EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000205609 (Gene tree)
Gene ID: 728689
Gene Symbol: EIF3CL
Alias: N
Full Name: eukaryotic translation initiation factor 3 subunit C like
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 24,301 bases
Position: chr16:28,379,579-28,403,879
Accession: 26347
RBP type: canonical RBP
Summary: The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000370258	eIF-3c_N	PF05470.12	2.6e-272	1	1
ENSP00000381917	eIF-3c_N	PF05470.12	2.6e-272	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000380876	EIF3CL-201	3085	-	ENSP00000370258	914 (aa)	-	B5ME19
ENST00000398944	EIF3CL-202	3053	XM_017023620	ENSP00000381917	914 (aa)	XP_016879109	B5ME19

Gene Model

Click here to download ENSG00000205609's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000205609's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000205609	EIF3CL	100	99.891	ENSG00000184110	EIF3C	100	100.000

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000205609	EIF3CL	99	75.866	ENSAPOG00000024092	eif3c	92	84.339	Acanthochromis_polyacanthus
ENSG00000205609	EIF3CL	100	98.578	ENSAMEG00000015454	-	100	98.578	Ailuropoda_melanoleuca
ENSG00000205609	EIF3CL	94	84.027	ENSACIG00000015082	eif3c	99	71.522	Amphilophus_citrinellus
ENSG00000205609	EIF3CL	94	84.158	ENSAOCG00000021466	eif3c	94	84.158	Amphiprion_ocellaris
ENSG00000205609	EIF3CL	94	84.158	ENSAPEG00000010521	eif3c	94	84.158	Amphiprion_percula
ENSG00000205609	EIF3CL	99	76.082	ENSATEG00000019001	eif3c	98	76.242	Anabas_testudineus
ENSG00000205609	EIF3CL	100	86.260	ENSACAG00000005937	-	100	85.496	Anolis_carolinensis
ENSG00000205609	EIF3CL	100	99.781	ENSANAG00000020640	-	100	99.781	Aotus_nancymaae
ENSG00000205609	EIF3CL	84	80.619	ENSACLG00000009322	eif3c	92	80.619	Astatotilapia_calliptera
ENSG00000205609	EIF3CL	84	83.471	ENSACLG00000009347	eif3c	98	83.471	Astatotilapia_calliptera
ENSG00000205609	EIF3CL	99	76.729	ENSAMXG00000020949	eif3c	98	76.772	Astyanax_mexicanus
ENSG00000205609	EIF3CL	100	97.921	ENSBTAG00000006543	EIF3CL	100	97.921	Bos_taurus
ENSG00000205609	EIF3CL	95	42.665	WBGene00001226	eif-3.C	93	43.195	Caenorhabditis_elegans
ENSG00000205609	EIF3CL	100	99.562	ENSCJAG00000006341	-	100	99.562	Callithrix_jacchus
ENSG00000205609	EIF3CL	100	98.468	ENSCAFG00000017143	-	100	98.468	Canis_familiaris
ENSG00000205609	EIF3CL	100	98.578	ENSCAFG00020017587	-	100	98.578	Canis_lupus_dingo
ENSG00000205609	EIF3CL	100	97.812	ENSCHIG00000024795	-	100	97.812	Capra_hircus
ENSG00000205609	EIF3CL	100	98.249	ENSTSYG00000003486	-	100	98.249	Carlito_syrichta
ENSG00000205609	EIF3CL	96	88.122	ENSCAPG00000015887	-	100	87.783	Cavia_aperea
ENSG00000205609	EIF3CL	100	98.031	ENSCPOG00000007533	-	100	98.031	Cavia_porcellus
ENSG00000205609	EIF3CL	100	94.530	ENSCCAG00000027724	-	100	94.530	Cebus_capucinus
ENSG00000205609	EIF3CL	99	84.378	ENSCCAG00000029099	-	99	82.547	Cebus_capucinus
ENSG00000205609	EIF3CL	100	98.578	ENSCCAG00000034928	-	100	98.578	Cebus_capucinus
ENSG00000205609	EIF3CL	100	99.781	ENSCATG00000032673	-	100	99.781	Cercocebus_atys
ENSG00000205609	EIF3CL	100	97.484	ENSCLAG00000011094	-	100	97.484	Chinchilla_lanigera
ENSG00000205609	EIF3CL	100	99.781	ENSCSAG00000006297	-	100	99.781	Chlorocebus_sabaeus
ENSG00000205609	EIF3CL	55	82.239	ENSCHOG00000003120	-	88	82.239	Choloepus_hoffmanni
ENSG00000205609	EIF3CL	71	92.038	ENSCPBG00000012407	-	92	83.537	Chrysemys_picta_bellii
ENSG00000205609	EIF3CL	79	56.336	ENSCSAVG00000006744	-	96	57.018	Ciona_savignyi
ENSG00000205609	EIF3CL	100	99.781	ENSCANG00000033626	-	100	99.781	Colobus_angolensis_palliatus
ENSG00000205609	EIF3CL	100	96.827	ENSCGRG00001015265	EIF3C	100	96.827	Cricetulus_griseus_chok1gshd
ENSG00000205609	EIF3CL	100	73.828	ENSCSEG00000017770	eif3c	100	74.267	Cynoglossus_semilaevis
ENSG00000205609	EIF3CL	99	75.517	ENSCVAG00000005402	eif3c	98	81.656	Cyprinodon_variegatus
ENSG00000205609	EIF3CL	99	76.496	ENSDARG00000016443	eif3c	98	76.554	Danio_rerio
ENSG00000205609	EIF3CL	100	98.359	ENSDNOG00000031497	-	100	98.359	Dasypus_novemcinctus
ENSG00000205609	EIF3CL	100	98.249	ENSDORG00000016471	Eif3c	100	98.249	Dipodomys_ordii
ENSG00000205609	EIF3CL	98	50.831	FBgn0034258	eIF3c	95	50.714	Drosophila_melanogaster
ENSG00000205609	EIF3CL	92	98.624	ENSETEG00000013527	-	92	98.624	Echinops_telfairi
ENSG00000205609	EIF3CL	99	62.701	ENSEBUG00000001629	eif3c	99	63.548	Eptatretus_burgeri
ENSG00000205609	EIF3CL	100	98.468	ENSECAG00000008746	-	100	98.468	Equus_caballus
ENSG00000205609	EIF3CL	87	97.372	ENSEEUG00000006148	-	100	97.372	Erinaceus_europaeus
ENSG00000205609	EIF3CL	64	64.286	ENSEEUG00000000726	-	64	64.286	Erinaceus_europaeus
ENSG00000205609	EIF3CL	99	76.227	ENSELUG00000022257	eif3c	92	83.748	Esox_lucius
ENSG00000205609	EIF3CL	100	98.359	ENSFCAG00000015782	-	100	98.359	Felis_catus
ENSG00000205609	EIF3CL	100	97.812	ENSFDAG00000003588	-	100	97.812	Fukomys_damarensis
ENSG00000205609	EIF3CL	99	76.134	ENSFHEG00000014154	EIF3C	93	83.660	Fundulus_heteroclitus
ENSG00000205609	EIF3CL	97	75.476	ENSGMOG00000016885	eif3c	99	76.148	Gadus_morhua
ENSG00000205609	EIF3CL	96	76.897	ENSGACG00000007652	eif3c	100	76.118	Gasterosteus_aculeatus
ENSG00000205609	EIF3CL	92	83.608	ENSGAGG00000006666	-	100	83.844	Gopherus_agassizii
ENSG00000205609	EIF3CL	99	97.363	ENSGGOG00000026919	EIF3C	100	99.659	Gorilla_gorilla
ENSG00000205609	EIF3CL	53	99.614	ENSGGOG00000022677	-	100	99.614	Gorilla_gorilla
ENSG00000205609	EIF3CL	100	97.593	ENSHGLG00000011445	EIF3C	100	97.593	Heterocephalus_glaber_female
ENSG00000205609	EIF3CL	100	97.593	ENSHGLG00100000217	EIF3C	100	97.593	Heterocephalus_glaber_male
ENSG00000205609	EIF3CL	99	75.054	ENSHCOG00000019694	eif3c	98	75.679	Hippocampus_comes
ENSG00000205609	EIF3CL	99	75.326	ENSIPUG00000016878	eif3c	97	84.502	Ictalurus_punctatus
ENSG00000205609	EIF3CL	100	98.578	ENSSTOG00000021278	-	100	98.578	Ictidomys_tridecemlineatus
ENSG00000205609	EIF3CL	100	96.937	ENSJJAG00000012722	Eif3c	100	96.937	Jaculus_jaculus
ENSG00000205609	EIF3CL	99	76.898	ENSKMAG00000021662	eif3c	97	75.813	Kryptolebias_marmoratus
ENSG00000205609	EIF3CL	99	75.828	ENSLBEG00000023370	eif3c	99	74.544	Labrus_bergylta
ENSG00000205609	EIF3CL	100	79.389	ENSLACG00000000770	eif3c	100	80.413	Latimeria_chalumnae
ENSG00000205609	EIF3CL	100	97.812	ENSLAFG00000027426	-	100	97.812	Loxodonta_africana
ENSG00000205609	EIF3CL	100	99.781	ENSMFAG00000041930	-	100	99.781	Macaca_fascicularis
ENSG00000205609	EIF3CL	100	99.781	ENSMMUG00000011798	-	100	99.781	Macaca_mulatta
ENSG00000205609	EIF3CL	100	99.781	ENSMNEG00000023915	-	100	99.781	Macaca_nemestrina
ENSG00000205609	EIF3CL	100	99.781	ENSMLEG00000027529	-	100	99.781	Mandrillus_leucophaeus
ENSG00000205609	EIF3CL	99	78.306	ENSMAMG00000012512	eif3c	95	84.667	Mastacembelus_armatus
ENSG00000205609	EIF3CL	84	83.471	ENSMZEG00005013699	eif3c	98	83.471	Maylandia_zebra
ENSG00000205609	EIF3CL	84	80.782	ENSMZEG00005013685	eif3c	92	80.782	Maylandia_zebra
ENSG00000205609	EIF3CL	100	96.718	ENSMAUG00000010621	Eif3c	100	96.718	Mesocricetus_auratus
ENSG00000205609	EIF3CL	100	98.359	ENSMICG00000036748	-	100	98.359	Microcebus_murinus
ENSG00000205609	EIF3CL	100	94.311	ENSMOCG00000004204	Eif3c	100	94.201	Microtus_ochrogaster
ENSG00000205609	EIF3CL	100	71.913	ENSMMOG00000001572	eif3c	94	82.673	Mola_mola
ENSG00000205609	EIF3CL	100	94.317	ENSMODG00000015579	-	100	94.208	Monodelphis_domestica
ENSG00000205609	EIF3CL	84	84.577	ENSMALG00000008907	eif3c	92	84.437	Monopterus_albus
ENSG00000205609	EIF3CL	100	96.608	MGP_CAROLIEiJ_G0030451	Eif3c	100	96.608	Mus_caroli
ENSG00000205609	EIF3CL	100	96.608	ENSMUSG00000030738	Eif3c	100	96.608	Mus_musculus
ENSG00000205609	EIF3CL	100	96.171	MGP_PahariEiJ_G0013661	Eif3c	100	96.171	Mus_pahari
ENSG00000205609	EIF3CL	100	96.608	MGP_SPRETEiJ_G0031565	Eif3c	100	96.608	Mus_spretus
ENSG00000205609	EIF3CL	96	97.957	ENSMPUG00000012732	-	100	97.957	Mustela_putorius_furo
ENSG00000205609	EIF3CL	100	96.937	ENSMLUG00000015558	-	100	96.937	Myotis_lucifugus
ENSG00000205609	EIF3CL	93	87.273	ENSNGAG00000010901	-	98	87.273	Nannospalax_galili
ENSG00000205609	EIF3CL	100	97.593	ENSNGAG00000007177	-	100	97.593	Nannospalax_galili
ENSG00000205609	EIF3CL	100	83.836	ENSNLEG00000001425	-	91	93.333	Nomascus_leucogenys
ENSG00000205609	EIF3CL	89	63.924	ENSMEUG00000005317	-	100	61.392	Notamacropus_eugenii
ENSG00000205609	EIF3CL	100	78.033	ENSMEUG00000009939	-	99	78.166	Notamacropus_eugenii
ENSG00000205609	EIF3CL	100	97.921	ENSOPRG00000000931	-	100	97.921	Ochotona_princeps
ENSG00000205609	EIF3CL	100	97.702	ENSODEG00000013508	-	100	97.702	Octodon_degus
ENSG00000205609	EIF3CL	66	63.201	ENSONIG00000011434	eif3c	99	63.201	Oreochromis_niloticus
ENSG00000205609	EIF3CL	100	90.527	ENSOANG00000011410	-	100	90.420	Ornithorhynchus_anatinus
ENSG00000205609	EIF3CL	100	98.468	ENSOCUG00000022489	-	100	98.468	Oryctolagus_cuniculus
ENSG00000205609	EIF3CL	99	75.388	ENSORLG00000006318	eif3c	98	72.402	Oryzias_latipes
ENSG00000205609	EIF3CL	93	82.283	ENSORLG00020015713	eif3c	96	82.881	Oryzias_latipes_hni
ENSG00000205609	EIF3CL	99	75.499	ENSORLG00015013772	eif3c	97	74.862	Oryzias_latipes_hsok
ENSG00000205609	EIF3CL	100	74.464	ENSOMEG00000020450	eif3c	100	74.464	Oryzias_melastigma
ENSG00000205609	EIF3CL	100	98.249	ENSOGAG00000012737	-	100	98.249	Otolemur_garnettii
ENSG00000205609	EIF3CL	100	97.812	ENSOARG00000002892	-	100	97.812	Ovis_aries
ENSG00000205609	EIF3CL	100	98.359	ENSPPRG00000012336	-	100	98.359	Panthera_pardus
ENSG00000205609	EIF3CL	100	98.359	ENSPTIG00000011712	-	100	98.359	Panthera_tigris_altaica
ENSG00000205609	EIF3CL	100	99.781	ENSPANG00000021151	-	100	99.781	Papio_anubis
ENSG00000205609	EIF3CL	99	76.714	ENSPKIG00000002049	eif3c	98	77.174	Paramormyrops_kingsleyae
ENSG00000205609	EIF3CL	89	84.743	ENSPMGG00000005409	eif3c	94	84.743	Periophthalmus_magnuspinnatus
ENSG00000205609	EIF3CL	100	94.748	ENSPEMG00000010899	Eif3c	100	94.639	Peromyscus_maniculatus_bairdii
ENSG00000205609	EIF3CL	100	94.317	ENSPCIG00000025206	-	100	94.208	Phascolarctos_cinereus
ENSG00000205609	EIF3CL	99	75.705	ENSPFOG00000004476	eif3c	98	75.461	Poecilia_formosa
ENSG00000205609	EIF3CL	100	71.585	ENSPLAG00000017480	eif3c	93	83.582	Poecilia_latipinna
ENSG00000205609	EIF3CL	99	75.896	ENSPMEG00000019512	eif3c	98	75.543	Poecilia_mexicana
ENSG00000205609	EIF3CL	100	71.475	ENSPREG00000023139	eif3c	100	71.475	Poecilia_reticulata
ENSG00000205609	EIF3CL	100	95.842	ENSPPYG00000007227	-	100	95.733	Pongo_abelii
ENSG00000205609	EIF3CL	66	98.502	ENSPCAG00000012710	-	100	98.502	Procavia_capensis
ENSG00000205609	EIF3CL	100	98.796	ENSPCOG00000019289	-	100	98.796	Propithecus_coquereli
ENSG00000205609	EIF3CL	100	98.031	ENSPVAG00000005804	-	100	98.031	Pteropus_vampyrus
ENSG00000205609	EIF3CL	65	69.079	ENSPNYG00000016530	eif3c	81	81.818	Pundamilia_nyererei
ENSG00000205609	EIF3CL	99	77.133	ENSPNAG00000024040	eif3c	93	83.389	Pygocentrus_nattereri
ENSG00000205609	EIF3CL	100	96.061	ENSRNOG00000018761	Eif3c	100	96.061	Rattus_norvegicus
ENSG00000205609	EIF3CL	97	99.774	ENSRBIG00000044009	-	98	97.324	Rhinopithecus_bieti
ENSG00000205609	EIF3CL	100	99.781	ENSRROG00000043626	-	100	99.781	Rhinopithecus_roxellana
ENSG00000205609	EIF3CL	77	31.365	YMR309C	-	81	30.699	Saccharomyces_cerevisiae
ENSG00000205609	EIF3CL	100	99.453	ENSSBOG00000032155	-	100	99.453	Saimiri_boliviensis_boliviensis
ENSG00000205609	EIF3CL	96	93.891	ENSSHAG00000011808	-	100	93.778	Sarcophilus_harrisii
ENSG00000205609	EIF3CL	99	76.144	ENSSFOG00015021823	eif3c	98	75.764	Scleropages_formosus
ENSG00000205609	EIF3CL	97	77.217	ENSSMAG00000016638	eif3c	97	76.880	Scophthalmus_maximus
ENSG00000205609	EIF3CL	97	79.825	ENSSDUG00000023117	eif3c	98	76.714	Seriola_dumerili
ENSG00000205609	EIF3CL	99	75.948	ENSSLDG00000009706	eif3c	93	83.660	Seriola_lalandi_dorsalis
ENSG00000205609	EIF3CL	100	83.734	ENSSPUG00000016470	-	100	83.734	Sphenodon_punctatus
ENSG00000205609	EIF3CL	100	76.000	ENSSPAG00000000426	eif3c	100	76.439	Stegastes_partitus
ENSG00000205609	EIF3CL	100	98.578	ENSSSCG00000034927	-	100	98.578	Sus_scrofa
ENSG00000205609	EIF3CL	99	74.411	ENSTRUG00000008951	eif3c	99	74.600	Takifugu_rubripes
ENSG00000205609	EIF3CL	100	74.159	ENSTNIG00000015210	eif3c	100	74.595	Tetraodon_nigroviridis
ENSG00000205609	EIF3CL	100	98.140	ENSTTRG00000005880	-	100	98.140	Tursiops_truncatus
ENSG00000205609	EIF3CL	72	98.628	ENSUAMG00000001127	-	91	100.000	Ursus_americanus
ENSG00000205609	EIF3CL	100	98.468	ENSUMAG00000010927	-	100	98.468	Ursus_maritimus
ENSG00000205609	EIF3CL	100	97.046	ENSVVUG00000025970	-	100	97.046	Vulpes_vulpes
ENSG00000205609	EIF3CL	100	78.510	ENSXETG00000002941	eif3c	100	79.180	Xenopus_tropicalis
ENSG00000205609	EIF3CL	100	75.512	ENSXMAG00000013796	eif3c	100	74.973	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001732	formation of cytoplasmic translation initiation complex	-	IEA	Process
GO:0003743	translation initiation factor activity	21873635.	IBA	Function
GO:0005852	eukaryotic translation initiation factor 3 complex	21873635.	IBA	Component
GO:0006413	translational initiation	21873635.	IBA	Process
GO:0016282	eukaryotic 43S preinitiation complex	-	IEA	Component
GO:0031369	translation initiation factor binding	21873635.	IBA	Function
GO:0033290	eukaryotic 48S preinitiation complex	-	IEA	Component