EuRBPDB

Description

Ensembl ID: ENSG00000198752 (Gene tree)
Gene ID: 9578
Gene Symbol: CDC42BPB
Alias: MRCKB|KIAA1124
Full Name: CDC42 binding protein kinase beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 125,084 bases
Position: chr14:102,932,379-103,057,462
Accession: 1738
RBP type: non-canonical RBP
Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000561271	CDC42BPB-208	572	-	-	- (aa)	-	-
ENST00000558867	CDC42BPB-203	635	-	-	- (aa)	-	-
ENST00000560492	CDC42BPB-207	646	-	-	- (aa)	-	-
ENST00000559245	CDC42BPB-205	738	-	-	- (aa)	-	-
ENST00000634889	CDC42BPB-209	507	-	-	- (aa)	-	-
ENST00000558321	CDC42BPB-202	528	-	ENSP00000489452	129 (aa)	-	A0A0U1RRC3
ENST00000361246	CDC42BPB-201	6758	XM_005268227	ENSP00000355237	1711 (aa)	XP_005268284	Q9Y5S2
ENST00000559043	CDC42BPB-204	1999	-	ENSP00000453384	666 (aa)	-	H0YLY0
ENST00000559790	CDC42BPB-206	713	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198752	Lymphoma, Large B-Cell, Diffuse	3E-7	21471979

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198752	rs751837	14	103018488	?	Large B-cell lymphoma	21471979	[2.13-5.88]	3.51	EFO_0000403
ENSG00000198752	rs117911063	14	103037856	T	Major depressive disorder (probable)	29662059	[0.012-0.026] unit increase	0.019	EFO_0003761
ENSG00000198752	rs12432253	14	102934867	G	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0069-0.0135] unit increase	0.0102347	EFO_0006527

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198752	CDC42BPB	88	85.965	ENSG00000143776	CDC42BPA	98	60.910	Homo_sapiens
ENSG00000198752	CDC42BPB	88	52.632	ENSG00000067900	ROCK1	78	34.295	Homo_sapiens
ENSG00000198752	CDC42BPB	86	55.856	ENSG00000122966	CIT	90	41.950	Homo_sapiens
ENSG00000198752	CDC42BPB	88	50.877	ENSG00000134318	ROCK2	98	52.206	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	-	ISS	Function
GO:0004672	protein kinase activity	21949762.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	-	ISS	Function
GO:0005524	ATP binding	-	ISS	Function
GO:0005737	cytoplasm	-	IEA	Component
GO:0005856	cytoskeleton	9418861.	TAS	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0005911	cell-cell junction	-	ISS	Component
GO:0006468	protein phosphorylation	21949762.	IDA	Process
GO:0006468	protein phosphorylation	-	ISS	Process
GO:0007010	cytoskeleton organization	9418861.	TAS	Process
GO:0007163	establishment or maintenance of cell polarity	9418861.	TAS	Process
GO:0007165	signal transduction	9418861.	TAS	Process
GO:0016477	cell migration	18854160.	IMP	Process
GO:0017048	Rho GTPase binding	-	IEA	Function
GO:0030027	lamellipodium	-	ISS	Component
GO:0031032	actomyosin structure organization	18854160.	IMP	Process
GO:0031252	cell leading edge	-	ISS	Component
GO:0031532	actin cytoskeleton reorganization	-	ISS	Process
GO:0035556	intracellular signal transduction	-	IEA	Process
GO:0042641	actomyosin	18854160.	IDA	Component
GO:0044877	protein-containing complex binding	25743393.	IPI	Function
GO:0070062	extracellular exosome	19056867.	HDA	Component