EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000204469 (Gene tree)
Gene ID: 7916
Gene Symbol: PRRC2A
Alias: G2|D6S51E|BAT2
Full Name: proline rich coiled-coil 2A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 17,105 bases
Position: chr6:31,620,673-31,637,777
Accession: 13918
RBP type: non-canonical RBP
Summary: A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000460302	PRRC2A-203	697	-	-	- (aa)	-	-
ENST00000487839	PRRC2A-213	1071	-	-	- (aa)	-	-
ENST00000487089	PRRC2A-212	732	-	-	- (aa)	-	-
ENST00000376033	PRRC2A-202	6893	-	ENSP00000365201	2157 (aa)	-	P48634
ENST00000376007	PRRC2A-201	6861	XM_017011274	ENSP00000365175	2157 (aa)	XP_016866763	P48634
ENST00000469577	PRRC2A-208	918	-	-	- (aa)	-	-
ENST00000469501	PRRC2A-207	347	-	-	- (aa)	-	-
ENST00000484787	PRRC2A-211	756	-	-	- (aa)	-	-
ENST00000482441	PRRC2A-209	719	-	-	- (aa)	-	-
ENST00000462617	PRRC2A-204	1015	-	-	- (aa)	-	-
ENST00000492691	PRRC2A-214	1118	-	-	- (aa)	-	-
ENST00000464079	PRRC2A-205	451	-	-	- (aa)	-	-
ENST00000483470	PRRC2A-210	916	-	-	- (aa)	-	-
ENST00000464890	PRRC2A-206	593	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000204469's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000204469	Lupus Erythematosus, Systemic	5.5511E-16	18204098
ENSG00000204469	Lupus Erythematosus, Systemic	3.7925E-13	18204098
ENSG00000204469	Lupus Erythematosus, Systemic	8.7291E-11	18204098
ENSG00000204469	Lupus Erythematosus, Systemic	6.6613E-16	18204098
ENSG00000204469	Diabetes Mellitus, Type 1	1.28E-124	19430480
ENSG00000204469	Diabetes Mellitus, Type 1	3.94E-109	19430480
ENSG00000204469	Diabetic Nephropathies	2.4000000E-005	16775037
ENSG00000204469	Lupus Erythematosus, Systemic	1.3E-5	18204446
ENSG00000204469	Body Height	4.789e-005	18193045
ENSG00000204469	Platelet Function Tests	6.8100000E-006	-
ENSG00000204469	Platelet Function Tests	3.1000000E-006	-
ENSG00000204469	Platelet Function Tests	3.2000000E-007	-
ENSG00000204469	Platelet Function Tests	3.2200000E-006	-
ENSG00000204469	Platelet Function Tests	1.2067200E-005	-
ENSG00000204469	Platelet Function Tests	1.3955300E-005	-
ENSG00000204469	Platelet Function Tests	1.3900000E-007	-
ENSG00000204469	Platelet Function Tests	1.2902300E-005	-
ENSG00000204469	Platelet Function Tests	3.1500000E-006	-
ENSG00000204469	Platelet Function Tests	1.2067200E-005	-
ENSG00000204469	Platelet Function Tests	6.9100000E-007	-
ENSG00000204469	Platelet Function Tests	1.0400000E-006	-
ENSG00000204469	Platelet Function Tests	1.8319000E-005	-
ENSG00000204469	Menopause	4E-11	23307926
ENSG00000204469	Schizophrenia	4E-6	23894747
ENSG00000204469	Metabolism	1E-14	24816252
ENSG00000204469	Psychotic Disorders	4E-6	24132900
ENSG00000204469	Glomerulonephritis, Membranous	7E-57	21323541
ENSG00000204469	Menopause	2E-16	22267201
ENSG00000204469	Body Height	3E-29	25282103

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000204469	rs115052633	6	31621487	C	Autism spectrum disorder or schizophrenia	28540026	[1.07-1.13]	1.1	EFO_0000692\|EFO_0003756
ENSG00000204469	rs1046089	6	31635190	G	Schizophrenia	23894747	[NR]	1.3	EFO_0000692
ENSG00000204469	rs3115663	6	31634066	G	Idiopathic membranous nephropathy	21323541	[NR]	3.04	EFO_0004254
ENSG00000204469	rs9267522	6	31635993	G	Idiopathic membranous nephropathy	21323541	[NR]	3.04	EFO_0004254
ENSG00000204469	rs1046080	6	31628105	A	Blood metabolite ratios	24816252	[0.019-0.035] unit increase	0.027	EFO_0005664
ENSG00000204469	rs2736172	6	31623121	?	Psychosis (atypical)	24132900			EFO_0005407
ENSG00000204469	rs1046089	6	31635190	A	Menopause (age at onset)	23307926	[0.13-0.25] years increase	0.1919	EFO_0004704
ENSG00000204469	rs190542992	6	31626404	?	Albumin-globulin ratio	29403010	[0.028-0.053] unit increase novel	0.04064	EFO_0005128
ENSG00000204469	rs190542992	6	31626404	?	Non-albumin protein levels	29403010	[0.027-0.053] unit decrease novel	0.04024	EFO_0004568
ENSG00000204469	rs1046089	6	31635190	A	Menopause (age at onset)	22267201	[0.16-0.26] years decrease	0.213	EFO_0004704
ENSG00000204469	rs2736155	6	31637422	C	Depression (broad)	29662059	[0.0035-0.0083] unit increase	0.0059	EFO_0003761
ENSG00000204469	rs2260051	6	31624141	T	Hand grip strength	29691431	[0.0014-0.0026] unit decrease	0.002	EFO_0006941
ENSG00000204469	rs2260051	6	31624141	A	Hand grip strength	29691431	[0.0014-0.0026] unit increase	0.002	EFO_0006941
ENSG00000204469	rs1046080	6	31628105	?	Body fat percentage	30593698	[0.082-0.174] unit increase	0.12785	EFO_0007800
ENSG00000204469	rs1046080	6	31628105	?	Body fat percentage	30593698	[0.078-0.191] unit increase	0.13448	EFO_0007800
ENSG00000204469	rs2736173	6	31621958	A	Takayasu arteritis	25604533	[2.14-5.98]	3.58	EFO_1001857
ENSG00000204469	rs7889	6	31637671	C	Smoking status (ever vs never smokers)	30643258	[0.0082-0.017] unit increase	0.012577614	EFO_0004318
ENSG00000204469	rs7889	6	31637671	C	Systolic blood pressure	30578418	[0.19-0.31] mmHg decrease	0.2499	EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204469's network

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000204469	PRRC2A	72	39.302	ENSG00000130723	PRRC2B	87	69.697	Homo_sapiens
ENSG00000204469	PRRC2A	100	89.119	ENSMUSG00000024393	Prrc2a	100	88.658	Mus_musculus
ENSG00000204469	PRRC2A	59	44.595	ENSMUSG00000039262	Prrc2b	54	45.191	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	16713569.20195357.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0070062	extracellular exosome	19056867.	HDA	Component