EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000198874 (Gene tree)
Gene ID: 55253
Gene Symbol: TYW1
Alias: FLJ10900|MGC23001|MGC60291|YPL207W|TYW1A|RSAFD1
Full Name: tRNA-yW synthesizing protein 1 homolog
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 244,348 bases
Position: chr7:66,995,173-67,239,520
Accession: 25598
RBP type: canonical RBP
Summary: Wybutosine (yW) is a hypermodified guanosine found in phenylalanine tRNA adjacent to the anticodon that stabilizes codon-anticodon interactions in the ribosome. In yeast, the homolog of this gene is essential for the synthesis of wybutosine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000478959	Wyosine_form	PF08608.12	3.5e-26	1	1
ENSP00000352645	Wyosine_form	PF08608.12	3.7e-26	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000495971	TYW1-206	1302	-	-	- (aa)	-	-
ENST00000475392	TYW1-204	574	-	-	- (aa)	-	-
ENST00000491969	TYW1-205	495	-	-	- (aa)	-	-
ENST00000442959	TYW1-203	563	-	ENSP00000398897	134 (aa)	-	C9J9Q4
ENST00000615572	TYW1-207	3156	-	ENSP00000478959	668 (aa)	-	A0A087WUV9
ENST00000359626	TYW1-201	3348	XM_011516372	ENSP00000352645	732 (aa)	XP_011514674	Q9NV66
ENST00000361660	TYW1-202	3255	-	ENSP00000354795	384 (aa)	-	Q9NV66

Gene Model

Click here to download ENSG00000198874's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198874	rs28413067	7	67159625	?	Decline in glucose metabolism in posterior cingulate cortex	29130521	[1.51-3.79] unit decrease	2.65	EFO_0009392\|EFO_0007738

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198874's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198874	TYW1	99	66.803	ENSAPOG00000014391	tyw1	97	67.619	Acanthochromis_polyacanthus
ENSG00000198874	TYW1	98	65.560	ENSACIG00000007325	tyw1	99	64.979	Amphilophus_citrinellus
ENSG00000198874	TYW1	99	66.349	ENSAOCG00000016792	tyw1	97	67.302	Amphiprion_ocellaris
ENSG00000198874	TYW1	99	66.349	ENSAPEG00000015939	tyw1	99	68.622	Amphiprion_percula
ENSG00000198874	TYW1	89	66.819	ENSATEG00000006856	tyw1	90	66.921	Anabas_testudineus
ENSG00000198874	TYW1	100	93.852	ENSANAG00000037051	-	100	93.852	Aotus_nancymaae
ENSG00000198874	TYW1	98	68.370	ENSACLG00000018688	tyw1	95	67.818	Astatotilapia_calliptera
ENSG00000198874	TYW1	98	68.560	ENSAMXG00000004157	tyw1	98	68.000	Astyanax_mexicanus
ENSG00000198874	TYW1	100	85.929	ENSBTAG00000008446	TYW1	100	85.929	Bos_taurus
ENSG00000198874	TYW1	100	93.033	ENSCJAG00000004295	-	100	93.033	Callithrix_jacchus
ENSG00000198874	TYW1	100	83.718	ENSCAFG00000010867	-	100	84.261	Canis_familiaris
ENSG00000198874	TYW1	100	81.751	ENSCAFG00020005367	-	100	81.751	Canis_lupus_dingo
ENSG00000198874	TYW1	100	86.612	ENSCHIG00000019510	-	100	86.612	Capra_hircus
ENSG00000198874	TYW1	96	85.831	ENSTSYG00000008236	-	100	90.137	Carlito_syrichta
ENSG00000198874	TYW1	93	81.260	ENSCAPG00000013569	-	100	80.225	Cavia_aperea
ENSG00000198874	TYW1	100	82.162	ENSCPOG00000011182	-	100	82.162	Cavia_porcellus
ENSG00000198874	TYW1	100	93.579	ENSCCAG00000026643	-	100	93.579	Cebus_capucinus
ENSG00000198874	TYW1	100	96.995	ENSCATG00000043677	-	100	96.995	Cercocebus_atys
ENSG00000198874	TYW1	100	82.497	ENSCLAG00000006321	-	100	82.497	Chinchilla_lanigera
ENSG00000198874	TYW1	100	95.522	ENSCSAG00000018274	-	100	84.563	Chlorocebus_sabaeus
ENSG00000198874	TYW1	68	93.590	ENSCHOG00000003801	-	84	93.590	Choloepus_hoffmanni
ENSG00000198874	TYW1	100	75.034	ENSCPBG00000014896	-	97	74.899	Chrysemys_picta_bellii
ENSG00000198874	TYW1	66	72.751	ENSCING00000004125	-	97	59.560	Ciona_intestinalis
ENSG00000198874	TYW1	75	70.513	ENSCSAVG00000005712	-	100	55.199	Ciona_savignyi
ENSG00000198874	TYW1	100	96.721	ENSCANG00000033209	-	100	96.721	Colobus_angolensis_palliatus
ENSG00000198874	TYW1	71	87.529	ENSCGRG00001003679	Tyw1	87	88.112	Cricetulus_griseus_chok1gshd
ENSG00000198874	TYW1	98	67.684	ENSCSEG00000005810	tyw1	94	66.574	Cynoglossus_semilaevis
ENSG00000198874	TYW1	89	66.311	ENSCVAG00000001054	tyw1	91	66.006	Cyprinodon_variegatus
ENSG00000198874	TYW1	98	68.975	ENSDARG00000062987	tyw1	95	70.083	Danio_rerio
ENSG00000198874	TYW1	100	87.705	ENSDNOG00000024165	-	100	86.885	Dasypus_novemcinctus
ENSG00000198874	TYW1	100	77.395	ENSDORG00000014772	Tyw1	99	77.395	Dipodomys_ordii
ENSG00000198874	TYW1	51	53.867	ENSETEG00000009904	-	84	53.867	Echinops_telfairi
ENSG00000198874	TYW1	65	73.611	ENSEBUG00000004494	tyw1	90	73.611	Eptatretus_burgeri
ENSG00000198874	TYW1	100	88.798	ENSEASG00005008818	-	100	88.798	Equus_asinus_asinus
ENSG00000198874	TYW1	100	79.372	ENSECAG00000023164	-	100	80.191	Equus_caballus
ENSG00000198874	TYW1	62	91.667	ENSEEUG00000005950	-	62	91.667	Erinaceus_europaeus
ENSG00000198874	TYW1	99	66.255	ENSELUG00000008449	tyw1	98	66.516	Esox_lucius
ENSG00000198874	TYW1	100	85.075	ENSFCAG00000014262	-	100	84.125	Felis_catus
ENSG00000198874	TYW1	99	67.394	ENSFALG00000013810	-	99	68.349	Ficedula_albicollis
ENSG00000198874	TYW1	99	83.607	ENSFDAG00000013270	-	99	83.607	Fukomys_damarensis
ENSG00000198874	TYW1	83	69.467	ENSFHEG00000020824	tyw1	81	68.982	Fundulus_heteroclitus
ENSG00000198874	TYW1	100	69.717	ENSGALG00000001110	-	99	71.390	Gallus_gallus
ENSG00000198874	TYW1	98	66.162	ENSGACG00000012692	tyw1	98	66.022	Gasterosteus_aculeatus
ENSG00000198874	TYW1	100	74.494	ENSGAGG00000022393	-	100	74.224	Gopherus_agassizii
ENSG00000198874	TYW1	97	97.710	ENSGGOG00000001473	TYW1	100	92.101	Gorilla_gorilla
ENSG00000198874	TYW1	98	68.414	ENSHBUG00000002640	tyw1	95	67.818	Haplochromis_burtoni
ENSG00000198874	TYW1	93	75.663	ENSHGLG00000012093	-	100	80.187	Heterocephalus_glaber_female
ENSG00000198874	TYW1	100	84.699	ENSHGLG00100011743	TYW1	100	84.699	Heterocephalus_glaber_male
ENSG00000198874	TYW1	98	61.389	ENSHCOG00000019949	tyw1	56	79.692	Hippocampus_comes
ENSG00000198874	TYW1	98	68.595	ENSIPUG00000016330	tyw1	95	68.655	Ictalurus_punctatus
ENSG00000198874	TYW1	100	83.060	ENSSTOG00000004067	-	92	81.967	Ictidomys_tridecemlineatus
ENSG00000198874	TYW1	100	81.437	ENSJJAG00000022959	Tyw1	100	81.437	Jaculus_jaculus
ENSG00000198874	TYW1	98	66.759	ENSKMAG00000018599	tyw1	96	67.310	Kryptolebias_marmoratus
ENSG00000198874	TYW1	99	66.849	ENSLACG00000018917	tyw1	96	66.849	Latimeria_chalumnae
ENSG00000198874	TYW1	99	69.891	ENSLOCG00000004035	tyw1	96	69.891	Lepisosteus_oculatus
ENSG00000198874	TYW1	100	96.721	ENSMFAG00000035457	-	100	96.721	Macaca_fascicularis
ENSG00000198874	TYW1	100	96.721	ENSMMUG00000030374	-	100	96.721	Macaca_mulatta
ENSG00000198874	TYW1	100	96.721	ENSMNEG00000041992	-	100	96.721	Macaca_nemestrina
ENSG00000198874	TYW1	100	96.995	ENSMLEG00000039741	-	100	96.995	Mandrillus_leucophaeus
ENSG00000198874	TYW1	98	67.448	ENSMAMG00000016089	tyw1	94	66.483	Mastacembelus_armatus
ENSG00000198874	TYW1	91	71.557	ENSMZEG00005024386	tyw1	97	70.475	Maylandia_zebra
ENSG00000198874	TYW1	100	70.081	ENSMGAG00000002176	-	100	71.159	Meleagris_gallopavo
ENSG00000198874	TYW1	100	80.601	ENSMAUG00000002959	Tyw1	100	80.601	Mesocricetus_auratus
ENSG00000198874	TYW1	99	89.793	ENSMICG00000014374	-	99	89.793	Microcebus_murinus
ENSG00000198874	TYW1	100	80.491	ENSMOCG00000017720	Tyw1	100	80.218	Microtus_ochrogaster
ENSG00000198874	TYW1	98	61.646	ENSMMOG00000005064	tyw1	97	61.080	Mola_mola
ENSG00000198874	TYW1	100	73.529	ENSMODG00000025697	-	100	73.522	Monodelphis_domestica
ENSG00000198874	TYW1	98	67.490	ENSMALG00000010238	tyw1	96	67.764	Monopterus_albus
ENSG00000198874	TYW1	99	80.468	MGP_CAROLIEiJ_G0027801	Tyw1	99	80.468	Mus_caroli
ENSG00000198874	TYW1	99	80.743	ENSMUSG00000056310	Tyw1	99	80.743	Mus_musculus
ENSG00000198874	TYW1	99	78.404	MGP_PahariEiJ_G0024383	Tyw1	99	79.367	Mus_pahari
ENSG00000198874	TYW1	99	80.468	MGP_SPRETEiJ_G0028799	Tyw1	99	80.468	Mus_spretus
ENSG00000198874	TYW1	95	81.097	ENSMPUG00000016191	-	100	79.365	Mustela_putorius_furo
ENSG00000198874	TYW1	100	84.261	ENSMLUG00000013582	-	100	84.261	Myotis_lucifugus
ENSG00000198874	TYW1	99	77.442	ENSNGAG00000002742	Tyw1	99	77.854	Nannospalax_galili
ENSG00000198874	TYW1	96	67.330	ENSNBRG00000016996	tyw1	99	67.045	Neolamprologus_brichardi
ENSG00000198874	TYW1	100	96.585	ENSNLEG00000013210	-	100	97.403	Nomascus_leucogenys
ENSG00000198874	TYW1	94	66.618	ENSOPRG00000008734	-	91	66.618	Ochotona_princeps
ENSG00000198874	TYW1	99	79.341	ENSODEG00000014729	-	99	79.341	Octodon_degus
ENSG00000198874	TYW1	98	68.428	ENSONIG00000005872	tyw1	95	68.150	Oreochromis_niloticus
ENSG00000198874	TYW1	100	85.519	ENSOCUG00000003173	-	100	85.519	Oryctolagus_cuniculus
ENSG00000198874	TYW1	98	66.575	ENSORLG00000001393	tyw1	98	65.139	Oryzias_latipes
ENSG00000198874	TYW1	98	66.713	ENSORLG00020019361	tyw1	98	65.556	Oryzias_latipes_hni
ENSG00000198874	TYW1	98	66.529	ENSORLG00015008095	tyw1	95	65.663	Oryzias_latipes_hsok
ENSG00000198874	TYW1	94	89.115	ENSOGAG00000016555	-	99	86.202	Otolemur_garnettii
ENSG00000198874	TYW1	100	86.296	ENSOARG00000010673	-	100	86.296	Ovis_aries
ENSG00000198874	TYW1	100	85.383	ENSPPRG00000004945	-	100	84.426	Panthera_pardus
ENSG00000198874	TYW1	100	85.656	ENSPTIG00000019545	-	100	84.699	Panthera_tigris_altaica
ENSG00000198874	TYW1	100	91.723	ENSPTRG00000023076	TYW1B	99	91.723	Pan_troglodytes
ENSG00000198874	TYW1	100	96.448	ENSPANG00000019053	-	100	96.448	Papio_anubis
ENSG00000198874	TYW1	99	66.576	ENSPKIG00000006545	tyw1	97	66.757	Paramormyrops_kingsleyae
ENSG00000198874	TYW1	96	65.963	ENSPMGG00000004240	tyw1	100	65.638	Periophthalmus_magnuspinnatus
ENSG00000198874	TYW1	99	80.605	ENSPEMG00000008274	Tyw1	99	80.605	Peromyscus_maniculatus_bairdii
ENSG00000198874	TYW1	99	68.207	ENSPFOG00000015855	tyw1	99	67.347	Poecilia_formosa
ENSG00000198874	TYW1	99	66.532	ENSPLAG00000000838	tyw1	100	66.097	Poecilia_latipinna
ENSG00000198874	TYW1	99	66.847	ENSPMEG00000019437	tyw1	100	64.903	Poecilia_mexicana
ENSG00000198874	TYW1	99	64.762	ENSPREG00000018773	tyw1	99	65.265	Poecilia_reticulata
ENSG00000198874	TYW1	100	98.224	ENSPPYG00000017514	TYW1	100	98.224	Pongo_abelii
ENSG00000198874	TYW1	100	72.268	ENSPCOG00000015294	-	94	84.444	Propithecus_coquereli
ENSG00000198874	TYW1	98	68.370	ENSPNYG00000022381	tyw1	95	67.818	Pundamilia_nyererei
ENSG00000198874	TYW1	98	69.051	ENSPNAG00000009001	tyw1	98	69.464	Pygocentrus_nattereri
ENSG00000198874	TYW1	100	81.557	ENSRNOG00000024352	Tyw1	100	81.557	Rattus_norvegicus
ENSG00000198874	TYW1	100	96.448	ENSRBIG00000039619	-	100	96.448	Rhinopithecus_bieti
ENSG00000198874	TYW1	100	96.585	ENSRROG00000039780	-	100	96.585	Rhinopithecus_roxellana
ENSG00000198874	TYW1	92	41.254	YPL207W	-	75	40.671	Saccharomyces_cerevisiae
ENSG00000198874	TYW1	100	91.803	ENSSBOG00000025873	-	100	91.803	Saimiri_boliviensis_boliviensis
ENSG00000198874	TYW1	100	73.370	ENSSHAG00000010346	-	100	73.241	Sarcophilus_harrisii
ENSG00000198874	TYW1	99	68.587	ENSSFOG00015001054	tyw1	98	69.851	Scleropages_formosus
ENSG00000198874	TYW1	98	66.850	ENSSMAG00000020514	tyw1	96	65.432	Scophthalmus_maximus
ENSG00000198874	TYW1	98	67.764	ENSSDUG00000001552	tyw1	95	70.398	Seriola_dumerili
ENSG00000198874	TYW1	98	67.901	ENSSLDG00000003554	tyw1	96	67.627	Seriola_lalandi_dorsalis
ENSG00000198874	TYW1	100	70.788	ENSSPUG00000002715	-	100	70.525	Sphenodon_punctatus
ENSG00000198874	TYW1	100	84.973	ENSSSCG00000007733	-	100	84.973	Sus_scrofa
ENSG00000198874	TYW1	91	67.665	ENSTGUG00000003428	-	100	68.862	Taeniopygia_guttata
ENSG00000198874	TYW1	98	65.890	ENSTRUG00000016107	tyw1	93	65.616	Takifugu_rubripes
ENSG00000198874	TYW1	90	70.765	ENSTNIG00000018999	tyw1	100	70.165	Tetraodon_nigroviridis
ENSG00000198874	TYW1	100	84.939	ENSUMAG00000015343	-	100	83.989	Ursus_maritimus
ENSG00000198874	TYW1	100	82.090	ENSVVUG00000016457	-	100	83.175	Vulpes_vulpes
ENSG00000198874	TYW1	99	69.837	ENSXETG00000010094	tyw1	99	70.501	Xenopus_tropicalis
ENSG00000198874	TYW1	99	65.989	ENSXMAG00000013125	tyw1	100	67.604	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0008033	tRNA processing	-	IEA	Process
GO:0010181	FMN binding	-	IEA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0051539	4 iron, 4 sulfur cluster binding	-	IEA	Function
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0102521	tRNA-4-demethylwyosine synthase activity	-	IEA	Function