EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000204569 (Gene tree)
Gene ID: 5514
Gene Symbol: PPP1R10
Alias: PNUTS|FB19|CAT53|p99
Full Name: protein phosphatase 1 regulatory subunit 10
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 18,213 bases
Position: chr6:30,600,400-30,618,612
Accession: 9284
RBP type: canonical RBP
Summary: This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000365694	zf-CCCH	PF00642.24	0.00031	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9450550	Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity.	FEBS Lett	1997 Dec 22	Kreivi JP	-
12574161	PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation.	J Biol Chem	2003 Apr 18	Kim YM	-
25416949	lncRNA directs cooperative epigenetic regulation downstream of chemokine signals.	Cell	2014 Nov 20	Xing Z	doi: 10.1016/j.cell.2014.10.013
28825698	A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.	Nat Cell Biol	2017 Sep	Grelet S	doi: 10.1038/ncb3595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000376511	PPP1R10-201	4525	XM_006715130	ENSP00000365694	940 (aa)	XP_006715193	Q96QC0
ENST00000496955	PPP1R10-207	476	-	-	- (aa)	-	-
ENST00000484449	PPP1R10-206	605	-	-	- (aa)	-	-
ENST00000461593	PPP1R10-202	566	-	-	- (aa)	-	-
ENST00000468181	PPP1R10-203	333	-	-	- (aa)	-	-
ENST00000476704	PPP1R10-205	559	-	-	- (aa)	-	-
ENST00000473954	PPP1R10-204	470	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000204569's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000204569	Behcet Syndrome	3.60526097182821E-05	20622878
ENSG00000204569	Behcet Syndrome	4.72190543189162E-05	20622878

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000204569	rs1264423	6	30603694	C	Mean corpuscular volume	27863252	[0.021-0.035] unit decrease	0.02836222	EFO_0004526
ENSG00000204569	rs114757170	6	30618254	?	Psoriatic arthritis	30552173	[NR] z-score increase	6.12	EFO_0003778
ENSG00000204569	rs9262122	6	30606065	?	Pemphigus vulgaris	30169916		2.73	EFO_0004719

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204569's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000204569	PPP1R10	77	86.486	ENSAPOG00000003740	ppp1r10	84	88.571	Acanthochromis_polyacanthus
ENSG00000204569	PPP1R10	100	96.292	ENSAMEG00000013293	PPP1R10	100	96.292	Ailuropoda_melanoleuca
ENSG00000204569	PPP1R10	68	86.486	ENSACIG00000013112	ppp1r10	85	88.571	Amphilophus_citrinellus
ENSG00000204569	PPP1R10	77	89.189	ENSAOCG00000008598	ppp1r10	84	91.429	Amphiprion_ocellaris
ENSG00000204569	PPP1R10	77	89.189	ENSAPEG00000008144	ppp1r10	84	91.429	Amphiprion_percula
ENSG00000204569	PPP1R10	69	89.189	ENSATEG00000012958	ppp1r10	84	91.429	Anabas_testudineus
ENSG00000204569	PPP1R10	100	97.024	ENSANAG00000032283	PPP1R10	100	97.024	Aotus_nancymaae
ENSG00000204569	PPP1R10	72	86.486	ENSACLG00000015430	ppp1r10	84	88.571	Astatotilapia_calliptera
ENSG00000204569	PPP1R10	69	94.595	ENSAMXG00000011836	ppp1r10	82	94.286	Astyanax_mexicanus
ENSG00000204569	PPP1R10	100	94.698	ENSBTAG00000006933	PPP1R10	100	94.698	Bos_taurus
ENSG00000204569	PPP1R10	100	97.134	ENSCJAG00000019956	PPP1R10	100	97.134	Callithrix_jacchus
ENSG00000204569	PPP1R10	100	96.170	ENSCAFG00000000406	PPP1R10	100	96.170	Canis_familiaris
ENSG00000204569	PPP1R10	100	94.894	ENSCHIG00000007066	PPP1R10	100	94.894	Capra_hircus
ENSG00000204569	PPP1R10	100	96.489	ENSTSYG00000003315	PPP1R10	100	96.489	Carlito_syrichta
ENSG00000204569	PPP1R10	65	86.371	ENSCAPG00000003849	PPP1R10	71	85.226	Cavia_aperea
ENSG00000204569	PPP1R10	81	86.414	ENSCPOG00000015402	PPP1R10	86	85.940	Cavia_porcellus
ENSG00000204569	PPP1R10	100	97.343	ENSCCAG00000030052	PPP1R10	100	97.343	Cebus_capucinus
ENSG00000204569	PPP1R10	100	99.362	ENSCATG00000039578	PPP1R10	100	99.362	Cercocebus_atys
ENSG00000204569	PPP1R10	100	91.489	ENSCLAG00000002371	PPP1R10	100	90.658	Chinchilla_lanigera
ENSG00000204569	PPP1R10	100	99.362	ENSCSAG00000008228	PPP1R10	100	99.362	Chlorocebus_sabaeus
ENSG00000204569	PPP1R10	100	99.150	ENSCANG00000043534	PPP1R10	100	99.150	Colobus_angolensis_palliatus
ENSG00000204569	PPP1R10	100	88.629	ENSCGRG00001020281	Ppp1r10	100	87.779	Cricetulus_griseus_chok1gshd
ENSG00000204569	PPP1R10	99	77.805	ENSCGRG00000002451	-	99	74.441	Cricetulus_griseus_crigri
ENSG00000204569	PPP1R10	100	90.436	ENSCGRG00000016957	-	100	90.329	Cricetulus_griseus_crigri
ENSG00000204569	PPP1R10	61	56.739	ENSCSEG00000018699	ppp1r10	83	94.286	Cynoglossus_semilaevis
ENSG00000204569	PPP1R10	70	86.486	ENSCVAG00000004813	ppp1r10	85	88.571	Cyprinodon_variegatus
ENSG00000204569	PPP1R10	70	92.683	ENSDARG00000032651	ppp1r10	81	100.000	Danio_rerio
ENSG00000204569	PPP1R10	79	94.792	ENSDNOG00000048565	PPP1R10	68	98.718	Dasypus_novemcinctus
ENSG00000204569	PPP1R10	100	90.426	ENSDORG00000003198	Ppp1r10	100	89.278	Dipodomys_ordii
ENSG00000204569	PPP1R10	88	91.984	ENSETEG00000009219	PPP1R10	100	83.187	Echinops_telfairi
ENSG00000204569	PPP1R10	69	79.412	ENSEBUG00000007387	ppp1r10	82	88.571	Eptatretus_burgeri
ENSG00000204569	PPP1R10	100	95.412	ENSEASG00005018919	PPP1R10	100	94.682	Equus_asinus_asinus
ENSG00000204569	PPP1R10	100	95.412	ENSECAG00000010033	PPP1R10	100	94.682	Equus_caballus
ENSG00000204569	PPP1R10	100	89.396	ENSEEUG00000013927	PPP1R10	100	87.196	Erinaceus_europaeus
ENSG00000204569	PPP1R10	69	91.667	ENSELUG00000023682	ppp1r10	84	91.429	Esox_lucius
ENSG00000204569	PPP1R10	100	96.918	ENSFCAG00000007682	PPP1R10	100	96.918	Felis_catus
ENSG00000204569	PPP1R10	100	87.447	ENSFDAG00000010758	PPP1R10	100	88.404	Fukomys_damarensis
ENSG00000204569	PPP1R10	77	86.486	ENSFHEG00000017874	ppp1r10	85	88.571	Fundulus_heteroclitus
ENSG00000204569	PPP1R10	77	87.097	ENSGAFG00000009040	ppp1r10	85	91.429	Gambusia_affinis
ENSG00000204569	PPP1R10	68	76.515	ENSGAGG00000018744	PPP1R10	75	75.606	Gopherus_agassizii
ENSG00000204569	PPP1R10	100	99.894	ENSGGOG00000011307	PPP1R10	100	99.894	Gorilla_gorilla
ENSG00000204569	PPP1R10	72	86.486	ENSHBUG00000008436	ppp1r10	84	88.571	Haplochromis_burtoni
ENSG00000204569	PPP1R10	94	90.649	ENSHGLG00000019477	PPP1R10	100	81.442	Heterocephalus_glaber_female
ENSG00000204569	PPP1R10	94	90.649	ENSHGLG00100008538	PPP1R10	100	81.442	Heterocephalus_glaber_male
ENSG00000204569	PPP1R10	72	91.667	ENSHCOG00000007003	ppp1r10	78	91.429	Hippocampus_comes
ENSG00000204569	PPP1R10	69	97.297	ENSIPUG00000013974	ppp1r10	81	97.143	Ictalurus_punctatus
ENSG00000204569	PPP1R10	100	89.408	ENSSTOG00000011840	PPP1R10	100	90.302	Ictidomys_tridecemlineatus
ENSG00000204569	PPP1R10	100	89.362	ENSJJAG00000006676	Ppp1r10	100	90.000	Jaculus_jaculus
ENSG00000204569	PPP1R10	77	87.097	ENSKMAG00000003424	ppp1r10	85	91.429	Kryptolebias_marmoratus
ENSG00000204569	PPP1R10	65	54.545	ENSLBEG00000013028	ppp1r10	84	91.429	Labrus_bergylta
ENSG00000204569	PPP1R10	73	65.455	ENSLACG00000003576	PPP1R10	84	88.235	Latimeria_chalumnae
ENSG00000204569	PPP1R10	85	94.760	ENSLAFG00000017271	PPP1R10	100	92.365	Loxodonta_africana
ENSG00000204569	PPP1R10	100	99.256	ENSMFAG00000035544	PPP1R10	100	99.256	Macaca_fascicularis
ENSG00000204569	PPP1R10	100	99.150	ENSMMUG00000006524	PPP1R10	100	99.150	Macaca_mulatta
ENSG00000204569	PPP1R10	100	99.256	ENSMNEG00000040255	PPP1R10	100	99.256	Macaca_nemestrina
ENSG00000204569	PPP1R10	100	92.910	ENSMLEG00000035721	PPP1R10	100	92.910	Mandrillus_leucophaeus
ENSG00000204569	PPP1R10	70	89.189	ENSMAMG00000020241	ppp1r10	84	91.429	Mastacembelus_armatus
ENSG00000204569	PPP1R10	72	86.486	ENSMZEG00005017906	ppp1r10	84	88.571	Maylandia_zebra
ENSG00000204569	PPP1R10	100	90.426	ENSMAUG00000010075	Ppp1r10	100	90.319	Mesocricetus_auratus
ENSG00000204569	PPP1R10	100	93.737	ENSMICG00000038776	PPP1R10	100	93.737	Microcebus_murinus
ENSG00000204569	PPP1R10	85	89.927	ENSMOCG00000008183	Ppp1r10	100	82.234	Microtus_ochrogaster
ENSG00000204569	PPP1R10	69	89.189	ENSMMOG00000012063	ppp1r10	80	91.429	Mola_mola
ENSG00000204569	PPP1R10	83	89.436	ENSMODG00000015941	PPP1R10	100	77.555	Monodelphis_domestica
ENSG00000204569	PPP1R10	70	89.189	ENSMALG00000019484	ppp1r10	85	91.429	Monopterus_albus
ENSG00000204569	PPP1R10	100	93.233	ENSMUSG00000039220	Ppp1r10	100	87.979	Mus_musculus
ENSG00000204569	PPP1R10	97	93.606	MGP_PahariEiJ_G0020536	Ppp1r10	100	86.596	Mus_pahari
ENSG00000204569	PPP1R10	100	93.358	MGP_SPRETEiJ_G0022449	Ppp1r10	100	88.085	Mus_spretus
ENSG00000204569	PPP1R10	100	95.293	ENSMPUG00000011774	PPP1R10	100	94.561	Mustela_putorius_furo
ENSG00000204569	PPP1R10	78	95.918	ENSMLUG00000008812	PPP1R10	100	83.579	Myotis_lucifugus
ENSG00000204569	PPP1R10	100	88.983	ENSNGAG00000007237	Ppp1r10	100	88.136	Nannospalax_galili
ENSG00000204569	PPP1R10	100	97.981	ENSNLEG00000005196	PPP1R10	100	97.981	Nomascus_leucogenys
ENSG00000204569	PPP1R10	100	88.960	ENSODEG00000018020	PPP1R10	100	89.172	Octodon_degus
ENSG00000204569	PPP1R10	72	84.615	ENSONIG00000015940	ppp1r10	81	88.571	Oreochromis_niloticus
ENSG00000204569	PPP1R10	74	86.486	ENSORLG00000010539	ppp1r10	84	88.571	Oryzias_latipes
ENSG00000204569	PPP1R10	74	86.486	ENSORLG00020018480	ppp1r10	84	88.571	Oryzias_latipes_hni
ENSG00000204569	PPP1R10	74	86.486	ENSORLG00015010204	ppp1r10	84	88.571	Oryzias_latipes_hsok
ENSG00000204569	PPP1R10	77	89.189	ENSOMEG00000008179	ppp1r10	80	91.429	Oryzias_melastigma
ENSG00000204569	PPP1R10	100	96.101	ENSOGAG00000004433	PPP1R10	100	96.101	Otolemur_garnettii
ENSG00000204569	PPP1R10	100	89.725	ENSOARG00000012809	PPP1R10	100	90.148	Ovis_aries
ENSG00000204569	PPP1R10	100	99.468	ENSPPAG00000038737	PPP1R10	100	99.468	Pan_paniscus
ENSG00000204569	PPP1R10	100	96.702	ENSPPRG00000004557	PPP1R10	100	96.702	Panthera_pardus
ENSG00000204569	PPP1R10	100	94.038	ENSPTIG00000016854	PPP1R10	100	93.515	Panthera_tigris_altaica
ENSG00000204569	PPP1R10	100	99.574	ENSPTRG00000017931	PPP1R10	100	99.574	Pan_troglodytes
ENSG00000204569	PPP1R10	100	99.362	ENSPANG00000020095	PPP1R10	100	99.362	Papio_anubis
ENSG00000204569	PPP1R10	69	92.857	ENSPKIG00000010930	ppp1r10	80	100.000	Paramormyrops_kingsleyae
ENSG00000204569	PPP1R10	69	91.667	ENSPKIG00000012161	-	81	91.429	Paramormyrops_kingsleyae
ENSG00000204569	PPP1R10	81	77.519	ENSPSIG00000009778	PPP1R10	70	76.124	Pelodiscus_sinensis
ENSG00000204569	PPP1R10	70	89.189	ENSPMGG00000020543	ppp1r10	84	91.429	Periophthalmus_magnuspinnatus
ENSG00000204569	PPP1R10	100	90.106	ENSPEMG00000015950	Ppp1r10	100	88.617	Peromyscus_maniculatus_bairdii
ENSG00000204569	PPP1R10	83	90.029	ENSPCIG00000014980	PPP1R10	100	78.316	Phascolarctos_cinereus
ENSG00000204569	PPP1R10	77	89.189	ENSPFOG00000016442	ppp1r10	85	91.429	Poecilia_formosa
ENSG00000204569	PPP1R10	77	89.189	ENSPLAG00000002557	ppp1r10	85	91.429	Poecilia_latipinna
ENSG00000204569	PPP1R10	77	89.189	ENSPMEG00000010957	ppp1r10	85	91.429	Poecilia_mexicana
ENSG00000204569	PPP1R10	77	89.189	ENSPREG00000012202	ppp1r10	85	91.429	Poecilia_reticulata
ENSG00000204569	PPP1R10	100	97.556	ENSPPYG00000016411	PPP1R10	100	97.981	Pongo_abelii
ENSG00000204569	PPP1R10	100	89.513	ENSPCAG00000017016	PPP1R10	100	86.138	Procavia_capensis
ENSG00000204569	PPP1R10	100	96.391	ENSPCOG00000018147	PPP1R10	100	96.391	Propithecus_coquereli
ENSG00000204569	PPP1R10	67	95.983	ENSPVAG00000003978	PPP1R10	91	95.983	Pteropus_vampyrus
ENSG00000204569	PPP1R10	72	86.486	ENSPNYG00000011242	ppp1r10	84	88.571	Pundamilia_nyererei
ENSG00000204569	PPP1R10	71	94.444	ENSPNAG00000029840	ppp1r10	85	94.118	Pygocentrus_nattereri
ENSG00000204569	PPP1R10	100	99.256	ENSRBIG00000029983	PPP1R10	100	99.256	Rhinopithecus_bieti
ENSG00000204569	PPP1R10	100	99.256	ENSRROG00000036243	PPP1R10	100	99.256	Rhinopithecus_roxellana
ENSG00000204569	PPP1R10	100	97.237	ENSSBOG00000021454	PPP1R10	100	97.237	Saimiri_boliviensis_boliviensis
ENSG00000204569	PPP1R10	76	89.731	ENSSHAG00000006485	PPP1R10	98	86.139	Sarcophilus_harrisii
ENSG00000204569	PPP1R10	70	92.857	ENSSFOG00015015630	ppp1r10	87	100.000	Scleropages_formosus
ENSG00000204569	PPP1R10	70	68.519	ENSSFOG00015020118	-	89	91.429	Scleropages_formosus
ENSG00000204569	PPP1R10	70	91.667	ENSSMAG00000020782	ppp1r10	84	91.429	Scophthalmus_maximus
ENSG00000204569	PPP1R10	69	89.189	ENSSDUG00000009482	ppp1r10	79	91.429	Seriola_dumerili
ENSG00000204569	PPP1R10	83	97.630	ENSSARG00000002766	PPP1R10	83	97.630	Sorex_araneus
ENSG00000204569	PPP1R10	77	89.189	ENSSPAG00000004460	ppp1r10	84	91.429	Stegastes_partitus
ENSG00000204569	PPP1R10	100	95.440	ENSSSCG00000001347	PPP1R10	100	95.440	Sus_scrofa
ENSG00000204569	PPP1R10	78	82.927	ENSTRUG00000014322	ppp1r10	83	91.429	Takifugu_rubripes
ENSG00000204569	PPP1R10	100	92.259	ENSTTRG00000008309	PPP1R10	100	93.107	Tursiops_truncatus
ENSG00000204569	PPP1R10	100	96.603	ENSUAMG00000005839	PPP1R10	100	96.603	Ursus_americanus
ENSG00000204569	PPP1R10	100	91.277	ENSUMAG00000019567	PPP1R10	100	91.485	Ursus_maritimus
ENSG00000204569	PPP1R10	100	95.745	ENSVVUG00000009608	PPP1R10	100	95.745	Vulpes_vulpes
ENSG00000204569	PPP1R10	77	87.097	ENSXCOG00000003022	ppp1r10	84	91.429	Xiphophorus_couchianus
ENSG00000204569	PPP1R10	77	87.097	ENSXMAG00000016711	ppp1r10	85	91.429	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000784	nuclear chromosome, telomeric region	24270157.	IDA	Component
GO:0000785	chromatin	-	ISS	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004864	protein phosphatase inhibitor activity	-	IEA	Function
GO:0005515	protein binding	15231748.28330616.	IPI	Function
GO:0005634	nucleus	9461602.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0006606	protein import into nucleus	9461602.	TAS	Process
GO:0010667	negative regulation of cardiac muscle cell apoptotic process	23426265.	IDA	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0032206	positive regulation of telomere maintenance	23426265.	IMP	Process
GO:0032515	negative regulation of phosphoprotein phosphatase activity	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0072357	PTW/PP1 phosphatase complex	-	ISS	Component
GO:1904290	negative regulation of mitotic DNA damage checkpoint	23426265.	IGI	Process