EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000204348 (Gene tree)
Gene ID: 1797
Gene Symbol: DXO
Alias: DOM3Z
Full Name: decapping exoribonuclease
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 2,483 bases
Position: chr6:31,969,810-31,972,292
Accession: 2992
RBP type: canonical RBP
Summary: This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000337759	RAI1	PF08652.11	6.2e-22	1	1
ENSP00000364498	RAI1	PF08652.11	6.2e-22	1	1
ENSP00000364505	RAI1	PF08652.11	6.2e-22	1	1
ENSP00000419588	RAI1	PF08652.11	7.4e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000485557	DXO-210	1878	-	-	- (aa)	-	-
ENST00000460058	DXO-204	737	-	-	- (aa)	-	-
ENST00000474587	DXO-206	1115	-	-	- (aa)	-	-
ENST00000480240	DXO-209	1346	-	ENSP00000418632	210 (aa)	-	F8WC68
ENST00000337523	DXO-201	1628	-	ENSP00000337759	396 (aa)	-	O77932
ENST00000478221	DXO-208	1132	-	-	- (aa)	-	-
ENST00000473976	DXO-205	2025	-	-	- (aa)	-	-
ENST00000487914	DXO-211	1016	-	-	- (aa)	-	-
ENST00000477826	DXO-207	2093	-	-	- (aa)	-	-
ENST00000495340	DXO-214	586	XM_017010329	ENSP00000419588	174 (aa)	XP_016865818	H7C5D2
ENST00000491327	DXO-212	1395	-	-	- (aa)	-	-
ENST00000375356	DXO-203	1533	-	ENSP00000364505	396 (aa)	-	O77932
ENST00000498357	DXO-215	1625	-	-	- (aa)	-	-
ENST00000375349	DXO-202	1667	XM_006715005	ENSP00000364498	396 (aa)	XP_006715068	O77932
ENST00000492946	DXO-213	1474	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000204348's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000204348	Lupus Erythematosus, Systemic	2.0759E-18	18204098
ENSG00000204348	Diabetes Mellitus, Type 1	8.47E-87	19430480
ENSG00000204348	Lupus Erythematosus, Systemic	9.42E-8	18204446
ENSG00000204348	Macular Degeneration	6.95E-9	-
ENSG00000204348	Macular Degeneration	1.914E-08	20385819
ENSG00000204348	Macular Degeneration	9.331E-05	20385819
ENSG00000204348	Glomerulonephritis, Membranous	8E-66	21323541
ENSG00000204348	Leukocyte Count	2E-8	23263863

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000204348	rs45531831	6	31970343	T	Blood protein levels	29875488	[1.59-1.91] unit decrease	1.75	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204348's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000204348	DXO	94	53.175	ENSAPOG00000017890	DXO	88	52.646	Acanthochromis_polyacanthus
ENSG00000204348	DXO	100	90.152	ENSAMEG00000002151	DXO	97	90.415	Ailuropoda_melanoleuca
ENSG00000204348	DXO	91	53.951	ENSAOCG00000001719	DXO	85	53.406	Amphiprion_ocellaris
ENSG00000204348	DXO	91	54.223	ENSAPEG00000012237	DXO	85	53.678	Amphiprion_percula
ENSG00000204348	DXO	92	52.830	ENSATEG00000024423	DXO	84	52.446	Anabas_testudineus
ENSG00000204348	DXO	98	61.168	ENSACAG00000012071	DXO	93	61.658	Anolis_carolinensis
ENSG00000204348	DXO	100	96.970	ENSANAG00000020757	DXO	92	96.970	Aotus_nancymaae
ENSG00000204348	DXO	91	54.743	ENSACLG00000027873	DXO	86	54.201	Astatotilapia_calliptera
ENSG00000204348	DXO	90	57.341	ENSAMXG00000032987	DXO	86	57.064	Astyanax_mexicanus
ENSG00000204348	DXO	98	90.102	ENSBTAG00000005588	DXO	97	90.231	Bos_taurus
ENSG00000204348	DXO	100	96.717	ENSCJAG00000002246	DXO	100	96.717	Callithrix_jacchus
ENSG00000204348	DXO	90	89.106	ENSCAFG00000000694	DXO	97	89.106	Canis_familiaris
ENSG00000204348	DXO	97	90.933	ENSCAFG00020000953	DXO	97	90.933	Canis_lupus_dingo
ENSG00000204348	DXO	99	91.049	ENSCHIG00000024555	DXO	98	90.933	Capra_hircus
ENSG00000204348	DXO	100	91.667	ENSTSYG00000037337	DXO	97	91.710	Carlito_syrichta
ENSG00000204348	DXO	51	66.949	ENSCAPG00000008333	-	100	93.220	Cavia_aperea
ENSG00000204348	DXO	100	91.667	ENSCPOG00000015108	DXO	97	91.710	Cavia_porcellus
ENSG00000204348	DXO	100	97.475	ENSCCAG00000036575	DXO	100	97.475	Cebus_capucinus
ENSG00000204348	DXO	100	98.232	ENSCATG00000001700	DXO	100	98.232	Cercocebus_atys
ENSG00000204348	DXO	97	90.415	ENSCLAG00000006682	DXO	97	90.415	Chinchilla_lanigera
ENSG00000204348	DXO	100	98.232	ENSCSAG00000009007	DXO	100	98.232	Chlorocebus_sabaeus
ENSG00000204348	DXO	90	65.278	ENSCPBG00000001233	DXO	91	65.278	Chrysemys_picta_bellii
ENSG00000204348	DXO	86	39.891	ENSCING00000000512	-	99	39.617	Ciona_intestinalis
ENSG00000204348	DXO	86	38.674	ENSCSAVG00000009527	-	99	38.398	Ciona_savignyi
ENSG00000204348	DXO	100	97.980	ENSCANG00000039839	DXO	100	97.980	Colobus_angolensis_palliatus
ENSG00000204348	DXO	100	88.221	ENSCGRG00001001718	Dxo	96	93.043	Cricetulus_griseus_chok1gshd
ENSG00000204348	DXO	92	53.533	ENSCSEG00000014295	DXO	86	52.989	Cynoglossus_semilaevis
ENSG00000204348	DXO	92	56.948	ENSCVAG00000019072	DXO	87	56.403	Cyprinodon_variegatus
ENSG00000204348	DXO	100	90.404	ENSDNOG00000038155	DXO	97	90.674	Dasypus_novemcinctus
ENSG00000204348	DXO	100	90.176	ENSDORG00000011708	Dxo	97	90.181	Dipodomys_ordii
ENSG00000204348	DXO	99	86.548	ENSETEG00000009525	DXO	98	86.269	Echinops_telfairi
ENSG00000204348	DXO	91	51.657	ENSEBUG00000003794	DXO	81	51.841	Eptatretus_burgeri
ENSG00000204348	DXO	97	94.301	ENSEASG00005015528	DXO	97	94.301	Equus_asinus_asinus
ENSG00000204348	DXO	97	94.301	ENSECAG00000019694	DXO	97	94.301	Equus_caballus
ENSG00000204348	DXO	79	88.889	ENSEEUG00000005411	DXO	97	88.889	Erinaceus_europaeus
ENSG00000204348	DXO	88	55.337	ENSELUG00000005464	DXO	83	54.372	Esox_lucius
ENSG00000204348	DXO	97	92.228	ENSFCAG00000004520	DXO	97	92.228	Felis_catus
ENSG00000204348	DXO	99	91.560	ENSFDAG00000004264	DXO	98	93.913	Fukomys_damarensis
ENSG00000204348	DXO	91	56.011	ENSFHEG00000014408	DXO	86	55.738	Fundulus_heteroclitus
ENSG00000204348	DXO	89	53.168	ENSGMOG00000008886	DXO	89	52.617	Gadus_morhua
ENSG00000204348	DXO	93	54.545	ENSGAFG00000020264	DXO	88	54.278	Gambusia_affinis
ENSG00000204348	DXO	98	53.671	ENSGACG00000011578	DXO	97	52.972	Gasterosteus_aculeatus
ENSG00000204348	DXO	100	99.747	ENSGGOG00000002277	DXO	100	99.747	Gorilla_gorilla
ENSG00000204348	DXO	91	55.014	ENSHBUG00000012997	DXO	86	54.472	Haplochromis_burtoni
ENSG00000204348	DXO	100	88.889	ENSHGLG00000016572	DOM3Z	100	88.312	Heterocephalus_glaber_female
ENSG00000204348	DXO	100	88.889	ENSHGLG00000016585	DOM3Z	97	89.119	Heterocephalus_glaber_female
ENSG00000204348	DXO	100	88.636	ENSHGLG00100013105	DXO	97	88.860	Heterocephalus_glaber_male
ENSG00000204348	DXO	94	44.032	ENSHCOG00000013410	-	97	43.767	Hippocampus_comes
ENSG00000204348	DXO	91	54.891	ENSHCOG00000018279	DXO	88	54.620	Hippocampus_comes
ENSG00000204348	DXO	90	49.587	ENSHCOG00000018381	DXO	99	49.311	Hippocampus_comes
ENSG00000204348	DXO	91	47.802	ENSHCOG00000018327	DXO	89	47.527	Hippocampus_comes
ENSG00000204348	DXO	90	56.044	ENSIPUG00000002976	dxo	91	53.886	Ictalurus_punctatus
ENSG00000204348	DXO	99	92.152	ENSSTOG00000027075	DXO	97	92.228	Ictidomys_tridecemlineatus
ENSG00000204348	DXO	100	87.626	ENSJJAG00000016118	Dxo	97	87.824	Jaculus_jaculus
ENSG00000204348	DXO	94	55.000	ENSKMAG00000018985	DXO	88	55.108	Kryptolebias_marmoratus
ENSG00000204348	DXO	91	54.201	ENSLBEG00000025439	DXO	86	53.930	Labrus_bergylta
ENSG00000204348	DXO	91	55.801	ENSLACG00000011329	DXO	99	55.801	Latimeria_chalumnae
ENSG00000204348	DXO	92	55.319	ENSLOCG00000008086	DXO	91	53.846	Lepisosteus_oculatus
ENSG00000204348	DXO	100	92.929	ENSLAFG00000014243	DXO	97	93.005	Loxodonta_africana
ENSG00000204348	DXO	100	97.980	ENSMFAG00000042173	DXO	100	97.980	Macaca_fascicularis
ENSG00000204348	DXO	100	98.232	ENSMMUG00000000741	DXO	100	98.232	Macaca_mulatta
ENSG00000204348	DXO	100	97.727	ENSMNEG00000032201	DXO	100	97.727	Macaca_nemestrina
ENSG00000204348	DXO	100	98.232	ENSMLEG00000035257	DXO	100	98.232	Mandrillus_leucophaeus
ENSG00000204348	DXO	91	54.743	ENSMZEG00005003714	DXO	86	54.201	Maylandia_zebra
ENSG00000204348	DXO	97	88.860	ENSMAUG00000022102	Dxo	97	88.889	Mesocricetus_auratus
ENSG00000204348	DXO	97	93.523	ENSMICG00000016605	DXO	97	93.523	Microcebus_murinus
ENSG00000204348	DXO	100	91.414	ENSMOCG00000005928	Dxo	96	93.043	Microtus_ochrogaster
ENSG00000204348	DXO	94	76.884	ENSMODG00000015027	DXO	83	80.226	Monodelphis_domestica
ENSG00000204348	DXO	100	90.152	MGP_CAROLIEiJ_G0021476	Dxo	100	90.678	Mus_caroli
ENSG00000204348	DXO	100	89.899	ENSMUSG00000040482	Dxo	100	91.525	Mus_musculus
ENSG00000204348	DXO	100	90.657	MGP_PahariEiJ_G0020471	Dxo	100	92.373	Mus_pahari
ENSG00000204348	DXO	100	90.404	MGP_SPRETEiJ_G0022381	Dxo	100	91.525	Mus_spretus
ENSG00000204348	DXO	100	88.384	ENSMPUG00000010562	DXO	97	88.601	Mustela_putorius_furo
ENSG00000204348	DXO	98	91.003	ENSMLUG00000027577	DXO	98	90.526	Myotis_lucifugus
ENSG00000204348	DXO	97	88.860	ENSNGAG00000021244	Dxo	96	91.304	Nannospalax_galili
ENSG00000204348	DXO	91	55.014	ENSNBRG00000001675	DXO	86	54.472	Neolamprologus_brichardi
ENSG00000204348	DXO	100	99.242	ENSNLEG00000006470	DXO	100	99.242	Nomascus_leucogenys
ENSG00000204348	DXO	99	83.123	ENSMEUG00000006110	DXO	96	82.990	Notamacropus_eugenii
ENSG00000204348	DXO	97	90.415	ENSODEG00000017552	DXO	96	92.174	Octodon_degus
ENSG00000204348	DXO	94	53.543	ENSONIG00000017143	DXO	90	53.930	Oreochromis_niloticus
ENSG00000204348	DXO	97	92.228	ENSOCUG00000007029	DXO	97	92.228	Oryctolagus_cuniculus
ENSG00000204348	DXO	93	54.692	ENSORLG00000008743	DXO	86	54.620	Oryzias_latipes
ENSG00000204348	DXO	91	54.768	ENSORLG00020018952	DXO	86	54.223	Oryzias_latipes_hni
ENSG00000204348	DXO	93	54.424	ENSORLG00015008419	DXO	86	54.348	Oryzias_latipes_hsok
ENSG00000204348	DXO	91	56.164	ENSOMEG00000011105	DXO	86	55.616	Oryzias_melastigma
ENSG00000204348	DXO	97	92.487	ENSOGAG00000009590	DXO	97	92.487	Otolemur_garnettii
ENSG00000204348	DXO	94	91.371	ENSOARG00000002332	DXO	84	92.507	Ovis_aries
ENSG00000204348	DXO	100	99.495	ENSPPAG00000041236	DXO	100	99.495	Pan_paniscus
ENSG00000204348	DXO	97	91.969	ENSPPRG00000005199	DXO	97	91.969	Panthera_pardus
ENSG00000204348	DXO	97	91.710	ENSPTIG00000021529	DXO	97	91.710	Panthera_tigris_altaica
ENSG00000204348	DXO	100	99.495	ENSPTRG00000045498	-	100	99.495	Pan_troglodytes
ENSG00000204348	DXO	100	99.747	ENSPTRG00000052503	-	100	99.747	Pan_troglodytes
ENSG00000204348	DXO	100	98.232	ENSPANG00000017587	DXO	100	98.232	Papio_anubis
ENSG00000204348	DXO	89	53.541	ENSPMGG00000022188	DXO	81	52.707	Periophthalmus_magnuspinnatus
ENSG00000204348	DXO	100	89.394	ENSPEMG00000009229	Dxo	95	92.982	Peromyscus_maniculatus_bairdii
ENSG00000204348	DXO	99	45.854	ENSPMAG00000008156	DXO	95	56.342	Petromyzon_marinus
ENSG00000204348	DXO	99	82.116	ENSPCIG00000018793	DXO	97	82.216	Phascolarctos_cinereus
ENSG00000204348	DXO	93	55.348	ENSPFOG00000004778	DXO	88	55.080	Poecilia_formosa
ENSG00000204348	DXO	93	55.348	ENSPLAG00000015246	DXO	88	55.080	Poecilia_latipinna
ENSG00000204348	DXO	93	55.348	ENSPMEG00000001371	DXO	88	55.080	Poecilia_mexicana
ENSG00000204348	DXO	100	98.990	ENSPPYG00000016473	DXO	100	98.990	Pongo_abelii
ENSG00000204348	DXO	97	90.130	ENSPCAG00000004354	DXO	97	90.130	Procavia_capensis
ENSG00000204348	DXO	100	93.434	ENSPCOG00000016641	DXO	97	93.523	Propithecus_coquereli
ENSG00000204348	DXO	100	91.414	ENSPVAG00000005137	DXO	97	91.710	Pteropus_vampyrus
ENSG00000204348	DXO	91	54.201	ENSPNYG00000018482	DXO	86	53.659	Pundamilia_nyererei
ENSG00000204348	DXO	90	57.341	ENSPNAG00000016499	DXO	86	56.787	Pygocentrus_nattereri
ENSG00000204348	DXO	100	90.657	ENSRNOG00000000422	Dxo	97	90.933	Rattus_norvegicus
ENSG00000204348	DXO	100	98.485	ENSRBIG00000044693	DXO	100	98.485	Rhinopithecus_bieti
ENSG00000204348	DXO	100	98.737	ENSRROG00000035555	DXO	100	98.737	Rhinopithecus_roxellana
ENSG00000204348	DXO	100	97.475	ENSSBOG00000035395	DXO	100	97.475	Saimiri_boliviensis_boliviensis
ENSG00000204348	DXO	99	80.711	ENSSHAG00000009052	DXO	98	80.412	Sarcophilus_harrisii
ENSG00000204348	DXO	95	54.082	ENSSFOG00015003736	dxo	86	56.389	Scleropages_formosus
ENSG00000204348	DXO	93	54.692	ENSSMAG00000015443	DXO	87	54.155	Scophthalmus_maximus
ENSG00000204348	DXO	94	52.394	ENSSDUG00000009756	DXO	92	52.235	Seriola_dumerili
ENSG00000204348	DXO	97	52.747	ENSSLDG00000022817	DXO	84	51.913	Seriola_lalandi_dorsalis
ENSG00000204348	DXO	85	62.222	ENSSPUG00000012861	DXO	76	63.314	Sphenodon_punctatus
ENSG00000204348	DXO	94	52.255	ENSSPAG00000009427	DXO	87	51.724	Stegastes_partitus
ENSG00000204348	DXO	97	91.192	ENSSSCG00000001425	DXO	97	91.192	Sus_scrofa
ENSG00000204348	DXO	94	51.862	ENSTRUG00000021219	DXO	91	51.330	Takifugu_rubripes
ENSG00000204348	DXO	91	49.727	ENSTNIG00000000151	-	97	49.584	Tetraodon_nigroviridis
ENSG00000204348	DXO	94	89.340	ENSTTRG00000005937	DXO	97	80.570	Tursiops_truncatus
ENSG00000204348	DXO	100	86.111	ENSUAMG00000024335	DXO	97	86.010	Ursus_americanus
ENSG00000204348	DXO	100	90.404	ENSUMAG00000012641	DXO	97	90.415	Ursus_maritimus
ENSG00000204348	DXO	54	91.150	ENSVPAG00000000292	-	99	92.893	Vicugna_pacos
ENSG00000204348	DXO	97	90.674	ENSVVUG00000023270	DXO	96	93.043	Vulpes_vulpes
ENSG00000204348	DXO	96	53.608	ENSXETG00000027585	dxo	99	53.093	Xenopus_tropicalis
ENSG00000204348	DXO	93	54.278	ENSXMAG00000001092	DXO	88	54.011	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000166	nucleotide binding	-	IEA	Function
GO:0000287	magnesium ion binding	-	ISS	Function
GO:0003729	mRNA binding	-	ISS	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006402	mRNA catabolic process	-	ISS	Process
GO:0008409	5'-3' exonuclease activity	-	ISS	Function
GO:0034353	RNA pyrophosphohydrolase activity	-	ISS	Function
GO:0050779	RNA destabilization	-	ISS	Process
GO:0071028	nuclear mRNA surveillance	-	ISS	Process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	ISS	Process