EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000204394 (Gene tree)
Gene ID: 7407
Gene Symbol: VARS
Alias: VARS2
Full Name: valyl-tRNA synthetase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 18,436 bases
Position: chr6:31,777,518-31,795,953
Accession: 12651
RBP type: canonical RBP
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000364815	tRNA-synt_1g	PF09334.11	5.1e-10	1	1
ENSP00000364815	Anticodon_1	PF08264.13	6.9e-32	1	1
ENSP00000364815	tRNA-synt_1	PF00133.22	5.5e-200	1	1
ENSP00000415679	tRNA-synt_1	PF00133.22	8.8e-66	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000483275	VARS-226	450	-	-	- (aa)	-	-
ENST00000463184	VARS-221	619	-	-	- (aa)	-	-
ENST00000461874	VARS-220	845	-	-	- (aa)	-	-
ENST00000470953	VARS-222	392	-	-	- (aa)	-	-
ENST00000482996	VARS-225	728	-	-	- (aa)	-	-
ENST00000375663	VARS-215	4312	XM_005249362	ENSP00000364815	1264 (aa)	XP_005249419	P26640
ENST00000428445	VARS-216	863	-	ENSP00000415679	288 (aa)	-	H0Y426
ENST00000495010	VARS-228	1007	-	-	- (aa)	-	-
ENST00000461328	VARS-219	662	-	-	- (aa)	-	-
ENST00000479051	VARS-224	612	-	-	- (aa)	-	-
ENST00000459667	VARS-218	793	-	-	- (aa)	-	-
ENST00000489979	VARS-227	658	-	-	- (aa)	-	-
ENST00000474643	VARS-223	885	-	-	- (aa)	-	-
ENST00000440048	VARS-217	804	-	ENSP00000413925	174 (aa)	-	A2ABF4

Gene Model

Click here to download ENSG00000204394's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000204394	Platelet Function Tests	2.8700000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000204394	rs9469054	6	31793286	A	Monocyte count	27863252	[0.084-0.129] unit increase	0.1068719	EFO_0005091
ENSG00000204394	rs2753960	6	31795067	T	Monocyte count	27863252	[0.021-0.035] unit increase	0.02776258	EFO_0005091
ENSG00000204394	rs915652	6	31781365	A	Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome)	26651848			Orphanet_797
ENSG00000204394	rs3115670	6	31794088	T	Mosquito bite size	28199695	[0.049-0.076] unit decrease	0.0626938	EFO_0008378
ENSG00000204394	rs3130491	6	31777687	A	Diastolic blood pressure	30578418	[0.23-0.4] mmHg decrease	0.317	EFO_0006336
ENSG00000204394	rs6899983	6	31791154	?	Aspartate aminotransferase levels in low alcohol consumption	30589442	[0.092-0.202] unit increase	0.1467	EFO_0004736\|EFO_0007878

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204394's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000204394	VARS	96	34.270	ENSG00000254772	EEF1G	57	34.231

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000204394	VARS	99	72.171	ENSAPOG00000020691	vars	99	64.395	Acanthochromis_polyacanthus
ENSG00000204394	VARS	99	72.171	ENSAPOG00000020921	vars	99	64.395	Acanthochromis_polyacanthus
ENSG00000204394	VARS	100	98.276	ENSAMEG00000006417	VARS	100	95.020	Ailuropoda_melanoleuca
ENSG00000204394	VARS	99	73.313	ENSACIG00000013752	vars	100	65.330	Amphilophus_citrinellus
ENSG00000204394	VARS	99	73.313	ENSAOCG00000002447	vars	100	64.201	Amphiprion_ocellaris
ENSG00000204394	VARS	99	73.006	ENSAPEG00000010638	vars	99	64.564	Amphiprion_percula
ENSG00000204394	VARS	99	71.472	ENSATEG00000020219	vars	100	64.145	Anabas_testudineus
ENSG00000204394	VARS	99	74.233	ENSACAG00000029133	-	99	70.165	Anolis_carolinensis
ENSG00000204394	VARS	100	97.701	ENSANAG00000015453	VARS	100	97.627	Aotus_nancymaae
ENSG00000204394	VARS	99	71.779	ENSACLG00000025699	vars	97	64.646	Astatotilapia_calliptera
ENSG00000204394	VARS	99	72.393	ENSAMXG00000017716	vars	95	65.721	Astyanax_mexicanus
ENSG00000204394	VARS	100	96.552	ENSBTAG00000005631	VARS	100	95.016	Bos_taurus
ENSG00000204394	VARS	100	97.706	ENSCJAG00000002604	VARS	100	97.706	Callithrix_jacchus
ENSG00000204394	VARS	100	97.126	ENSCAFG00000000636	VARS	100	94.462	Canis_familiaris
ENSG00000204394	VARS	100	96.552	ENSCAFG00020020790	VARS	96	94.341	Canis_lupus_dingo
ENSG00000204394	VARS	100	95.977	ENSCHIG00000011008	VARS	100	95.095	Capra_hircus
ENSG00000204394	VARS	100	97.701	ENSTSYG00000001567	VARS	100	96.044	Carlito_syrichta
ENSG00000204394	VARS	91	90.398	ENSCAPG00000013736	VARS	99	90.398	Cavia_aperea
ENSG00000204394	VARS	100	91.535	ENSCPOG00000000870	VARS	100	91.535	Cavia_porcellus
ENSG00000204394	VARS	100	97.864	ENSCCAG00000035656	VARS	100	97.864	Cebus_capucinus
ENSG00000204394	VARS	100	98.851	ENSCATG00000022394	VARS	100	98.576	Cercocebus_atys
ENSG00000204394	VARS	99	82.822	ENSCLAG00000009470	VARS	92	89.764	Chinchilla_lanigera
ENSG00000204394	VARS	100	99.051	ENSCSAG00000008784	VARS	100	99.051	Chlorocebus_sabaeus
ENSG00000204394	VARS	99	73.926	ENSCPBG00000007943	VARS	96	74.230	Chrysemys_picta_bellii
ENSG00000204394	VARS	100	98.734	ENSCANG00000033570	VARS	100	98.734	Colobus_angolensis_palliatus
ENSG00000204394	VARS	100	93.117	ENSCGRG00001005686	Vars	100	93.117	Cricetulus_griseus_chok1gshd
ENSG00000204394	VARS	92	88.023	ENSCGRG00000013352	Vars	78	88.023	Cricetulus_griseus_crigri
ENSG00000204394	VARS	99	71.692	ENSCSEG00000019652	vars	100	64.506	Cynoglossus_semilaevis
ENSG00000204394	VARS	99	72.393	ENSCVAG00000022398	vars	100	65.035	Cyprinodon_variegatus
ENSG00000204394	VARS	99	73.006	ENSDARG00000044575	vars	100	64.802	Danio_rerio
ENSG00000204394	VARS	99	84.049	ENSDORG00000016433	Vars	95	93.133	Dipodomys_ordii
ENSG00000204394	VARS	99	79.141	ENSETEG00000003824	VARS	76	86.076	Echinops_telfairi
ENSG00000204394	VARS	99	68.098	ENSEBUG00000004637	vars	100	61.951	Eptatretus_burgeri
ENSG00000204394	VARS	99	68.098	ENSEBUG00000007086	vars	72	69.459	Eptatretus_burgeri
ENSG00000204394	VARS	100	98.276	ENSEASG00005015673	VARS	100	95.807	Equus_asinus_asinus
ENSG00000204394	VARS	100	98.276	ENSECAG00000014620	VARS	100	95.257	Equus_caballus
ENSG00000204394	VARS	83	93.772	ENSEEUG00000004116	VARS	83	93.772	Erinaceus_europaeus
ENSG00000204394	VARS	99	71.779	ENSELUG00000006550	vars	97	64.225	Esox_lucius
ENSG00000204394	VARS	100	97.701	ENSFCAG00000004510	VARS	100	94.937	Felis_catus
ENSG00000204394	VARS	99	82.822	ENSFDAG00000011401	VARS	100	91.546	Fukomys_damarensis
ENSG00000204394	VARS	99	73.006	ENSFHEG00000010672	vars	100	65.113	Fundulus_heteroclitus
ENSG00000204394	VARS	99	71.166	ENSGMOG00000014908	vars	97	65.890	Gadus_morhua
ENSG00000204394	VARS	99	72.699	ENSGAFG00000021630	vars	100	65.370	Gambusia_affinis
ENSG00000204394	VARS	99	70.245	ENSGACG00000009601	vars	98	65.917	Gasterosteus_aculeatus
ENSG00000204394	VARS	100	49.438	ENSGAGG00000006508	-	91	64.669	Gopherus_agassizii
ENSG00000204394	VARS	100	99.425	ENSGGOG00000011364	VARS	100	99.367	Gorilla_gorilla
ENSG00000204394	VARS	99	71.779	ENSHBUG00000017151	vars	97	64.569	Haplochromis_burtoni
ENSG00000204394	VARS	100	94.253	ENSHGLG00000011646	VARS	100	90.269	Heterocephalus_glaber_female
ENSG00000204394	VARS	99	88.502	ENSHGLG00100018062	VARS	100	82.973	Heterocephalus_glaber_male
ENSG00000204394	VARS	99	70.859	ENSHCOG00000012198	vars	99	64.358	Hippocampus_comes
ENSG00000204394	VARS	99	72.393	ENSIPUG00000005218	vars	100	65.058	Ictalurus_punctatus
ENSG00000204394	VARS	100	97.126	ENSSTOG00000013112	VARS	100	94.783	Ictidomys_tridecemlineatus
ENSG00000204394	VARS	100	71.835	ENSJJAG00000015343	-	100	71.835	Jaculus_jaculus
ENSG00000204394	VARS	100	91.379	ENSJJAG00000019749	-	100	90.665	Jaculus_jaculus
ENSG00000204394	VARS	99	71.692	ENSKMAG00000009455	vars	100	64.771	Kryptolebias_marmoratus
ENSG00000204394	VARS	99	72.086	ENSLBEG00000010341	vars	100	64.348	Labrus_bergylta
ENSG00000204394	VARS	93	70.684	ENSLACG00000015232	VARS	99	62.787	Latimeria_chalumnae
ENSG00000204394	VARS	99	73.006	ENSLOCG00000004240	vars	100	66.562	Lepisosteus_oculatus
ENSG00000204394	VARS	100	97.701	ENSLAFG00000023090	VARS	100	93.354	Loxodonta_africana
ENSG00000204394	VARS	100	98.972	ENSMFAG00000001032	VARS	100	98.972	Macaca_fascicularis
ENSG00000204394	VARS	100	98.972	ENSMMUG00000006828	VARS	100	98.972	Macaca_mulatta
ENSG00000204394	VARS	100	98.972	ENSMNEG00000042072	VARS	100	98.972	Macaca_nemestrina
ENSG00000204394	VARS	100	98.851	ENSMLEG00000039307	VARS	100	98.734	Mandrillus_leucophaeus
ENSG00000204394	VARS	99	71.779	ENSMAMG00000003949	vars	100	64.665	Mastacembelus_armatus
ENSG00000204394	VARS	99	71.779	ENSMZEG00005018327	vars	100	64.325	Maylandia_zebra
ENSG00000204394	VARS	100	93.103	ENSMAUG00000006715	Vars	100	92.563	Mesocricetus_auratus
ENSG00000204394	VARS	100	97.126	ENSMICG00000003548	VARS	100	95.522	Microcebus_murinus
ENSG00000204394	VARS	100	89.953	ENSMOCG00000015404	Vars	100	89.794	Microtus_ochrogaster
ENSG00000204394	VARS	99	71.472	ENSMMOG00000015801	vars	100	64.129	Mola_mola
ENSG00000204394	VARS	100	86.551	ENSMODG00000015204	-	100	86.551	Monodelphis_domestica
ENSG00000204394	VARS	99	71.779	ENSMALG00000022532	vars	99	64.381	Monopterus_albus
ENSG00000204394	VARS	100	93.038	MGP_CAROLIEiJ_G0021491	Vars	100	92.563	Mus_caroli
ENSG00000204394	VARS	100	93.038	ENSMUSG00000007029	Vars	100	92.563	Mus_musculus
ENSG00000204394	VARS	100	93.103	MGP_PahariEiJ_G0020486	Vars	100	92.009	Mus_pahari
ENSG00000204394	VARS	100	93.117	MGP_SPRETEiJ_G0022396	Vars	100	92.642	Mus_spretus
ENSG00000204394	VARS	100	97.126	ENSMPUG00000010821	VARS	100	94.858	Mustela_putorius_furo
ENSG00000204394	VARS	100	95.402	ENSMLUG00000013126	VARS	100	93.421	Myotis_lucifugus
ENSG00000204394	VARS	100	92.168	ENSNGAG00000012151	Vars	100	92.484	Nannospalax_galili
ENSG00000204394	VARS	99	71.779	ENSNBRG00000020520	vars	100	64.336	Neolamprologus_brichardi
ENSG00000204394	VARS	100	98.851	ENSNLEG00000006351	VARS	100	98.734	Nomascus_leucogenys
ENSG00000204394	VARS	100	86.207	ENSMEUG00000011378	VARS	100	82.753	Notamacropus_eugenii
ENSG00000204394	VARS	100	93.750	ENSOPRG00000003607	VARS	100	93.750	Ochotona_princeps
ENSG00000204394	VARS	100	91.379	ENSODEG00000017681	VARS	100	90.585	Octodon_degus
ENSG00000204394	VARS	99	72.086	ENSONIG00000013064	vars	99	67.826	Oreochromis_niloticus
ENSG00000204394	VARS	100	59.195	ENSOANG00000005400	VARS	98	78.147	Ornithorhynchus_anatinus
ENSG00000204394	VARS	100	96.552	ENSOCUG00000022463	VARS	100	92.035	Oryctolagus_cuniculus
ENSG00000204394	VARS	99	72.699	ENSORLG00000013063	vars	100	64.390	Oryzias_latipes
ENSG00000204394	VARS	99	73.313	ENSORLG00020003504	vars	100	64.919	Oryzias_latipes_hni
ENSG00000204394	VARS	99	73.313	ENSORLG00015009001	vars	100	64.815	Oryzias_latipes_hsok
ENSG00000204394	VARS	99	73.006	ENSOMEG00000015016	vars	100	64.660	Oryzias_melastigma
ENSG00000204394	VARS	100	95.977	ENSOGAG00000007515	VARS	100	95.174	Otolemur_garnettii
ENSG00000204394	VARS	76	81.061	ENSOARG00000004625	-	90	90.584	Ovis_aries
ENSG00000204394	VARS	100	99.604	ENSPPAG00000034012	VARS	100	99.604	Pan_paniscus
ENSG00000204394	VARS	100	97.701	ENSPPRG00000014855	VARS	100	95.095	Panthera_pardus
ENSG00000204394	VARS	99	84.663	ENSPTIG00000010462	VARS	95	95.055	Panthera_tigris_altaica
ENSG00000204394	VARS	100	99.525	ENSPTRG00000017985	VARS	100	99.525	Pan_troglodytes
ENSG00000204394	VARS	100	98.851	ENSPANG00000014565	VARS	100	97.161	Papio_anubis
ENSG00000204394	VARS	99	70.859	ENSPKIG00000016304	vars	100	63.861	Paramormyrops_kingsleyae
ENSG00000204394	VARS	64	84.324	ENSPSIG00000004456	-	99	84.324	Pelodiscus_sinensis
ENSG00000204394	VARS	99	72.086	ENSPMGG00000023909	vars	100	65.485	Periophthalmus_magnuspinnatus
ENSG00000204394	VARS	100	93.671	ENSPEMG00000006639	Vars	100	93.671	Peromyscus_maniculatus_bairdii
ENSG00000204394	VARS	100	85.997	ENSPCIG00000018553	VARS	100	85.997	Phascolarctos_cinereus
ENSG00000204394	VARS	99	72.699	ENSPFOG00000015690	vars	100	65.603	Poecilia_formosa
ENSG00000204394	VARS	99	72.699	ENSPLAG00000009590	vars	100	65.854	Poecilia_latipinna
ENSG00000204394	VARS	99	72.699	ENSPMEG00000004708	vars	100	65.603	Poecilia_mexicana
ENSG00000204394	VARS	99	73.006	ENSPREG00000013264	vars	100	63.636	Poecilia_reticulata
ENSG00000204394	VARS	100	99.425	ENSPPYG00000016460	VARS	100	97.706	Pongo_abelii
ENSG00000204394	VARS	100	96.552	ENSPCAG00000013565	VARS	86	92.639	Procavia_capensis
ENSG00000204394	VARS	100	97.701	ENSPCOG00000010942	VARS	100	95.810	Propithecus_coquereli
ENSG00000204394	VARS	97	98.225	ENSPVAG00000012403	VARS	100	91.535	Pteropus_vampyrus
ENSG00000204394	VARS	99	71.779	ENSPNYG00000022511	vars	100	64.569	Pundamilia_nyererei
ENSG00000204394	VARS	99	72.393	ENSPNAG00000020962	vars	100	64.313	Pygocentrus_nattereri
ENSG00000204394	VARS	100	93.434	ENSRNOG00000000867	Vars	100	93.434	Rattus_norvegicus
ENSG00000204394	VARS	100	98.972	ENSRBIG00000041669	VARS	100	98.972	Rhinopithecus_bieti
ENSG00000204394	VARS	100	98.972	ENSRROG00000045490	VARS	100	98.972	Rhinopithecus_roxellana
ENSG00000204394	VARS	100	97.389	ENSSBOG00000035402	VARS	100	97.389	Saimiri_boliviensis_boliviensis
ENSG00000204394	VARS	100	81.304	ENSSHAG00000006937	VARS	100	81.540	Sarcophilus_harrisii
ENSG00000204394	VARS	99	70.552	ENSSFOG00015014272	vars	100	64.402	Scleropages_formosus
ENSG00000204394	VARS	99	70.245	ENSSMAG00000009596	vars	99	63.460	Scophthalmus_maximus
ENSG00000204394	VARS	99	71.779	ENSSDUG00000014177	vars	100	64.236	Seriola_dumerili
ENSG00000204394	VARS	99	71.779	ENSSLDG00000025316	vars	100	64.158	Seriola_lalandi_dorsalis
ENSG00000204394	VARS	99	72.699	ENSSPAG00000017068	vars	100	64.798	Stegastes_partitus
ENSG00000204394	VARS	100	97.701	ENSSSCG00000038950	VARS	100	93.755	Sus_scrofa
ENSG00000204394	VARS	94	70.382	ENSTRUG00000012307	vars	98	64.279	Takifugu_rubripes
ENSG00000204394	VARS	99	72.086	ENSTNIG00000008011	vars	100	64.969	Tetraodon_nigroviridis
ENSG00000204394	VARS	75	80.784	ENSTBEG00000004728	-	60	95.880	Tupaia_belangeri
ENSG00000204394	VARS	100	96.552	ENSTTRG00000014128	VARS	100	86.155	Tursiops_truncatus
ENSG00000204394	VARS	100	98.851	ENSUAMG00000010424	VARS	100	91.431	Ursus_americanus
ENSG00000204394	VARS	100	98.851	ENSUMAG00000013486	VARS	98	94.286	Ursus_maritimus
ENSG00000204394	VARS	54	87.097	ENSVPAG00000001757	-	55	94.304	Vicugna_pacos
ENSG00000204394	VARS	100	97.126	ENSVVUG00000021323	VARS	100	93.755	Vulpes_vulpes
ENSG00000204394	VARS	99	70.552	ENSXETG00000024076	vars	98	62.055	Xenopus_tropicalis
ENSG00000204394	VARS	99	72.393	ENSXCOG00000019172	vars	100	65.512	Xiphophorus_couchianus
ENSG00000204394	VARS	99	72.699	ENSXMAG00000010927	vars	100	65.292	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002161	aminoacyl-tRNA editing activity	-	IEA	Function
GO:0004832	valine-tRNA ligase activity	21873635.	IBA	Function
GO:0004832	valine-tRNA ligase activity	8428657.	IDA	Function
GO:0004832	valine-tRNA ligase activity	-	TAS	Function
GO:0005515	protein binding	24965446.25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0006438	valyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr6	31779626	Frame_Shift_Del	novel	*Y1091Tfs22**	0.48
ACC	chr6	31779261	Silent	rs769749489	G1144G	0.92
ACC	chr6	31791636	Silent	rs770135399	N358N	0.17
ACC	chr6	31791635	Missense_Mutation	novel	A359T	0.88
BLCA	chr6	31783127	Silent	rs746698385	F577F	0.16
BLCA	chr6	31792786	Missense_Mutation	NA	S211L	0.72	tRNA-synt_1g
BLCA	chr6	31781033	Missense_Mutation	novel	G879R	0.4
BLCA	chr6	31792852	Missense_Mutation	NA	R189H	0.2	tRNA-synt_1g
BLCA	chr6	31779769	Missense_Mutation	novel	E1043K	0.19
BLCA	chr6	31782792	Missense_Mutation	rs761390538	R606W	0.06
BRCA	chr6	31782123	Frame_Shift_Del	novel	*F735Lfs21**	0.07
BRCA	chr6	31784485	Silent	NA	L495L	0.28
BRCA	chr6	31791969	Missense_Mutation	novel	V292F	0.11
BRCA	chr6	31795206	Silent	novel	L4L	0.09
CESC	chr6	31784489	Missense_Mutation	novel	E494G	0.69
CESC	chr6	31780918	Silent	novel	L890L	0.47
CESC	chr6	31779518	Missense_Mutation	rs765817222	E1103K	0.52
CESC	chr6	31784657	Missense_Mutation	novel	Y469H	0.11
CESC	chr6	31795086	Silent	novel	P44P	0.32
CESC	chr6	31778975	Missense_Mutation	novel	E1240K	0.17
CESC	chr6	31779164	Missense_Mutation	rs756380009	A1177T	0.27
CESC	chr6	31780736	Silent	novel	L922L	0.17
CESC	chr6	31782158	Nonsense_Mutation	NA	Q724*	0.27
COAD	chr6	31795153	Missense_Mutation	novel	A22V	0.37
COAD	chr6	31791900	Nonsense_Mutation	NA	Q315*	0.19
COAD	chr6	31791678	Frame_Shift_Del	NA	*N345Mfs2**	0.27
COAD	chr6	31792876	Missense_Mutation	rs144131888	R181H	0.19	tRNA-synt_1g
COAD	chr6	31782582	Missense_Mutation	rs758159125	R647W	0.41
COAD	chr6	31785256	Missense_Mutation	NA	T446S	0.15
COAD	chr6	31782750	Frame_Shift_Del	novel	*A620Pfs25**	0.23
COAD	chr6	31778986	Missense_Mutation	NA	Q1236R	0.25
COAD	chr6	31785290	Missense_Mutation	NA	G435S	0.34
COAD	chr6	31779620	Silent	rs746743378	P1092P	0.26
COAD	chr6	31781707	Frame_Shift_Del	novel	*L801Wfs10**	0.3
COAD	chr6	31781911	Silent	novel	A761A	0.16
COAD	chr6	31785288	Silent	NA	G435G	0.44
COAD	chr6	31782792	Missense_Mutation	rs761390538	R606W	0.11
COAD	chr6	31781753	Missense_Mutation	NA	V786I	0.44
COAD	chr6	31785713	Missense_Mutation	novel	T374I	0.1
COAD	chr6	31782285	Missense_Mutation	rs773917211	R717Q	0.31
COAD	chr6	31784300	Missense_Mutation	rs748675721	E529K	0.25
ESCA	chr6	31781940	Missense_Mutation	rs368988920	R752W	0.1
ESCA	chr6	31779455	Missense_Mutation	novel	D1124N	0.34
GBM	chr6	31781953	Splice_Site	NA	X748_splice	0.09
GBM	chr6	31779473	Missense_Mutation	rs543142503	V1118M	0.19
GBM	chr6	31784434	Silent	rs369896276	F512F	0.36
GBM	chr6	31779053	Missense_Mutation	novel	Q1214K	0.97
GBM	chr6	31785657	Nonsense_Mutation	novel	E393*	0.8
GBM	chr6	31778983	Missense_Mutation	NA	E1237G	0.3
GBM	chr6	31780897	Silent	rs575457128	S897S	0.37
GBM	chr6	31780079	Frame_Shift_Ins	novel	*Q1000Hfs22**	0.1
GBM	chr6	31782569	Missense_Mutation	novel	R651H	0.14
GBM	chr6	31785659	Missense_Mutation	novel	V392G	0.44
GBM	chr6	31783178	Missense_Mutation	novel	K560N	0.07
GBM	chr6	31783180	Missense_Mutation	novel	K560E	0.07
HNSC	chr6	31795234	5'UTR	rs751300115		0.45
HNSC	chr6	31784483	Missense_Mutation	NA	T496I	0.26
HNSC	chr6	31779532	Missense_Mutation	novel	S1098F	0.17
HNSC	chr6	31784690	Missense_Mutation	rs762674443	A458S	0.32
HNSC	chr6	31780115	Silent	novel	R988R	0.38
HNSC	chr6	31782341	Silent	novel	L698L	0.25
HNSC	chr6	31794828	Splice_Region	novel		0.22
HNSC	chr6	31779519	Silent	rs776018811	P1102P	0.1
HNSC	chr6	31781603	Missense_Mutation	novel	E808K	0.25
KIRC	chr6	31792257	Silent	NA	V277V	0.36
KIRC	chr6	31784284	Missense_Mutation	NA	A534V	0.12
KIRP	chr6	31794977	Missense_Mutation	NA	P81T	0.18	tRNA-synt_1g
LAML	chr6	31784434	Silent	rs369896276	F512F	0.4
LGG	chr6	31777538	3'UTR	novel		0.07
LGG	chr6	31777562	3'UTR	rs368043725		0.52
LGG	chr6	31784467	Silent	novel	L501L	0.08
LGG	chr6	31792252	Missense_Mutation	novel	T279I	0.4
LIHC	chr6	31779432	Silent	novel	R1131R	0.29
LIHC	chr6	31792392	Missense_Mutation	novel	E262D	0.19
LIHC	chr6	31792986	Splice_Region	rs138074588	Y174Y	0.34
LIHC	chr6	31782806	Missense_Mutation	rs767158154	Y601C	0.15
LIHC	chr6	31782117	Silent	novel	T737T	0.11
LUAD	chr6	31781901	Nonsense_Mutation	NA	E765*	0.65
LUAD	chr6	31784297	Nonsense_Mutation	novel	E530*	0.36
LUAD	chr6	31791650	Missense_Mutation	novel	H354D	0.36
LUAD	chr6	31780145	Silent	NA	G978G	0.59
LUAD	chr6	31781762	Splice_Site	NA	X783_splice	0.35
LUAD	chr6	31782422	Missense_Mutation	novel	E671D	0.2
LUAD	chr6	31777567	3'UTR	novel		0.17
LUAD	chr6	31779505	Missense_Mutation	novel	A1107G	0.25
LUAD	chr6	31779019	Missense_Mutation	rs766331691	S1225L	0.33
LUAD	chr6	31792783	Missense_Mutation	NA	G212V	0.33	tRNA-synt_1g
LUSC	chr6	31782822	Missense_Mutation	novel	H596Y	0.35
LUSC	chr6	31781911	Silent	NA	A761A	0.68
LUSC	chr6	31793047	Missense_Mutation	NA	G154V	0.66	tRNA-synt_1g
LUSC	chr6	31780482	Missense_Mutation	rs780044529	R962C	0.33
LUSC	chr6	31785606	Missense_Mutation	rs758503469	E410K	0.15
LUSC	chr6	31781904	Missense_Mutation	rs55786236	R764W	0.22
LUSC	chr6	31784605	Missense_Mutation	NA	S486C	0.09
LUSC	chr6	31782364	Missense_Mutation	novel	A691S	0.07
LUSC	chr6	31782530	Missense_Mutation	novel	N664S	0.17
LUSC	chr6	31785578	Nonsense_Mutation	NA	W419*	0.29
LUSC	chr6	31793058	Silent	NA	T150T	0.43
LUSC	chr6	31793059	Missense_Mutation	NA	T150I	0.46	tRNA-synt_1g
LUSC	chr6	31779216	Silent	rs765007630	S1159S	0.32
LUSC	chr6	31781719	Missense_Mutation	novel	P797L	0.25
LUSC	chr6	31781502	Silent	novel	T841T	0.17
LUSC	chr6	31784499	Missense_Mutation	novel	D491N	0.24
LUSC	chr6	31784501	Missense_Mutation	novel	V490A	0.24
LUSC	chr6	31779211	Missense_Mutation	novel	G1161A	0.09
MESO	chr6	31791668	Missense_Mutation	novel	G348S	0.36
OV	chr6	31785603	Missense_Mutation	novel	A411T	0.09
OV	chr6	31791895	Silent	novel	Q316Q	0.07
OV	chr6	31779628	Missense_Mutation	NA	P1090A	0.41
OV	chr6	31778998	Missense_Mutation	NA	P1232L	0.38
OV	chr6	31782109	Missense_Mutation	novel	D740V	0.33
OV	chr6	31785608	Missense_Mutation	novel	R409P	0.59
OV	chr6	31781876	Frame_Shift_Ins	novel	*V773Dfs4**	0.04
OV	chr6	31792830	Frame_Shift_Ins	NA	*Q197Vfs11**	0.38	tRNA-synt_1g
OV	chr6	31785653	Missense_Mutation	novel	K394T	0.1
PAAD	chr6	31781703	Silent	novel	G802G	0.16
PAAD	chr6	31781922	Missense_Mutation	NA	R758C	0.18
PAAD	chr6	31780745	Silent	rs745663284	T919T	0.19
PAAD	chr6	31784595	Splice_Region	rs752386634	E489E	0.05
PRAD	chr6	31780740	Missense_Mutation	novel	A921G	0.38
PRAD	chr6	31784477	Missense_Mutation	rs199533729	R498H	0.37
PRAD	chr6	31791955	Missense_Mutation	novel	M296I	0.36
READ	chr6	31783126	Missense_Mutation	rs772861226	D578N	0.24
READ	chr6	31785632	Missense_Mutation	NA	G401E	0.53
READ	chr6	31784713	Missense_Mutation	NA	K450T	0.5
READ	chr6	31792461	Missense_Mutation	NA	K239N	0.08	tRNA-synt_1g
SARC	chr6	31778996	Missense_Mutation	novel	L1233I	0.08
SARC	chr6	31780542	Silent	novel	R942R	0.17
SKCM	chr6	31795114	Frame_Shift_Del	novel	*A27Efs73**	0.28
SKCM	chr6	31792275	Silent	NA	E271E	0.18
SKCM	chr6	31779505	Missense_Mutation	NA	A1107V	0.46
SKCM	chr6	31783181	Silent	NA	L559L	0.09
SKCM	chr6	31781049	Silent	novel	P873P	0.32
SKCM	chr6	31781051	Missense_Mutation	NA	P873S	0.18
SKCM	chr6	31779781	Nonsense_Mutation	rs765740144	Q1039*	0.27
SKCM	chr6	31784434	Silent	rs369896276	F512F	0.26
SKCM	chr6	31793111	Missense_Mutation	NA	G133R	0.13	tRNA-synt_1g
SKCM	chr6	31794963	Frame_Shift_Del	novel	*L84Afs22**	0.13	tRNA-synt_1g
SKCM	chr6	31781713	Missense_Mutation	NA	S799F	0.18
SKCM	chr6	31792499	Missense_Mutation	novel	L227F	0.21	tRNA-synt_1g
SKCM	chr6	31782134	Missense_Mutation	novel	P732S	0.34
SKCM	chr6	31783163	Silent	NA	I565I	0.27
SKCM	chr6	31785282	Silent	novel	S437S	0.25
SKCM	chr6	31780444	Silent	novel	S974S	0.28
SKCM	chr6	31779288	Silent	NA	F1135F	0.43
SKCM	chr6	31779465	Silent	NA	S1120S	0.59
SKCM	chr6	31779505	Missense_Mutation	NA	A1107V	0.69
SKCM	chr6	31784425	Silent	NA	L515L	0.12
SKCM	chr6	31792878	Silent	NA	A180A	0.21
SKCM	chr6	31795119	Nonsense_Mutation	NA	W33*	0.44
SKCM	chr6	31792811	Missense_Mutation	novel	V203L	0.16	tRNA-synt_1g
SKCM	chr6	31779702	Missense_Mutation	NA	P1065L	0.27
SKCM	chr6	31795133	Missense_Mutation	NA	E29K	0.33
SKCM	chr6	31779466	Missense_Mutation	novel	S1120F	0.28
SKCM	chr6	31791621	Silent	NA	S363S	0.35
SKCM	chr6	31791622	Missense_Mutation	novel	S363F	0.35
SKCM	chr6	31791738	Splice_Site	NA	X325_splice	0.12
SKCM	chr6	31795104	Silent	NA	P38P	0.18
SKCM	chr6	31780445	Missense_Mutation	NA	S974F	0.83
SKCM	chr6	31779029	Missense_Mutation	rs375257266	R1222C	0.14
SKCM	chr6	31784469	Missense_Mutation	NA	L501F	0.12
SKCM	chr6	31792767	Silent	NA	S217S	0.09
SKCM	chr6	31781854	Silent	NA	L780L	0.42
SKCM	chr6	31779483	Silent	NA	I1114I	0.63
SKCM	chr6	31781025	Silent	NA	S881S	0.22
SKCM	chr6	31785670	Silent	NA	T388T	0.36
SKCM	chr6	31785625	Silent	NA	S403S	0.16
SKCM	chr6	31780772	Silent	novel	F910F	0.23
SKCM	chr6	31792221	Missense_Mutation	novel	K289N	0.47
SKCM	chr6	31784467	Silent	rs767371765	L501L	0.36
SKCM	chr6	31792295	Missense_Mutation	novel	P265S	0.37
SKCM	chr6	31781734	Missense_Mutation	NA	S792F	0.37
SKCM	chr6	31782420	Missense_Mutation	novel	P672L	0.53
SKCM	chr6	31791665	Missense_Mutation	novel	S349A	0.36
SKCM	chr6	31791734	Missense_Mutation	NA	P326S	0.28
STAD	chr6	31792458	In_Frame_Del	novel	E237_K240del	0.14	tRNA-synt_1g
STAD	chr6	31792787	Missense_Mutation	NA	S211T	0.1	tRNA-synt_1g
STAD	chr6	31779215	Missense_Mutation	NA	A1160T	0.81
STAD	chr6	31794924	Frame_Shift_Del	novel	*R91Gfs9**	0.18	tRNA-synt_1g
STAD	chr6	31779056	Missense_Mutation	rs749404027	R1213W	0.37
STAD	chr6	31779625	Frame_Shift_Ins	novel	*Y1091Lfs19**	0.33
STAD	chr6	31779723	Missense_Mutation	rs769369302	R1058Q	0.42
STAD	chr6	31784431	Silent	NA	G513G	0.28
STAD	chr6	31792802	In_Frame_Del	novel	G205del	0.44	tRNA-synt_1g
STAD	chr6	31781530	Missense_Mutation	rs200725336	R832Q	0.48
STAD	chr6	31779454	Missense_Mutation	NA	D1124V	0.17
STAD	chr6	31779215	Missense_Mutation	NA	A1160T	0.88
STAD	chr6	31780482	Missense_Mutation	rs780044529	R962C	0.18
STAD	chr6	31779710	Silent	NA	P1062P	0.33
STAD	chr6	31782315	Missense_Mutation	NA	R707H	0.35
STAD	chr6	31780000	Splice_Region	NA	L1027L	0.24
STAD	chr6	31785323	Missense_Mutation	novel	G424S	0.33
STAD	chr6	31777617	Missense_Mutation	NA	A1258S	0.25
STAD	chr6	31782749	Frame_Shift_Ins	novel	*A620Gfs16**	0.22
STAD	chr6	31782286	Missense_Mutation	rs771466994	R717W	0.33
STAD	chr6	31785608	Missense_Mutation	rs755082499	R409H	0.44
STAD	chr6	31781939	Missense_Mutation	rs376163798	R752Q	0.26
STAD	chr6	31792390	Splice_Site	NA	X262_splice	0.51
STAD	chr6	31779461	Missense_Mutation	rs138566905	R1122W	0.12
THYM	chr6	31792766	Missense_Mutation	rs780115933	H218Y	0.42	tRNA-synt_1g
UCEC	chr6	31785671	Missense_Mutation	NA	T388I	0.5
UCEC	chr6	31780744	Missense_Mutation	rs370606971	D920N	0.32
UCEC	chr6	31782315	Missense_Mutation	NA	R707H	0.4
UCEC	chr6	31784303	Missense_Mutation	NA	D528N	0.11
UCEC	chr6	31785599	Missense_Mutation	novel	F412S	0.6
UCEC	chr6	31795081	Frame_Shift_Del	novel	*P46Rfs62**	0.69	tRNA-synt_1g
UCEC	chr6	31782437	Silent	rs765077498	S666S	0.54
UCEC	chr6	31784484	Missense_Mutation	novel	T496A	0.44
UCEC	chr6	31784612	Missense_Mutation	novel	A484T	0.44
UCEC	chr6	31784301	Silent	novel	D528D	0.44
UCEC	chr6	31778993	Missense_Mutation	rs139977182	E1234K	0.45
UCEC	chr6	31779724	Missense_Mutation	novel	R1058W	0.51
UCEC	chr6	31780868	Splice_Site	novel	X906_splice	0.44
UCEC	chr6	31783138	Missense_Mutation	novel	P574S	0.48
UCEC	chr6	31782139	Missense_Mutation	rs781064928	R730H	0.51
UCEC	chr6	31780055	Silent	rs759494295	P1008P	0.07
UCEC	chr6	31791699	Missense_Mutation	novel	F337L	0.13
UCEC	chr6	31780067	Silent	novel	A1004A	0.38
UCEC	chr6	31779247	Missense_Mutation	novel	A1149V	0.3
UCEC	chr6	31780481	Missense_Mutation	rs570418189	R962H	0.59
UCEC	chr6	31782139	Missense_Mutation	rs781064928	R730H	0.34
UCEC	chr6	31782593	Missense_Mutation	rs568855918	A643V	0.3
UCEC	chr6	31792500	Silent	novel	A226A	0.45
UCEC	chr6	31795163	Missense_Mutation	novel	L19I	0.31
UCEC	chr6	31777622	Missense_Mutation	NA	A1256V	0.39
UCEC	chr6	31781102	Nonsense_Mutation	rs761810499	R856*	0.48
UCEC	chr6	31783127	Silent	rs746698385	F577F	0.57
UCEC	chr6	31782750	Frame_Shift_Del	novel	*A620Pfs25**	0.44
UCEC	chr6	31784665	Missense_Mutation	novel	G466A	0.3
UCEC	chr6	31791920	Missense_Mutation	novel	A308V	0.1
UCEC	chr6	31795183	Missense_Mutation	novel	A12V	0.45
UCEC	chr6	31781496	Silent	novel	R843R	0.22
UCEC	chr6	31791713	Missense_Mutation	novel	P333S	0.39
UCEC	chr6	31793020	Missense_Mutation	rs779660431	A163V	0.36	tRNA-synt_1g
UCEC	chr6	31795213	Missense_Mutation	novel	S2F	0.3
UCEC	chr6	31779057	Silent	novel	Q1212Q	0.52
UCEC	chr6	31785723	Missense_Mutation	rs367554724	R371C	0.47
UCEC	chr6	31782361	Missense_Mutation	rs747824231	A692T	0.41
UCEC	chr6	31785607	Silent	rs777942430	R409R	0.45
UCEC	chr6	31782286	Missense_Mutation	rs771466994	R717W	0.3
UCEC	chr6	31779277	Missense_Mutation	novel	A1139V	0.31
UCEC	chr6	31784607	Silent	novel	I485I	0.43
UCEC	chr6	31778988	Silent	novel	V1235V	0.44
UCEC	chr6	31792514	Missense_Mutation	NA	P222S	0.37	tRNA-synt_1g
UCEC	chr6	31782389	Silent	rs746154288	C682C	0.3
UCEC	chr6	31793100	Silent	rs752958092	G136G	0.31
UCEC	chr6	31785684	Missense_Mutation	novel	A384S	0.59
UCEC	chr6	31779277	Missense_Mutation	novel	A1139V	0.36
UCEC	chr6	31780710	Missense_Mutation	novel	S931Y	0.23
UCEC	chr6	31781881	Silent	rs145442830	F771F	0.1
UCEC	chr6	31784425	Silent	NA	L515L	0.47
UCEC	chr6	31791646	Missense_Mutation	novel	A355V	0.41
UCEC	chr6	31793119	Missense_Mutation	novel	A130D	0.22	tRNA-synt_1g
UCEC	chr6	31779043	In_Frame_Del	novel	Q1214_R1217del	0.41
UCEC	chr6	31791722	Missense_Mutation	novel	A330T	0.52
UCEC	chr6	31780897	Silent	rs575457128	S897S	0.44
UCEC	chr6	31783146	Missense_Mutation	rs763341394	R571Q	0.41
UCEC	chr6	31784645	Missense_Mutation	rs770013428	R473C	0.47
UCEC	chr6	31785722	Missense_Mutation	rs374047504	R371H	0.8
UCEC	chr6	31779217	Missense_Mutation	novel	S1159N	0.3
UCEC	chr6	31782605	Missense_Mutation	novel	A639V	0.4
UCEC	chr6	31783104	Missense_Mutation	novel	F585C	0.28

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.1042	0.011841

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.048	Kaplan-Meier Survival Analysis
SARC	0.00013	Kaplan-Meier Survival Analysis
MESO	0.017	Kaplan-Meier Survival Analysis
HNSC	0.047	Kaplan-Meier Survival Analysis
SKCM	0.0009	Kaplan-Meier Survival Analysis
CESC	0.0084	Kaplan-Meier Survival Analysis
LAML	0.0013	Kaplan-Meier Survival Analysis
GBM	0.0081	Kaplan-Meier Survival Analysis
LIHC	0.0023	Kaplan-Meier Survival Analysis
LGG	0.011	Kaplan-Meier Survival Analysis
LUAD	0.02	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742