EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000204120 (Gene tree)
Gene ID: 26058
Gene Symbol: GIGYF2
Alias: KIAA0642|GYF2|PERQ2|PERQ3|TNRC15|PARK11
Full Name: GRB10 interacting GYF protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 163,279 bases
Position: chr2:232,697,299-232,860,577
Accession: 11960
RBP type: non-canonical RBP
Summary: This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29554310	4EHP-independent repression of endogenous mRNAs by the RNA-binding protein GIGYF2.	Nucleic Acids Res	2018 Jun 20	Amaya Ramirez CC	doi: 10.1093/nar/gky198.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000489328	GIGYF2-242	1116	-	-	- (aa)	-	-
ENST00000409547	GIGYF2-205	5978	-	ENSP00000386537	1299 (aa)	-	Q6Y7W6
ENST00000424038	GIGYF2-210	626	-	ENSP00000399064	92 (aa)	-	F8WCD5
ENST00000428883	GIGYF2-216	544	-	ENSP00000402712	115 (aa)	-	C9JRZ2
ENST00000490229	GIGYF2-243	863	-	-	- (aa)	-	-
ENST00000409196	GIGYF2-202	5747	-	ENSP00000387070	1293 (aa)	-	Q6Y7W6
ENST00000421433	GIGYF2-207	564	-	ENSP00000402053	93 (aa)	-	C9JPV7
ENST00000474312	GIGYF2-231	4687	-	-	- (aa)	-	-
ENST00000490612	GIGYF2-244	567	-	-	- (aa)	-	-
ENST00000426102	GIGYF2-213	561	-	ENSP00000415037	149 (aa)	-	C9JH18
ENST00000473170	GIGYF2-230	550	-	-	- (aa)	-	-
ENST00000421778	GIGYF2-208	564	-	ENSP00000390325	90 (aa)	-	C9JH78
ENST00000427233	GIGYF2-214	530	-	ENSP00000396590	13 (aa)	-	C9JC65
ENST00000409480	GIGYF2-204	5976	-	ENSP00000386765	1321 (aa)	-	I1E4Y6
ENST00000471011	GIGYF2-229	539	-	-	- (aa)	-	-
ENST00000456491	GIGYF2-223	466	-	ENSP00000413612	68 (aa)	-	C9JW88
ENST00000373563	GIGYF2-201	5847	-	ENSP00000362664	1299 (aa)	-	Q6Y7W6
ENST00000484409	GIGYF2-239	367	-	-	- (aa)	-	-
ENST00000469843	GIGYF2-228	550	-	-	- (aa)	-	-
ENST00000488734	GIGYF2-241	796	-	-	- (aa)	-	-
ENST00000475530	GIGYF2-234	287	-	-	- (aa)	-	-
ENST00000423659	GIGYF2-209	2329	-	ENSP00000404195	720 (aa)	-	C9JHW1
ENST00000482952	GIGYF2-237	618	-	-	- (aa)	-	-
ENST00000629305	GIGYF2-246	7878	-	ENSP00000487548	1321 (aa)	-	I1E4Y6
ENST00000427649	GIGYF2-215	677	-	ENSP00000398055	143 (aa)	-	C9J7G1
ENST00000436349	GIGYF2-219	547	-	ENSP00000400076	62 (aa)	-	C9J1A6
ENST00000464805	GIGYF2-227	1196	NR_103494	-	- (aa)	-	-
ENST00000482666	GIGYF2-236	1261	NR_103493	-	- (aa)	-	-
ENST00000455139	GIGYF2-222	556	-	ENSP00000395299	62 (aa)	-	A0A1U8QZH8
ENST00000475359	GIGYF2-233	825	NR_103495	-	- (aa)	-	-
ENST00000424414	GIGYF2-211	583	-	ENSP00000401261	71 (aa)	-	C9JZC0
ENST00000440945	GIGYF2-220	2658	-	ENSP00000410297	836 (aa)	-	E7ESB6
ENST00000458528	GIGYF2-224	566	-	ENSP00000389322	59 (aa)	-	F8WBF1
ENST00000409451	GIGYF2-203	5937	-	ENSP00000387170	1320 (aa)	-	Q6Y7W6
ENST00000483164	GIGYF2-238	577	-	-	- (aa)	-	-
ENST00000430720	GIGYF2-218	561	-	ENSP00000396958	112 (aa)	-	C9JHT0
ENST00000425040	GIGYF2-212	588	-	ENSP00000407161	99 (aa)	-	C9JXQ0
ENST00000445650	GIGYF2-221	588	-	ENSP00000392218	119 (aa)	-	C9IYH5
ENST00000492910	GIGYF2-245	685	-	-	- (aa)	-	-
ENST00000464402	GIGYF2-226	529	-	-	- (aa)	-	-
ENST00000463554	GIGYF2-225	1085	-	-	- (aa)	-	-
ENST00000476995	GIGYF2-235	766	-	-	- (aa)	-	-
ENST00000474465	GIGYF2-232	625	-	-	- (aa)	-	-
ENST00000410033	GIGYF2-206	957	-	ENSP00000387276	176 (aa)	-	B8ZZD2
ENST00000488629	GIGYF2-240	562	-	-	- (aa)	-	-
ENST00000429187	GIGYF2-217	606	-	ENSP00000392991	106 (aa)	-	C9J0V6

Gene Model

Click here to download ENSG00000204120's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000204120	Platelet Function Tests	2.6645350E-015	-
ENSG00000204120	Schizophrenia	2E-12	25056061

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000204120	rs6704768	2	232727791	?	Autism spectrum disorder or schizophrenia	28540026	[1.04-1.09]	1.0638298	EFO_0000692\|EFO_0003756
ENSG00000204120	rs6704768	2	232727791	G	Schizophrenia	25056061	[1.05-1.1]	1.0752687	EFO_0000692
ENSG00000204120	rs1801251	2	232768750	A	Coronary artery disease	29212778	[0.029-0.055] unit increase	0.0416	EFO_0000378
ENSG00000204120	rs6704768	2	232727791	A	Educational attainment (MTAG)	30038396	[0.011-0.016] unit decrease	0.0134	EFO_0004784
ENSG00000204120	rs6704768	2	232727791	A	Self-reported math ability (MTAG)	30038396	[0.016-0.023] unit decrease	0.0193	EFO_0004875
ENSG00000204120	rs6704768	2	232727791	A	Highest math class taken (MTAG)	30038396	[0.018-0.024] unit decrease	0.021	EFO_0004875
ENSG00000204120	rs12694917	2	232842901	T	Cognitive performance (MTAG)	30038396	[0.012-0.022] unit increase	0.017	EFO_0008354
ENSG00000204120	rs4144797	2	232697487	?	Schizophrenia	29483656	[1.07-1.1]	1.085	EFO_0000692
ENSG00000204120	rs6704768	2	232727791	A	Educational attainment (years of education)	30038396	[0.0089-0.0143] unit decrease	0.0116	EFO_0004784

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204120's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000204120	GIGYF2	100	100.000	ENSMUSG00000048000	Gigyf2	100	96.429	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	20670374.20696395.20878056.27157137.	IPI	Function
GO:0005768	endosome	20670374.	IDA	Component
GO:0005783	endoplasmic reticulum	20696395.	IDA	Component
GO:0005794	Golgi apparatus	20696395.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0007631	feeding behavior	-	IEA	Process
GO:0008344	adult locomotory behavior	-	IEA	Process
GO:0009791	post-embryonic development	-	IEA	Process
GO:0010494	cytoplasmic stress granule	20696395.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016441	posttranscriptional gene silencing	27157137.	IDA	Process
GO:0017148	negative regulation of translation	22751931.	IMP	Process
GO:0021522	spinal cord motor neuron differentiation	-	IEA	Process
GO:0031571	mitotic G1 DNA damage checkpoint	-	IEA	Process
GO:0032991	protein-containing complex	20878056.	IDA	Component
GO:0035264	multicellular organism growth	-	IEA	Process
GO:0043204	perikaryon	20670374.	IDA	Component
GO:0044267	cellular protein metabolic process	-	IEA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0048009	insulin-like growth factor receptor signaling pathway	20670374.	IMP	Process
GO:0048873	homeostasis of number of cells within a tissue	-	IEA	Process
GO:0050881	musculoskeletal movement	-	IEA	Process
GO:0050885	neuromuscular process controlling balance	-	IEA	Process
GO:0061157	mRNA destabilization	27157137.	IDA	Process
GO:0070064	proline-rich region binding	20696395.	IDA	Function
GO:1990635	proximal dendrite	20670374.	IDA	Component