00000022023	gpn1	94	78.415	Oryzias_melastigma
ENSG00000198522	GPN1	91	95.506	ENSOGAG00000014057	GPN1	99	93.017	Otolemur_garnettii
ENSG00000198522	GPN1	100	100.000	ENSPPAG00000022926	GPN1	100	99.485	Pan_paniscus
ENSG00000198522	GPN1	100	96.271	ENSPPRG00000001472	GPN1	100	95.699	Panthera_pardus
ENSG00000198522	GPN1	100	96.610	ENSPTIG00000007504	GPN1	100	96.057	Panthera_tigris_altaica
ENSG00000198522	GPN1	100	99.661	ENSPTRG00000011776	GPN1	100	98.969	Pan_troglodytes
ENSG00000198522	GPN1	100	99.322	ENSPANG00000011578	GPN1	100	98.454	Papio_anubis
ENSG00000198522	GPN1	100	78.983	ENSPKIG00000007460	gpn1	90	79.888	Paramormyrops_kingsleyae
ENSG00000198522	GPN1	99	71.088	ENSPMGG00000013238	gpn1	90	70.055	Periophthalmus_magnuspinnatus
ENSG00000198522	GPN1	99	93.174	ENSPEMG00000003913	Gpn1	98	92.582	Peromyscus_maniculatus_bairdii
ENSG00000198522	GPN1	100	87.119	ENSPCIG00000026182	GPN1	94	87.989	Phascolarctos_cinereus
ENSG00000198522	GPN1	99	76.139	ENSPFOG00000000034	gpn1	93	75.339	Poecilia_formosa
ENSG00000198522	GPN1	99	75.871	ENSPLAG00000023798	gpn1	91	76.602	Poecilia_latipinna
ENSG00000198522	GPN1	99	75.871	ENSPMEG00000002283	gpn1	91	76.602	Poecilia_mexicana
ENSG00000198522	GPN1	99	76.139	ENSPREG00000009028	gpn1	98	72.701	Poecilia_reticulata
ENSG00000198522	GPN1	93	98.529	ENSPPYG00000012538	GPN1	97	99.383	Pongo_abelii
ENSG00000198522	GPN1	100	96.271	ENSPCOG00000028038	GPN1	100	95.455	Propithecus_coquereli
ENSG00000198522	GPN1	93	90.751	ENSPVAG00000015220	GPN1	100	90.751	Pteropus_vampyrus
ENSG00000198522	GPN1	100	78.305	ENSPNYG00000019130	gpn1	90	78.512	Pundamilia_nyererei
ENSG00000198522	GPN1	97	74.658	ENSPNAG00000010900	gpn1	83	77.551	Pygocentrus_nattereri
ENSG00000198522	GPN1	99	92.150	ENSRNOG00000004941	Gpn1	98	91.758	Rattus_norvegicus
ENSG00000198522	GPN1	100	99.322	ENSRBIG00000038211	GPN1	100	98.711	Rhinopithecus_bieti
ENSG00000198522	GPN1	100	99.322	ENSRROG00000026146	GPN1	100	99.322	Rhinopithecus_roxellana
ENSG00000198522	GPN1	99	46.580	YJR072C	NPA3	79	54.455	Saccharomyces_cerevisiae
ENSG00000198522	GPN1	100	98.305	ENSSBOG00000025586	GPN1	99	97.416	Saimiri_boliviensis_boliviensis
ENSG00000198522	GPN1	100	79.322	ENSSFOG00015019441	gpn1	91	79.890	Scleropages_formosus
ENSG00000198522	GPN1	100	74.497	ENSSMAG00000005973	gpn1	91	75.956	Scophthalmus_maximus
ENSG00000198522	GPN1	100	77.027	ENSSDUG00000006929	gpn1	94	74.247	Seriola_dumerili
ENSG00000198522	GPN1	100	77.027	ENSSLDG00000014532	gpn1	89	78.992	Seriola_lalandi_dorsalis
ENSG00000198522	GPN1	83	81.877	ENSSPAG00000015690	gpn1	82	80.380	Stegastes_partitus
ENSG00000198522	GPN1	99	94.881	ENSSSCG00000008546	GPN1	97	94.751	Sus_scrofa
ENSG00000198522	GPN1	96	83.158	ENSTGUG00000014626	GPN1	96	83.526	Taeniopygia_guttata
ENSG00000198522	GPN1	99	75.338	ENSTRUG00000004290	gpn1	91	76.374	Takifugu_rubripes
ENSG00000198522	GPN1	99	76.949	ENSTNIG00000002572	gpn1	94	78.652	Tetraodon_nigroviridis
ENSG00000198522	GPN1	100	95.932	ENSTBEG00000007425	GPN1	98	95.628	Tupaia_belangeri
ENSG00000198522	GPN1	100	93.898	ENSTTRG00000012531	GPN1	100	91.444	Tursiops_truncatus
ENSG00000198522	GPN1	100	84.407	ENSUAMG00000012406	-	95	91.342	Ursus_americanus
ENSG00000198522	GPN1	100	96.610	ENSUMAG00000020247	GPN1	91	95.866	Ursus_maritimus
ENSG00000198522	GPN1	99	74.866	ENSXMAG00000005436	gpn1	84	74.255	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005515	protein binding	25241168.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component