EuRBPDB

Description

Ensembl ID: ENSG00000204256 (Gene tree)
Gene ID: 6046
Gene Symbol: BRD2
Alias: KIAA9001|RING3|D6S113E|NAT|FSRG1|BRD2-IT1
Full Name: bromodomain containing 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 12,846 bases
Position: chr6:32,968,660-32,981,505
Accession: 1103
RBP type: non-canonical RBP
Summary: This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20422051	Single cell analysis of transcriptional activation dynamics.	PLoS One	2010 Apr 21	Rafalska-Metcalf IU	doi: 10.1371/journal.pone.0010272.
31311960	Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production.	Sci Rep	2019 Jul 16	Gibbons HR	doi: 10.1038/s41598-019-46516-x.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000495733	BRD2-213	3404	-	ENSP00000436322	401 (aa)	-	E9PIQ3
ENST00000463639	BRD2-207	946	-	-	- (aa)	-	-
ENST00000469132	BRD2-209	1628	-	-	- (aa)	-	-
ENST00000606059	BRD2-218	565	-	ENSP00000475288	159 (aa)	-	U3KPW0
ENST00000482914	BRD2-212	4834	-	ENSP00000431514	147 (aa)	-	E9PKQ9
ENST00000584808	BRD2-217	547	-	-	- (aa)	-	-
ENST00000395287	BRD2-203	3467	-	ENSP00000378702	836 (aa)	-	P25440
ENST00000449025	BRD2-204	3210	-	ENSP00000409613	807 (aa)	-	H0Y6K2
ENST00000481259	BRD2-210	667	-	ENSP00000433751	137 (aa)	-	H0YDJ7
ENST00000607833	BRD2-219	2338	-	ENSP00000475691	552 (aa)	-	U3KQA6
ENST00000374825	BRD2-201	4894	-	ENSP00000363958	801 (aa)	-	P25440
ENST00000464592	BRD2-208	1590	-	-	- (aa)	-	-
ENST00000374831	BRD2-202	4807	-	ENSP00000363964	801 (aa)	-	P25440
ENST00000456339	BRD2-206	887	-	ENSP00000411195	296 (aa)	-	H0Y799
ENST00000482838	BRD2-211	759	-	-	- (aa)	-	-
ENST00000580234	BRD2-215	718	-	-	- (aa)	-	-
ENST00000581002	BRD2-216	550	-	-	- (aa)	-	-
ENST00000496118	BRD2-214	735	-	ENSP00000464077	162 (aa)	-	J3QR72
ENST00000449085	BRD2-205	3210	-	ENSP00000409145	754 (aa)	-	P25440

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000204256	Triglycerides	8.89171146536435E-5	17903299
ENSG00000204256	Triglycerides	5.60146183386526E-5	17903299
ENSG00000204256	Blood Pressure	6.4190000E-005	-
ENSG00000204256	Blood Pressure	9.6690000E-005	-
ENSG00000204256	Platelet Function Tests	1.6634800E-005	-
ENSG00000204256	Platelet Function Tests	1.3600800E-005	-
ENSG00000204256	Dextroamphetamine	2.5861000E-005	-
ENSG00000204256	Crohn Disease	3E-7	28008999
ENSG00000204256	Immunoglobulins	5E-6	23382691
ENSG00000204256	Inflammatory Bowel Diseases	2E-8	28008999
ENSG00000204256	Crohn Disease	5E-9	28008999
ENSG00000204256	Crohn Disease	3E-6	28008999
ENSG00000204256	Inflammatory Bowel Diseases	9E-10	28008999
ENSG00000204256	Immunoglobulins	6E-7	23382691
ENSG00000204256	Immunoglobulins	6E-6	23382691
ENSG00000204256	Immunoglobulins	6E-6	23382691
ENSG00000204256	Immunoglobulins	7E-6	23382691
ENSG00000204256	Immunoglobulins	3E-6	23382691
ENSG00000204256	Colitis, Ulcerative	3E-7	28008999
ENSG00000204256	Colitis, Ulcerative	2E-8	28008999
ENSG00000204256	Inflammatory Bowel Diseases	5E-11	28008999
ENSG00000204256	Immunoglobulins	2E-6	23382691
ENSG00000204256	Asthma	4E-9	21804548

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000204256	rs1049526	6	32981027	?	Ulcerative colitis	28008999	[1.74-3.26]	2.3810558	EFO_0000729
ENSG00000204256	rs1049526	6	32981027	?	Ulcerative colitis	28008999	[1.87-3.90]	2.697503	EFO_0000729
ENSG00000204256	rs1049526	6	32981027	?	Inflammatory bowel disease	28008999	[1.83-3.24]	2.434453	EFO_0003767
ENSG00000204256	rs1049526	6	32981027	?	Inflammatory bowel disease	28008999	[1.73-3.19]	2.3504539	EFO_0003767
ENSG00000204256	rs1049526	6	32981027	?	Inflammatory bowel disease	28008999	[1.93-3.66]	2.659634	EFO_0003767
ENSG00000204256	rs1049526	6	32981027	?	Crohn's disease	28008999	[1.79-3.33]	2.4428785	EFO_0000384
ENSG00000204256	rs1049526	6	32981027	?	Crohn's disease	28008999	[1.73-3.70]	2.530363	EFO_0000384
ENSG00000204256	rs1049526	6	32981027	?	Crohn's disease	28008999	[1.72-3.42]	2.4273632	EFO_0000384
ENSG00000204256	rs3918142	6	32977922	?	Tonsillectomy	28928442	[0.072-0.162] unit decrease	0.117	EFO_0007924
ENSG00000204256	rs76088152	6	32978545	?	Tuberculosis	28928442	[0.16-0.32] unit decrease	0.2377	EFO_0008407

Protein-Protein Interaction (PPI)

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000204256	BRD2	88	66.116	ENSG00000169925	BRD3	82	80.620	Homo_sapiens
ENSG00000204256	BRD2	100	98.551	ENSMUSG00000024335	Brd2	98	100.000	Mus_musculus
ENSG00000204256	BRD2	88	67.769	ENSMUSG00000026918	Brd3	88	80.952	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003682	chromatin binding	18406326.	IDA	Function
GO:0005515	protein binding	20709061.24229708.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006334	nucleosome assembly	18406326.	IMP	Process
GO:0006357	regulation of transcription by RNA polymerase II	18406326.	IDA	Process
GO:0007283	spermatogenesis	9693039.	TAS	Process
GO:0016032	viral process	-	IEA	Process
GO:0016607	nuclear speck	-	IDA	Component
GO:0070577	lysine-acetylated histone binding	18406326.	IDA	Function