EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000198839 (Gene tree)
Gene ID: 11179
Gene Symbol: ZNF277
Alias: NRIF4|ZNF277P
Full Name: zinc finger protein 277
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 137,347 bases
Position: chr7:112,206,588-112,343,934
Accession: 13070
RBP type: canonical RBP
Summary: (Zinc Finger Protein 277) is a Protein Coding gene. Diseases associated with ZNF277 include Specific Language Impairment and Speech And Communication Disorders. Gene Ontology (GO) annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000354501	zf-met	PF12874.7	0.00011	1	1
ENSP00000390359	zf-C2H2_jaz	PF12171.8	7.6e-05	1	1
ENSP00000402292	zf-C2H2_jaz	PF12171.8	0.00013	1	1
ENSP00000354501	zf-C2H2_jaz	PF12171.8	0.00022	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000457808	ZNF277-207	891	-	ENSP00000402846	107 (aa)	-	F8WBE4
ENST00000421864	ZNF277-204	651	-	ENSP00000415735	118 (aa)	-	H7C460
ENST00000361946	ZNF277-202	1736	-	ENSP00000355043	50 (aa)	-	E7EW13
ENST00000421043	ZNF277-203	2218	-	ENSP00000410538	98 (aa)	-	C9J3B6
ENST00000450657	ZNF277-206	1075	-	ENSP00000402292	290 (aa)	-	G5E9M4
ENST00000361822	ZNF277-201	1849	XM_005250129	ENSP00000354501	450 (aa)	XP_005250186	Q9NRM2
ENST00000425229	ZNF277-205	617	-	ENSP00000390359	199 (aa)	-	C9JH62

Gene Model

Click here to download ENSG00000198839's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198839	Respiratory Function Tests	6.94359161942029E-6	17903307
ENSG00000198839	Body Weights and Measures	5.02907131264186E-9	17903300
ENSG00000198839	Body Weights and Measures	4.40603476077569E-9	17903300
ENSG00000198839	Blood Pressure	2.73014683951906E-7	17903302
ENSG00000198839	Blood Pressure	9.31959867825656E-9	17903302
ENSG00000198839	Mental Competency	7.14344638281231E-12	17903295
ENSG00000198839	Mental Competency	7.28321411487312E-12	17903295
ENSG00000198839	Platelet Function Tests	1.5058300E-005	-
ENSG00000198839	Longevity	7E-6	27015805

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198839	rs10254160	7	112327235	?	Parental extreme longevity (95 years and older)	27015805	[0.011-0.027] unit decrease	0.01885	EFO_0007796
ENSG00000198839	rs139244147	7	112272683	A	Educational attainment (MTAG)	30038396	[0.014-0.025] unit decrease	0.0191	EFO_0004784
ENSG00000198839	rs139244147	7	112272683	A	Educational attainment (years of education)	30038396	[0.013-0.025] unit decrease	0.0193	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198839's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198839	ZNF277	93	93.095	ENSAMEG00000005673	ZNF277	99	93.095	Ailuropoda_melanoleuca
ENSG00000198839	ZNF277	93	86.275	ENSAPLG00000013207	ZNF277	99	73.121	Anas_platyrhynchos
ENSG00000198839	ZNF277	83	86.000	ENSACAG00000007100	ZNF277	91	73.227	Anolis_carolinensis
ENSG00000198839	ZNF277	100	99.020	ENSANAG00000023318	ZNF277	97	97.111	Aotus_nancymaae
ENSG00000198839	ZNF277	100	96.078	ENSBTAG00000013050	ZNF277	99	86.667	Bos_taurus
ENSG00000198839	ZNF277	100	98.039	ENSCJAG00000016891	-	99	97.111	Callithrix_jacchus
ENSG00000198839	ZNF277	100	98.039	ENSCAFG00000003317	ZNF277	99	91.111	Canis_familiaris
ENSG00000198839	ZNF277	100	98.039	ENSCAFG00020007148	ZNF277	93	91.111	Canis_lupus_dingo
ENSG00000198839	ZNF277	100	98.039	ENSCHIG00000009269	ZNF277	99	90.222	Capra_hircus
ENSG00000198839	ZNF277	100	97.059	ENSTSYG00000001399	ZNF277	99	92.222	Carlito_syrichta
ENSG00000198839	ZNF277	100	96.078	ENSCPOG00000024990	ZNF277	99	93.810	Cavia_porcellus
ENSG00000198839	ZNF277	100	99.020	ENSCCAG00000010585	ZNF277	99	95.778	Cebus_capucinus
ENSG00000198839	ZNF277	100	98.222	ENSCATG00000030331	ZNF277	99	98.222	Cercocebus_atys
ENSG00000198839	ZNF277	100	95.098	ENSCLAG00000006282	ZNF277	99	90.667	Chinchilla_lanigera
ENSG00000198839	ZNF277	100	100.000	ENSCSAG00000011126	ZNF277	99	98.667	Chlorocebus_sabaeus
ENSG00000198839	ZNF277	100	79.592	ENSCHOG00000002208	-	100	81.726	Choloepus_hoffmanni
ENSG00000198839	ZNF277	99	67.500	ENSCHOG00000006650	-	99	90.909	Choloepus_hoffmanni
ENSG00000198839	ZNF277	85	87.255	ENSCPBG00000026314	ZNF277	98	76.798	Chrysemys_picta_bellii
ENSG00000198839	ZNF277	100	100.000	ENSCANG00000039145	ZNF277	99	98.099	Colobus_angolensis_palliatus
ENSG00000198839	ZNF277	99	96.000	ENSCGRG00001022696	Zfp277	99	87.333	Cricetulus_griseus_chok1gshd
ENSG00000198839	ZNF277	99	96.000	ENSCGRG00000008982	Zfp277	99	87.333	Cricetulus_griseus_crigri
ENSG00000198839	ZNF277	83	92.204	ENSDNOG00000010505	ZNF277	98	92.204	Dasypus_novemcinctus
ENSG00000198839	ZNF277	100	94.118	ENSDORG00000012687	Zfp277	99	87.805	Dipodomys_ordii
ENSG00000198839	ZNF277	83	90.860	ENSETEG00000006045	ZNF277	89	90.860	Echinops_telfairi
ENSG00000198839	ZNF277	100	99.020	ENSEASG00005008780	ZNF277	99	93.111	Equus_asinus_asinus
ENSG00000198839	ZNF277	100	99.020	ENSECAG00000019865	ZNF277	99	93.111	Equus_caballus
ENSG00000198839	ZNF277	90	92.683	ENSEEUG00000008866	ZNF277	99	80.667	Erinaceus_europaeus
ENSG00000198839	ZNF277	100	98.039	ENSFCAG00000015127	-	99	89.778	Felis_catus
ENSG00000198839	ZNF277	87	96.078	ENSFCAG00000039937	-	95	88.235	Felis_catus
ENSG00000198839	ZNF277	100	95.098	ENSFDAG00000009004	ZNF277	99	91.556	Fukomys_damarensis
ENSG00000198839	ZNF277	83	87.255	ENSGALG00000009454	ZNF277	98	77.566	Gallus_gallus
ENSG00000198839	ZNF277	85	86.275	ENSGAGG00000000915	ZNF277	94	78.797	Gopherus_agassizii
ENSG00000198839	ZNF277	85	100.000	ENSGGOG00000005587	ZNF277	99	100.000	Gorilla_gorilla
ENSG00000198839	ZNF277	100	96.078	ENSHGLG00000016417	-	99	90.444	Heterocephalus_glaber_female
ENSG00000198839	ZNF277	100	96.078	ENSHGLG00100009483	-	99	90.222	Heterocephalus_glaber_male
ENSG00000198839	ZNF277	87	92.157	ENSJJAG00000022259	Zfp277	99	81.351	Jaculus_jaculus
ENSG00000198839	ZNF277	91	80.392	ENSLACG00000008138	ZNF277	98	71.230	Latimeria_chalumnae
ENSG00000198839	ZNF277	93	92.381	ENSLAFG00000004008	ZNF277	99	92.381	Loxodonta_africana
ENSG00000198839	ZNF277	100	100.000	ENSMFAG00000035406	ZNF277	99	98.667	Macaca_fascicularis
ENSG00000198839	ZNF277	100	100.000	ENSMMUG00000015965	ZNF277	98	98.925	Macaca_mulatta
ENSG00000198839	ZNF277	100	99.020	ENSMNEG00000039581	ZNF277	99	98.222	Macaca_nemestrina
ENSG00000198839	ZNF277	100	99.020	ENSMLEG00000037475	ZNF277	99	98.667	Mandrillus_leucophaeus
ENSG00000198839	ZNF277	83	87.255	ENSMGAG00000009151	ZNF277	98	77.804	Meleagris_gallopavo
ENSG00000198839	ZNF277	94	90.499	ENSMAUG00000009201	Zfp277	97	90.499	Mesocricetus_auratus
ENSG00000198839	ZNF277	100	97.059	ENSMICG00000014129	ZNF277	98	95.699	Microcebus_murinus
ENSG00000198839	ZNF277	99	95.050	ENSMOCG00000017178	Zfp277	99	84.889	Microtus_ochrogaster
ENSG00000198839	ZNF277	99	96.040	MGP_CAROLIEiJ_G0017720	-	99	87.638	Mus_caroli
ENSG00000198839	ZNF277	99	96.040	ENSMUSG00000055917	Zfp277	99	87.196	Mus_musculus
ENSG00000198839	ZNF277	99	95.050	MGP_PahariEiJ_G0029477	-	98	87.389	Mus_pahari
ENSG00000198839	ZNF277	99	96.040	MGP_SPRETEiJ_G0018562	-	99	87.196	Mus_spretus
ENSG00000198839	ZNF277	100	98.039	ENSMPUG00000007745	ZNF277	99	90.000	Mustela_putorius_furo
ENSG00000198839	ZNF277	90	86.667	ENSNGAG00000023537	-	95	91.005	Nannospalax_galili
ENSG00000198839	ZNF277	99	94.059	ENSNGAG00000016384	-	100	85.753	Nannospalax_galili
ENSG00000198839	ZNF277	96	96.528	ENSNLEG00000011240	ZNF277	98	96.528	Nomascus_leucogenys
ENSG00000198839	ZNF277	78	77.841	ENSOPRG00000008888	ZNF277	78	77.841	Ochotona_princeps
ENSG00000198839	ZNF277	100	96.078	ENSODEG00000006915	ZNF277	99	90.222	Octodon_degus
ENSG00000198839	ZNF277	59	80.588	ENSOANG00000004478	-	100	80.000	Ornithorhynchus_anatinus
ENSG00000198839	ZNF277	94	91.211	ENSOCUG00000007998	ZNF277	99	88.222	Oryctolagus_cuniculus
ENSG00000198839	ZNF277	94	96.078	ENSOGAG00000005326	ZNF277	95	95.272	Otolemur_garnettii
ENSG00000198839	ZNF277	100	98.039	ENSOARG00000002557	ZNF277	99	90.000	Ovis_aries
ENSG00000198839	ZNF277	100	99.111	ENSPPAG00000029852	ZNF277	99	99.111	Pan_paniscus
ENSG00000198839	ZNF277	100	98.039	ENSPPRG00000008827	-	99	89.778	Panthera_pardus
ENSG00000198839	ZNF277	93	86.811	ENSPPRG00000024189	-	92	86.811	Panthera_pardus
ENSG00000198839	ZNF277	100	98.039	ENSPTIG00000014016	ZNF277	99	89.333	Panthera_tigris_altaica
ENSG00000198839	ZNF277	100	99.333	ENSPTRG00000024152	ZNF277	99	99.333	Pan_troglodytes
ENSG00000198839	ZNF277	100	99.020	ENSPANG00000012693	ZNF277	99	98.444	Papio_anubis
ENSG00000198839	ZNF277	90	79.208	ENSPKIG00000001137	znf277	97	63.048	Paramormyrops_kingsleyae
ENSG00000198839	ZNF277	85	87.255	ENSPSIG00000010933	ZNF277	93	76.790	Pelodiscus_sinensis
ENSG00000198839	ZNF277	99	90.099	ENSPEMG00000016665	Zfp277	99	84.444	Peromyscus_maniculatus_bairdii
ENSG00000198839	ZNF277	100	98.039	ENSPPYG00000017917	ZNF277	99	98.000	Pongo_abelii
ENSG00000198839	ZNF277	90	98.780	ENSPCAG00000016198	ZNF277	99	85.333	Procavia_capensis
ENSG00000198839	ZNF277	100	99.020	ENSPCOG00000021226	ZNF277	99	94.000	Propithecus_coquereli
ENSG00000198839	ZNF277	99	97.030	ENSRNOG00000045854	Zfp277	93	86.696	Rattus_norvegicus
ENSG00000198839	ZNF277	100	100.000	ENSRBIG00000032544	ZNF277	95	98.226	Rhinopithecus_bieti
ENSG00000198839	ZNF277	100	100.000	ENSRROG00000042269	ZNF277	99	98.667	Rhinopithecus_roxellana
ENSG00000198839	ZNF277	100	99.020	ENSSBOG00000026035	-	99	96.444	Saimiri_boliviensis_boliviensis
ENSG00000198839	ZNF277	100	96.078	ENSSARG00000013792	ZNF277	100	88.222	Sorex_araneus
ENSG00000198839	ZNF277	86	78.400	ENSSPUG00000007219	ZNF277	92	69.626	Sphenodon_punctatus
ENSG00000198839	ZNF277	100	96.078	ENSSSCG00000025910	ZNF277	98	93.684	Sus_scrofa
ENSG00000198839	ZNF277	83	86.275	ENSTGUG00000005465	ZNF277	99	75.837	Taeniopygia_guttata
ENSG00000198839	ZNF277	93	89.928	ENSTBEG00000004140	ZNF277	99	89.928	Tupaia_belangeri
ENSG00000198839	ZNF277	100	97.059	ENSTTRG00000011667	ZNF277	99	90.000	Tursiops_truncatus
ENSG00000198839	ZNF277	90	91.811	ENSUAMG00000004260	ZNF277	99	91.811	Ursus_americanus
ENSG00000198839	ZNF277	100	95.098	ENSUMAG00000007049	ZNF277	99	89.333	Ursus_maritimus
ENSG00000198839	ZNF277	100	95.050	ENSVPAG00000002112	ZNF277	99	89.087	Vicugna_pacos
ENSG00000198839	ZNF277	100	97.059	ENSVVUG00000010862	ZNF277	93	90.444	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0070301	cellular response to hydrogen peroxide	-	IEA	Process
GO:2000772	regulation of cellular senescence	-	IEA	Process