EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000205339 (Gene tree)
Gene ID: 10527
Gene Symbol: IPO7
Alias: Imp7|RANBP7
Full Name: importin 7
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 63,506 bases
Position: chr11:9,384,622-9,448,127
Accession: 9852
RBP type: canonical RBP
Summary: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000369042	IBN_N	PF03810.19	7.6e-22	1	1
ENSP00000435235	IBN_N	PF03810.19	0.00022	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30195762	LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions.	Mol Ther Nucleic Acids	2018 Sep 7	Barbagallo C	doi: 10.1016/j.omtn.2018.05.009

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000530037	IPO7-204	347	-	-	- (aa)	-	-
ENST00000527431	IPO7-202	607	-	ENSP00000435235	130 (aa)	-	E9PLB2
ENST00000533680	IPO7-207	639	-	-	- (aa)	-	-
ENST00000630083	IPO7-208	195	-	ENSP00000486575	64 (aa)	-	E9PLJ0
ENST00000528833	IPO7-203	355	-	-	- (aa)	-	-
ENST00000533233	IPO7-206	578	-	ENSP00000433313	64 (aa)	-	E9PLJ0
ENST00000379719	IPO7-201	6191	-	ENSP00000369042	1038 (aa)	-	O95373
ENST00000531235	IPO7-205	283	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000205339's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000205339	rs12279202	11	9410543	T	Interleukin-10 levels	22205395	[NR] unit decrease	0.06	EFO_0004750

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000205339's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000205339	IPO7	56	63.889	ENSG00000126653	NSRP1	53	63.889
ENSG00000205339	IPO7	99	64.666	ENSG00000133704	IPO8	100	65.563

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000205339	IPO7	100	86.237	ENSAPOG00000014238	ipo7	100	86.429	Acanthochromis_polyacanthus
ENSG00000205339	IPO7	100	100.000	ENSAMEG00000003914	IPO7	100	99.615	Ailuropoda_melanoleuca
ENSG00000205339	IPO7	100	81.792	ENSACIG00000000608	ipo7	100	81.923	Amphilophus_citrinellus
ENSG00000205339	IPO7	100	86.526	ENSAOCG00000009342	ipo7	100	86.718	Amphiprion_ocellaris
ENSG00000205339	IPO7	100	86.526	ENSAPEG00000009820	ipo7	100	86.718	Amphiprion_percula
ENSG00000205339	IPO7	100	85.178	ENSATEG00000006501	ipo7	100	85.659	Anabas_testudineus
ENSG00000205339	IPO7	99	94.574	ENSAPLG00000016161	IPO7	100	96.146	Anas_platyrhynchos
ENSG00000205339	IPO7	100	97.013	ENSACAG00000009452	IPO7	100	97.013	Anolis_carolinensis
ENSG00000205339	IPO7	100	99.904	ENSANAG00000037854	IPO7	100	99.904	Aotus_nancymaae
ENSG00000205339	IPO7	99	77.519	ENSACLG00000026148	-	87	78.489	Astatotilapia_calliptera
ENSG00000205339	IPO7	100	85.659	ENSACLG00000027247	ipo7	100	86.333	Astatotilapia_calliptera
ENSG00000205339	IPO7	100	78.887	ENSAMXG00000009895	ipo7	100	78.215	Astyanax_mexicanus
ENSG00000205339	IPO7	100	100.000	ENSBTAG00000027722	IPO7	100	99.904	Bos_taurus
ENSG00000205339	IPO7	100	100.000	ENSCJAG00000011395	IPO7	100	100.000	Callithrix_jacchus
ENSG00000205339	IPO7	100	100.000	ENSCAFG00000007259	IPO7	100	100.000	Canis_familiaris
ENSG00000205339	IPO7	100	100.000	ENSCAFG00020011426	IPO7	100	100.000	Canis_lupus_dingo
ENSG00000205339	IPO7	100	100.000	ENSCHIG00000024527	IPO7	100	99.711	Capra_hircus
ENSG00000205339	IPO7	100	99.615	ENSTSYG00000004959	IPO7	100	99.615	Carlito_syrichta
ENSG00000205339	IPO7	100	100.000	ENSCPOG00000013623	IPO7	100	99.807	Cavia_porcellus
ENSG00000205339	IPO7	100	99.231	ENSCCAG00000020955	IPO7	100	98.381	Cebus_capucinus
ENSG00000205339	IPO7	100	100.000	ENSCATG00000042452	IPO7	100	92.486	Cercocebus_atys
ENSG00000205339	IPO7	100	99.518	ENSCLAG00000015913	IPO7	100	99.518	Chinchilla_lanigera
ENSG00000205339	IPO7	100	100.000	ENSCSAG00000004504	IPO7	100	100.000	Chlorocebus_sabaeus
ENSG00000205339	IPO7	100	97.977	ENSCPBG00000022842	IPO7	98	97.977	Chrysemys_picta_bellii
ENSG00000205339	IPO7	98	52.050	ENSCING00000008592	-	99	51.643	Ciona_intestinalis
ENSG00000205339	IPO7	99	55.077	ENSCSAVG00000011751	-	99	55.268	Ciona_savignyi
ENSG00000205339	IPO7	100	100.000	ENSCANG00000032804	IPO7	100	99.776	Colobus_angolensis_palliatus
ENSG00000205339	IPO7	100	99.711	ENSCGRG00001019770	Ipo7	100	99.711	Cricetulus_griseus_chok1gshd
ENSG00000205339	IPO7	100	99.711	ENSCGRG00000016689	Ipo7	100	99.711	Cricetulus_griseus_crigri
ENSG00000205339	IPO7	100	86.141	ENSCSEG00000009451	ipo7	100	85.852	Cynoglossus_semilaevis
ENSG00000205339	IPO7	100	85.467	ENSCVAG00000017260	ipo7	100	85.563	Cyprinodon_variegatus
ENSG00000205339	IPO7	100	84.793	ENSDARG00000035751	ipo7	100	84.986	Danio_rerio
ENSG00000205339	IPO7	100	100.000	ENSDNOG00000016138	IPO7	100	99.807	Dasypus_novemcinctus
ENSG00000205339	IPO7	100	99.518	ENSDORG00000013699	Ipo7	100	99.518	Dipodomys_ordii
ENSG00000205339	IPO7	99	53.169	FBgn0026252	msk	100	53.075	Drosophila_melanogaster
ENSG00000205339	IPO7	92	94.368	ENSETEG00000001023	IPO7	92	94.368	Echinops_telfairi
ENSG00000205339	IPO7	99	59.690	ENSEBUG00000016040	-	99	67.756	Eptatretus_burgeri
ENSG00000205339	IPO7	100	63.820	ENSEBUG00000003477	ipo7	100	63.628	Eptatretus_burgeri
ENSG00000205339	IPO7	100	99.231	ENSEASG00005003575	IPO7	100	99.598	Equus_asinus_asinus
ENSG00000205339	IPO7	100	99.807	ENSECAG00000015965	IPO7	100	99.807	Equus_caballus
ENSG00000205339	IPO7	85	99.208	ENSEEUG00000014059	IPO7	85	99.208	Erinaceus_europaeus
ENSG00000205339	IPO7	100	86.333	ENSELUG00000007853	ipo7	100	86.333	Esox_lucius
ENSG00000205339	IPO7	100	100.000	ENSFCAG00000030327	IPO7	100	100.000	Felis_catus
ENSG00000205339	IPO7	96	97.085	ENSFALG00000000979	IPO7	100	97.085	Ficedula_albicollis
ENSG00000205339	IPO7	100	99.133	ENSFDAG00000011342	IPO7	100	99.133	Fukomys_damarensis
ENSG00000205339	IPO7	98	81.737	ENSFHEG00000007582	ipo7	99	81.836	Fundulus_heteroclitus
ENSG00000205339	IPO7	89	86.749	ENSGMOG00000001681	ipo7	98	86.749	Gadus_morhua
ENSG00000205339	IPO7	100	97.688	ENSGALG00000005807	IPO7	100	97.688	Gallus_gallus
ENSG00000205339	IPO7	100	85.563	ENSGAFG00000017037	ipo7	100	85.756	Gambusia_affinis
ENSG00000205339	IPO7	100	86.141	ENSGACG00000015677	ipo7	100	86.429	Gasterosteus_aculeatus
ENSG00000205339	IPO7	100	97.881	ENSGAGG00000020412	IPO7	98	97.881	Gopherus_agassizii
ENSG00000205339	IPO7	100	100.000	ENSGGOG00000002260	IPO7	100	100.000	Gorilla_gorilla
ENSG00000205339	IPO7	100	78.420	ENSGGOG00000026484	-	100	78.131	Gorilla_gorilla
ENSG00000205339	IPO7	100	85.756	ENSHBUG00000017323	ipo7	100	86.429	Haplochromis_burtoni
ENSG00000205339	IPO7	100	75.385	ENSHGLG00000000256	-	100	68.798	Heterocephalus_glaber_female
ENSG00000205339	IPO7	100	100.000	ENSHGLG00000005147	IPO7	100	99.711	Heterocephalus_glaber_female
ENSG00000205339	IPO7	100	100.000	ENSHGLG00100013871	IPO7	99	99.702	Heterocephalus_glaber_male
ENSG00000205339	IPO7	100	75.385	ENSHGLG00100017940	-	100	68.607	Heterocephalus_glaber_male
ENSG00000205339	IPO7	100	85.178	ENSHCOG00000002290	ipo7	100	84.986	Hippocampus_comes
ENSG00000205339	IPO7	100	85.467	ENSIPUG00000020136	ipo7	100	85.659	Ictalurus_punctatus
ENSG00000205339	IPO7	100	99.711	ENSSTOG00000009601	IPO7	100	99.711	Ictidomys_tridecemlineatus
ENSG00000205339	IPO7	100	99.231	ENSJJAG00000018743	Ipo7	100	94.514	Jaculus_jaculus
ENSG00000205339	IPO7	100	84.216	ENSKMAG00000004961	ipo7	100	84.793	Kryptolebias_marmoratus
ENSG00000205339	IPO7	100	86.044	ENSLBEG00000027402	ipo7	100	86.237	Labrus_bergylta
ENSG00000205339	IPO7	100	90.865	ENSLACG00000017593	IPO7	100	90.865	Latimeria_chalumnae
ENSG00000205339	IPO7	100	89.423	ENSLOCG00000003606	ipo7	100	89.423	Lepisosteus_oculatus
ENSG00000205339	IPO7	100	99.518	ENSLAFG00000014194	IPO7	100	99.518	Loxodonta_africana
ENSG00000205339	IPO7	100	100.000	ENSMFAG00000040326	IPO7	100	89.788	Macaca_fascicularis
ENSG00000205339	IPO7	100	100.000	ENSMMUG00000023636	IPO7	100	92.204	Macaca_mulatta
ENSG00000205339	IPO7	100	100.000	ENSMNEG00000034866	IPO7	100	100.000	Macaca_nemestrina
ENSG00000205339	IPO7	100	100.000	ENSMLEG00000043163	IPO7	100	100.000	Mandrillus_leucophaeus
ENSG00000205339	IPO7	100	85.563	ENSMAMG00000021798	ipo7	100	86.141	Mastacembelus_armatus
ENSG00000205339	IPO7	100	85.659	ENSMZEG00005015042	ipo7	100	86.333	Maylandia_zebra
ENSG00000205339	IPO7	97	97.335	ENSMGAG00000006243	IPO7	97	97.335	Meleagris_gallopavo
ENSG00000205339	IPO7	86	95.658	ENSMAUG00000014758	Ipo7	96	95.658	Mesocricetus_auratus
ENSG00000205339	IPO7	100	100.000	ENSMICG00000007465	IPO7	100	99.904	Microcebus_murinus
ENSG00000205339	IPO7	100	99.711	ENSMOCG00000005483	Ipo7	100	99.711	Microtus_ochrogaster
ENSG00000205339	IPO7	100	82.676	ENSMMOG00000017072	ipo7	100	83.446	Mola_mola
ENSG00000205339	IPO7	100	98.170	ENSMODG00000007836	IPO7	100	98.170	Monodelphis_domestica
ENSG00000205339	IPO7	97	86.594	ENSMALG00000020135	ipo7	99	87.090	Monopterus_albus
ENSG00000205339	IPO7	100	99.422	ENSMUSG00000066232	Ipo7	100	99.422	Mus_musculus
ENSG00000205339	IPO7	100	100.000	ENSMPUG00000012785	IPO7	100	100.000	Mustela_putorius_furo
ENSG00000205339	IPO7	100	98.655	ENSMLUG00000027687	IPO7	100	98.655	Myotis_lucifugus
ENSG00000205339	IPO7	100	98.462	ENSNGAG00000006507	Ipo7	100	96.724	Nannospalax_galili
ENSG00000205339	IPO7	100	100.000	ENSNLEG00000017560	IPO7	100	100.000	Nomascus_leucogenys
ENSG00000205339	IPO7	100	93.846	ENSMEUG00000001986	IPO7	88	97.586	Notamacropus_eugenii
ENSG00000205339	IPO7	100	99.231	ENSOPRG00000005430	IPO7	100	96.733	Ochotona_princeps
ENSG00000205339	IPO7	100	99.231	ENSODEG00000008218	IPO7	100	93.756	Octodon_degus
ENSG00000205339	IPO7	100	85.467	ENSONIG00000006069	ipo7	100	86.237	Oreochromis_niloticus
ENSG00000205339	IPO7	75	94.898	ENSOANG00000030525	-	91	96.250	Ornithorhynchus_anatinus
ENSG00000205339	IPO7	100	83.572	ENSOCUG00000000045	-	100	83.572	Oryctolagus_cuniculus
ENSG00000205339	IPO7	100	99.711	ENSOCUG00000007093	-	100	99.711	Oryctolagus_cuniculus
ENSG00000205339	IPO7	100	86.622	ENSORLG00000007093	ipo7	100	86.333	Oryzias_latipes
ENSG00000205339	IPO7	100	86.814	ENSORLG00020011226	ipo7	100	86.526	Oryzias_latipes_hni
ENSG00000205339	IPO7	100	87.007	ENSORLG00015009331	ipo7	100	86.718	Oryzias_latipes_hsok
ENSG00000205339	IPO7	97	86.265	ENSOMEG00000001444	ipo7	97	86.759	Oryzias_melastigma
ENSG00000205339	IPO7	100	99.807	ENSOGAG00000011507	IPO7	100	99.807	Otolemur_garnettii
ENSG00000205339	IPO7	100	100.000	ENSOARG00000012687	IPO7	100	99.807	Ovis_aries
ENSG00000205339	IPO7	100	100.000	ENSPPAG00000039367	IPO7	100	100.000	Pan_paniscus
ENSG00000205339	IPO7	100	100.000	ENSPPRG00000013728	IPO7	100	100.000	Panthera_pardus
ENSG00000205339	IPO7	100	100.000	ENSPTIG00000011093	IPO7	100	99.904	Panthera_tigris_altaica
ENSG00000205339	IPO7	100	99.904	ENSPTRG00000028713	IPO7	100	99.904	Pan_troglodytes
ENSG00000205339	IPO7	100	100.000	ENSPANG00000017378	IPO7	100	100.000	Papio_anubis
ENSG00000205339	IPO7	100	86.814	ENSPKIG00000022252	ipo7	100	86.910	Paramormyrops_kingsleyae
ENSG00000205339	IPO7	97	97.431	ENSPSIG00000006313	IPO7	100	97.431	Pelodiscus_sinensis
ENSG00000205339	IPO7	100	99.518	ENSPEMG00000005751	Ipo7	100	99.518	Peromyscus_maniculatus_bairdii
ENSG00000205339	IPO7	100	97.977	ENSPCIG00000005946	IPO7	100	97.977	Phascolarctos_cinereus
ENSG00000205339	IPO7	100	85.756	ENSPFOG00000009302	ipo7	100	86.141	Poecilia_formosa
ENSG00000205339	IPO7	100	85.659	ENSPLAG00000014371	ipo7	100	86.044	Poecilia_latipinna
ENSG00000205339	IPO7	100	85.756	ENSPMEG00000002604	ipo7	100	86.141	Poecilia_mexicana
ENSG00000205339	IPO7	100	86.044	ENSPREG00000023089	ipo7	100	86.237	Poecilia_reticulata
ENSG00000205339	IPO7	100	98.462	ENSPCAG00000007493	IPO7	82	99.180	Procavia_capensis
ENSG00000205339	IPO7	79	99.308	ENSPVAG00000013029	IPO7	79	99.308	Pteropus_vampyrus
ENSG00000205339	IPO7	100	85.563	ENSPNYG00000008534	ipo7	100	86.237	Pundamilia_nyererei
ENSG00000205339	IPO7	100	86.814	ENSPNAG00000028115	ipo7	100	87.007	Pygocentrus_nattereri
ENSG00000205339	IPO7	100	99.615	ENSRNOG00000010427	Ipo7	100	99.615	Rattus_norvegicus
ENSG00000205339	IPO7	100	100.000	ENSRBIG00000031871	IPO7	100	100.000	Rhinopithecus_bieti
ENSG00000205339	IPO7	100	100.000	ENSRROG00000031816	IPO7	100	100.000	Rhinopithecus_roxellana
ENSG00000205339	IPO7	100	99.231	ENSSBOG00000029640	IPO7	100	96.040	Saimiri_boliviensis_boliviensis
ENSG00000205339	IPO7	100	86.237	ENSSFOG00015013937	ipo7	100	86.333	Scleropages_formosus
ENSG00000205339	IPO7	100	86.058	ENSSMAG00000021418	ipo7	100	86.346	Scophthalmus_maximus
ENSG00000205339	IPO7	100	86.526	ENSSDUG00000000611	ipo7	100	86.718	Seriola_dumerili
ENSG00000205339	IPO7	100	86.526	ENSSLDG00000021417	ipo7	100	86.718	Seriola_lalandi_dorsalis
ENSG00000205339	IPO7	100	97.692	ENSSARG00000005190	IPO7	94	97.541	Sorex_araneus
ENSG00000205339	IPO7	100	91.715	ENSSPUG00000014319	IPO7	100	91.715	Sphenodon_punctatus
ENSG00000205339	IPO7	100	86.622	ENSSPAG00000020296	ipo7	100	86.814	Stegastes_partitus
ENSG00000205339	IPO7	100	99.711	ENSSSCG00000028886	IPO7	100	99.711	Sus_scrofa
ENSG00000205339	IPO7	97	96.937	ENSTGUG00000008189	IPO7	100	96.937	Taeniopygia_guttata
ENSG00000205339	IPO7	100	84.119	ENSTRUG00000017414	ipo7	100	84.312	Takifugu_rubripes
ENSG00000205339	IPO7	100	85.207	ENSTNIG00000009369	ipo7	100	85.207	Tetraodon_nigroviridis
ENSG00000205339	IPO7	100	97.692	ENSTTRG00000015352	IPO7	100	96.917	Tursiops_truncatus
ENSG00000205339	IPO7	100	100.000	ENSUAMG00000001673	IPO7	100	99.326	Ursus_americanus
ENSG00000205339	IPO7	100	100.000	ENSUMAG00000012870	IPO7	100	99.904	Ursus_maritimus
ENSG00000205339	IPO7	100	100.000	ENSVPAG00000003917	IPO7	100	98.555	Vicugna_pacos
ENSG00000205339	IPO7	100	99.711	ENSVVUG00000025822	IPO7	100	99.711	Vulpes_vulpes
ENSG00000205339	IPO7	99	93.157	ENSVVUG00000013293	-	100	93.157	Vulpes_vulpes
ENSG00000205339	IPO7	100	91.049	ENSXETG00000024201	ipo7	100	91.049	Xenopus_tropicalis
ENSG00000205339	IPO7	100	79.500	ENSXCOG00000011269	ipo7	100	79.692	Xiphophorus_couchianus
ENSG00000205339	IPO7	100	85.756	ENSXMAG00000009410	ipo7	100	85.948	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005215	transporter activity	9214382.	TAS	Function
GO:0005515	protein binding	15282309.26878725.	IPI	Function
GO:0005635	nuclear envelope	21873635.	IBA	Component
GO:0005643	nuclear pore	9214382.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006606	protein import into nucleus	21873635.	IBA	Process
GO:0007165	signal transduction	9214382.	TAS	Process
GO:0008536	Ran GTPase binding	-	IEA	Function
GO:0008565	protein transporter activity	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0030695	GTPase regulator activity	9214382.	TAS	Function
GO:0042393	histone binding	-	IEA	Function
GO:0045087	innate immune response	-	IEA	Process
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	17491008.	TAS	Process
GO:0046332	SMAD binding	26878725.	IPI	Function