EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000198589 (Gene tree)
Gene ID: 987
Gene Symbol: LRBA
Alias: BGL|LAB300|LBA|CDC4L
Full Name: LPS responsive beige-like anchor protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 751,197 bases
Position: chr4:150,264,531-151,015,727
Accession: 1742
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000510841	LRBA-210	2288	-	-	- (aa)	-	-
ENST00000508396	LRBA-205	234	-	-	- (aa)	-	-
ENST00000648626	LRBA-214	4078	-	-	- (aa)	-	-
ENST00000513021	LRBA-211	568	-	-	- (aa)	-	-
ENST00000503716	LRBA-203	3712	-	-	- (aa)	-	-
ENST00000514435	LRBA-212	2140	-	-	- (aa)	-	-
ENST00000509835	LRBA-207	5578	-	ENSP00000426669	1505 (aa)	-	H0YAC6
ENST00000510157	LRBA-208	1636	-	-	- (aa)	-	-
ENST00000515096	LRBA-213	2914	-	-	- (aa)	-	-
ENST00000648823	LRBA-215	3346	-	ENSP00000498057	242 (aa)	-	-
ENST00000649874	LRBA-217	713	-	ENSP00000497438	237 (aa)	-	-
ENST00000648878	LRBA-216	3120	XM_017008873	ENSP00000497002	686 (aa)	XP_016864362	-
ENST00000510413	LRBA-209	10032	XM_005263374	ENSP00000421552	2851 (aa)	XP_005263431	P50851
ENST00000508606	LRBA-206	633	-	ENSP00000425852	147 (aa)	-	H0YA17
ENST00000357115	LRBA-201	10129	XM_005263372	ENSP00000349629	2863 (aa)	XP_005263429	P50851
ENST00000502839	LRBA-202	814	-	ENSP00000424640	134 (aa)	-	H0Y9N9
ENST00000507224	LRBA-204	8826	-	ENSP00000422180	2575 (aa)	-	E9PEM5

Gene Model

Click here to download ENSG00000198589's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198589	Lipoproteins, VLDL	9.7391619140625E-5	17903299
ENSG00000198589	Body Mass Index	3.8150000E-005	-
ENSG00000198589	Anthropometry	5.1360000E-005	-
ENSG00000198589	Anthropometry	4.5510000E-006	-
ENSG00000198589	Waist Circumference	8.7980000E-005	-
ENSG00000198589	Body Weight	1.3960000E-005	-
ENSG00000198589	Body Weight	4.7230000E-006	-
ENSG00000198589	Body Weight	2.2220000E-007	-
ENSG00000198589	Platelet Function Tests	1.2617900E-005	-
ENSG00000198589	Chemical and Drug Induced Liver Injury	5E-9	28043905
ENSG00000198589	Ear, External	2E-8	26105758
ENSG00000198589	Ear, External	4E-8	26105758

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198589	rs17027158	4	150873055	?	Clostridium difficile infection in multiple myeloma	29594489			EFO_0009130\|EFO_0001378
ENSG00000198589	rs1960918	4	150301114	A	Helix rolling	26105758	unit decrease	0.066	EFO_0007670
ENSG00000198589	rs1960918	4	150301114	A	Ear morphology	26105758			EFO_0007664
ENSG00000198589	rs12711271	4	150338612	?	Lobe attachment (rater-scored or self-reported)	29198719			EFO_0007667
ENSG00000198589	rs62344660	4	150452488	?	Lobe attachment (rater-scored or self-reported)	29198719			EFO_0007667
ENSG00000198589	rs7674861	4	150556729	?	Lobe attachment (rater-scored or self-reported)	29198719			EFO_0007667
ENSG00000198589	rs11944485	4	150667674	?	Lobe attachment (rater-scored or self-reported)	29198719			EFO_0007667
ENSG00000198589	rs6846361	4	150840447	?	Lobe attachment (rater-scored or self-reported)	29198719			EFO_0007667
ENSG00000198589	rs28521457	4	150759175	?	Drug-induced hepatocellular liver injury	28043905	1.6-2.7	2.1	EFO_0004228
ENSG00000198589	rs13147122	4	150740962	?	Peripheral arterial disease (traffic-related air pollution interaction)	27082954	[23.4-28.06]	25.73	EFO_0004265\|EFO_0007908
ENSG00000198589	rs2290846	4	150277928	?	Gallstone disease	30504769	[1.09-1.14]	1.12	EFO_0004210
ENSG00000198589	rs2290846	4	150277928	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000198589	rs6823767	4	150373933	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000198589	rs17588356	4	150289525	?	White blood cell count	30595370			EFO_0004308
ENSG00000198589	rs6823767	4	150373933	T	Systolic blood pressure	30224653	[0.15-0.28] mmHg decrease	0.2129	EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198589's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0005764	lysosome	-	IEA	Component
GO:0005783	endoplasmic reticulum	-	IEA	Component
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0008150	biological_process	-	ND	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component