EuRBPDB

Description

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000204574 (Gene tree)
Gene ID: 23
Gene Symbol: ABCF1
Alias: EST123147|ABC50
Full Name: ATP binding cassette subfamily F member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 25,804 bases
Position: chr6:30,571,376-30,597,179
Accession: 70
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24552478	ATP-binding cassette transporter A1 (ABCA1) promotes arsenic tolerance in human cells by reducing cellular arsenic accumulation.	Clin Exp Pharmacol Physiol	2014 Apr	Tan X	doi: 10.1111/1440-1681.12219.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000468958	ABCF1-204	606	-	ENSP00000440893	105 (aa)	-	F5GYK6
ENST00000326195	ABCF1-201	3481	-	ENSP00000313603	845 (aa)	-	Q8NE71
ENST00000376545	ABCF1-202	3131	-	ENSP00000365728	807 (aa)	-	Q8NE71
ENST00000479542	ABCF1-206	893	-	-	- (aa)	-	-
ENST00000441867	ABCF1-203	1074	-	ENSP00000405512	339 (aa)	-	Q5STZ8
ENST00000475993	ABCF1-205	2860	-	ENSP00000445100	596 (aa)	-	H0YGW7
ENST00000542772	ABCF1-207	223	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000204574's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000204574	Lupus Erythematosus, Systemic	1.14596E-8	18204098
ENSG00000204574	Influenza A Virus, H1N1 Subtype	1E-8	26379185
ENSG00000204574	Graves Disease	1E-13	21900946

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000204574	rs4148247	6	30571428	?	Mild influenza (H1N1) infection	26379185	[5.27-6.66]	5.963	EFO_1001488
ENSG00000204574	rs3132610	6	30576624	G	Breast cancer	29059683	[0.03-0.07] unit decrease	0.0499	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204574's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000204574	ABCF1	96	63.966	FBgn0030321	CG1703	66	63.790	Drosophila_melanogaster
ENSG00000204574	ABCF1	99	96.975	ENSMUSG00000038762	Abcf1	100	90.555	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	17894550.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005635	nuclear envelope	-	IEA	Component
GO:0005654	nucleoplasm	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005840	ribosome	-	IEA	Component
GO:0006412	translation	9790762.	TAS	Process
GO:0006954	inflammatory response	9790762.	TAS	Process
GO:0008135	translation factor activity, RNA binding	9790762.	TAS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016887	ATPase activity	-	IEA	Function
GO:0055085	transmembrane transport	-	TAS	Process