EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000205944 (Gene tree)
Gene ID: 57055
Gene Symbol: DAZ2
Alias: pDP1678|MGC126442
Full Name: deleted in azoospermia 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 71,923 bases
Position: chrY:23,219,434-23,291,356
Accession: 15964
RBP type: canonical RBP
Summary: This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000371731	RRM_1	PF00076.22	8.8e-11	1	1
ENSP00000414113	RRM_1	PF00076.22	9.7e-11	1	1
ENSP00000383340	RRM_1	PF00076.22	1.2e-10	1	1
ENSP00000371868	RRM_1	PF00076.22	1.4e-10	1	1
ENSP00000371743	RRM_1	PF00076.22	1.5e-10	1	1
ENSP00000371887	RRM_1	PF00076.22	1.5e-10	1	1
ENSP00000371861	RRM_1	PF00076.22	1.6e-10	1	1
ENSP00000371870	RRM_1	PF00076.22	1.6e-10	1	1
ENSP00000371877	RRM_1	PF00076.22	2e-10	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000382440	DAZ2-206	4119	-	ENSP00000371877	654 (aa)	-	E9PBY2
ENST00000382294	DAZ2-201	3277	-	ENSP00000371731	366 (aa)	-	E7EU39
ENST00000382424	DAZ2-203	3853	-	ENSP00000371861	558 (aa)	-	Q13117
ENST00000382306	DAZ2-202	3781	-	ENSP00000371743	534 (aa)	-	Q13117
ENST00000382431	DAZ2-204	3637	-	ENSP00000371868	486 (aa)	-	I3L0B6
ENST00000382449	DAZ2-207	3791	-	ENSP00000371887	534 (aa)	-	Q13117
ENST00000382433	DAZ2-205	2405	-	ENSP00000371870	558 (aa)	-	Q13117
ENST00000400493	DAZ2-208	3516	-	ENSP00000383340	438 (aa)	-	E7ENA6
ENST00000449947	DAZ2-209	3372	-	ENSP00000414113	390 (aa)	-	UPI000000DBFC

Gene Model

Click here to download ENSG00000205944's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000205944's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000205944	DAZ2	100	100.000	ENSG00000205916	DAZ4	100	100.000
ENSG00000205944	DAZ2	100	100.000	ENSG00000188120	DAZ1	100	100.000
ENSG00000205944	DAZ2	100	99.315	ENSG00000187191	DAZ3	100	99.315
ENSG00000205944	DAZ2	67	82.564	ENSG00000092345	DAZL	81	85.455

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000205944	DAZ2	78	81.538	ENSAMEG00000009059	-	71	81.538	Ailuropoda_melanoleuca
ENSG00000205944	DAZ2	59	56.364	ENSAPLG00000007738	-	66	53.636	Anas_platyrhynchos
ENSG00000205944	DAZ2	60	57.919	ENSACAG00000007822	-	64	55.656	Anolis_carolinensis
ENSG00000205944	DAZ2	64	81.443	ENSANAG00000034405	DAZL	67	81.443	Aotus_nancymaae
ENSG00000205944	DAZ2	81	82.143	ENSBTAG00000000502	DAZL	73	82.143	Bos_taurus
ENSG00000205944	DAZ2	69	82.653	ENSCJAG00000039120	DAZL	82	82.653	Callithrix_jacchus
ENSG00000205944	DAZ2	79	82.653	ENSCAFG00000005867	-	99	54.839	Canis_familiaris
ENSG00000205944	DAZ2	58	75.581	ENSCAFG00020027335	-	65	75.309	Canis_lupus_dingo
ENSG00000205944	DAZ2	74	82.143	ENSCHIG00000017877	DAZL	71	82.143	Capra_hircus
ENSG00000205944	DAZ2	65	78.173	ENSTSYG00000000788	DAZL	71	78.173	Carlito_syrichta
ENSG00000205944	DAZ2	54	77.778	ENSCAPG00000003209	DAZL	69	77.160	Cavia_aperea
ENSG00000205944	DAZ2	58	71.362	ENSCPOG00000007628	DAZL	72	71.362	Cavia_porcellus
ENSG00000205944	DAZ2	69	82.143	ENSCCAG00000035747	DAZL	73	82.143	Cebus_capucinus
ENSG00000205944	DAZ2	66	83.673	ENSCATG00000009078	DAZL	73	83.673	Cercocebus_atys
ENSG00000205944	DAZ2	63	78.462	ENSCLAG00000006407	DAZL	70	78.462	Chinchilla_lanigera
ENSG00000205944	DAZ2	82	83.590	ENSCSAG00000009976	DAZL	73	83.590	Chlorocebus_sabaeus
ENSG00000205944	DAZ2	99	70.238	ENSCSAG00000017742	-	99	69.011	Chlorocebus_sabaeus
ENSG00000205944	DAZ2	78	72.222	ENSCHOG00000005264	-	65	72.222	Choloepus_hoffmanni
ENSG00000205944	DAZ2	50	62.500	ENSCPBG00000022547	-	62	64.242	Chrysemys_picta_bellii
ENSG00000205944	DAZ2	66	83.673	ENSCANG00000006852	DAZL	73	83.673	Colobus_angolensis_palliatus
ENSG00000205944	DAZ2	81	79.082	ENSCGRG00001021961	Dazl	70	79.082	Cricetulus_griseus_chok1gshd
ENSG00000205944	DAZ2	81	78.571	ENSCGRG00000013515	Dazl	69	78.571	Cricetulus_griseus_crigri
ENSG00000205944	DAZ2	52	81.579	ENSDNOG00000019085	-	68	83.158	Dasypus_novemcinctus
ENSG00000205944	DAZ2	69	78.082	ENSDORG00000011497	Dazl	63	78.082	Dipodomys_ordii
ENSG00000205944	DAZ2	77	81.481	ENSEASG00005005756	-	69	81.481	Equus_asinus_asinus
ENSG00000205944	DAZ2	78	82.143	ENSECAG00000010923	-	71	82.143	Equus_caballus
ENSG00000205944	DAZ2	81	79.487	ENSEEUG00000005973	-	71	79.487	Erinaceus_europaeus
ENSG00000205944	DAZ2	81	82.653	ENSFCAG00000023607	-	68	82.653	Felis_catus
ENSG00000205944	DAZ2	57	72.464	ENSFDAG00000017861	DAZL	71	72.464	Fukomys_damarensis
ENSG00000205944	DAZ2	59	58.065	ENSGALG00000011243	DAZL	66	53.917	Gallus_gallus
ENSG00000205944	DAZ2	67	82.564	ENSGGOG00000023632	DAZL	73	82.653	Gorilla_gorilla
ENSG00000205944	DAZ2	63	78.571	ENSHGLG00000013488	DAZL	70	78.571	Heterocephalus_glaber_female
ENSG00000205944	DAZ2	63	78.571	ENSHGLG00100019389	DAZL	70	78.571	Heterocephalus_glaber_male
ENSG00000205944	DAZ2	56	76.214	ENSSTOG00000022122	-	70	76.214	Ictidomys_tridecemlineatus
ENSG00000205944	DAZ2	66	76.531	ENSJJAG00000010767	Dazl	68	77.041	Jaculus_jaculus
ENSG00000205944	DAZ2	60	52.466	ENSLACG00000002895	-	67	51.570	Latimeria_chalumnae
ENSG00000205944	DAZ2	81	80.000	ENSLAFG00000009132	-	71	80.000	Loxodonta_africana
ENSG00000205944	DAZ2	83	84.946	ENSMFAG00000002406	DAZL	78	84.946	Macaca_fascicularis
ENSG00000205944	DAZ2	100	72.222	ENSMMUG00000045289	-	100	72.222	Macaca_mulatta
ENSG00000205944	DAZ2	97	83.240	ENSMMUG00000041692	-	98	83.240	Macaca_mulatta
ENSG00000205944	DAZ2	66	84.184	ENSMMUG00000011361	DAZL	81	87.273	Macaca_mulatta
ENSG00000205944	DAZ2	66	84.184	ENSMNEG00000038455	DAZL	73	84.184	Macaca_nemestrina
ENSG00000205944	DAZ2	65	83.590	ENSMLEG00000038997	DAZL	68	83.590	Mandrillus_leucophaeus
ENSG00000205944	DAZ2	59	56.364	ENSMGAG00000010878	-	66	53.636	Meleagris_gallopavo
ENSG00000205944	DAZ2	78	78.462	ENSMAUG00000018931	Dazl	68	78.462	Mesocricetus_auratus
ENSG00000205944	DAZ2	81	81.122	ENSMICG00000049389	-	71	81.122	Microcebus_murinus
ENSG00000205944	DAZ2	81	77.551	ENSMOCG00000016627	Dazl	70	77.551	Microtus_ochrogaster
ENSG00000205944	DAZ2	66	81.122	ENSMODG00000014730	-	70	81.122	Monodelphis_domestica
ENSG00000205944	DAZ2	81	77.041	MGP_CAROLIEiJ_G0021735	Dazl	70	77.041	Mus_caroli
ENSG00000205944	DAZ2	81	77.551	ENSMUSG00000010592	Dazl	70	77.551	Mus_musculus
ENSG00000205944	DAZ2	79	76.531	MGP_PahariEiJ_G0020724	Dazl	70	76.531	Mus_pahari
ENSG00000205944	DAZ2	81	77.551	MGP_SPRETEiJ_G0022647	Dazl	70	77.551	Mus_spretus
ENSG00000205944	DAZ2	78	81.726	ENSMPUG00000001426	-	71	81.726	Mustela_putorius_furo
ENSG00000205944	DAZ2	63	80.423	ENSMLUG00000011337	-	68	80.423	Myotis_lucifugus
ENSG00000205944	DAZ2	60	80.435	ENSNGAG00000009472	Dazl	69	76.190	Nannospalax_galili
ENSG00000205944	DAZ2	69	81.538	ENSNLEG00000033788	DAZL	73	81.633	Nomascus_leucogenys
ENSG00000205944	DAZ2	52	67.016	ENSMEUG00000007283	-	69	67.016	Notamacropus_eugenii
ENSG00000205944	DAZ2	67	72.308	ENSOPRG00000001387	-	66	72.308	Ochotona_princeps
ENSG00000205944	DAZ2	84	75.000	ENSODEG00000006167	DAZL	70	75.000	Octodon_degus
ENSG00000205944	DAZ2	54	64.390	ENSOANG00000006742	-	57	68.280	Ornithorhynchus_anatinus
ENSG00000205944	DAZ2	81	81.026	ENSOCUG00000012635	-	71	81.026	Oryctolagus_cuniculus
ENSG00000205944	DAZ2	81	82.051	ENSOGAG00000006983	-	71	82.051	Otolemur_garnettii
ENSG00000205944	DAZ2	62	80.503	ENSOARG00000015474	-	67	80.503	Ovis_aries
ENSG00000205944	DAZ2	63	82.564	ENSPPAG00000037518	DAZL	73	82.564	Pan_paniscus
ENSG00000205944	DAZ2	81	82.564	ENSPPRG00000008794	-	68	82.653	Panthera_pardus
ENSG00000205944	DAZ2	81	82.564	ENSPTIG00000020895	-	68	82.653	Panthera_tigris_altaica
ENSG00000205944	DAZ2	94	78.155	ENSPTRG00000050343	-	99	78.673	Pan_troglodytes
ENSG00000205944	DAZ2	96	74.766	ENSPTRG00000047116	-	99	77.315	Pan_troglodytes
ENSG00000205944	DAZ2	96	88.827	ENSPTRG00000028811	-	99	88.827	Pan_troglodytes
ENSG00000205944	DAZ2	67	82.564	ENSPTRG00000014674	DAZL	73	82.653	Pan_troglodytes
ENSG00000205944	DAZ2	100	91.473	ENSPTRG00000023120	-	100	91.473	Pan_troglodytes
ENSG00000205944	DAZ2	66	83.673	ENSPANG00000015077	DAZL	73	83.673	Papio_anubis
ENSG00000205944	DAZ2	53	66.169	ENSPSIG00000009803	-	62	63.184	Pelodiscus_sinensis
ENSG00000205944	DAZ2	65	77.397	ENSPEMG00000019679	Dazl	85	77.397	Peromyscus_maniculatus_bairdii
ENSG00000205944	DAZ2	66	81.122	ENSPCIG00000028322	-	73	81.122	Phascolarctos_cinereus
ENSG00000205944	DAZ2	84	82.653	ENSPPYG00000014080	DAZL	73	82.653	Pongo_abelii
ENSG00000205944	DAZ2	63	82.447	ENSPCAG00000016182	-	68	82.447	Procavia_capensis
ENSG00000205944	DAZ2	63	81.443	ENSPVAG00000007836	-	69	81.443	Pteropus_vampyrus
ENSG00000205944	DAZ2	80	81.481	ENSRNOG00000023474	Dazl	77	74.519	Rattus_norvegicus
ENSG00000205944	DAZ2	65	83.590	ENSRBIG00000039636	DAZL	71	81.132	Rhinopithecus_bieti
ENSG00000205944	DAZ2	66	83.673	ENSRROG00000036493	DAZL	73	83.673	Rhinopithecus_roxellana
ENSG00000205944	DAZ2	69	81.633	ENSSBOG00000033845	DAZL	73	81.633	Saimiri_boliviensis_boliviensis
ENSG00000205944	DAZ2	65	81.026	ENSSHAG00000005944	-	71	81.026	Sarcophilus_harrisii
ENSG00000205944	DAZ2	81	79.487	ENSSARG00000008473	-	71	79.487	Sorex_araneus
ENSG00000205944	DAZ2	57	62.736	ENSSPUG00000001799	-	60	61.224	Sphenodon_punctatus
ENSG00000205944	DAZ2	78	82.051	ENSSSCG00000030671	-	71	82.051	Sus_scrofa
ENSG00000205944	DAZ2	59	55.046	ENSTGUG00000003145	-	58	56.771	Taeniopygia_guttata
ENSG00000205944	DAZ2	83	81.026	ENSTBEG00000012225	-	66	81.026	Tupaia_belangeri
ENSG00000205944	DAZ2	73	80.952	ENSUAMG00000020299	-	64	80.952	Ursus_americanus
ENSG00000205944	DAZ2	81	79.487	ENSVPAG00000000468	-	71	79.487	Vicugna_pacos
ENSG00000205944	DAZ2	79	82.653	ENSVVUG00000000673	-	71	82.653	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	7670487.	TAS	Function
GO:0003730	mRNA 3'-UTR binding	21873635.	IBA	Function
GO:0005515	protein binding	10857750.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0007275	multicellular organism development	-	IEA	Process
GO:0007281	germ cell development	-	IEA	Process
GO:0007283	spermatogenesis	-	IEA	Process
GO:0007338	single fertilization	8896558.	TAS	Process
GO:0008494	translation activator activity	21873635.	IBA	Function
GO:0032991	protein-containing complex	10857750.	IDA	Component
GO:0045948	positive regulation of translational initiation	21873635.	IBA	Process
GO:0070935	3'-UTR-mediated mRNA stabilization	21873635.	IBA	Process