EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000203791 (Gene tree)
Gene ID: 399818
Gene Symbol: EEF1AKMT2
Alias: Efm4|C10orf138|METTL10
Full Name: EEF1A lysine methyltransferase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 43,793 bases
Position: chr10:124,748,149-124,791,941
Accession: 33787
RBP type: canonical RBP
Summary: (EEF1A Lysine Methyltransferase 2) is a Protein Coding gene. Among its related pathways are Protein methylation and Metabolism of proteins. An important paralog of this gene is ENSG00000258539.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000357829	Methyltransf_31	PF13847.6	6.2e-20	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000466270	EEF1AKMT2-203	3587	-	ENSP00000451190	104 (aa)	-	G3V238
ENST00000368836	EEF1AKMT2-201	1462	-	ENSP00000357829	291 (aa)	-	Q5JPI9
ENST00000498770	EEF1AKMT2-206	787	-	-	- (aa)	-	-
ENST00000464099	EEF1AKMT2-202	1013	-	ENSP00000450447	104 (aa)	-	G3V238
ENST00000495711	EEF1AKMT2-205	524	-	ENSP00000470332	31 (aa)	-	M0QZ67
ENST00000468738	EEF1AKMT2-204	430	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000203791's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000203791	rs10510138	10	124749450	A	Obesity-related traits	23251661	[NR] µIU/mL increase	0.02	EFO_0004748
ENSG00000203791	rs141185973	10	124775546	?	Childhood ear infection	28928442	[0.04-0.098] unit increase	0.0689	EFO_0007904
ENSG00000203791	rs111456533	10	124750812	G	Inflammatory bowel disease	28067908	1.08-1.14	1.11	EFO_0003767
ENSG00000203791	rs111456533	10	124750812	?	Crohn's disease	28067908			EFO_0000384
ENSG00000203791	rs111456533	10	124750812	?	Ulcerative colitis	28067908			EFO_0000729
ENSG00000203791	rs12218858	10	124785631	C	Total hippocampal volume	30279459	NR mm3 increase	43.75	EFO_0005035
ENSG00000203791	rs12218858	10	124785631	C	Hippocampal subfield CA4 volume	30279459	NR mm3 increase	3.87	EFO_0009396
ENSG00000203791	rs12218858	10	124785631	C	Dentate gyrus granule cell layer volume	30279459	NR mm3 increase	4.45	EFO_0009403
ENSG00000203791	rs2363340	10	124772799	C	Hippocampal tail volume	30279459	NR mm3 increase	9.45	EFO_0009398

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000203791's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000203791	EEF1AKMT2	97	60.000	ENSAPOG00000001439	eef1akmt2	66	60.326	Acanthochromis_polyacanthus
ENSG00000203791	EEF1AKMT2	94	89.655	ENSAMEG00000004197	-	83	92.361	Ailuropoda_melanoleuca
ENSG00000203791	EEF1AKMT2	97	60.000	ENSACIG00000005482	eef1akmt2	81	55.670	Amphilophus_citrinellus
ENSG00000203791	EEF1AKMT2	97	60.000	ENSAOCG00000004496	eef1akmt2	66	59.783	Amphiprion_ocellaris
ENSG00000203791	EEF1AKMT2	97	60.000	ENSAPEG00000007081	eef1akmt2	66	59.783	Amphiprion_percula
ENSG00000203791	EEF1AKMT2	97	60.000	ENSATEG00000007817	eef1akmt2	78	58.152	Anabas_testudineus
ENSG00000203791	EEF1AKMT2	94	82.759	ENSAPLG00000015137	-	87	72.832	Anas_platyrhynchos
ENSG00000203791	EEF1AKMT2	90	75.000	ENSACAG00000014407	-	85	76.216	Anolis_carolinensis
ENSG00000203791	EEF1AKMT2	93	89.691	ENSANAG00000020212	EEF1AKMT2	81	95.312	Aotus_nancymaae
ENSG00000203791	EEF1AKMT2	97	60.000	ENSACLG00000017498	eef1akmt2	91	52.174	Astatotilapia_calliptera
ENSG00000203791	EEF1AKMT2	97	70.000	ENSAMXG00000011707	eef1akmt2	81	61.749	Astyanax_mexicanus
ENSG00000203791	EEF1AKMT2	94	96.552	ENSBTAG00000050151	-	81	91.146	Bos_taurus
ENSG00000203791	EEF1AKMT2	69	44.444	WBGene00017919	F29B9.1	79	36.702	Caenorhabditis_elegans
ENSG00000203791	EEF1AKMT2	93	88.660	ENSCJAG00000012593	EEF1AKMT2	94	77.778	Callithrix_jacchus
ENSG00000203791	EEF1AKMT2	94	89.655	ENSCAFG00000012755	-	83	93.706	Canis_familiaris
ENSG00000203791	EEF1AKMT2	80	90.361	ENSCAFG00020015392	-	80	92.188	Canis_lupus_dingo
ENSG00000203791	EEF1AKMT2	81	68.000	ENSCHIG00000017265	-	74	75.824	Capra_hircus
ENSG00000203791	EEF1AKMT2	94	96.552	ENSCHIG00000004811	-	81	90.625	Capra_hircus
ENSG00000203791	EEF1AKMT2	97	96.667	ENSTSYG00000026659	EEF1AKMT2	89	95.858	Carlito_syrichta
ENSG00000203791	EEF1AKMT2	94	86.207	ENSCAPG00000010392	-	82	94.118	Cavia_aperea
ENSG00000203791	EEF1AKMT2	94	86.207	ENSCPOG00000005341	-	77	91.667	Cavia_porcellus
ENSG00000203791	EEF1AKMT2	93	91.753	ENSCCAG00000003096	EEF1AKMT2	94	83.571	Cebus_capucinus
ENSG00000203791	EEF1AKMT2	97	96.667	ENSCATG00000030673	-	88	95.652	Cercocebus_atys
ENSG00000203791	EEF1AKMT2	94	86.207	ENSCLAG00000003615	-	79	92.708	Chinchilla_lanigera
ENSG00000203791	EEF1AKMT2	97	96.667	ENSCSAG00000004519	-	73	97.906	Chlorocebus_sabaeus
ENSG00000203791	EEF1AKMT2	94	82.759	ENSCPBG00000028069	-	81	80.435	Chrysemys_picta_bellii
ENSG00000203791	EEF1AKMT2	94	58.621	ENSCING00000003952	-	79	39.205	Ciona_intestinalis
ENSG00000203791	EEF1AKMT2	90	67.857	ENSCSAVG00000004091	-	83	39.394	Ciona_savignyi
ENSG00000203791	EEF1AKMT2	97	96.667	ENSCANG00000035139	EEF1AKMT2	85	97.143	Colobus_angolensis_palliatus
ENSG00000203791	EEF1AKMT2	94	93.103	ENSCGRG00001018428	Eef1akmt2	79	85.938	Cricetulus_griseus_chok1gshd
ENSG00000203791	EEF1AKMT2	94	93.103	ENSCGRG00000004819	Eef1akmt2	79	85.938	Cricetulus_griseus_crigri
ENSG00000203791	EEF1AKMT2	94	58.621	ENSCSEG00000015275	eef1akmt2	76	52.973	Cynoglossus_semilaevis
ENSG00000203791	EEF1AKMT2	97	66.667	ENSCVAG00000019478	eef1akmt2	80	58.289	Cyprinodon_variegatus
ENSG00000203791	EEF1AKMT2	94	68.966	ENSDARG00000102144	eef1akmt2	77	61.290	Danio_rerio
ENSG00000203791	EEF1AKMT2	94	96.552	ENSDNOG00000049387	-	73	90.576	Dasypus_novemcinctus
ENSG00000203791	EEF1AKMT2	93	84.536	ENSDORG00000016286	Eef1akmt2	86	86.567	Dipodomys_ordii
ENSG00000203791	EEF1AKMT2	68	47.945	FBgn0031485	CG9643	82	47.222	Drosophila_melanogaster
ENSG00000203791	EEF1AKMT2	94	93.103	ENSEASG00005013990	-	81	93.229	Equus_asinus_asinus
ENSG00000203791	EEF1AKMT2	94	93.103	ENSECAG00000007838	FAM53B	81	93.750	Equus_caballus
ENSG00000203791	EEF1AKMT2	97	53.333	ENSELUG00000000203	eef1akmt2	78	59.893	Esox_lucius
ENSG00000203791	EEF1AKMT2	94	89.655	ENSFCAG00000018244	-	80	93.229	Felis_catus
ENSG00000203791	EEF1AKMT2	94	79.310	ENSFALG00000004816	-	82	76.879	Ficedula_albicollis
ENSG00000203791	EEF1AKMT2	94	89.655	ENSFDAG00000021123	EEF1AKMT2	80	93.085	Fukomys_damarensis
ENSG00000203791	EEF1AKMT2	97	63.333	ENSFHEG00000021112	eef1akmt2	67	57.219	Fundulus_heteroclitus
ENSG00000203791	EEF1AKMT2	97	50.000	ENSGMOG00000018298	eef1akmt2	98	49.065	Gadus_morhua
ENSG00000203791	EEF1AKMT2	94	79.310	ENSGALG00000034013	-	95	76.630	Gallus_gallus
ENSG00000203791	EEF1AKMT2	97	63.333	ENSGAFG00000011872	eef1akmt2	82	59.278	Gambusia_affinis
ENSG00000203791	EEF1AKMT2	97	66.667	ENSGACG00000009677	eef1akmt2	97	57.592	Gasterosteus_aculeatus
ENSG00000203791	EEF1AKMT2	94	82.759	ENSGAGG00000019118	-	81	79.891	Gopherus_agassizii
ENSG00000203791	EEF1AKMT2	97	100.000	ENSGGOG00000024976	EEF1AKMT2	100	99.606	Gorilla_gorilla
ENSG00000203791	EEF1AKMT2	97	60.000	ENSHBUG00000016969	eef1akmt2	91	52.609	Haplochromis_burtoni
ENSG00000203791	EEF1AKMT2	94	93.103	ENSHGLG00000011000	EEF1AKMT2	80	93.750	Heterocephalus_glaber_female
ENSG00000203791	EEF1AKMT2	94	93.103	ENSHGLG00100005124	EEF1AKMT2	80	93.750	Heterocephalus_glaber_male
ENSG00000203791	EEF1AKMT2	97	60.000	ENSHCOG00000016501	eef1akmt2	78	54.639	Hippocampus_comes
ENSG00000203791	EEF1AKMT2	97	66.667	ENSIPUG00000020556	mettl10	79	60.109	Ictalurus_punctatus
ENSG00000203791	EEF1AKMT2	94	93.103	ENSJJAG00000010893	Eef1akmt2	79	89.583	Jaculus_jaculus
ENSG00000203791	EEF1AKMT2	97	56.667	ENSKMAG00000020780	eef1akmt2	78	51.304	Kryptolebias_marmoratus
ENSG00000203791	EEF1AKMT2	97	63.333	ENSLBEG00000022458	eef1akmt2	75	54.348	Labrus_bergylta
ENSG00000203791	EEF1AKMT2	94	68.966	ENSLACG00000013816	eef1akmt2	75	65.054	Latimeria_chalumnae
ENSG00000203791	EEF1AKMT2	94	72.414	ENSLOCG00000008027	eef1akmt2	82	61.497	Lepisosteus_oculatus
ENSG00000203791	EEF1AKMT2	94	96.552	ENSLAFG00000007509	-	81	92.632	Loxodonta_africana
ENSG00000203791	EEF1AKMT2	65	95.000	ENSMFAG00000002265	-	60	95.699	Macaca_fascicularis
ENSG00000203791	EEF1AKMT2	97	96.667	ENSMNEG00000029600	-	88	95.652	Macaca_nemestrina
ENSG00000203791	EEF1AKMT2	97	96.667	ENSMLEG00000036372	-	85	96.571	Mandrillus_leucophaeus
ENSG00000203791	EEF1AKMT2	97	60.000	ENSMAMG00000017142	eef1akmt2	82	57.216	Mastacembelus_armatus
ENSG00000203791	EEF1AKMT2	97	60.000	ENSMZEG00005027455	eef1akmt2	91	52.609	Maylandia_zebra
ENSG00000203791	EEF1AKMT2	94	79.310	ENSMGAG00000011686	-	79	73.514	Meleagris_gallopavo
ENSG00000203791	EEF1AKMT2	94	93.103	ENSMAUG00000004683	Eef1akmt2	79	86.979	Mesocricetus_auratus
ENSG00000203791	EEF1AKMT2	94	96.552	ENSMICG00000029191	-	81	95.812	Microcebus_murinus
ENSG00000203791	EEF1AKMT2	94	93.103	ENSMOCG00000015688	Eef1akmt2	79	85.417	Microtus_ochrogaster
ENSG00000203791	EEF1AKMT2	97	60.000	ENSMMOG00000008195	eef1akmt2	88	50.224	Mola_mola
ENSG00000203791	EEF1AKMT2	94	79.310	ENSMODG00000010207	-	85	77.660	Monodelphis_domestica
ENSG00000203791	EEF1AKMT2	97	53.333	ENSMALG00000018358	eef1akmt2	82	58.247	Monopterus_albus
ENSG00000203791	EEF1AKMT2	94	93.103	MGP_CAROLIEiJ_G0030581	Eef1akmt2	79	85.417	Mus_caroli
ENSG00000203791	EEF1AKMT2	94	93.103	ENSMUSG00000030960	Eef1akmt2	79	86.458	Mus_musculus
ENSG00000203791	EEF1AKMT2	94	93.103	MGP_SPRETEiJ_G0031695	Eef1akmt2	79	85.938	Mus_spretus
ENSG00000203791	EEF1AKMT2	94	89.655	ENSMPUG00000002730	-	81	92.670	Mustela_putorius_furo
ENSG00000203791	EEF1AKMT2	94	93.103	ENSMLUG00000026925	-	85	88.824	Myotis_lucifugus
ENSG00000203791	EEF1AKMT2	94	96.552	ENSNGAG00000006986	Eef1akmt2	81	89.583	Nannospalax_galili
ENSG00000203791	EEF1AKMT2	97	60.000	ENSNBRG00000016151	eef1akmt2	91	52.174	Neolamprologus_brichardi
ENSG00000203791	EEF1AKMT2	100	96.564	ENSNLEG00000000539	EEF1AKMT2	100	96.564	Nomascus_leucogenys
ENSG00000203791	EEF1AKMT2	71	83.784	ENSMEUG00000008844	-	95	84.066	Notamacropus_eugenii
ENSG00000203791	EEF1AKMT2	99	77.885	ENSOPRG00000003353	-	92	85.340	Ochotona_princeps
ENSG00000203791	EEF1AKMT2	94	86.207	ENSODEG00000017201	-	80	91.667	Octodon_degus
ENSG00000203791	EEF1AKMT2	94	62.069	ENSONIG00000000522	eef1akmt2	92	52.863	Oreochromis_niloticus
ENSG00000203791	EEF1AKMT2	94	89.655	ENSOCUG00000004774	-	60	93.194	Oryctolagus_cuniculus
ENSG00000203791	EEF1AKMT2	97	60.000	ENSORLG00000005635	EEF1AKMT2	81	57.513	Oryzias_latipes
ENSG00000203791	EEF1AKMT2	97	60.000	ENSORLG00020009481	eef1akmt2	81	58.031	Oryzias_latipes_hni
ENSG00000203791	EEF1AKMT2	97	60.000	ENSORLG00015014487	eef1akmt2	81	56.477	Oryzias_latipes_hsok
ENSG00000203791	EEF1AKMT2	97	63.333	ENSOMEG00000008648	eef1akmt2	79	58.289	Oryzias_melastigma
ENSG00000203791	EEF1AKMT2	90	82.143	ENSOGAG00000027770	-	81	75.393	Otolemur_garnettii
ENSG00000203791	EEF1AKMT2	66	81.771	ENSOGAG00000011015	-	93	81.771	Otolemur_garnettii
ENSG00000203791	EEF1AKMT2	94	96.552	ENSOARG00000010457	-	99	92.973	Ovis_aries
ENSG00000203791	EEF1AKMT2	100	98.969	ENSPPAG00000034943	EEF1AKMT2	100	98.969	Pan_paniscus
ENSG00000203791	EEF1AKMT2	79	91.463	ENSPPRG00000017084	-	91	92.347	Panthera_pardus
ENSG00000203791	EEF1AKMT2	75	93.590	ENSPTIG00000017308	-	94	92.746	Panthera_tigris_altaica
ENSG00000203791	EEF1AKMT2	100	99.313	ENSPTRG00000032571	EEF1AKMT2	100	99.313	Pan_troglodytes
ENSG00000203791	EEF1AKMT2	97	96.667	ENSPANG00000020335	-	88	95.652	Papio_anubis
ENSG00000203791	EEF1AKMT2	97	60.000	ENSPKIG00000001059	eef1akmt2	77	63.243	Paramormyrops_kingsleyae
ENSG00000203791	EEF1AKMT2	94	82.759	ENSPSIG00000009720	-	85	77.720	Pelodiscus_sinensis
ENSG00000203791	EEF1AKMT2	97	70.000	ENSPMGG00000014806	eef1akmt2	76	60.894	Periophthalmus_magnuspinnatus
ENSG00000203791	EEF1AKMT2	88	86.813	ENSPEMG00000012513	Eef1akmt2	80	86.458	Peromyscus_maniculatus_bairdii
ENSG00000203791	EEF1AKMT2	94	58.621	ENSPMAG00000000651	eef1akmt2	78	50.265	Petromyzon_marinus
ENSG00000203791	EEF1AKMT2	94	82.759	ENSPCIG00000023106	-	80	84.492	Phascolarctos_cinereus
ENSG00000203791	EEF1AKMT2	97	66.667	ENSPFOG00000017870	eef1akmt2	82	57.732	Poecilia_formosa
ENSG00000203791	EEF1AKMT2	97	66.667	ENSPLAG00000014862	eef1akmt2	82	57.732	Poecilia_latipinna
ENSG00000203791	EEF1AKMT2	97	66.667	ENSPMEG00000011135	eef1akmt2	82	57.732	Poecilia_mexicana
ENSG00000203791	EEF1AKMT2	97	66.667	ENSPREG00000011465	eef1akmt2	79	59.893	Poecilia_reticulata
ENSG00000203791	EEF1AKMT2	100	96.907	ENSPPYG00000002742	EEF1AKMT2	100	96.907	Pongo_abelii
ENSG00000203791	EEF1AKMT2	65	81.481	ENSPCAG00000006220	-	91	81.481	Procavia_capensis
ENSG00000203791	EEF1AKMT2	78	92.593	ENSPCOG00000017778	EEF1AKMT2	93	96.842	Propithecus_coquereli
ENSG00000203791	EEF1AKMT2	70	73.659	ENSPVAG00000003023	-	100	73.659	Pteropus_vampyrus
ENSG00000203791	EEF1AKMT2	97	60.000	ENSPNYG00000003960	eef1akmt2	91	52.609	Pundamilia_nyererei
ENSG00000203791	EEF1AKMT2	97	70.000	ENSPNAG00000022223	eef1akmt2	80	63.243	Pygocentrus_nattereri
ENSG00000203791	EEF1AKMT2	97	96.667	ENSRBIG00000032554	EEF1AKMT2	88	94.737	Rhinopithecus_bieti
ENSG00000203791	EEF1AKMT2	97	96.667	ENSRROG00000044657	-	81	97.382	Rhinopithecus_roxellana
ENSG00000203791	EEF1AKMT2	65	40.541	YIL064W	-	71	38.462	Saccharomyces_cerevisiae
ENSG00000203791	EEF1AKMT2	97	96.667	ENSSBOG00000023032	-	81	94.792	Saimiri_boliviensis_boliviensis
ENSG00000203791	EEF1AKMT2	94	86.207	ENSSHAG00000000955	-	62	82.456	Sarcophilus_harrisii
ENSG00000203791	EEF1AKMT2	97	53.333	ENSSFOG00015009906	mettl10	85	58.115	Scleropages_formosus
ENSG00000203791	EEF1AKMT2	97	60.000	ENSSMAG00000019714	eef1akmt2	81	55.959	Scophthalmus_maximus
ENSG00000203791	EEF1AKMT2	97	63.333	ENSSDUG00000016179	eef1akmt2	79	57.754	Seriola_dumerili
ENSG00000203791	EEF1AKMT2	97	63.333	ENSSLDG00000016698	eef1akmt2	79	57.754	Seriola_lalandi_dorsalis
ENSG00000203791	EEF1AKMT2	50	80.272	ENSSARG00000003739	-	100	80.272	Sorex_araneus
ENSG00000203791	EEF1AKMT2	94	82.759	ENSSPUG00000012992	-	80	73.016	Sphenodon_punctatus
ENSG00000203791	EEF1AKMT2	97	66.667	ENSSPAG00000011418	eef1akmt2	72	57.500	Stegastes_partitus
ENSG00000203791	EEF1AKMT2	94	93.103	ENSSSCG00000023560	-	83	81.690	Sus_scrofa
ENSG00000203791	EEF1AKMT2	94	82.759	ENSTGUG00000011451	-	88	76.087	Taeniopygia_guttata
ENSG00000203791	EEF1AKMT2	97	56.667	ENSTRUG00000001336	eef1akmt2	82	54.639	Takifugu_rubripes
ENSG00000203791	EEF1AKMT2	94	65.517	ENSTNIG00000013345	eef1akmt2	76	57.297	Tetraodon_nigroviridis
ENSG00000203791	EEF1AKMT2	73	93.421	ENSTTRG00000013700	-	93	94.211	Tursiops_truncatus
ENSG00000203791	EEF1AKMT2	94	89.655	ENSUMAG00000005375	-	89	93.258	Ursus_maritimus
ENSG00000203791	EEF1AKMT2	58	95.833	ENSVPAG00000010652	-	100	95.833	Vicugna_pacos
ENSG00000203791	EEF1AKMT2	94	89.655	ENSVVUG00000005997	-	79	93.229	Vulpes_vulpes
ENSG00000203791	EEF1AKMT2	94	65.517	ENSXETG00000030721	-	84	63.934	Xenopus_tropicalis
ENSG00000203791	EEF1AKMT2	97	63.333	ENSXCOG00000009889	eef1akmt2	82	57.732	Xiphophorus_couchianus
ENSG00000203791	EEF1AKMT2	97	63.333	ENSXMAG00000012537	eef1akmt2	82	58.763	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005634	nucleus	25144183.	IDA	Component
GO:0005737	cytoplasm	25144183.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006479	protein methylation	-	TAS	Process
GO:0008168	methyltransferase activity	25144183.	IDA	Function
GO:0016279	protein-lysine N-methyltransferase activity	25144183.	IDA	Function
GO:0016279	protein-lysine N-methyltransferase activity	-	TAS	Function
GO:0018022	peptidyl-lysine methylation	25144183.	IDA	Process