EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000204560 (Gene tree)
Gene ID
8449
Gene Symbol
DHX16
Alias
DBP2|Prp2|PRPF2|DDX16
Full Name
DEAH-box helicase 16
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
19,935 bases
Position
chr6:30,653,119-30,673,053
Accession
2739
RBP type
canonical RBP
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000365625DEADPF00270.292.7e-0611
ENSP00000365620HA2PF04408.232.8e-2011
ENSP00000365625HA2PF04408.231.4e-1911
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
25579587Measuring helicase inhibition of the DEAD-box protein Dbp2 by Yra1.Methods Mol Biol2015Ma WKdoi: 10.1007/978-1-4939-2214-7_12.
8112302The splicing factor PRP2, a putative RNA helicase, interacts directly with pre-mRNA.EMBO J1994 Feb 15Teigelkamp S-
15542821Interaction between a G-patch protein and a spliceosomal DEXD/H-box ATPase that is critical for splicing.Mol Cell Biol2004 DecSilverman EJ-
23721653The DEAD-box protein Dbp2 functions with the RNA-binding protein Yra1 to promote mRNP assembly.J Mol Biol2013 Oct 23Ma WKdoi: 10.1016/j.jmb.2013.05.016
26876600Recruitment, Duplex Unwinding and Protein-Mediated Inhibition of the Dead-Box RNA Helicase Dbp2 at Actively Transcribed Chromatin.J Mol Biol2016 Mar 27Ma WKdoi: 10.1016/j.jmb.2016.02.005
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000415603DHX16-203892-ENSP00000399101295 (aa)-A2AB15
ENST00000376437DHX16-2011933XM_011514940ENSP00000365620560 (aa)XP_011513242Q5SQH5
ENST00000480966DHX16-204797--- (aa)--
ENST00000376442DHX16-2023445XM_011514938ENSP000003656251041 (aa)XP_011513240O60231
Gene Model
Click here to download ENSG00000204560's gene model file
Pathways
Pathway IDPathway NameSource
hsa03040SpliceosomeKEGG
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000204560Breast Neoplasms2.378E-0917660530
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000204560rs74917683630661180?Shingles28928442[0.1-0.19] unit increase0.1491EFO_0008401
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204560's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000204560DHX169030.916ENSG00000089876DHX328632.303
ENSG00000204560DHX169338.652ENSG00000108406DHX409048.963
ENSG00000204560DHX169449.146ENSG00000140829DHX388348.148
ENSG00000204560DHX169044.639ENSG00000005100DHX339146.177
ENSG00000204560DHX169041.463ENSG00000150990DHX377241.700
ENSG00000204560DHX169351.036ENSG00000109606DHX158252.301
ENSG00000204560DHX169046.360ENSG00000101452DHX359148.292
ENSG00000204560DHX169031.538ENSG00000144045DQX110035.833
ENSG00000204560DHX169430.981ENSG00000132153DHX305533.883
ENSG00000204560DHX169156.667ENSG00000067596DHX87660.000
ENSG00000204560DHX169139.506ENSG00000174953DHX369835.185
ENSG00000204560DHX168346.296ENSG00000163214DHX577246.296
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000204560DHX169485.769ENSAPOG00000008825dhx169969.312Acanthochromis_polyacanthus
ENSG00000204560DHX1610097.699ENSAMEG00000013213DHX1610097.699Ailuropoda_melanoleuca
ENSG00000204560DHX169485.769ENSACIG00000021825dhx169972.867Amphilophus_citrinellus
ENSG00000204560DHX169485.769ENSAOCG00000024217dhx169970.172Amphiprion_ocellaris
ENSG00000204560DHX169481.025ENSAPEG00000022508dhx169970.076Amphiprion_percula
ENSG00000204560DHX169485.769ENSATEG00000006665dhx169972.529Anabas_testudineus
ENSG00000204560DHX169487.335ENSACAG00000010952DHX169974.313Anolis_carolinensis
ENSG00000204560DHX1610099.107ENSANAG00000024212DHX1610099.107Aotus_nancymaae
ENSG00000204560DHX169485.932ENSACLG00000010932dhx169972.227Astatotilapia_calliptera
ENSG00000204560DHX169485.009ENSAMXG00000005181dhx169972.348Astyanax_mexicanus
ENSG00000204560DHX1610097.608ENSBTAG00000006960DHX1610097.608Bos_taurus
ENSG00000204560DHX169468.561WBGene00003392mog-48660.248Caenorhabditis_elegans
ENSG00000204560DHX1610098.929ENSCJAG00000019914DHX1610098.929Callithrix_jacchus
ENSG00000204560DHX1610097.124ENSCAFG00000000427DHX1610097.124Canis_familiaris
ENSG00000204560DHX1610096.740ENSCAFG00020017623DHX1610096.740Canis_lupus_dingo
ENSG00000204560DHX1610096.503ENSCHIG00000013356DHX1610096.503Capra_hircus
ENSG00000204560DHX1610098.467ENSTSYG00000029805DHX1610098.467Carlito_syrichta
ENSG00000204560DHX169499.430ENSCAPG00000000092DHX169795.385Cavia_aperea
ENSG00000204560DHX1610095.302ENSCPOG00000015415DHX1610095.014Cavia_porcellus
ENSG00000204560DHX1610098.851ENSCCAG00000025435DHX1610098.851Cebus_capucinus
ENSG00000204560DHX1610099.425ENSCATG00000021666DHX1610099.425Cercocebus_atys
ENSG00000204560DHX169499.051ENSCLAG00000002398DHX1610095.292Chinchilla_lanigera
ENSG00000204560DHX1610099.425ENSCSAG00000008258DHX1610099.425Chlorocebus_sabaeus
ENSG00000204560DHX169488.783ENSCHOG00000001224DHX168089.701Choloepus_hoffmanni
ENSG00000204560DHX169586.792ENSCPBG00000018837DHX169975.862Chrysemys_picta_bellii
ENSG00000204560DHX169576.822ENSCING00000006565-10077.839Ciona_intestinalis
ENSG00000204560DHX169577.757ENSCSAVG00000003870-9476.497Ciona_savignyi
ENSG00000204560DHX1610099.234ENSCANG00000043736DHX1610099.234Colobus_angolensis_palliatus
ENSG00000204560DHX1610095.889ENSCGRG00001008329Dhx1610095.889Cricetulus_griseus_chok1gshd
ENSG00000204560DHX169499.051ENSCGRG00000014687Dhx1610093.404Cricetulus_griseus_crigri
ENSG00000204560DHX169484.630ENSCSEG00000012134dhx169970.857Cynoglossus_semilaevis
ENSG00000204560DHX169958.565ENSCVAG00000007009dhx169958.278Cyprinodon_variegatus
ENSG00000204560DHX169484.791ENSDARG00000013150dhx169971.943Danio_rerio
ENSG00000204560DHX169788.435ENSDNOG00000030864DHX1610087.047Dasypus_novemcinctus
ENSG00000204560DHX1610096.360ENSDORG00000003203Dhx1610096.360Dipodomys_ordii
ENSG00000204560DHX169374.904FBgn0086444l(2)37Cb9865.801Drosophila_melanogaster
ENSG00000204560DHX169498.482ENSETEG00000003121DHX169994.269Echinops_telfairi
ENSG00000204560DHX168782.887ENSEBUG00000001802dhx169969.431Eptatretus_burgeri
ENSG00000204560DHX169499.431ENSEASG00005019124DHX169998.562Equus_asinus_asinus
ENSG00000204560DHX1610098.278ENSECAG00000008537DHX1610098.278Equus_caballus
ENSG00000204560DHX169485.009ENSELUG00000015727dhx169971.810Esox_lucius
ENSG00000204560DHX1610097.414ENSFCAG00000007693DHX1610097.414Felis_catus
ENSG00000204560DHX169499.241ENSFDAG00000017458DHX1610096.414Fukomys_damarensis
ENSG00000204560DHX169485.551ENSFHEG00000021509dhx169972.106Fundulus_heteroclitus
ENSG00000204560DHX169582.486ENSGMOG00000009282dhx168475.425Gadus_morhua
ENSG00000204560DHX169486.148ENSGAFG00000014389dhx169971.334Gambusia_affinis
ENSG00000204560DHX169484.820ENSGACG00000001768dhx169876.932Gasterosteus_aculeatus
ENSG00000204560DHX169586.792ENSGAGG00000003115DHX169380.605Gopherus_agassizii
ENSG00000204560DHX1610099.821ENSGGOG00000022943DHX1610099.821Gorilla_gorilla
ENSG00000204560DHX169478.558ENSHBUG00000009952dhx169968.929Haplochromis_burtoni
ENSG00000204560DHX1610095.590ENSHGLG00000019290DHX1610095.590Heterocephalus_glaber_female
ENSG00000204560DHX1610095.494ENSHGLG00100017127DHX1610095.494Heterocephalus_glaber_male
ENSG00000204560DHX169484.440ENSHCOG00000006805dhx169970.888Hippocampus_comes
ENSG00000204560DHX169484.981ENSIPUG00000001025DHX169971.943Ictalurus_punctatus
ENSG00000204560DHX1610097.797ENSSTOG00000011881DHX1610097.797Ictidomys_tridecemlineatus
ENSG00000204560DHX169499.620ENSJJAG00000000186Dhx169996.277Jaculus_jaculus
ENSG00000204560DHX169485.579ENSKMAG00000009246dhx169971.863Kryptolebias_marmoratus
ENSG00000204560DHX169481.801ENSLBEG00000017249dhx169970.170Labrus_bergylta
ENSG00000204560DHX169471.881ENSLACG00000002450DHX169974.141Latimeria_chalumnae
ENSG00000204560DHX1610097.797ENSLAFG00000026904DHX1610097.797Loxodonta_africana
ENSG00000204560DHX1610099.425ENSMFAG00000003575DHX1610099.425Macaca_fascicularis
ENSG00000204560DHX1610099.425ENSMMUG00000019960DHX1610099.425Macaca_mulatta
ENSG00000204560DHX1610099.425ENSMNEG00000014580DHX1610099.425Macaca_nemestrina
ENSG00000204560DHX1610099.425ENSMLEG00000043805DHX1610099.425Mandrillus_leucophaeus
ENSG00000204560DHX169485.579ENSMAMG00000009784dhx169972.779Mastacembelus_armatus
ENSG00000204560DHX169485.769ENSMZEG00005027755dhx169972.365Maylandia_zebra
ENSG00000204560DHX1610095.602ENSMAUG00000001696Dhx1610095.602Mesocricetus_auratus
ENSG00000204560DHX1610097.701ENSMICG00000014819DHX1610097.701Microcebus_murinus
ENSG00000204560DHX1610095.411ENSMOCG00000010715Dhx1610093.881Microtus_ochrogaster
ENSG00000204560DHX169484.440ENSMMOG00000016621dhx169972.100Mola_mola
ENSG00000204560DHX169497.529ENSMODG00000015890DHX169995.260Monodelphis_domestica
ENSG00000204560DHX169486.338ENSMALG00000003384dhx169970.459Monopterus_albus
ENSG00000204560DHX169498.859MGP_CAROLIEiJ_G0021538Dhx1610094.570Mus_caroli
ENSG00000204560DHX1610095.502ENSMUSG00000024422Dhx1610094.450Mus_musculus
ENSG00000204560DHX1610095.502MGP_PahariEiJ_G0020532Dhx1610094.450Mus_pahari
ENSG00000204560DHX1610091.866MGP_SPRETEiJ_G0022445Dhx1610090.909Mus_spretus
ENSG00000204560DHX1610097.507ENSMPUG00000011719DHX169497.507Mustela_putorius_furo
ENSG00000204560DHX1610094.349ENSMLUG00000008932DHX1610094.151Myotis_lucifugus
ENSG00000204560DHX1610095.793ENSNGAG00000001106Dhx1610095.793Nannospalax_galili
ENSG00000204560DHX169485.958ENSNBRG00000005624dhx169972.275Neolamprologus_brichardi
ENSG00000204560DHX1610098.929ENSNLEG00000005270DHX1610098.929Nomascus_leucogenys
ENSG00000204560DHX168597.581ENSMEUG00000012522DHX168597.581Notamacropus_eugenii
ENSG00000204560DHX1610095.502ENSOPRG00000001864DHX1610094.833Ochotona_princeps
ENSG00000204560DHX169598.315ENSODEG00000017885DHX169999.051Octodon_degus
ENSG00000204560DHX169485.660ENSONIG00000002234dhx169972.495Oreochromis_niloticus
ENSG00000204560DHX1610095.881ENSOCUG00000002163DHX1610095.881Oryctolagus_cuniculus
ENSG00000204560DHX169485.741ENSORLG00000015982dhx169986.074Oryzias_latipes
ENSG00000204560DHX169485.741ENSORLG00020014134dhx169972.555Oryzias_latipes_hni
ENSG00000204560DHX169585.206ENSORLG00015020617dhx169985.255Oryzias_latipes_hsok
ENSG00000204560DHX169485.579ENSOMEG00000019560dhx169972.417Oryzias_melastigma
ENSG00000204560DHX1610097.893ENSOGAG00000008300DHX1610097.893Otolemur_garnettii
ENSG00000204560DHX1610096.555ENSOARG00000012046DHX1610096.555Ovis_aries
ENSG00000204560DHX16100100.000ENSPPAG00000025169DHX16100100.000Pan_paniscus
ENSG00000204560DHX1610097.414ENSPPRG00000000329DHX1610097.414Panthera_pardus
ENSG00000204560DHX1610096.938ENSPTIG00000010694DHX1610096.938Panthera_tigris_altaica
ENSG00000204560DHX16100100.000ENSPTRG00000017935DHX16100100.000Pan_troglodytes
ENSG00000204560DHX1610096.435ENSPANG00000018482DHX1610096.435Papio_anubis
ENSG00000204560DHX169485.551ENSPKIG00000012693dhx169971.902Paramormyrops_kingsleyae
ENSG00000204560DHX169576.415ENSPSIG00000012007DHX169968.497Pelodiscus_sinensis
ENSG00000204560DHX169484.820ENSPMGG00000000154dhx169969.421Periophthalmus_magnuspinnatus
ENSG00000204560DHX1610095.985ENSPEMG00000017508Dhx1610095.985Peromyscus_maniculatus_bairdii
ENSG00000204560DHX1610092.234ENSPCIG00000014991DHX1610090.988Phascolarctos_cinereus
ENSG00000204560DHX169486.148ENSPFOG00000002575dhx169972.038Poecilia_formosa
ENSG00000204560DHX169485.769ENSPLAG00000014305dhx169971.970Poecilia_latipinna
ENSG00000204560DHX169486.148ENSPMEG00000006632dhx1610071.578Poecilia_mexicana
ENSG00000204560DHX169485.958ENSPREG00000003371dhx1610072.000Poecilia_reticulata
ENSG00000204560DHX1610099.042ENSPPYG00000016415DHX1610099.042Pongo_abelii
ENSG00000204560DHX1610092.050ENSPCAG00000017034DHX1610091.762Procavia_capensis
ENSG00000204560DHX1610098.180ENSPCOG00000013298DHX1610098.180Propithecus_coquereli
ENSG00000204560DHX169499.431ENSPVAG00000003984DHX169298.910Pteropus_vampyrus
ENSG00000204560DHX169485.932ENSPNYG00000018755dhx169872.727Pundamilia_nyererei
ENSG00000204560DHX169484.630ENSPNAG00000018065dhx169971.727Pygocentrus_nattereri
ENSG00000204560DHX1610095.885ENSRNOG00000030157Dhx1610095.885Rattus_norvegicus
ENSG00000204560DHX1610099.138ENSRBIG00000039655DHX1610099.138Rhinopithecus_bieti
ENSG00000204560DHX1610099.138ENSRROG00000031909DHX1610099.138Rhinopithecus_roxellana
ENSG00000204560DHX169046.555YNR011CPRP28347.067Saccharomyces_cerevisiae
ENSG00000204560DHX1610098.929ENSSBOG00000020142DHX1610098.929Saimiri_boliviensis_boliviensis
ENSG00000204560DHX169497.154ENSSHAG00000007234DHX1610090.412Sarcophilus_harrisii
ENSG00000204560DHX169485.009ENSSFOG00015019853dhx169873.029Scleropages_formosus
ENSG00000204560DHX168480.338ENSSMAG00000019598dhx169969.301Scophthalmus_maximus
ENSG00000204560DHX169485.199ENSSDUG00000006948dhx169972.433Seriola_dumerili
ENSG00000204560DHX169485.199ENSSLDG00000012742dhx169972.424Seriola_lalandi_dorsalis
ENSG00000204560DHX169488.046ENSSPUG00000015145DHX169976.141Sphenodon_punctatus
ENSG00000204560DHX169485.579ENSSPAG00000012416dhx169981.304Stegastes_partitus
ENSG00000204560DHX1610097.512ENSSSCG00000001376DHX1610097.512Sus_scrofa
ENSG00000204560DHX169485.009ENSTRUG00000004927dhx169971.198Takifugu_rubripes
ENSG00000204560DHX169485.009ENSTNIG00000011641dhx168677.303Tetraodon_nigroviridis
ENSG00000204560DHX169499.049ENSTTRG00000008323DHX168796.897Tursiops_truncatus
ENSG00000204560DHX1610097.220ENSUAMG00000026299DHX169999.430Ursus_americanus
ENSG00000204560DHX1610097.701ENSUMAG00000019661DHX169497.701Ursus_maritimus
ENSG00000204560DHX1610097.028ENSVVUG00000009831DHX1610097.028Vulpes_vulpes
ENSG00000204560DHX169380.460ENSXETG00000024069dhx1610065.476Xenopus_tropicalis
ENSG00000204560DHX168786.831ENSXCOG00000003774dhx169971.881Xiphophorus_couchianus
ENSG00000204560DHX169485.958ENSXMAG00000013293dhx169971.497Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000398mRNA splicing, via spliceosome20423332.25296192.IMPProcess
GO:0000398mRNA splicing, via spliceosome-TASProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003723RNA binding21873635.IBAFunction
GO:0003724RNA helicase activity9547260.TASFunction
GO:0005515protein binding22365833.25296192.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus20423332.25296192.IDAComponent
GO:0005654nucleoplasm20423332.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005681spliceosomal complex21873635.IBAComponent
GO:0005681spliceosomal complex25296192.IDAComponent
GO:0008380RNA splicing9547260.TASProcess
GO:0016887ATPase activity20423332.EXPFunction
GO:0034459ATP-dependent 3'-5' RNA helicase activity21873635.IBAFunction

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