EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000204843 (Gene tree)
Gene ID: 1639
Gene Symbol: DCTN1
Alias: N
Full Name: dynactin subunit 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 30,934 bases
Position: chr2:74,361,154-74,392,087
Accession: 2711
RBP type: non-canonical RBP
Summary: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26504169	Microtubule plus end-associated CLIP-170 initiates HSV-1 retrograde transport in primary human cells.	J Cell Biol	2015 Oct 26	Jovasevic V	doi: 10.1083/jcb.201505123.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000495895	DCTN1-224	503	-	-	- (aa)	-	-
ENST00000409567	DCTN1-205	4024	-	ENSP00000386843	1253 (aa)	-	Q14203
ENST00000437375	DCTN1-211	598	-	ENSP00000395312	87 (aa)	-	C9JJN7
ENST00000491465	DCTN1-221	2444	-	-	- (aa)	-	-
ENST00000458655	DCTN1-215	565	-	ENSP00000414315	186 (aa)	-	E9PCY0
ENST00000413111	DCTN1-207	593	-	ENSP00000413268	76 (aa)	-	C9JZA4
ENST00000421392	DCTN1-209	542	-	ENSP00000409363	76 (aa)	-	C9JTE5
ENST00000449655	DCTN1-213	561	-	ENSP00000407484	13 (aa)	-	C9JUI8
ENST00000463583	DCTN1-217	569	-	-	- (aa)	-	-
ENST00000462813	DCTN1-216	342	-	-	- (aa)	-	-
ENST00000409868	DCTN1-206	4202	-	ENSP00000387327	1256 (aa)	-	E7EX90
ENST00000394003	DCTN1-202	4479	-	ENSP00000377571	1271 (aa)	-	Q14203
ENST00000361874	DCTN1-201	4500	-	ENSP00000354791	1278 (aa)	-	Q14203
ENST00000454119	DCTN1-214	627	-	ENSP00000404038	121 (aa)	-	C9JJD0
ENST00000477966	DCTN1-220	766	-	-	- (aa)	-	-
ENST00000495643	DCTN1-223	673	-	-	- (aa)	-	-
ENST00000409438	DCTN1-204	4145	-	ENSP00000387270	1139 (aa)	-	Q14203
ENST00000409240	DCTN1-203	4365	-	ENSP00000386406	1236 (aa)	-	Q14203
ENST00000633691	DCTN1-227	4160	-	ENSP00000487724	1144 (aa)	-	Q14203
ENST00000492717	DCTN1-222	371	-	-	- (aa)	-	-
ENST00000417090	DCTN1-208	556	-	ENSP00000402509	135 (aa)	-	C9JKG6
ENST00000440727	DCTN1-212	521	-	ENSP00000400059	64 (aa)	-	C9J1B7
ENST00000466110	DCTN1-218	5414	-	-	- (aa)	-	-
ENST00000628224	DCTN1-226	4485	-	ENSP00000487279	1256 (aa)	-	E7EX90
ENST00000497666	DCTN1-225	479	-	-	- (aa)	-	-
ENST00000434055	DCTN1-210	4229	-	ENSP00000416711	890 (aa)	-	Q6AWB1
ENST00000470351	DCTN1-219	557	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000204843's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04962	Vasopressin-regulated water reabsorption	KEGG
hsa05016	Huntington disease	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000204843's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000132	establishment of mitotic spindle orientation	22327364.	IMP	Process
GO:0000278	mitotic cell cycle	1828535.	NAS	Process
GO:0000776	kinetochore	19468067.23027904.	IDA	Component
GO:0000922	spindle pole	14718566.	IDA	Component
GO:0003774	motor activity	-	IEA	Function
GO:0005515	protein binding	9361024.9722614.12857853.15107855.17139249.17532294.17828275.17828277.17932487.18000879.18615096.18922795.19619496.19935774.20133940.20679239.20719959.20978158.22159412.22261744.22777741.22797915.23414759.23524952.23874158.24867236.24997520.25189619.26496610.26638075.26972003.27173435.28394342.	IPI	Function
GO:0005635	nuclear envelope	20679239.	IDA	Component
GO:0005737	cytoplasm	18305234.	IDA	Component
GO:0005813	centrosome	20719959.21399614.23985322.25774020.	IDA	Component
GO:0005814	centriole	23213374.23386061.25774020.	IDA	Component
GO:0005819	spindle	25774020.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005869	dynactin complex	-	IEA	Component
GO:0005874	microtubule	21525035.22777741.25774020.	IDA	Component
GO:0005875	microtubule associated complex	16505168.	IMP	Component
GO:0005938	cell cortex	23027904.	IDA	Component
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0007399	nervous system development	17360970.	NAS	Process
GO:0007528	neuromuscular junction development	18305234.	IMP	Process
GO:0008017	microtubule binding	23874158.26972003.	IDA	Function
GO:0008017	microtubule binding	16505168.	IMP	Function
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0010457	centriole-centriole cohesion	23386061.	IMP	Process
GO:0015631	tubulin binding	23874158.	IDA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0019901	protein kinase binding	17139249.	IPI	Function
GO:0021517	ventral spinal cord development	18305234.	IMP	Process
GO:0030286	dynein complex	-	IEA	Component
GO:0030424	axon	-	IEA	Component
GO:0030904	retromer complex	19619496.	IDA	Component
GO:0031116	positive regulation of microtubule polymerization	23874158.	IDA	Process
GO:0031116	positive regulation of microtubule polymerization	16505168.	IMP	Process
GO:0034454	microtubule anchoring at centrosome	23386061.	IMP	Process
GO:0035371	microtubule plus-end	26972003.	IDA	Component
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0042147	retrograde transport, endosome to Golgi	19619496.	IMP	Process
GO:0043005	neuron projection	18364389.	IDA	Component
GO:0043025	neuronal cell body	18364389.	IDA	Component
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0048156	tau protein binding	28386764.	NAS	Function
GO:0050905	neuromuscular process	18305234.	IMP	Process
GO:0051081	nuclear envelope disassembly	20679239.	IMP	Process
GO:0051301	cell division	-	IEA	Process
GO:0060236	regulation of mitotic spindle organization	23027904.	IMP	Process
GO:0061744	motor behavior	18305234.18364389.	IMP	Process
GO:0070050	neuron cellular homeostasis	18305234.	IMP	Process
GO:0070840	dynein complex binding	-	IEA	Function
GO:0090063	positive regulation of microtubule nucleation	23874158.	IDA	Process
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process
GO:0098930	axonal transport	18364389.	IMP	Process
GO:0099558	maintenance of synapse structure	18305234.	TAS	Process
GO:0099738	cell cortex region	22327364.	IDA	Component
GO:0120103	centriolar subdistal appendage	23213374.	IDA	Component
GO:1904398	positive regulation of neuromuscular junction development	18364389.	IMP	Process
GO:1905515	non-motile cilium assembly	25774020.	IMP	Process
GO:1990535	neuron projection maintenance	18305234.18364389.	IMP	Process