EuRBPDB

Description

Ensembl ID: ENSG00000198824 (Gene tree)
Gene ID: 283489
Gene Symbol: CHAMP1
Alias: CAMP|CHAMP|C13orf8|ZNF828
Full Name: chromosome alignment maintaining phosphoprotein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 23,292 bases
Position: chr13:114,314,335-114,337,626
Accession: 20311
RBP type: non-canonical RBP
Summary: This gene encodes a zinc finger protein that functions as a regulator of chromosome segregation in mitosis. The encoded protein is required for correct alignment of chromosomes on the metaphase plate, and plays a role in maintaining the attachment of sister kinetochores to microtubules from opposite spindle poles. Mutations in this gene are associated with an autosomal dominant form of intellectual disability. [provided by RefSeq, Jul 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18562690	JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function.	Mol Biol Cell	2008 Sep	Chen J	doi: 10.1091/mbc.E08-02-0175
16934214	Effect of salt bridge on transcription activation of CRP-dependent lactose operon in Escherichia coli.	Arch Biochem Biophys	2006 Sep 15	Tutar Y	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000646956	CHAMP1-208	355	-	-	- (aa)	-	-
ENST00000645174	CHAMP1-206	659	-	ENSP00000494031	122 (aa)	-	A0A2R8Y4S6
ENST00000643483	CHAMP1-204	5122	-	ENSP00000496699	812 (aa)	-	Q96JM3
ENST00000646155	CHAMP1-207	193	-	-	- (aa)	-	-
ENST00000478022	CHAMP1-203	615	-	-	- (aa)	-	-
ENST00000644294	CHAMP1-205	810	-	ENSP00000495985	194 (aa)	-	A0A2R8Y735
ENST00000463003	CHAMP1-202	768	-	ENSP00000474448	145 (aa)	-	S4R3K0
ENST00000361283	CHAMP1-201	3975	-	ENSP00000354730	812 (aa)	-	Q96JM3

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198824	Amyotrophic Lateral Sclerosis	1.0510000E-005	18057069
ENSG00000198824	Amyotrophic Lateral Sclerosis	1.6650000E-005	18057069

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198824	CHAMP1	100	75.123	ENSMUSG00000047710	Champ1	100	74.632	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000777	condensed chromosome kinetochore	21873635.	IBA	Component
GO:0000777	condensed chromosome kinetochore	21063390.	IDA	Component
GO:0000793	condensed chromosome	21063390.	IDA	Component
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0005515	protein binding	20850016.21063390.26496610.29656893.29789392.	IPI	Function
GO:0005634	nucleus	21063390.	IDA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0005819	spindle	21873635.	IBA	Component
GO:0005819	spindle	21063390.	IDA	Component
GO:0031134	sister chromatid biorientation	21873635.	IBA	Process
GO:0031134	sister chromatid biorientation	21063390.	IMP	Process
GO:0034501	protein localization to kinetochore	21873635.	IBA	Process
GO:0034501	protein localization to kinetochore	21063390.	IMP	Process
GO:0035372	protein localization to microtubule	21873635.	IBA	Process
GO:0035372	protein localization to microtubule	21063390.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051315	attachment of mitotic spindle microtubules to kinetochore	21873635.	IBA	Process
GO:0051315	attachment of mitotic spindle microtubules to kinetochore	21063390.	IMP	Process
GO:0090543	Flemming body	-	IDA	Component