EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000198890 (Gene tree)
Gene ID: 55170
Gene Symbol: PRMT6
Alias: FLJ10559|HRMT1L6
Full Name: protein arginine methyltransferase 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 10,992 bases
Position: chr1:107,056,645-107,067,636
Accession: 18241
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000359095	MTS	PF05175.14	0.00041	1	1
ENSP00000359095	Met_10	PF02475.16	0.00063	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26178996	pUL69 of Human Cytomegalovirus Recruits the Cellular Protein Arginine Methyltransferase 6 via a Domain That Is Crucial for mRNA Export and Efficient Viral Replication.	J Virol	2015 Sep	Thomas M	doi: 10.1128/JVI.01399-15
17176473	PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA.	Retrovirology	2006 Dec 18	Invernizzi CF	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000649727	PRMT6-202	908	-	-	- (aa)	-	-
ENST00000370078	PRMT6-201	2616	-	ENSP00000359095	375 (aa)	-	Q96LA8
ENST00000650338	PRMT6-203	2715	-	ENSP00000497826	313 (aa)	-	-

Gene Model

Click here to download ENSG00000198890's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000198890	Anger	3.711e-005	-
ENSG00000198890	Anger	3.781e-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000198890	rs2232016	1	107057296	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198890's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000198890	PRMT6	100	59.105	ENSAPOG00000017409	prmt6	95	58.017	Acanthochromis_polyacanthus
ENSG00000198890	PRMT6	100	55.096	ENSACIG00000021067	prmt6	94	55.689	Amphilophus_citrinellus
ENSG00000198890	PRMT6	100	57.508	ENSAOCG00000023707	prmt6	97	56.560	Amphiprion_ocellaris
ENSG00000198890	PRMT6	100	56.869	ENSAPEG00000008762	prmt6	97	55.977	Amphiprion_percula
ENSG00000198890	PRMT6	100	55.272	ENSATEG00000021203	prmt6	93	55.655	Anabas_testudineus
ENSG00000198890	PRMT6	94	94.898	ENSANAG00000020517	-	100	88.000	Aotus_nancymaae
ENSG00000198890	PRMT6	100	100.000	ENSANAG00000002736	-	100	99.733	Aotus_nancymaae
ENSG00000198890	PRMT6	100	55.911	ENSACLG00000014684	prmt6	93	56.456	Astatotilapia_calliptera
ENSG00000198890	PRMT6	100	59.105	ENSAMXG00000025997	prmt6	91	59.159	Astyanax_mexicanus
ENSG00000198890	PRMT6	100	93.610	ENSBTAG00000039951	PRMT6	100	92.533	Bos_taurus
ENSG00000198890	PRMT6	100	99.733	ENSCJAG00000022625	PRMT6	84	99.733	Callithrix_jacchus
ENSG00000198890	PRMT6	100	93.291	ENSCHIG00000006399	PRMT6	100	92.267	Capra_hircus
ENSG00000198890	PRMT6	100	96.805	ENSCPOG00000030946	PRMT6	100	94.933	Cavia_porcellus
ENSG00000198890	PRMT6	100	99.733	ENSCCAG00000031625	-	100	99.733	Cebus_capucinus
ENSG00000198890	PRMT6	100	100.000	ENSCATG00000043273	PRMT6	100	99.467	Cercocebus_atys
ENSG00000198890	PRMT6	100	96.486	ENSCLAG00000017949	PRMT6	100	93.085	Chinchilla_lanigera
ENSG00000198890	PRMT6	100	100.000	ENSCSAG00000000161	PRMT6	100	100.000	Chlorocebus_sabaeus
ENSG00000198890	PRMT6	100	96.486	ENSCHOG00000007750	PRMT6	100	94.933	Choloepus_hoffmanni
ENSG00000198890	PRMT6	99	46.984	ENSCING00000001803	-	97	46.264	Ciona_intestinalis
ENSG00000198890	PRMT6	99	48.333	ENSCSAVG00000002845	-	73	47.619	Ciona_savignyi
ENSG00000198890	PRMT6	100	99.681	ENSCANG00000008600	PRMT6	100	99.467	Colobus_angolensis_palliatus
ENSG00000198890	PRMT6	100	97.444	ENSCGRG00001012887	Prmt6	92	96.830	Cricetulus_griseus_chok1gshd
ENSG00000198890	PRMT6	100	58.147	ENSCSEG00000013496	prmt6	97	56.851	Cynoglossus_semilaevis
ENSG00000198890	PRMT6	100	55.272	ENSCVAG00000002641	prmt6	95	55.357	Cyprinodon_variegatus
ENSG00000198890	PRMT6	100	55.911	ENSDARG00000069706	prmt6	95	54.651	Danio_rerio
ENSG00000198890	PRMT6	100	94.888	ENSDNOG00000002236	PRMT6	100	93.600	Dasypus_novemcinctus
ENSG00000198890	PRMT6	100	92.332	ENSDORG00000015482	Prmt6	90	92.647	Dipodomys_ordii
ENSG00000198890	PRMT6	100	95.208	ENSEASG00005022613	PRMT6	100	94.400	Equus_asinus_asinus
ENSG00000198890	PRMT6	96	94.983	ENSECAG00000003427	PRMT6	95	92.265	Equus_caballus
ENSG00000198890	PRMT6	100	90.415	ENSEEUG00000010272	PRMT6	100	88.000	Erinaceus_europaeus
ENSG00000198890	PRMT6	100	57.188	ENSELUG00000002245	prmt6	94	56.725	Esox_lucius
ENSG00000198890	PRMT6	100	94.888	ENSFCAG00000014050	PRMT6	100	93.867	Felis_catus
ENSG00000198890	PRMT6	100	95.527	ENSFDAG00000021017	PRMT6	100	94.133	Fukomys_damarensis
ENSG00000198890	PRMT6	100	55.911	ENSFHEG00000020586	prmt6	95	56.250	Fundulus_heteroclitus
ENSG00000198890	PRMT6	100	52.866	ENSGMOG00000020376	prmt6	99	52.326	Gadus_morhua
ENSG00000198890	PRMT6	100	57.188	ENSGAFG00000017234	prmt6	95	57.143	Gambusia_affinis
ENSG00000198890	PRMT6	100	55.591	ENSGACG00000002056	prmt6	97	55.621	Gasterosteus_aculeatus
ENSG00000198890	PRMT6	100	100.000	ENSGGOG00000028522	PRMT6	100	99.733	Gorilla_gorilla
ENSG00000198890	PRMT6	100	55.591	ENSHBUG00000015926	prmt6	93	56.156	Haplochromis_burtoni
ENSG00000198890	PRMT6	100	97.125	ENSHGLG00000009142	PRMT6	100	94.933	Heterocephalus_glaber_female
ENSG00000198890	PRMT6	100	97.125	ENSHGLG00100016337	PRMT6	100	94.667	Heterocephalus_glaber_male
ENSG00000198890	PRMT6	100	53.185	ENSHCOG00000017120	prmt6	97	53.235	Hippocampus_comes
ENSG00000198890	PRMT6	100	57.188	ENSIPUG00000002889	prmt6	97	56.522	Ictalurus_punctatus
ENSG00000198890	PRMT6	100	97.764	ENSSTOG00000010675	PRMT6	100	96.533	Ictidomys_tridecemlineatus
ENSG00000198890	PRMT6	100	57.508	ENSKMAG00000017402	prmt6	93	57.440	Kryptolebias_marmoratus
ENSG00000198890	PRMT6	100	56.550	ENSLOCG00000017743	prmt6	94	57.057	Lepisosteus_oculatus
ENSG00000198890	PRMT6	100	97.444	ENSLAFG00000025614	PRMT6	100	96.533	Loxodonta_africana
ENSG00000198890	PRMT6	100	100.000	ENSMFAG00000017156	PRMT6	100	99.733	Macaca_fascicularis
ENSG00000198890	PRMT6	100	100.000	ENSMMUG00000006802	PRMT6	100	99.733	Macaca_mulatta
ENSG00000198890	PRMT6	100	100.000	ENSMNEG00000037964	PRMT6	100	99.733	Macaca_nemestrina
ENSG00000198890	PRMT6	100	99.681	ENSMLEG00000009047	PRMT6	100	99.467	Mandrillus_leucophaeus
ENSG00000198890	PRMT6	100	57.188	ENSMAMG00000007319	prmt6	98	56.232	Mastacembelus_armatus
ENSG00000198890	PRMT6	100	55.911	ENSMZEG00005020230	prmt6	93	56.456	Maylandia_zebra
ENSG00000198890	PRMT6	100	98.083	ENSMICG00000016977	PRMT6	100	96.543	Microcebus_murinus
ENSG00000198890	PRMT6	100	96.486	ENSMOCG00000005923	Prmt6	100	94.667	Microtus_ochrogaster
ENSG00000198890	PRMT6	100	53.994	ENSMMOG00000005313	prmt6	98	53.353	Mola_mola
ENSG00000198890	PRMT6	100	88.818	ENSMODG00000002823	PRMT6	88	89.189	Monodelphis_domestica
ENSG00000198890	PRMT6	100	93.291	MGP_CAROLIEiJ_G0025550	Prmt6	91	93.084	Mus_caroli
ENSG00000198890	PRMT6	100	94.249	ENSMUSG00000049300	Prmt6	92	93.660	Mus_musculus
ENSG00000198890	PRMT6	100	94.888	MGP_PahariEiJ_G0026996	Prmt6	92	94.236	Mus_pahari
ENSG00000198890	PRMT6	100	94.249	MGP_SPRETEiJ_G0026500	Prmt6	95	93.660	Mus_spretus
ENSG00000198890	PRMT6	100	94.569	ENSMPUG00000019442	PRMT6	100	93.600	Mustela_putorius_furo
ENSG00000198890	PRMT6	100	86.581	ENSMLUG00000007086	PRMT6	100	83.421	Myotis_lucifugus
ENSG00000198890	PRMT6	100	97.444	ENSNGAG00000012858	Prmt6	100	95.733	Nannospalax_galili
ENSG00000198890	PRMT6	100	55.911	ENSNBRG00000012177	prmt6	93	56.456	Neolamprologus_brichardi
ENSG00000198890	PRMT6	100	99.733	ENSNLEG00000032446	PRMT6	100	99.733	Nomascus_leucogenys
ENSG00000198890	PRMT6	100	89.137	ENSMEUG00000000402	PRMT6	92	87.755	Notamacropus_eugenii
ENSG00000198890	PRMT6	100	85.032	ENSOPRG00000002067	PRMT6	100	84.840	Ochotona_princeps
ENSG00000198890	PRMT6	100	94.249	ENSODEG00000019666	PRMT6	100	89.920	Octodon_degus
ENSG00000198890	PRMT6	97	55.410	ENSONIG00000004768	prmt6	91	55.657	Oreochromis_niloticus
ENSG00000198890	PRMT6	100	56.230	ENSORLG00000005704	prmt6	93	56.250	Oryzias_latipes
ENSG00000198890	PRMT6	100	56.230	ENSORLG00020005446	prmt6	93	56.250	Oryzias_latipes_hni
ENSG00000198890	PRMT6	100	55.911	ENSORLG00015002130	prmt6	95	55.952	Oryzias_latipes_hsok
ENSG00000198890	PRMT6	100	56.230	ENSOMEG00000017676	prmt6	95	56.250	Oryzias_melastigma
ENSG00000198890	PRMT6	100	96.805	ENSOGAG00000033307	PRMT6	100	96.000	Otolemur_garnettii
ENSG00000198890	PRMT6	100	93.291	ENSOARG00000011289	PRMT6	100	92.267	Ovis_aries
ENSG00000198890	PRMT6	100	100.000	ENSPPAG00000013532	PRMT6	100	100.000	Pan_paniscus
ENSG00000198890	PRMT6	100	95.208	ENSPPRG00000021476	PRMT6	100	94.133	Panthera_pardus
ENSG00000198890	PRMT6	100	94.888	ENSPTIG00000005241	PRMT6	100	93.867	Panthera_tigris_altaica
ENSG00000198890	PRMT6	100	100.000	ENSPTRG00000001022	PRMT6	100	100.000	Pan_troglodytes
ENSG00000198890	PRMT6	100	100.000	ENSPANG00000004113	PRMT6	100	99.733	Papio_anubis
ENSG00000198890	PRMT6	100	60.383	ENSPKIG00000008857	prmt6	94	60.417	Paramormyrops_kingsleyae
ENSG00000198890	PRMT6	100	57.006	ENSPMGG00000015586	prmt6	94	56.105	Periophthalmus_magnuspinnatus
ENSG00000198890	PRMT6	100	97.444	ENSPEMG00000014774	Prmt6	100	95.200	Peromyscus_maniculatus_bairdii
ENSG00000198890	PRMT6	100	88.818	ENSPCIG00000010181	PRMT6	100	82.586	Phascolarctos_cinereus
ENSG00000198890	PRMT6	100	57.508	ENSPFOG00000019926	prmt6	95	57.738	Poecilia_formosa
ENSG00000198890	PRMT6	100	57.508	ENSPLAG00000002189	prmt6	93	57.738	Poecilia_latipinna
ENSG00000198890	PRMT6	100	57.508	ENSPMEG00000017819	prmt6	93	57.738	Poecilia_mexicana
ENSG00000198890	PRMT6	100	57.827	ENSPREG00000010222	prmt6	95	58.036	Poecilia_reticulata
ENSG00000198890	PRMT6	100	100.000	ENSPPYG00000010685	PRMT6	100	99.724	Pongo_abelii
ENSG00000198890	PRMT6	100	96.486	ENSPCAG00000011732	PRMT6	100	94.400	Procavia_capensis
ENSG00000198890	PRMT6	100	97.444	ENSPCOG00000010650	PRMT6	100	96.533	Propithecus_coquereli
ENSG00000198890	PRMT6	100	55.911	ENSPNYG00000020634	prmt6	93	56.456	Pundamilia_nyererei
ENSG00000198890	PRMT6	100	57.827	ENSPNAG00000015218	prmt6	86	56.322	Pygocentrus_nattereri
ENSG00000198890	PRMT6	100	95.847	ENSRNOG00000017187	Prmt6	100	93.867	Rattus_norvegicus
ENSG00000198890	PRMT6	100	95.847	ENSRNOG00000048996	LOC108348173	100	93.867	Rattus_norvegicus
ENSG00000198890	PRMT6	100	100.000	ENSRBIG00000009563	PRMT6	100	100.000	Rhinopithecus_bieti
ENSG00000198890	PRMT6	100	100.000	ENSRROG00000021523	PRMT6	100	100.000	Rhinopithecus_roxellana
ENSG00000198890	PRMT6	100	98.722	ENSSBOG00000018871	PRMT6	100	98.667	Saimiri_boliviensis_boliviensis
ENSG00000198890	PRMT6	100	56.550	ENSSMAG00000020345	prmt6	96	54.810	Scophthalmus_maximus
ENSG00000198890	PRMT6	100	55.911	ENSSDUG00000006628	prmt6	96	54.942	Seriola_dumerili
ENSG00000198890	PRMT6	100	55.911	ENSSLDG00000007963	prmt6	95	55.102	Seriola_lalandi_dorsalis
ENSG00000198890	PRMT6	100	57.188	ENSSPAG00000005623	prmt6	97	56.268	Stegastes_partitus
ENSG00000198890	PRMT6	100	92.971	ENSSSCG00000006853	PRMT6	100	93.038	Sus_scrofa
ENSG00000198890	PRMT6	100	55.272	ENSTRUG00000022052	prmt6	96	55.389	Takifugu_rubripes
ENSG00000198890	PRMT6	100	55.272	ENSTRUG00000019594	prmt6	96	55.389	Takifugu_rubripes
ENSG00000198890	PRMT6	99	54.984	ENSTNIG00000018964	prmt6	99	53.959	Tetraodon_nigroviridis
ENSG00000198890	PRMT6	100	95.527	ENSTBEG00000006318	PRMT6	100	95.200	Tupaia_belangeri
ENSG00000198890	PRMT6	100	94.249	ENSTTRG00000002369	PRMT6	100	93.333	Tursiops_truncatus
ENSG00000198890	PRMT6	99	58.521	ENSXETG00000009939	prmt6	99	58.309	Xenopus_tropicalis
ENSG00000198890	PRMT6	100	56.869	ENSXCOG00000005017	prmt6	93	57.143	Xiphophorus_couchianus
ENSG00000198890	PRMT6	100	57.508	ENSXMAG00000006494	prmt6	95	57.738	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0003682	chromatin binding	-	IEA	Function
GO:0005515	protein binding	16157300.16293633.16600869.23455924.25416956.	IPI	Function
GO:0005634	nucleus	11724789.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0006284	base-excision repair	16600869.	TAS	Process
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0008469	histone-arginine N-methyltransferase activity	19509293.22777353.	EXP	Function
GO:0008469	histone-arginine N-methyltransferase activity	21873635.	IBA	Function
GO:0008469	histone-arginine N-methyltransferase activity	23980157.	IDA	Function
GO:0008469	histone-arginine N-methyltransferase activity	-	TAS	Function
GO:0016032	viral process	-	IEA	Process
GO:0016274	protein-arginine N-methyltransferase activity	-	TAS	Function
GO:0016571	histone methylation	19405910.	IDA	Process
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	21873635.	IBA	Process
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	17898714.18079182.	IDA	Process
GO:0034969	histone arginine methylation	21873635.	IBA	Process
GO:0034970	histone H3-R2 methylation	17898714.18079182.	IDA	Process
GO:0035241	protein-arginine omega-N monomethyltransferase activity	11724789.16157300.16600869.	IDA	Function
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	21873635.	IBA	Function
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	11724789.16157300.17898714.18079182.	IDA	Function
GO:0042054	histone methyltransferase activity	19405910.	IDA	Function
GO:0042393	histone binding	17898714.18079182.	IDA	Function
GO:0043985	histone H4-R3 methylation	-	IEA	Process
GO:0044020	histone methyltransferase activity (H4-R3 specific)	18079182.	IDA	Function
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0045892	negative regulation of transcription, DNA-templated	18079182.	IDA	Process
GO:0051572	negative regulation of histone H3-K4 methylation	-	IEA	Process
GO:0070611	histone methyltransferase activity (H3-R2 specific)	17898714.18079182.	IDA	Function
GO:0070612	histone methyltransferase activity (H2A-R3 specific)	18079182.	IDA	Function
GO:0090398	cellular senescence	-	IEA	Process
GO:1901796	regulation of signal transduction by p53 class mediator	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26436589	PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents.	Oncotarget	2015 Oct 13	Nakakido M	doi: 10.18632/oncotarget.5143.
27323813	Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer.	Oncotarget	2016 Aug 16	Almeida-Rios D	doi: 10.18632/oncotarget.10061.
22673335	Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes.	Endocr Relat Cancer	2012 Jul 22	Dowhan DH	doi: 10.1530/ERC-12-0100
20473859	Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers.	Int J Cancer	2011 Feb 1	Yoshimatsu M	doi: 10.1002/ijc.25366.
23380452	PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: its implication in motility and invasion.	Biochem Biophys Res Commun	2013 Mar 1	Kim NH	doi: 10.1016/j.bbrc.2013.01.085
29262320	The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.	Cell Rep	2017 Dec 19	Veland N	doi: 10.1016/j.celrep.2017.11.082.
29927001	Significant association of PRMT6 hypomethylation with colorectal cancer.	J Clin Lab Anal	2018 Nov	Pan R	doi: 10.1002/jcla.22590

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr1	107058325	3'UTR	novel		0.22
ACC	chr1	107058326	3'UTR	novel		0.22
BLCA	chr1	107056907	Silent	rs748458420	R64R	0.24
BLCA	chr1	107057178	Missense_Mutation	rs776469766	E155Q	0.32	MTS
BLCA	chr1	107056907	Silent	rs748458420	R64R	0.26
BLCA	chr1	107057690	Silent	novel	L325L	0.16
BLCA	chr1	107057557	Missense_Mutation	novel	G281D	0.39
BLCA	chr1	107057466	Frame_Shift_Ins	novel	*F253Gfs169**	0.59
BLCA	chr1	107057597	Silent	rs770036088	V294V	0.67
BRCA	chr1	107057655	Missense_Mutation	NA	P314S	0.38
BRCA	chr1	107057976	3'UTR	novel		0.3
BRCA	chr1	107057145	Missense_Mutation	rs779233712	E144Q	0.24	MTS
CESC	chr1	107056960	Missense_Mutation	NA	R82Q	0.23	MTS
CESC	chr1	107057813	Silent	novel	E366E	0.54
COAD	chr1	107057735	Silent	NA	E340E	0.27
COAD	chr1	107059065	3'UTR	novel		0.13
COAD	chr1	107058066	3'UTR	novel		0.23
COAD	chr1	107057258	Silent	rs377462998	G181G	0.33
COAD	chr1	107056875	Missense_Mutation	novel	V54I	0.08
COAD	chr1	107058038	3'UTR	novel		0.32
COAD	chr1	107056748	Frame_Shift_Del	NA	*G13Afs48**	0.45
COAD	chr1	107058631	3'UTR	novel		0.3
COAD	chr1	107059160	3'UTR	novel		0.13
COAD	chr1	107058278	3'UTR	novel		0.37
COAD	chr1	107057712	Nonsense_Mutation	novel	Q333*	0.35
COAD	chr1	107058462	3'UTR	novel		0.38
COAD	chr1	107057058	Missense_Mutation	novel	A115T	0.24	MTS
COAD	chr1	107058620	3'UTR	novel		0.3
COAD	chr1	107057851	3'UTR	novel		0.41
COAD	chr1	107058384	3'UTR	novel		0.12
COAD	chr1	107058649	3'UTR	novel		0.1
COAD	chr1	107057451	Missense_Mutation	NA	V246M	0.5
COAD	chr1	107057678	Silent	novel	A321A	0.56
COAD	chr1	107058702	3'UTR	novel		0.35
COAD	chr1	107058820	3'UTR	novel		0.04
COAD	chr1	107057156	Silent	NA	E147E	0.43
COAD	chr1	107057276	Silent	NA	A187A	0.14
COAD	chr1	107057795	Missense_Mutation	novel	K360N	0.19
COAD	chr1	107058973	3'UTR	novel		0.15
COAD	chr1	107056858	Missense_Mutation	rs751008530	Y48C	0.23
COAD	chr1	107056754	Silent	NA	G13G	0.23
ESCA	chr1	107058746	3'UTR	novel		0.21
ESCA	chr1	107057481	Silent	novel	L256L	0.31
GBM	chr1	107057574	Missense_Mutation	novel	G287R	0.16
GBM	chr1	107057224	Missense_Mutation	novel	V170A	0.05
GBM	chr1	107057690	Silent	novel	L325L	0.09
KIRC	chr1	107056938	Missense_Mutation	NA	L75I	0.29
KIRC	chr1	107057225	Silent	novel	V170V	0.28
KIRP	chr1	107057120	Silent	NA	V135V	0.33
KIRP	chr1	107058566	3'UTR	novel		0.53
LGG	chr1	107057144	Silent	rs769059268	V143V	0.31
LGG	chr1	107057199	Missense_Mutation	NA	L162M	0.24
LIHC	chr1	107058399	3'UTR	novel		0.12
LIHC	chr1	107058689	3'UTR	novel		0.28
LIHC	chr1	107056740	Missense_Mutation	NA	L9F	0.43
LIHC	chr1	107057496	Missense_Mutation	NA	A261S	0.58
LIHC	chr1	107058069	3'UTR	novel		0.46
LIHC	chr1	107056718	Translation_Start_Site	novel	M1?	0.33
LUAD	chr1	107057423	Missense_Mutation	NA	I236M	0.14
LUAD	chr1	107057465	Silent	novel	P250P	0.25
LUAD	chr1	107057767	Missense_Mutation	NA	R351P	0.37
LUAD	chr1	107057118	Missense_Mutation	novel	V135F	0.06	MTS
LUAD	chr1	107057494	Missense_Mutation	NA	R260L	0.43
LUAD	chr1	107056941	Missense_Mutation	NA	R76W	0.25
LUAD	chr1	107057337	Missense_Mutation	novel	W208R	0.26
LUAD	chr1	107057279	Silent	novel	S188S	0.13
LUAD	chr1	107057127	Missense_Mutation	novel	G138R	0.18	MTS
LUSC	chr1	107057644	Missense_Mutation	NA	S310L	0.1
PAAD	chr1	107057001	Missense_Mutation	novel	L96M	0.24	MTS
PRAD	chr1	107057405	Silent	NA	L230L	0.27
READ	chr1	107056876	Missense_Mutation	novel	V54A	0.22
READ	chr1	107056962	Missense_Mutation	novel	G83C	0.17	MTS
READ	chr1	107056913	Silent	NA	R66R	0.23
SARC	chr1	107057607	Missense_Mutation	novel	G298R	0.27
SARC	chr1	107058119	3'UTR	novel		0.31
STAD	chr1	107057128	Missense_Mutation	NA	G138V	0.29	MTS
STAD	chr1	107057199	Missense_Mutation	NA	L162M	0.08
STAD	chr1	107056993	Missense_Mutation	NA	T93I	0.35	MTS
UCEC	chr1	107058645	3'UTR	novel		0.15
UCEC	chr1	107057320	Missense_Mutation	NA	E202A	0.38
UCEC	chr1	107059089	3'UTR	novel		0.39
UCEC	chr1	107057999	3'UTR	novel		0.17
UCEC	chr1	107058210	3'UTR	novel		0.08
UCEC	chr1	107058823	3'UTR	novel		0.28
UCEC	chr1	107058097	3'UTR	novel		0.34
UCEC	chr1	107056739	Silent	novel	K8K	0.29
UCEC	chr1	107058809	3'UTR	novel		0.12
UCEC	chr1	107057679	Missense_Mutation	rs749594291	L322F	0.38
UCEC	chr1	107057821	Missense_Mutation	novel	K369T	0.19
UCEC	chr1	107059042	3'UTR	novel		0.27
UCEC	chr1	107058599	3'UTR	novel		0.46
UCEC	chr1	107059098	3'UTR	novel		0.36
UCEC	chr1	107057458	Missense_Mutation	NA	A248V	0.4
UCEC	chr1	107058646	3'UTR	novel		0.35
UCEC	chr1	107059029	3'UTR	novel		0.11
UCEC	chr1	107058046	3'UTR	novel		0.21
UCEC	chr1	107058496	3'UTR	novel		0.22
UCEC	chr1	107057333	Frame_Shift_Ins	NA	*W208Lfs212**	0.41
UCEC	chr1	107059056	3'UTR	novel		0.29
UCEC	chr1	107059245	3'UTR	novel		0.24
UCEC	chr1	107059029	3'UTR	novel		0.42
UCEC	chr1	107057804	Silent	novel	D363D	0.26
UCEC	chr1	107058635	3'UTR	novel		0.38
UCEC	chr1	107058140	3'UTR	novel		0.38
UCEC	chr1	107058303	3'UTR	novel		0.28
UCEC	chr1	107056828	Missense_Mutation	novel	R38M	0.35
UCEC	chr1	107058641	3'UTR	novel		0.25
UCEC	chr1	107059079	3'UTR	novel		0.42
UCEC	chr1	107059049	3'UTR	novel		0.35
UCEC	chr1	107057792	Nonsense_Mutation	NA	Y359*	0.42
UCEC	chr1	107059201	3'UTR	novel		0.16
UCEC	chr1	107057449	Missense_Mutation	novel	D245G	0.26
UCEC	chr1	107058331	3'UTR	novel		0.23
UCEC	chr1	107058672	3'UTR	novel		0.33
UCEC	chr1	107056815	Missense_Mutation	novel	E34K	0.42
UCEC	chr1	107057823	Missense_Mutation	rs369986727	D370Y	0.41
UCEC	chr1	107059166	3'UTR	novel		0.37
UCEC	chr1	107058004	3'UTR	novel		0.47
UCEC	chr1	107059287	3'UTR	novel		0.42
UCEC	chr1	107058124	3'UTR	novel		0.29
UCEC	chr1	107058995	3'UTR	novel		0.43
UCEC	chr1	107057954	3'UTR	novel		0.38
UCEC	chr1	107058138	3'UTR	novel		0.45
UCEC	chr1	107058441	3'UTR	novel		0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2593	5.7821e-10
CESC	DEL	0.0847	0.01281
COAD	DEL	0.2239	0.00038973
DLBC	DEL	0.0833	0.0017831
LUAD	DEL	0.2384	2.5961e-13
MESO	DEL	0.3793	5.9874e-12
PRAD	DEL	0.065	0.0061054
READ	DEL	0.2848	0.013822
SKCM	DEL	0.188	9.7877e-07
STAD	DEL	0.1519	0.0040659
TGCT	AMP	0.18	0.088103

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.026	Kaplan-Meier Survival Analysis
MESO	0.032	Kaplan-Meier Survival Analysis
BRCA	0.015	Kaplan-Meier Survival Analysis
BLCA	0.0062	Kaplan-Meier Survival Analysis
UCEC	0.00019	Kaplan-Meier Survival Analysis
LIHC	0.0028	Kaplan-Meier Survival Analysis
UVM	0.041	Kaplan-Meier Survival Analysis
OV	0.043	Kaplan-Meier Survival Analysis