EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000198682 (Gene tree)
Gene ID: 9060
Gene Symbol: PAPSS2
Alias: ATPSK2
Full Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 88,093 bases
Position: chr10:87,659,613-87,747,705
Accession: 8604
RBP type: non-canonical RBP
Summary: Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000456849	PAPSS2-202	3856	-	ENSP00000406157	619 (aa)	-	O95340
ENST00000482258	PAPSS2-204	424	-	-	- (aa)	-	-
ENST00000465996	PAPSS2-203	275	-	-	- (aa)	-	-
ENST00000361175	PAPSS2-201	3949	-	ENSP00000354436	614 (aa)	-	O95340

Gene Model

Click here to download ENSG00000198682's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00230	Purine metabolism	KEGG
hsa00450	Selenocompound metabolism	KEGG
hsa00920	Sulfur metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198682	Exercise	4E-6	19727025

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198682	rs10887741	10	87683553	T	Leisure-time exercise behaviour	19727025	[1.17-1.49]	1.32	EFO_0000483
ENSG00000198682	rs17173698	10	87709196	?	Heel bone mineral density	30048462	[0.044-0.07] unit decrease	0.0574583	EFO_0009270
ENSG00000198682	rs7896505	10	87717352	?	Heel bone mineral density	30048462	[0.013-0.021] unit increase	0.0170634	EFO_0009270
ENSG00000198682	rs17173698	10	87709196	G	Heel bone mineral density	30598549	[0.028-0.051] unit decrease	0.0391802	EFO_0009270
ENSG00000198682	rs10887745	10	87722114	G	Heel bone mineral density	30598549	[0.0097-0.0172] unit increase	0.0134668	EFO_0009270
ENSG00000198682	rs17173698	10	87709196	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198682's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198682	PAPSS2	98	78.369	ENSG00000138801	PAPSS1	96	78.369	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000103	sulfate assimilation	21873635.	IBA	Process
GO:0000103	sulfate assimilation	-	IEA	Process
GO:0001501	skeletal system development	9771708.	TAS	Process
GO:0004020	adenylylsulfate kinase activity	21873635.	IBA	Function
GO:0004781	sulfate adenylyltransferase (ATP) activity	-	ISS	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005829	cytosol	-	TAS	Component
GO:0007596	blood coagulation	-	IEA	Process
GO:0016310	phosphorylation	-	IEA	Process
GO:0016779	nucleotidyltransferase activity	-	ISS	Function
GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	21873635.	IBA	Process
GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	-	TAS	Process
GO:0060348	bone development	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr10	87709300	Silent	rs753690800	T44T	0.38
BLCA	chr10	87745151	Silent	rs7918595	L542L	0.83
BLCA	chr10	87715063	Missense_Mutation	novel	E240K	0.42
BLCA	chr10	87741325	Silent	NA	L388L	0.1
BLCA	chr10	87745992	3'UTR	novel		0.15
BLCA	chr10	87713172	Silent	NA	V81V	0.61
BLCA	chr10	87741304	Missense_Mutation	novel	D381N	0.39
BRCA	chr10	87714105	Missense_Mutation	novel	V148E	0.11
BRCA	chr10	87727355	Missense_Mutation	novel	C313G	0.28
BRCA	chr10	87714854	Silent	NA	L210L	0.1
BRCA	chr10	87745919	Silent	NA	P598P	0.4
BRCA	chr10	87743501	Missense_Mutation	rs373228712	G446S	0.41
BRCA	chr10	87714047	Missense_Mutation	NA	R129C	0.14
BRCA	chr10	87743537	Missense_Mutation	rs756961458	R458W	0.35
CESC	chr10	87727470	Missense_Mutation	novel	T351K	0.58
CESC	chr10	87747534	3'UTR	novel		0.44
CESC	chr10	87743453	Silent	NA	L430L	0.12
CESC	chr10	87659993	Missense_Mutation	NA	I4M	0.7
CESC	chr10	87714095	Missense_Mutation	NA	E145Q	0.39
COAD	chr10	87727322	Missense_Mutation	rs762088120	V302I	0.41
COAD	chr10	87714096	Missense_Mutation	novel	E145A	0.38
COAD	chr10	87659903	5'UTR	novel		0.32
COAD	chr10	87727448	Missense_Mutation	NA	R344C	0.36
COAD	chr10	87713305	Missense_Mutation	rs549258954	A126T	0.24
COAD	chr10	87741358	Nonsense_Mutation	NA	E399*	0.28
COAD	chr10	87659907	5'UTR	novel		0.55
COAD	chr10	87714764	Silent	NA	S180S	0.35
COAD	chr10	87659908	5'UTR	rs10677560		0.21
ESCA	chr10	87659993	Silent	novel	I4I	0.42
ESCA	chr10	87727406	Missense_Mutation	novel	D330N	0.29
GBM	chr10	87713100	Silent	novel	T57T	0.18
GBM	chr10	87745178	Silent	novel	R551R	0.21
HNSC	chr10	87743396	Missense_Mutation	rs374301331	R411C	0.2
HNSC	chr10	87659961	5'UTR	novel		0.17
HNSC	chr10	87713188	Frame_Shift_Del	novel	*R87Kfs18**	0.16
HNSC	chr10	87743414	Missense_Mutation	novel	G417S	0.11
HNSC	chr10	87715063	Missense_Mutation	novel	E240K	0.38
KIRC	chr10	87714129	Missense_Mutation	NA	E156G	0.23
KIRP	chr10	87741255	Silent	rs771350788	D364D	0.3
KIRP	chr10	87743556	Missense_Mutation	NA	A464V	0.54
KIRP	chr10	87714808	Frame_Shift_Ins	novel	*L196Ffs6**	0.34
LAML	chr10	87713198	Missense_Mutation	novel	G90A	0.06
LIHC	chr10	87713101	Missense_Mutation	novel	I58V	0.33
LUAD	chr10	87714149	Missense_Mutation	NA	L163I	0.19
LUAD	chr10	87745069	Missense_Mutation	NA	A515V	0.1
LUAD	chr10	87713104	Missense_Mutation	novel	S59R	0.04
LUAD	chr10	87745140	Frame_Shift_Ins	novel	*G541Wfs26**	0.67
LUAD	chr10	87715779	Silent	NA	P267P	0.13
LUAD	chr10	87741363	Missense_Mutation	novel	M400I	0.09
LUAD	chr10	87745833	Missense_Mutation	novel	H570Y	0.51
LUAD	chr10	87715783	Missense_Mutation	NA	K269Q	0.31
LUAD	chr10	87743474	Missense_Mutation	rs755518410	P437S	0.13
LUAD	chr10	87709293	Missense_Mutation	novel	G42V	0.06
LUAD	chr10	87714814	Missense_Mutation	novel	S197F	0.19
LUSC	chr10	87746081	3'UTR	novel		0.16
LUSC	chr10	87659883	5'UTR	novel		0.86
LUSC	chr10	87743442	Missense_Mutation	rs755679218	R426H	0.25
LUSC	chr10	87743563	Silent	rs749432936	L466L	0.32
LUSC	chr10	87713176	Missense_Mutation	novel	H83D	0.25
OV	chr10	87727357	Nonsense_Mutation	novel	C313*	0.07
OV	chr10	87743439	Missense_Mutation	NA	T425S	0.44
OV	chr10	87743409	Frame_Shift_Ins	novel	*N416Qfs36**	0.06
PAAD	chr10	87660010	Splice_Site	novel	X9_splice	0.1
PAAD	chr10	87713275	Missense_Mutation	novel	V116I	0.19
PAAD	chr10	87727353	Missense_Mutation	novel	G312E	0.17
PRAD	chr10	87745932	Missense_Mutation	NA	V603I	0.08
READ	chr10	87746032	3'UTR	novel		0.64
READ	chr10	87743438	Missense_Mutation	novel	T425P	0.23
READ	chr10	87713077	Missense_Mutation	novel	L50I	0.39
READ	chr10	87741348	Missense_Mutation	novel	Q395H	0.43
SKCM	chr10	87745022	Silent	novel	S499S	0.47
SKCM	chr10	87713090	Missense_Mutation	NA	G54E	0.22
SKCM	chr10	87713158	Missense_Mutation	NA	D77N	0.55
SKCM	chr10	87745177	Missense_Mutation	rs758144732	R551Q	0.58
SKCM	chr10	87715777	Missense_Mutation	NA	P267S	0.41
SKCM	chr10	87713090	Missense_Mutation	NA	G54E	0.43
SKCM	chr10	87714776	Silent	novel	K184K	0.48
SKCM	chr10	87715034	Missense_Mutation	NA	P230Q	0.39
SKCM	chr10	87715844	Splice_Site	novel	X289_splice	0.3
SKCM	chr10	87709234	Silent	NA	A22A	0.27
SKCM	chr10	87709272	Missense_Mutation	novel	G35E	0.52
SKCM	chr10	87714095	Missense_Mutation	novel	E145K	0.42
STAD	chr10	87745200	Frame_Shift_Del	novel	*A561Pfs21**	0.31
STAD	chr10	87709238	Missense_Mutation	NA	H24N	0.09
STAD	chr10	87727409	Missense_Mutation	rs766402310	A331T	0.36
STAD	chr10	87741267	Frame_Shift_Del	novel	*D370Efs6**	0.55
STAD	chr10	87727345	Silent	NA	R309R	0.35
STAD	chr10	87709301	Missense_Mutation	rs142362349	V45M	0.13
STAD	chr10	87713233	Missense_Mutation	NA	R102W	0.2
STAD	chr10	87727396	Silent	novel	A326A	0.1
STAD	chr10	87743436	Missense_Mutation	rs201906347	D424G	0.11
UCEC	chr10	87713196	Silent	rs144784084	L89L	0.33
UCEC	chr10	87715021	Missense_Mutation	rs780333884	E226K	0.34
UCEC	chr10	87660007	Missense_Mutation	novel	T9M	0.36
UCEC	chr10	87741322	Missense_Mutation	rs751041210	R387C	0.4
UCEC	chr10	87727334	Missense_Mutation	NA	D306N	0.41
UCEC	chr10	87747598	3'UTR	novel		0.4
UCEC	chr10	87743445	Missense_Mutation	rs758670430	R427H	0.47
UCEC	chr10	87714142	Frame_Shift_Del	novel	*G162Afs38**	0.35
UCEC	chr10	87714758	Silent	novel	I178I	0.4
UCEC	chr10	87745863	Nonsense_Mutation	novel	R580*	0.27
UCEC	chr10	87743476	Silent	rs369464332	P437P	0.54
UCEC	chr10	87745176	Nonsense_Mutation	rs138386772	R551*	0.46
UCEC	chr10	87745882	Missense_Mutation	rs749884085	R586Q	0.45
UCEC	chr10	87715786	Missense_Mutation	NA	G270S	0.18
UCEC	chr10	87747636	3'UTR	novel		0.42
UCEC	chr10	87745146	Missense_Mutation	novel	G541S	0.13
UCEC	chr10	87713100	Silent	novel	T57T	0.52
UCEC	chr10	87715021	Missense_Mutation	rs780333884	E226K	0.09
UCEC	chr10	87743554	Silent	rs538183527	A463A	0.39
UCEC	chr10	87713196	Silent	rs144784084	L89L	0.64
UCEC	chr10	87745853	Silent	novel	I576I	0.13
UCEC	chr10	87746075	3'UTR	novel		0.31
UCEC	chr10	87747595	3'UTR	novel		0.38
UCEC	chr10	87747529	3'UTR	novel		0.67
UCEC	chr10	87713226	Silent	novel	N99N	0.37
UCEC	chr10	87727460	Missense_Mutation	novel	T348A	0.41
UCEC	chr10	87715021	Missense_Mutation	rs780333884	E226K	0.33
UCEC	chr10	87743518	Silent	rs377483950	D451D	0.43
UCEC	chr10	87747443	3'UTR	novel		0.6
UCEC	chr10	87714145	Missense_Mutation	novel	K161N	0.58
UCEC	chr10	87747520	3'UTR	novel		0.67
UCEC	chr10	87743413	Silent	novel	N416N	0.33
UCEC	chr10	87714175	Missense_Mutation	novel	E171D	0.31
UCEC	chr10	87747520	3'UTR	novel		0.16
UCEC	chr10	87713238	Silent	NA	I103I	0.37
UCEC	chr10	87709249	Missense_Mutation	novel	R27S	0.09
UCEC	chr10	87745207	Missense_Mutation	novel	A561D	0.26
UCEC	chr10	87727299	Missense_Mutation	novel	M294T	0.18
UCEC	chr10	87727343	Missense_Mutation	rs199576612	R309W	0.17
UCEC	chr10	87714810	Missense_Mutation	novel	L196V	0.42
UCEC	chr10	87745028	Missense_Mutation	novel	M501I	0.33
UCEC	chr10	87715021	Missense_Mutation	rs780333884	E226K	0.18
UCEC	chr10	87747530	3'UTR	novel		0.54
UCEC	chr10	87714172	Silent	novel	G170G	0.37
UCEC	chr10	87743563	Silent	rs749432936	L466L	0.11
UCEC	chr10	87741295	Silent	NA	R378R	0.54
UCEC	chr10	87727283	Splice_Site	novel	X289_splice	0.28
UCEC	chr10	87714755	Silent	novel	G177G	0.24
UCEC	chr10	87745952	Silent	novel	R609R	0.19
UCEC	chr10	87713099	Missense_Mutation	NA	T57M	0.26
UCEC	chr10	87714182	Nonsense_Mutation	NA	G174*	0.33
UCEC	chr10	87727359	Missense_Mutation	novel	S314I	0.1
UCEC	chr10	87713288	Missense_Mutation	novel	S120N	0.57
UCEC	chr10	87714818	Silent	novel	T198T	0.18
UCEC	chr10	87713230	Missense_Mutation	novel	R101C	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1111	0.19593
COAD	DEL	0.1818	1.3301e-14
PAAD	DEL	0.125	0.169
READ	DEL	0.2606	0.014135
THCA	DEL	0.024	0.011063
THYM	DEL	0.0325	0.10563
UCS	DEL	0.3036	0.1218

Survival Analysis

Cancer	P-value	Q-value
STAD	0.0041	Kaplan-Meier Survival Analysis
UCS	0.03	Kaplan-Meier Survival Analysis
SKCM	0.0068	Kaplan-Meier Survival Analysis
LUSC	0.04	Kaplan-Meier Survival Analysis
BRCA	0.014	Kaplan-Meier Survival Analysis
COAD	0.016	Kaplan-Meier Survival Analysis
PAAD	0.0087	Kaplan-Meier Survival Analysis
BLCA	0.0039	Kaplan-Meier Survival Analysis
CESC	0.0032	Kaplan-Meier Survival Analysis
LAML	0.018	Kaplan-Meier Survival Analysis
CHOL	0.016	Kaplan-Meier Survival Analysis
THCA	0.0021	Kaplan-Meier Survival Analysis
LUAD	0.017	Kaplan-Meier Survival Analysis
UVM	0.00011	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742