EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000204356 (Gene tree)
Gene ID: 7936
Gene Symbol: NELFE
Alias: RD|D6S45|NELF-E|RDP|RDBP
Full Name: negative elongation factor complex member E
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 7,024 bases
Position: chr6:31,952,087-31,959,110
Accession: 13974
RBP type: canonical RBP
Summary: The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000397914	RRM_1	PF00076.22	7.8e-11	1	1
ENSP00000388400	RRM_1	PF00076.22	8.3e-11	1	1
ENSP00000364578	RRM_1	PF00076.22	9.6e-11	1	1
ENSP00000364574	RRM_1	PF00076.22	9.9e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12612062	Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.	Mol Cell Biol	2003 Mar	Narita T	-
11940650	Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA.	Mol Cell Biol	2002 May	Yamaguchi Y	-
19556007	Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology.	Ophthalmology	2009 Aug	Kondo N	doi: 10.1016/j.ophtha.2009.03.004
22614758	Overexpression of the RD RNA binding protein in hepatitis C virus-related hepatocellular carcinoma.	Oncol Rep	2012 Aug	Iida M	doi: 10.3892/or.2012.1821
24453987	Defining NELF-E RNA binding in HIV-1 and promoter-proximal pause regions.	PLoS Genet	2014 Jan	Pagano JM	doi: 10.1371/journal.pgen.1004090
28697339	Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma.	Cancer Cell	2017 Jul 10	Dang H	doi: 10.1016/j.ccell.2017.06.002.
29523821	p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage.	Nat Commun	2018 Mar 9	Borisova ME	doi: 10.1038/s41467-018-03417-3.
30833661	NELFE-Dependent MYC Signature Identifies a Unique Cancer Subtype in Hepatocellular Carcinoma.	Sci Rep	2019 Mar 4	Dang H	doi: 10.1038/s41598-019-39727-9.
24809628	Comprehensive analysis of RNA-protein interactions by high-throughput sequencing-RNA affinity profiling.	Nat Methods	2014 Jun	Tome JM	doi: 10.1038/nmeth.2970
24553662	High-throughput binding characterization of RNA aptamer selections using a microplate-based multiplex microcolumn device.	Anal Bioanal Chem	2014 Apr	Szeto K	doi: 10.1007/s00216-014-7661-7

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000488426	NELFE-209	1855	-	-	- (aa)	-	-
ENST00000375425	NELFE-201	1405	-	ENSP00000364574	387 (aa)	-	P18615
ENST00000375429	NELFE-202	1584	XM_006715205	ENSP00000364578	380 (aa)	XP_006715268	P18615
ENST00000481121	NELFE-208	1543	-	-	- (aa)	-	-
ENST00000444811	NELFE-206	1202	-	ENSP00000388400	350 (aa)	-	P18615
ENST00000492539	NELFE-212	583	-	ENSP00000419183	57 (aa)	-	E7EWR7
ENST00000426722	NELFE-203	765	-	ENSP00000394340	159 (aa)	-	A2ABK4
ENST00000494956	NELFE-213	568	-	ENSP00000420205	36 (aa)	-	E7ENC7
ENST00000454913	NELFE-207	914	-	ENSP00000409389	293 (aa)	-	A0A0A0MT02
ENST00000492185	NELFE-211	1786	-	-	- (aa)	-	-
ENST00000436289	NELFE-204	906	-	ENSP00000414029	260 (aa)	-	E9PD43
ENST00000491139	NELFE-210	582	-	-	- (aa)	-	-
ENST00000441998	NELFE-205	1075	-	ENSP00000397914	333 (aa)	-	A0A0A0MSN9
ENST00000625905	NELFE-214	111	-	ENSP00000486884	36 (aa)	-	E7ENC7

Gene Model

Click here to download ENSG00000204356's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000204356	Breast Neoplasms	1.47E-10	17660530
ENSG00000204356	Macular Degeneration	5.68E-19	-
ENSG00000204356	Macular Degeneration	6.1E-10	-
ENSG00000204356	Macular Degeneration	4.889E-18	20385819
ENSG00000204356	Macular Degeneration	1.74E-09	20385819
ENSG00000204356	Macular Degeneration	3E-7	23577725
ENSG00000204356	Macular Degeneration	2E-10	23577725

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000204356	rs9501161	6	31956550	A	Blood protein levels	29875488	[0.21-0.37] unit decrease	0.29	EFO_0007937
ENSG00000204356	rs35917342	6	31955937	AT	Blood protein levels	29875488	[1.1-1.26] unit increase	1.18	EFO_0007937
ENSG00000204356	rs4151665	6	31953289	C	Blood protein levels	29875488	[0.3-0.5] unit increase	0.4	EFO_0007937
ENSG00000204356	rs522162	6	31952140	?	Age-related macular degeneration	23577725	[1.82-3.03]	2.33	EFO_0001365
ENSG00000204356	rs522162	6	31952140	?	Age-related macular degeneration (extreme sampling)	23577725	[1.69-3.33]	2.38	EFO_0001365
ENSG00000204356	rs550513	6	31952910	T	Blood protein levels	28240269	[0.55-0.85] unit increase	0.702	EFO_0008096
ENSG00000204356	rs80082277	6	31958071	C	vWF levels	30586737	[0.035-0.073] unit decrease	0.0536	EFO_0004629

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204356's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000204356	NELFE	91	74.483	ENSAPOG00000008274	nelfe	99	68.079	Acanthochromis_polyacanthus
ENSG00000204356	NELFE	100	98.742	ENSAMEG00000002062	NELFE	99	96.364	Ailuropoda_melanoleuca
ENSG00000204356	NELFE	91	75.172	ENSAOCG00000017263	nelfe	99	68.378	Amphiprion_ocellaris
ENSG00000204356	NELFE	91	75.172	ENSAPEG00000001209	nelfe	99	70.809	Amphiprion_percula
ENSG00000204356	NELFE	86	77.372	ENSATEG00000007587	nelfe	90	67.204	Anabas_testudineus
ENSG00000204356	NELFE	98	77.707	ENSACAG00000011678	NELFE	100	69.149	Anolis_carolinensis
ENSG00000204356	NELFE	100	98.742	ENSANAG00000038256	NELFE	100	97.368	Aotus_nancymaae
ENSG00000204356	NELFE	91	74.483	ENSACLG00000006848	nelfe	99	66.573	Astatotilapia_calliptera
ENSG00000204356	NELFE	97	74.839	ENSAMXG00000011495	nelfe	99	67.751	Astyanax_mexicanus
ENSG00000204356	NELFE	100	98.113	ENSBTAG00000007453	NELFE	100	95.263	Bos_taurus
ENSG00000204356	NELFE	100	99.371	ENSCJAG00000002368	-	100	97.416	Callithrix_jacchus
ENSG00000204356	NELFE	100	98.742	ENSCAFG00020000938	NELFE	100	95.789	Canis_lupus_dingo
ENSG00000204356	NELFE	100	98.113	ENSCHIG00000013713	NELFE	100	93.947	Capra_hircus
ENSG00000204356	NELFE	100	96.855	ENSTSYG00000012132	-	100	94.359	Carlito_syrichta
ENSG00000204356	NELFE	97	92.453	ENSCAPG00000015145	NELFE	89	95.252	Cavia_aperea
ENSG00000204356	NELFE	100	96.226	ENSCPOG00000031829	NELFE	100	95.288	Cavia_porcellus
ENSG00000204356	NELFE	100	99.371	ENSCCAG00000014945	NELFE	100	97.135	Cebus_capucinus
ENSG00000204356	NELFE	100	99.371	ENSCATG00000028969	NELFE	100	97.668	Cercocebus_atys
ENSG00000204356	NELFE	100	94.474	ENSCLAG00000009684	NELFE	100	94.474	Chinchilla_lanigera
ENSG00000204356	NELFE	100	99.371	ENSCSAG00000008969	NELFE	100	97.368	Chlorocebus_sabaeus
ENSG00000204356	NELFE	91	82.192	ENSCPBG00000000225	NELFE	97	58.754	Chrysemys_picta_bellii
ENSG00000204356	NELFE	53	48.529	ENSCSAVG00000004231	-	84	37.168	Ciona_savignyi
ENSG00000204356	NELFE	100	99.371	ENSCANG00000022451	NELFE	100	97.468	Colobus_angolensis_palliatus
ENSG00000204356	NELFE	100	96.226	ENSCGRG00001016608	Nelfe	100	91.777	Cricetulus_griseus_chok1gshd
ENSG00000204356	NELFE	93	89.375	ENSCGRG00000014034	Nelfe	90	90.964	Cricetulus_griseus_crigri
ENSG00000204356	NELFE	91	71.724	ENSCSEG00000011352	nelfe	99	67.246	Cynoglossus_semilaevis
ENSG00000204356	NELFE	91	76.552	ENSCVAG00000003087	nelfe	99	68.497	Cyprinodon_variegatus
ENSG00000204356	NELFE	91	71.034	ENSDARG00000004343	nelfe	100	68.012	Danio_rerio
ENSG00000204356	NELFE	93	80.563	ENSDNOG00000006996	-	94	81.493	Dasypus_novemcinctus
ENSG00000204356	NELFE	100	98.742	ENSDNOG00000041886	-	100	95.812	Dasypus_novemcinctus
ENSG00000204356	NELFE	100	98.113	ENSDORG00000011705	Nelfe	89	78.611	Dipodomys_ordii
ENSG00000204356	NELFE	92	66.892	ENSEBUG00000017070	nelfe	99	59.563	Eptatretus_burgeri
ENSG00000204356	NELFE	100	98.742	ENSEASG00005015538	NELFE	100	94.402	Equus_asinus_asinus
ENSG00000204356	NELFE	100	98.742	ENSECAG00000012274	NELFE	88	97.403	Equus_caballus
ENSG00000204356	NELFE	100	95.597	ENSEEUG00000005004	NELFE	75	97.778	Erinaceus_europaeus
ENSG00000204356	NELFE	99	69.182	ENSELUG00000005830	nelfe	71	76.289	Esox_lucius
ENSG00000204356	NELFE	100	98.742	ENSFCAG00000004518	NELFE	100	97.368	Felis_catus
ENSG00000204356	NELFE	100	94.969	ENSFDAG00000011589	NELFE	100	85.175	Fukomys_damarensis
ENSG00000204356	NELFE	91	76.552	ENSFHEG00000008694	nelfe	99	68.000	Fundulus_heteroclitus
ENSG00000204356	NELFE	91	82.192	ENSGALG00000045676	NELFE	95	76.378	Gallus_gallus
ENSG00000204356	NELFE	99	58.861	ENSGAFG00000002349	nelfe	87	65.667	Gambusia_affinis
ENSG00000204356	NELFE	91	74.483	ENSGACG00000002935	nelfe	99	66.667	Gasterosteus_aculeatus
ENSG00000204356	NELFE	91	82.192	ENSGAGG00000005411	NELFE	100	65.517	Gopherus_agassizii
ENSG00000204356	NELFE	100	99.371	ENSGGOG00000002265	NELFE	100	97.933	Gorilla_gorilla
ENSG00000204356	NELFE	91	74.483	ENSHBUG00000023659	nelfe	99	69.253	Haplochromis_burtoni
ENSG00000204356	NELFE	72	87.591	ENSHGLG00000016601	NELFE	92	87.004	Heterocephalus_glaber_female
ENSG00000204356	NELFE	97	88.387	ENSHGLG00100014073	NELFE	100	73.077	Heterocephalus_glaber_male
ENSG00000204356	NELFE	91	73.793	ENSHCOG00000007147	nelfe	97	62.632	Hippocampus_comes
ENSG00000204356	NELFE	99	69.620	ENSIPUG00000016138	nelfe	99	68.529	Ictalurus_punctatus
ENSG00000204356	NELFE	100	96.855	ENSSTOG00000027409	NELFE	100	93.158	Ictidomys_tridecemlineatus
ENSG00000204356	NELFE	94	90.169	ENSJJAG00000014005	Nelfe	90	89.851	Jaculus_jaculus
ENSG00000204356	NELFE	91	76.552	ENSKMAG00000002391	nelfe	99	66.129	Kryptolebias_marmoratus
ENSG00000204356	NELFE	86	75.182	ENSLBEG00000013181	nelfe	100	68.182	Labrus_bergylta
ENSG00000204356	NELFE	100	97.484	ENSLAFG00000028155	NELFE	100	96.073	Loxodonta_africana
ENSG00000204356	NELFE	99	77.143	ENSMFAG00000031089	-	50	69.841	Macaca_fascicularis
ENSG00000204356	NELFE	100	99.371	ENSMFAG00000036108	-	100	99.211	Macaca_fascicularis
ENSG00000204356	NELFE	96	76.316	ENSMMUG00000041521	-	100	76.901	Macaca_mulatta
ENSG00000204356	NELFE	100	99.371	ENSMMUG00000000735	-	100	99.211	Macaca_mulatta
ENSG00000204356	NELFE	100	99.371	ENSMNEG00000032542	NELFE	100	98.438	Macaca_nemestrina
ENSG00000204356	NELFE	100	99.371	ENSMLEG00000030245	NELFE	100	97.710	Mandrillus_leucophaeus
ENSG00000204356	NELFE	99	70.701	ENSMAMG00000003031	nelfe	94	65.897	Mastacembelus_armatus
ENSG00000204356	NELFE	91	74.483	ENSMZEG00005026412	nelfe	99	66.573	Maylandia_zebra
ENSG00000204356	NELFE	62	87.500	ENSMGAG00000001297	NELFE	66	87.500	Meleagris_gallopavo
ENSG00000204356	NELFE	100	94.969	ENSMAUG00000016812	Nelfe	100	85.175	Mesocricetus_auratus
ENSG00000204356	NELFE	100	98.113	ENSMICG00000003287	NELFE	100	92.895	Microcebus_murinus
ENSG00000204356	NELFE	100	96.226	ENSMOCG00000003723	Nelfe	100	93.801	Microtus_ochrogaster
ENSG00000204356	NELFE	91	75.172	ENSMMOG00000014544	nelfe	99	65.882	Mola_mola
ENSG00000204356	NELFE	93	95.946	ENSMODG00000015063	NELFE	96	94.857	Monodelphis_domestica
ENSG00000204356	NELFE	98	69.855	ENSMALG00000010624	nelfe	100	70.317	Monopterus_albus
ENSG00000204356	NELFE	100	94.340	MGP_CAROLIEiJ_G0021478	Nelfe	100	91.689	Mus_caroli
ENSG00000204356	NELFE	100	94.340	ENSMUSG00000024369	Nelfe	100	91.644	Mus_musculus
ENSG00000204356	NELFE	100	94.969	MGP_PahariEiJ_G0020473	Nelfe	100	92.453	Mus_pahari
ENSG00000204356	NELFE	100	94.340	MGP_SPRETEiJ_G0022383	Nelfe	100	91.689	Mus_spretus
ENSG00000204356	NELFE	100	98.742	ENSMPUG00000010581	NELFE	99	96.104	Mustela_putorius_furo
ENSG00000204356	NELFE	100	96.855	ENSMLUG00000000622	-	99	91.384	Myotis_lucifugus
ENSG00000204356	NELFE	100	83.684	ENSMLUG00000030380	-	100	79.221	Myotis_lucifugus
ENSG00000204356	NELFE	99	72.487	ENSMLUG00000028808	-	100	75.397	Myotis_lucifugus
ENSG00000204356	NELFE	100	80.469	ENSMLUG00000028069	-	100	79.744	Myotis_lucifugus
ENSG00000204356	NELFE	100	85.093	ENSMLUG00000028182	-	100	80.412	Myotis_lucifugus
ENSG00000204356	NELFE	100	98.113	ENSNGAG00000016248	Nelfe	100	90.027	Nannospalax_galili
ENSG00000204356	NELFE	91	67.785	ENSNBRG00000018756	nelfe	99	68.421	Neolamprologus_brichardi
ENSG00000204356	NELFE	100	83.073	ENSMEUG00000006053	NELFE	100	83.333	Notamacropus_eugenii
ENSG00000204356	NELFE	100	96.855	ENSOPRG00000003942	NELFE	100	93.005	Ochotona_princeps
ENSG00000204356	NELFE	100	96.226	ENSODEG00000017670	NELFE	100	95.418	Octodon_degus
ENSG00000204356	NELFE	91	75.172	ENSONIG00000013513	nelfe	99	69.209	Oreochromis_niloticus
ENSG00000204356	NELFE	100	98.742	ENSOCUG00000007012	NELFE	100	95.103	Oryctolagus_cuniculus
ENSG00000204356	NELFE	86	74.638	ENSORLG00000001948	nelfe	61	63.934	Oryzias_latipes
ENSG00000204356	NELFE	86	74.638	ENSORLG00020000791	nelfe	99	66.038	Oryzias_latipes_hni
ENSG00000204356	NELFE	86	73.913	ENSORLG00015016824	nelfe	99	65.527	Oryzias_latipes_hsok
ENSG00000204356	NELFE	91	73.288	ENSOMEG00000008581	nelfe	99	57.618	Oryzias_melastigma
ENSG00000204356	NELFE	99	98.101	ENSOGAG00000009574	NELFE	99	95.561	Otolemur_garnettii
ENSG00000204356	NELFE	100	98.113	ENSOARG00000002616	NELFE	99	94.256	Ovis_aries
ENSG00000204356	NELFE	100	99.371	ENSPPAG00000039942	NELFE	100	98.972	Pan_paniscus
ENSG00000204356	NELFE	100	98.742	ENSPPRG00000004421	NELFE	100	97.368	Panthera_pardus
ENSG00000204356	NELFE	100	98.742	ENSPTIG00000003753	NELFE	100	97.368	Panthera_tigris_altaica
ENSG00000204356	NELFE	100	98.742	ENSPTRG00000017996	NELFE	100	98.715	Pan_troglodytes
ENSG00000204356	NELFE	100	99.371	ENSPANG00000019366	NELFE	100	97.710	Papio_anubis
ENSG00000204356	NELFE	97	72.674	ENSPKIG00000012048	nelfe	99	72.093	Paramormyrops_kingsleyae
ENSG00000204356	NELFE	75	73.950	ENSPMGG00000019716	nelfe	99	63.395	Periophthalmus_magnuspinnatus
ENSG00000204356	NELFE	100	95.597	ENSPEMG00000015423	Nelfe	100	91.467	Peromyscus_maniculatus_bairdii
ENSG00000204356	NELFE	92	95.890	ENSPCIG00000018791	NELFE	100	81.980	Phascolarctos_cinereus
ENSG00000204356	NELFE	99	71.975	ENSPFOG00000003019	nelfe	99	67.797	Poecilia_formosa
ENSG00000204356	NELFE	99	71.975	ENSPLAG00000018174	nelfe	96	68.286	Poecilia_latipinna
ENSG00000204356	NELFE	99	71.975	ENSPMEG00000006918	nelfe	96	67.797	Poecilia_mexicana
ENSG00000204356	NELFE	70	76.786	ENSPREG00000002338	nelfe	89	52.367	Poecilia_reticulata
ENSG00000204356	NELFE	100	98.691	ENSPPYG00000016471	NELFE	100	98.691	Pongo_abelii
ENSG00000204356	NELFE	68	94.186	ENSPCAG00000004108	NELFE	68	93.411	Procavia_capensis
ENSG00000204356	NELFE	100	96.855	ENSPCOG00000024944	NELFE	100	95.526	Propithecus_coquereli
ENSG00000204356	NELFE	100	98.113	ENSPVAG00000005135	NELFE	100	95.263	Pteropus_vampyrus
ENSG00000204356	NELFE	91	74.483	ENSPNYG00000017837	nelfe	99	69.253	Pundamilia_nyererei
ENSG00000204356	NELFE	91	75.862	ENSPNAG00000011802	nelfe	99	67.204	Pygocentrus_nattereri
ENSG00000204356	NELFE	100	94.969	ENSRNOG00000000420	Nelfe	100	92.453	Rattus_norvegicus
ENSG00000204356	NELFE	100	99.371	ENSRBIG00000028593	-	100	96.316	Rhinopithecus_bieti
ENSG00000204356	NELFE	97	89.032	ENSRBIG00000028905	-	100	73.670	Rhinopithecus_bieti
ENSG00000204356	NELFE	100	99.371	ENSRROG00000041993	NELFE	100	96.154	Rhinopithecus_roxellana
ENSG00000204356	NELFE	100	99.371	ENSSBOG00000035865	NELFE	100	97.674	Saimiri_boliviensis_boliviensis
ENSG00000204356	NELFE	100	93.082	ENSSHAG00000008908	NELFE	100	89.460	Sarcophilus_harrisii
ENSG00000204356	NELFE	91	75.862	ENSSFOG00015017039	nelfe	99	67.742	Scleropages_formosus
ENSG00000204356	NELFE	91	77.931	ENSSMAG00000020170	nelfe	100	68.800	Scophthalmus_maximus
ENSG00000204356	NELFE	91	75.172	ENSSDUG00000020062	nelfe	99	67.568	Seriola_dumerili
ENSG00000204356	NELFE	91	66.897	ENSSLDG00000024412	nelfe	99	67.341	Seriola_lalandi_dorsalis
ENSG00000204356	NELFE	93	90.986	ENSSARG00000003684	NELFE	94	92.537	Sorex_araneus
ENSG00000204356	NELFE	98	78.981	ENSSPUG00000012971	NELFE	100	64.362	Sphenodon_punctatus
ENSG00000204356	NELFE	91	75.172	ENSSPAG00000012953	nelfe	79	66.667	Stegastes_partitus
ENSG00000204356	NELFE	100	98.742	ENSSSCG00000001423	NELFE	100	96.579	Sus_scrofa
ENSG00000204356	NELFE	91	74.483	ENSTRUG00000025596	nelfe	84	69.653	Takifugu_rubripes
ENSG00000204356	NELFE	100	98.113	ENSTTRG00000005923	NELFE	100	94.474	Tursiops_truncatus
ENSG00000204356	NELFE	100	98.113	ENSUAMG00000024338	NELFE	100	96.073	Ursus_americanus
ENSG00000204356	NELFE	100	98.113	ENSUMAG00000012674	NELFE	100	96.073	Ursus_maritimus
ENSG00000204356	NELFE	87	76.812	ENSXETG00000010931	nelfe	71	77.778	Xenopus_tropicalis
ENSG00000204356	NELFE	97	60.811	ENSXCOG00000019513	nelfe	99	64.826	Xiphophorus_couchianus
ENSG00000204356	NELFE	99	71.975	ENSXMAG00000014078	nelfe	99	67.416	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003682	chromatin binding	-	IEA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003723	RNA binding	2119325.	NAS	Function
GO:0005515	protein binding	12612062.14667819.25416956.26496610.	IPI	Function
GO:0005634	nucleus	2119325.	NAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006366	transcription by RNA polymerase II	-	TAS	Process
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0032021	NELF complex	12612062.	IDA	Component
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter	-	IEA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0050434	positive regulation of viral transcription	-	TAS	Process
GO:0051571	positive regulation of histone H3-K4 methylation	-	IEA	Process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IEA	Process
GO:1900364	negative regulation of mRNA polyadenylation	19575011.	IMP	Process