EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000198925 (Gene tree)
Gene ID: 79065
Gene Symbol: ATG9A
Alias: FLJ22169|APG9L1
Full Name: autophagy related 9A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 10,338 bases
Position: chr2:219,219,380-219,229,717
Accession: 22408
RBP type: non-canonical RBP
Summary: (Autophagy Related 9A) is a Protein Coding gene. Diseases associated with ATG9A include Age-Related Hearing Loss. Among its related pathways are Mitophagy - animal and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include heme-copper terminal oxidase activity. An important paralog of this gene is ATG9B.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409422	ATG9A-204	2512	-	ENSP00000386535	778 (aa)	-	Q7Z3C6
ENST00000396761	ATG9A-202	3799	-	ENSP00000379983	839 (aa)	-	Q7Z3C6
ENST00000457841	ATG9A-217	699	-	ENSP00000404750	172 (aa)	-	C9JDK4
ENST00000412355	ATG9A-206	574	-	ENSP00000393708	98 (aa)	-	F2Z3I6
ENST00000436856	ATG9A-212	893	-	ENSP00000401530	187 (aa)	-	C9JXG2
ENST00000466217	ATG9A-218	594	-	-	- (aa)	-	-
ENST00000409033	ATG9A-203	3701	-	ENSP00000386482	528 (aa)	-	Q7Z3C6
ENST00000456708	ATG9A-216	576	-	ENSP00000390704	98 (aa)	-	F2Z3I6
ENST00000434939	ATG9A-211	568	-	ENSP00000394345	93 (aa)	-	C9JS65
ENST00000431715	ATG9A-209	581	-	ENSP00000396404	133 (aa)	-	C9JD65
ENST00000488833	ATG9A-221	487	-	-	- (aa)	-	-
ENST00000432520	ATG9A-210	796	-	ENSP00000406785	144 (aa)	-	C9IYZ9
ENST00000361242	ATG9A-201	3130	-	ENSP00000355173	839 (aa)	-	Q7Z3C6
ENST00000409618	ATG9A-205	4025	-	ENSP00000386710	839 (aa)	-	Q7Z3C6
ENST00000439812	ATG9A-213	589	-	ENSP00000413569	131 (aa)	-	C9JX27
ENST00000428226	ATG9A-207	700	-	ENSP00000409164	169 (aa)	-	C9JKV7
ENST00000475339	ATG9A-219	812	-	-	- (aa)	-	-
ENST00000443140	ATG9A-214	685	-	ENSP00000416435	97 (aa)	-	C9JFV2
ENST00000486766	ATG9A-220	579	-	-	- (aa)	-	-
ENST00000455079	ATG9A-215	558	-	-	- (aa)	-	-
ENST00000429920	ATG9A-208	733	-	ENSP00000400234	244 (aa)	-	H7C1G6

Gene Model

Click here to download ENSG00000198925's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04136	Autophagy - other	KEGG
hsa04137	Mitophagy - animal	KEGG
hsa04140	Autophagy - animal	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000198925's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000045	autophagosome assembly	21873635.	IBA	Process
GO:0000045	autophagosome assembly	15755735.22456507.	IMP	Process
GO:0000407	phagophore assembly site	21873635.	IBA	Component
GO:0000407	phagophore assembly site	22456507.	IDA	Component
GO:0000421	autophagosome membrane	22456507.	IDA	Component
GO:0000422	autophagy of mitochondrion	21873635.	IBA	Process
GO:0005515	protein binding	19893488.21903422.24603492.25416956.	IPI	Function
GO:0005768	endosome	23093945.	IDA	Component
GO:0005770	late endosome	22456507.	IDA	Component
GO:0005776	autophagosome	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	IEA	Component
GO:0005802	trans-Golgi network	22456507.23093945.	IDA	Component
GO:0015031	protein transport	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0031902	late endosome membrane	-	IEA	Component
GO:0034497	protein localization to phagophore assembly site	21873635.	IBA	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0044805	late nucleophagy	21873635.	IBA	Process
GO:0055037	recycling endosome	22456507.	IDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24085552	ATG9A overexpression is associated with disease recurrence and poor survival in patients with oral squamous cell carcinoma.	Virchows Arch	2013 Dec	Tang JY	doi: 10.1007/s00428-013-1482-5
29048433	TMEM74 promotes tumor cell survival by inducing autophagy via interactions with ATG16L1 and ATG9A.	Cell Death Dis	2017 Aug 31	Sun Y	doi: 10.1038/cddis.2017.370.
27758042	Mammalian autophagy and the plasma membrane.	FEBS J	2017 Mar	Pavel M	doi: 10.1111/febs.13931

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr2	219226893	Missense_Mutation	novel	L63R	0.19
BLCA	chr2	219226894	Missense_Mutation	novel	L63I	0.19
BLCA	chr2	219224579	Silent	NA	L264L	0.3
BLCA	chr2	219222666	Silent	novel	Q609Q	0.15
BLCA	chr2	219225144	Missense_Mutation	novel	I148T	0.92
BLCA	chr2	219220865	Missense_Mutation	NA	S799C	0.2
BLCA	chr2	219220858	Silent	NA	F801F	0.23
BRCA	chr2	219223683	Missense_Mutation	NA	I501L	0.27
BRCA	chr2	219222772	Frame_Shift_Del	novel	*R571Qfs4**	0.16
BRCA	chr2	219224520	Missense_Mutation	novel	Q284R	0.08
BRCA	chr2	219222701	Missense_Mutation	NA	L598M	0.15
BRCA	chr2	219222382	Silent	novel	L639L	0.15
BRCA	chr2	219223668	Nonsense_Mutation	NA	R506*	0.3
BRCA	chr2	219225458	Silent	NA	K109K	0.23
CESC	chr2	219220225	3'UTR	novel		0.24
CESC	chr2	219222445	Silent	novel	L618L	0.09
CESC	chr2	219223904	Missense_Mutation	NA	R462W	0.12
CESC	chr2	219229583	5'UTR	novel		0.5
CESC	chr2	219229583	5'UTR	novel		0.78
CESC	chr2	219224349	Missense_Mutation	novel	R341H	0.51
CESC	chr2	219222416	Missense_Mutation	NA	S628L	0.45
CHOL	chr2	219222436	Silent	novel	I621I	0.09
COAD	chr2	219224222	Silent	rs756437040	F383F	0.4
COAD	chr2	219226913	Missense_Mutation	novel	K56N	0.32
COAD	chr2	219223699	Silent	novel	R495R	0.44
COAD	chr2	219220289	3'UTR	novel		0.25
COAD	chr2	219220750	Silent	NA	H837H	0.16
COAD	chr2	219224703	Missense_Mutation	novel	V223A	0.08
COAD	chr2	219228018	Nonsense_Mutation	novel	Q3*	0.14
COAD	chr2	219224825	Silent	NA	E182E	0.8
COAD	chr2	219226870	Missense_Mutation	rs757225337	M71V	0.22
COAD	chr2	219224304	Missense_Mutation	rs570750110	R356H	0.3
COAD	chr2	219221224	Missense_Mutation	rs777855989	A742T	0.44
COAD	chr2	219224524	Missense_Mutation	NA	A283T	0.23
COAD	chr2	219224348	Silent	novel	R341R	0.22
COAD	chr2	219224712	Missense_Mutation	novel	V220A	0.36
ESCA	chr2	219223971	Silent	rs372559203	R439R	0.33
ESCA	chr2	219224680	Missense_Mutation	rs200810317	R231C	0.21
ESCA	chr2	219224739	Missense_Mutation	rs763159203	R211H	0.33
ESCA	chr2	219223823	Splice_Site	novel	X469_splice	0.1
GBM	chr2	219224814	Missense_Mutation	novel	R186Q	0.68
GBM	chr2	219224296	Missense_Mutation	novel	K359Q	0.63
HNSC	chr2	219220853	Missense_Mutation	novel	R803Q	0.2
HNSC	chr2	219226933	Missense_Mutation	rs761159469	V50I	0.17
HNSC	chr2	219222786	Frame_Shift_Del	novel	*W567Cfs9**	0.04
KIRP	chr2	219225567	Missense_Mutation	NA	F73C	0.36
KIRP	chr2	219225515	Silent	rs770730811	D90D	0.28
KIRP	chr2	219220374	3'UTR	novel		0.39
LGG	chr2	219224844	Missense_Mutation	rs770289897	P176L	0.43
LIHC	chr2	219222345	Missense_Mutation	novel	L652V	0.29
LUAD	chr2	219225533	Silent	rs762494956	V84V	0.25
LUAD	chr2	219222422	Missense_Mutation	novel	A626V	0.18
LUAD	chr2	219225086	Silent	novel	A167A	0.53
LUAD	chr2	219222777	Silent	NA	E572E	0.28
LUAD	chr2	219220848	Missense_Mutation	novel	P805A	0.31
LUAD	chr2	219220351	3'UTR	novel		0.11
LUAD	chr2	219227970	Missense_Mutation	NA	P19S	0.15
LUAD	chr2	219224326	Missense_Mutation	rs761352054	E349K	0.09
LUAD	chr2	219222381	Nonsense_Mutation	NA	Q640*	0.59
LUSC	chr2	219224730	Missense_Mutation	novel	R214H	0.28
LUSC	chr2	219224637	Missense_Mutation	rs771444739	R245H	0.26
LUSC	chr2	219225206	Missense_Mutation	novel	Q127H	0.47
LUSC	chr2	219224689	Silent	NA	L228L	0.23
LUSC	chr2	219222666	Missense_Mutation	novel	Q609H	0.55
LUSC	chr2	219222334	Silent	novel	F655F	0.27
OV	chr2	219223938	Missense_Mutation	novel	D450E	0.11
OV	chr2	219222745	Frame_Shift_Ins	novel	*Q583Lfs10**	0.07
OV	chr2	219224394	Missense_Mutation	novel	A326D	0.31
OV	chr2	219223913	Missense_Mutation	novel	S459T	0.15
OV	chr2	219226907	Silent	novel	G58G	0.08
OV	chr2	219227804	Missense_Mutation	novel	H38P	0.04
OV	chr2	219224490	Missense_Mutation	novel	G294A	0.18
OV	chr2	219224832	Missense_Mutation	novel	W180L	0.27
OV	chr2	219222858	Nonsense_Mutation	novel	Y545*	0.07
OV	chr2	219225083	Silent	novel	L168L	0.12
OV	chr2	219224751	Missense_Mutation	novel	D207G	0.09
OV	chr2	219224024	Splice_Site	novel	X422_splice	0.26
OV	chr2	219224679	Missense_Mutation	NA	R231P	0.17
PAAD	chr2	219224505	Missense_Mutation	rs766744605	R289H	0.21
PAAD	chr2	219224177	Silent	rs759315800	D398D	0.19
PRAD	chr2	219222681	Silent	NA	L604L	0.14
PRAD	chr2	219223639	Frame_Shift_Del	novel	*V513Gfs34**	0.06
PRAD	chr2	219224688	Missense_Mutation	novel	L228P	0.42
PRAD	chr2	219226934	Splice_Site	NA	X50_splice	0.28
READ	chr2	219224559	Missense_Mutation	novel	A271V	0.13
READ	chr2	219227935	Silent	rs774573448	A30A	0.26
READ	chr2	219225475	Missense_Mutation	NA	P104S	0.64
READ	chr2	219221251	Missense_Mutation	rs781020199	R733W	0.34
READ	chr2	219220873	Missense_Mutation	novel	R796S	0.17
READ	chr2	219222663	Silent	NA	S610S	0.38
SKCM	chr2	219224444	Silent	NA	I309I	0.31
SKCM	chr2	219223736	Missense_Mutation	NA	P483L	0.19
SKCM	chr2	219225142	Missense_Mutation	NA	K149E	0.36
SKCM	chr2	219222300	Missense_Mutation	rs545980763	R667W	0.2
SKCM	chr2	219223691	Missense_Mutation	NA	A498V	0.48
SKCM	chr2	219224486	Silent	rs568908389	I295I	0.21
SKCM	chr2	219221148	Missense_Mutation	novel	P767L	0.25
SKCM	chr2	219224486	Silent	rs568908389	I295I	0.21
SKCM	chr2	219220760	Frame_Shift_Del	novel	*P834Lfs10**	0.21
SKCM	chr2	219223902	Silent	novel	R462R	0.08
SKCM	chr2	219223903	Missense_Mutation	novel	R462Q	0.07
SKCM	chr2	219224210	Missense_Mutation	NA	I387M	0.41
SKCM	chr2	219225563	Silent	NA	L74L	0.77
SKCM	chr2	219222413	Missense_Mutation	NA	S629F	0.14
SKCM	chr2	219223968	Silent	novel	V440V	0.18
SKCM	chr2	219223648	Silent	rs752664977	V512V	0.24
SKCM	chr2	219225475	Missense_Mutation	NA	P104S	0.2
SKCM	chr2	219225563	Silent	NA	L74L	0.18
SKCM	chr2	219224285	Silent	NA	S362S	0.32
STAD	chr2	219222150	Missense_Mutation	NA	A682G	0.17
STAD	chr2	219224834	Silent	rs373511038	T179T	0.21
STAD	chr2	219226933	Missense_Mutation	rs761159469	V50I	0.18
STAD	chr2	219225442	Missense_Mutation	rs766008146	A115T	0.26
STAD	chr2	219223912	Missense_Mutation	NA	S459L	0.21
STAD	chr2	219222353	Missense_Mutation	NA	A649V	0.32
STAD	chr2	219224685	Missense_Mutation	novel	P229H	0.35
STAD	chr2	219221143	Missense_Mutation	novel	P769A	0.19
STAD	chr2	219224105	Splice_Site	novel	X422_splice	0.38
STAD	chr2	219224421	Missense_Mutation	NA	A317V	0.13
STAD	chr2	219220794	Missense_Mutation	NA	V823M	0.28
STAD	chr2	219223940	Missense_Mutation	NA	D450N	0.27
STAD	chr2	219222685	Missense_Mutation	novel	A603V	0.07
STAD	chr2	219222688	Frame_Shift_Del	novel	*N602Mfs17**	0.06
STAD	chr2	219225527	Silent	rs541694613	C86C	0.47
THYM	chr2	219226889	Silent	novel	I64I	0.31
UCEC	chr2	219221188	Frame_Shift_Del	NA	*Q754Sfs90**	0.22
UCEC	chr2	219224120	Silent	rs369031181	T417T	0.44
UCEC	chr2	219225466	Missense_Mutation	novel	P107T	0.16
UCEC	chr2	219222683	Missense_Mutation	novel	L604I	0.08
UCEC	chr2	219223904	Missense_Mutation	NA	R462W	0.15
UCEC	chr2	219227996	Missense_Mutation	novel	R10H	0.19
UCEC	chr2	219223647	Missense_Mutation	rs199801466	V513I	0.25
UCEC	chr2	219224824	Missense_Mutation	novel	V183M	0.52
UCEC	chr2	219228455	5'UTR	novel		0.1
UCEC	chr2	219222342	Missense_Mutation	rs762480185	R653C	0.4
UCEC	chr2	219225565	Missense_Mutation	novel	L74I	0.28
UCEC	chr2	219224469	Missense_Mutation	novel	C301F	0.43
UCEC	chr2	219222365	Missense_Mutation	NA	R645M	0.38
UCEC	chr2	219221093	Silent	rs758970707	Y785Y	0.42
UCEC	chr2	219224401	Missense_Mutation	NA	P324S	0.21
UCEC	chr2	219224809	Missense_Mutation	rs201418627	V188M	0.23
UCEC	chr2	219224548	Missense_Mutation	NA	R275C	0.34
UCEC	chr2	219220839	Missense_Mutation	novel	G808W	0.22
UCEC	chr2	219223648	Silent	rs752664977	V512V	0.5
UCEC	chr2	219228019	Silent	rs751128242	A2A	0.38
UCEC	chr2	219219441	3'Flank	novel		0.43
UCEC	chr2	219219595	3'Flank	novel		0.44
UCEC	chr2	219227998	Silent	novel	Q9Q	0.11
UCEC	chr2	219220382	3'UTR	novel		0.33
UCEC	chr2	219221175	Missense_Mutation	rs377367353	R758H	0.37
UCEC	chr2	219220370	3'UTR	novel		0.64
UCEC	chr2	219220879	Silent	novel	V794V	0.36
UCEC	chr2	219222744	Missense_Mutation	novel	Q583H	0.29
UCEC	chr2	219224385	Missense_Mutation	novel	A329V	0.44
UCEC	chr2	219219317	3'Flank	novel		0.53
UCEC	chr2	219221184	Missense_Mutation	novel	S755Y	0.42
UCEC	chr2	219222830	Silent	NA	L555L	0.16
UCEC	chr2	219225085	Silent	NA	L168L	0.38
UCEC	chr2	219225463	Missense_Mutation	rs117094218	V108I	0.36
UCEC	chr2	219229584	5'UTR	novel		0.47
UCEC	chr2	219219446	3'Flank	novel		0.27
UCEC	chr2	219228032	5'UTR	rs373711135		0.34
UCEC	chr2	219224518	Missense_Mutation	novel	R285C	0.32
UCEC	chr2	219224252	Silent	novel	L373L	0.24
UCEC	chr2	219224450	Nonsense_Mutation	novel	W307*	0.1
UCEC	chr2	219224780	Silent	novel	C197C	0.07
UCEC	chr2	219219587	3'Flank	novel		0.3
UCEC	chr2	219222379	Missense_Mutation	novel	Q640H	0.27
UCEC	chr2	219224003	Missense_Mutation	novel	H429Y	0.34
UCEC	chr2	219223667	Missense_Mutation	NA	R506Q	0.42
UCEC	chr2	219220794	Missense_Mutation	NA	V823M	0.33
UCEC	chr2	219223972	Missense_Mutation	rs199900351	R439H	0.2
UCEC	chr2	219224361	Missense_Mutation	rs766730899	R337H	0.29
UCEC	chr2	219220789	Silent	novel	P824P	0.42
UCEC	chr2	219223994	Missense_Mutation	novel	F432V	0.15
UCEC	chr2	219224485	Missense_Mutation	rs549042911	A296T	0.25
UCEC	chr2	219225134	Silent	novel	I151I	0.27
UCEC	chr2	219227768	Splice_Site	novel	X49_splice	0.21
UCEC	chr2	219224680	Missense_Mutation	rs200810317	R231C	0.41
UCEC	chr2	219227971	Silent	novel	S18S	0.37
UCEC	chr2	219222870	Missense_Mutation	NA	E541D	0.13
UCEC	chr2	219222811	Missense_Mutation	novel	A561V	0.43
UCEC	chr2	219219459	3'Flank	novel		0.32
UCEC	chr2	219222789	Silent	novel	Q568Q	0.28
UCEC	chr2	219220246	3'UTR	novel		0.34
UVM	chr2	219221302	Missense_Mutation	novel	L716V	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
HNSC	DEL	0.2165	1.278e-25
KIRP	DEL	0.0382	5.174e-05
LUSC	DEL	0.2395	1.3904e-19
MESO	DEL	0.1149	0.014499
PAAD	AMP	0.0707	0.1091
PAAD	DEL	0.038	0.2014
THCA	DEL	0.024	0.040844
THYM	DEL	0.0163	0.10691

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.038	Kaplan-Meier Survival Analysis
SARC	0.019	Kaplan-Meier Survival Analysis
MESO	0.0023	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
SKCM	0.00012	Kaplan-Meier Survival Analysis
BRCA	0.039	Kaplan-Meier Survival Analysis
KIRP	0.025	Kaplan-Meier Survival Analysis
BLCA	0.024	Kaplan-Meier Survival Analysis
UCEC	0.04	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
UVM	0.038	Kaplan-Meier Survival Analysis
OV	0.016	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742