EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000206418 (Gene tree)
Gene ID: 201475
Gene Symbol: RAB12
Alias: -
Full Name: RAB12, member RAS oncogene family
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 29,947 bases
Position: chr18:8,609,437-8,639,383
Accession: 31332
RBP type: canonical RBP
Summary: RAB12 (RAB12, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB12 include Pustulosis Of Palm And Sole. Among its related pathways are RAB geranylgeranylation and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB10.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000331748	MMR_HSR1	PF01926.23	7.9e-07	1	1
ENSP00000497886	MMR_HSR1	PF01926.23	1.7e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000580987	RAB12-202	504	-	-	- (aa)	-	-
ENST00000649141	RAB12-203	2145	-	ENSP00000497886	340 (aa)	-	UPI00001D7AB0
ENST00000329286	RAB12-201	2138	XM_006722300	ENSP00000331748	244 (aa)	XP_006722363	Q6IQ22

Gene Model

Click here to download ENSG00000206418's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000206418	Psoriasis	4E-16	25574825

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000206418	rs9955120	18	8622034	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000206418's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000206418	RAB12	91	91.892	ENSAMEG00000007452	RAB12	96	91.892	Ailuropoda_melanoleuca
ENSG00000206418	RAB12	91	87.892	ENSACIG00000020616	rab12	100	80.162	Amphilophus_citrinellus
ENSG00000206418	RAB12	100	84.553	ENSAOCG00000002130	rab12	100	81.301	Amphiprion_ocellaris
ENSG00000206418	RAB12	100	84.553	ENSAPEG00000013255	rab12	100	81.301	Amphiprion_percula
ENSG00000206418	RAB12	100	84.016	ENSATEG00000019683	rab12	100	80.738	Anabas_testudineus
ENSG00000206418	RAB12	91	96.833	ENSACAG00000003360	RAB12	87	96.429	Anolis_carolinensis
ENSG00000206418	RAB12	91	87.892	ENSACLG00000007696	rab12	100	80.894	Astatotilapia_calliptera
ENSG00000206418	RAB12	92	86.161	ENSAMXG00000004882	rab12	83	86.829	Astyanax_mexicanus
ENSG00000206418	RAB12	100	97.131	ENSBTAG00000010356	RAB12	100	97.131	Bos_taurus
ENSG00000206418	RAB12	100	99.592	ENSCJAG00000015468	RAB12	100	96.491	Callithrix_jacchus
ENSG00000206418	RAB12	100	99.590	ENSCAFG00020023721	RAB12	100	84.118	Canis_lupus_dingo
ENSG00000206418	RAB12	100	97.131	ENSCHIG00000016103	RAB12	100	97.131	Capra_hircus
ENSG00000206418	RAB12	86	97.619	ENSCPOG00000022689	RAB12	100	97.619	Cavia_porcellus
ENSG00000206418	RAB12	100	99.592	ENSCCAG00000022862	RAB12	100	99.592	Cebus_capucinus
ENSG00000206418	RAB12	99	97.521	ENSCATG00000037784	RAB12	97	100.000	Cercocebus_atys
ENSG00000206418	RAB12	100	97.984	ENSCSAG00000017569	RAB12	100	96.243	Chlorocebus_sabaeus
ENSG00000206418	RAB12	100	93.878	ENSCPBG00000028375	RAB12	100	93.878	Chrysemys_picta_bellii
ENSG00000206418	RAB12	98	93.724	ENSCANG00000031453	RAB12	100	100.000	Colobus_angolensis_palliatus
ENSG00000206418	RAB12	100	95.492	ENSCGRG00001006958	Rab12	83	95.492	Cricetulus_griseus_chok1gshd
ENSG00000206418	RAB12	100	83.740	ENSCSEG00000016933	rab12	100	80.488	Cynoglossus_semilaevis
ENSG00000206418	RAB12	91	87.444	ENSCVAG00000003539	rab12	100	77.912	Cyprinodon_variegatus
ENSG00000206418	RAB12	100	83.197	ENSDARG00000089428	rab12	93	83.111	Danio_rerio
ENSG00000206418	RAB12	100	97.951	ENSDNOG00000046064	RAB12	73	84.706	Dasypus_novemcinctus
ENSG00000206418	RAB12	93	98.238	ENSDORG00000008920	Rab12	100	98.238	Dipodomys_ordii
ENSG00000206418	RAB12	79	66.321	ENSEBUG00000006581	rab12	92	66.321	Eptatretus_burgeri
ENSG00000206418	RAB12	100	99.180	ENSEASG00005002926	RAB12	83	99.180	Equus_asinus_asinus
ENSG00000206418	RAB12	100	99.180	ENSECAG00000007384	RAB12	100	90.962	Equus_caballus
ENSG00000206418	RAB12	100	83.197	ENSELUG00000007123	rab12	93	84.000	Esox_lucius
ENSG00000206418	RAB12	100	99.180	ENSFCAG00000027710	RAB12	100	93.235	Felis_catus
ENSG00000206418	RAB12	90	87.215	ENSFHEG00000004319	rab12	100	77.823	Fundulus_heteroclitus
ENSG00000206418	RAB12	85	85.577	ENSGMOG00000012335	rab12	87	85.577	Gadus_morhua
ENSG00000206418	RAB12	100	93.200	ENSGALG00000033608	RAB12	100	92.400	Gallus_gallus
ENSG00000206418	RAB12	91	80.631	ENSGACG00000016639	rab12	90	85.644	Gasterosteus_aculeatus
ENSG00000206418	RAB12	100	93.469	ENSGAGG00000007278	RAB12	100	93.469	Gopherus_agassizii
ENSG00000206418	RAB12	91	87.892	ENSHBUG00000008497	rab12	100	80.894	Haplochromis_burtoni
ENSG00000206418	RAB12	99	88.889	ENSHGLG00000006189	RAB12	90	88.889	Heterocephalus_glaber_female
ENSG00000206418	RAB12	100	81.707	ENSHCOG00000012376	rab12	100	77.642	Hippocampus_comes
ENSG00000206418	RAB12	92	86.222	ENSIPUG00000017401	rab12	84	86.829	Ictalurus_punctatus
ENSG00000206418	RAB12	93	96.916	ENSSTOG00000025122	RAB12	100	96.916	Ictidomys_tridecemlineatus
ENSG00000206418	RAB12	93	100.000	ENSJJAG00000019064	Rab12	100	100.000	Jaculus_jaculus
ENSG00000206418	RAB12	100	81.148	ENSKMAG00000020056	rab12	93	81.778	Kryptolebias_marmoratus
ENSG00000206418	RAB12	100	84.016	ENSLBEG00000013756	rab12	93	84.444	Labrus_bergylta
ENSG00000206418	RAB12	91	90.583	ENSLACG00000010461	RAB12	90	90.625	Latimeria_chalumnae
ENSG00000206418	RAB12	100	85.141	ENSLOCG00000002680	rab12	100	85.081	Lepisosteus_oculatus
ENSG00000206418	RAB12	100	98.780	ENSMFAG00000043551	RAB12	100	98.780	Macaca_fascicularis
ENSG00000206418	RAB12	96	99.573	ENSMNEG00000040853	RAB12	92	99.573	Macaca_nemestrina
ENSG00000206418	RAB12	100	83.607	ENSMAMG00000006862	rab12	93	84.000	Mastacembelus_armatus
ENSG00000206418	RAB12	91	87.892	ENSMZEG00005024316	rab12	100	80.894	Maylandia_zebra
ENSG00000206418	RAB12	84	98.529	ENSMGAG00000009197	RAB12	100	98.529	Meleagris_gallopavo
ENSG00000206418	RAB12	100	95.902	ENSMAUG00000008371	Rab12	83	95.902	Mesocricetus_auratus
ENSG00000206418	RAB12	98	99.163	ENSMICG00000030661	RAB12	99	98.734	Microcebus_murinus
ENSG00000206418	RAB12	90	98.174	ENSMOCG00000000452	Rab12	100	98.174	Microtus_ochrogaster
ENSG00000206418	RAB12	100	96.748	ENSMODG00000021452	RAB12	100	78.531	Monodelphis_domestica
ENSG00000206418	RAB12	92	85.268	ENSMALG00000015762	rab12	93	83.628	Monopterus_albus
ENSG00000206418	RAB12	100	95.902	MGP_CAROLIEiJ_G0021839	Rab12	84	95.902	Mus_caroli
ENSG00000206418	RAB12	100	95.902	ENSMUSG00000023460	Rab12	100	95.902	Mus_musculus
ENSG00000206418	RAB12	100	95.902	MGP_PahariEiJ_G0020826	Rab12	100	95.902	Mus_pahari
ENSG00000206418	RAB12	100	95.902	MGP_SPRETEiJ_G0022750	Rab12	85	94.355	Mus_spretus
ENSG00000206418	RAB12	100	98.361	ENSMLUG00000002883	RAB12	100	98.361	Myotis_lucifugus
ENSG00000206418	RAB12	95	97.425	ENSNGAG00000024103	-	99	97.425	Nannospalax_galili
ENSG00000206418	RAB12	100	86.885	ENSNGAG00000019722	-	100	86.885	Nannospalax_galili
ENSG00000206418	RAB12	91	87.892	ENSNBRG00000014428	rab12	100	80.894	Neolamprologus_brichardi
ENSG00000206418	RAB12	100	99.590	ENSNLEG00000006939	RAB12	100	99.590	Nomascus_leucogenys
ENSG00000206418	RAB12	100	96.341	ENSMEUG00000000493	RAB12	100	96.341	Notamacropus_eugenii
ENSG00000206418	RAB12	90	97.717	ENSODEG00000006414	RAB12	100	97.717	Octodon_degus
ENSG00000206418	RAB12	91	87.892	ENSONIG00000018469	rab12	93	84.581	Oreochromis_niloticus
ENSG00000206418	RAB12	100	83.607	ENSORLG00000003902	rab12	100	80.328	Oryzias_latipes
ENSG00000206418	RAB12	100	83.607	ENSORLG00020005131	rab12	93	84.000	Oryzias_latipes_hni
ENSG00000206418	RAB12	100	83.197	ENSORLG00015007869	rab12	100	79.918	Oryzias_latipes_hsok
ENSG00000206418	RAB12	100	83.607	ENSOMEG00000008191	rab12	100	80.328	Oryzias_melastigma
ENSG00000206418	RAB12	86	99.524	ENSOGAG00000028002	RAB12	99	99.524	Otolemur_garnettii
ENSG00000206418	RAB12	86	97.619	ENSOARG00000000728	RAB12	92	94.619	Ovis_aries
ENSG00000206418	RAB12	84	100.000	ENSPPAG00000009152	RAB12	97	100.000	Pan_paniscus
ENSG00000206418	RAB12	100	99.180	ENSPPRG00000024521	RAB12	100	99.180	Panthera_pardus
ENSG00000206418	RAB12	100	100.000	ENSPTRG00000009853	RAB12	100	100.000	Pan_troglodytes
ENSG00000206418	RAB12	100	97.976	ENSPANG00000009320	RAB12	100	97.976	Papio_anubis
ENSG00000206418	RAB12	78	90.526	ENSPKIG00000008579	rab12	93	85.778	Paramormyrops_kingsleyae
ENSG00000206418	RAB12	100	80.738	ENSPMGG00000001890	rab12	84	85.854	Periophthalmus_magnuspinnatus
ENSG00000206418	RAB12	100	96.311	ENSPEMG00000021032	Rab12	84	96.311	Peromyscus_maniculatus_bairdii
ENSG00000206418	RAB12	100	96.341	ENSPCIG00000010453	RAB12	85	83.526	Phascolarctos_cinereus
ENSG00000206418	RAB12	100	82.186	ENSPFOG00000001579	rab12	93	81.579	Poecilia_formosa
ENSG00000206418	RAB12	100	82.186	ENSPLAG00000013594	rab12	93	81.579	Poecilia_latipinna
ENSG00000206418	RAB12	100	82.186	ENSPMEG00000010417	rab12	93	81.579	Poecilia_mexicana
ENSG00000206418	RAB12	100	82.186	ENSPREG00000017487	rab12	93	81.579	Poecilia_reticulata
ENSG00000206418	RAB12	100	100.000	ENSPPYG00000009015	-	100	99.412	Pongo_abelii
ENSG00000206418	RAB12	100	98.770	ENSPCAG00000015007	RAB12	100	98.770	Procavia_capensis
ENSG00000206418	RAB12	100	99.590	ENSPCOG00000019816	RAB12	100	99.590	Propithecus_coquereli
ENSG00000206418	RAB12	100	99.180	ENSPVAG00000002757	RAB12	100	99.180	Pteropus_vampyrus
ENSG00000206418	RAB12	91	87.892	ENSPNYG00000005654	rab12	100	80.894	Pundamilia_nyererei
ENSG00000206418	RAB12	91	87.892	ENSPNYG00000023905	rab12	100	80.894	Pundamilia_nyererei
ENSG00000206418	RAB12	92	87.500	ENSPNAG00000015031	rab12	83	88.293	Pygocentrus_nattereri
ENSG00000206418	RAB12	100	89.069	ENSRNOG00000019295	Rab12	100	88.259	Rattus_norvegicus
ENSG00000206418	RAB12	95	100.000	ENSRBIG00000028760	RAB12	100	100.000	Rhinopithecus_bieti
ENSG00000206418	RAB12	93	100.000	ENSRROG00000019249	RAB12	95	100.000	Rhinopithecus_roxellana
ENSG00000206418	RAB12	86	98.585	ENSSBOG00000021125	RAB12	81	98.585	Saimiri_boliviensis_boliviensis
ENSG00000206418	RAB12	92	94.690	ENSSHAG00000001489	RAB12	100	93.805	Sarcophilus_harrisii
ENSG00000206418	RAB12	100	82.787	ENSSMAG00000012678	rab12	100	79.508	Scophthalmus_maximus
ENSG00000206418	RAB12	100	84.016	ENSSDUG00000008505	rab12	100	80.738	Seriola_dumerili
ENSG00000206418	RAB12	100	84.016	ENSSLDG00000022239	rab12	100	80.738	Seriola_lalandi_dorsalis
ENSG00000206418	RAB12	100	93.902	ENSSPUG00000003222	RAB12	100	93.902	Sphenodon_punctatus
ENSG00000206418	RAB12	91	87.892	ENSSPAG00000010822	rab12	100	80.894	Stegastes_partitus
ENSG00000206418	RAB12	100	97.131	ENSSSCG00000038026	RAB12	100	97.131	Sus_scrofa
ENSG00000206418	RAB12	100	93.200	ENSTGUG00000009889	RAB12	100	92.400	Taeniopygia_guttata
ENSG00000206418	RAB12	97	84.810	ENSTRUG00000024455	rab12	84	87.805	Takifugu_rubripes
ENSG00000206418	RAB12	100	82.449	ENSTNIG00000014859	rab12	91	83.036	Tetraodon_nigroviridis
ENSG00000206418	RAB12	91	97.748	ENSTTRG00000008711	RAB12	100	97.748	Tursiops_truncatus
ENSG00000206418	RAB12	100	99.590	ENSUAMG00000018092	RAB12	100	99.590	Ursus_americanus
ENSG00000206418	RAB12	92	97.333	ENSVVUG00000011748	RAB12	99	99.087	Vulpes_vulpes
ENSG00000206418	RAB12	100	88.306	ENSXETG00000004289	rab12	80	87.649	Xenopus_tropicalis
ENSG00000206418	RAB12	100	82.186	ENSXCOG00000019310	rab12	100	78.138	Xiphophorus_couchianus
ENSG00000206418	RAB12	100	82.591	ENSXMAG00000023617	rab12	100	78.543	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	21873635.	IBA	Component
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005515	protein binding	26824392.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005764	lysosome	-	ISS	Component
GO:0005765	lysosomal membrane	-	IEA	Component
GO:0005776	autophagosome	-	IEA	Component
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005802	trans-Golgi network	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006914	autophagy	-	IEA	Process
GO:0008333	endosome to lysosome transport	-	ISS	Process
GO:0016239	positive regulation of macroautophagy	-	IEA	Process
GO:0019003	GDP binding	20937701.	IDA	Function
GO:0032482	Rab protein signal transduction	21873635.	IBA	Process
GO:0044257	cellular protein catabolic process	-	ISS	Process
GO:0045335	phagocytic vesicle	-	IEA	Component
GO:0055038	recycling endosome membrane	-	ISS	Component
GO:0055038	recycling endosome membrane	-	TAS	Component
GO:0071346	cellular response to interferon-gamma	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr18	8624971	Missense_Mutation	NA	R87T	0.18
BLCA	chr18	8625000	Splice_Site	NA	X96_splice	0.3
BLCA	chr18	8633292	Missense_Mutation	rs373725842	D131H	0.04
BLCA	chr18	8633279	Missense_Mutation	novel	K126N	0.23
BRCA	chr18	8638655	3'UTR	novel		0.24
BRCA	chr18	8639075	3'UTR	novel		0.5
BRCA	chr18	8638173	Missense_Mutation	NA	E216K	0.34	MMR_HSR1
CESC	chr18	8638854	3'UTR	novel		0.57
CESC	chr18	8638224	Missense_Mutation	NA	E233Q	0.45	MMR_HSR1
CESC	chr18	8638501	3'UTR	novel		0.67
CESC	chr18	8638678	3'UTR	novel		0.39
CESC	chr18	8638195	Missense_Mutation	novel	S223L	0.44	MMR_HSR1
COAD	chr18	8638307	3'UTR	novel		0.44
COAD	chr18	8635588	Missense_Mutation	rs184470375	T161M	0.28	MMR_HSR1
COAD	chr18	8633248	Missense_Mutation	novel	K116R	0.16
COAD	chr18	8638307	3'UTR	novel		0.24
COAD	chr18	8638250	Silent	NA	V241V	0.13
COAD	chr18	8638195	Missense_Mutation	novel	S223L	0.08	MMR_HSR1
ESCA	chr18	8638158	Missense_Mutation	novel	D211H	0.06	MMR_HSR1
ESCA	chr18	8635618	Missense_Mutation	novel	E171G	0.6	MMR_HSR1
HNSC	chr18	8638231	Missense_Mutation	novel	P235L	0.08	MMR_HSR1
HNSC	chr18	8638169	Silent	novel	R214R	0.09
HNSC	chr18	8624996	Missense_Mutation	novel	I95M	0.14
KIRP	chr18	8638333	3'UTR	novel		0.17
LUAD	chr18	8638356	3'UTR	novel		1
LUSC	chr18	8624948	Silent	NA	F79F	0.28
LUSC	chr18	8609909	Missense_Mutation	NA	R61H	0.29
LUSC	chr18	8609901	Silent	rs201144141	L58L	0.25
LUSC	chr18	8609901	Silent	rs201144141	L58L	0.4
OV	chr18	8609925	Frame_Shift_Ins	novel	*F67Qfs30**	0.59
OV	chr18	8638195	Frame_Shift_Ins	novel	*L224Vfs11**	0.06	MMR_HSR1
PAAD	chr18	8636250	Splice_Site	novel	X173_splice	0.3
SARC	chr18	8639237	3'UTR	novel		0.46
STAD	chr18	8635598	Silent	novel	E164E	0.12
STAD	chr18	8609830	Frame_Shift_Del	NA	*R37Gfs22**	0.14
STAD	chr18	8638259	Silent	rs370554407	C244C	0.29
STAD	chr18	8633245	Missense_Mutation	novel	A115V	0.41
STAD	chr18	8609944	Missense_Mutation	rs769658729	S73P	0.28
STAD	chr18	8635549	Missense_Mutation	NA	A148V	0.09	MMR_HSR1
STAD	chr18	8636340	Missense_Mutation	NA	D202N	0.18	MMR_HSR1
STAD	chr18	8636352	Frame_Shift_Del	novel	*K207Rfs7**	0.23	MMR_HSR1
STAD	chr18	8609921	Missense_Mutation	NA	D65V	0.4
STAD	chr18	8633210	Silent	NA	R103R	0.06
TGCT	chr18	8609902	Missense_Mutation	novel	M59L	0.46
UCEC	chr18	8624998	Missense_Mutation	NA	W96L	0.46
UCEC	chr18	8633290	Missense_Mutation	NA	F130C	0.34
UCEC	chr18	8638625	3'UTR	novel		0.5
UCEC	chr18	8639141	3'UTR	novel		0.56
UCEC	chr18	8639233	3'UTR	novel		0.47
UCEC	chr18	8638282	3'UTR	novel		0.38
UCEC	chr18	8633267	Nonsense_Mutation	novel	Y122*	0.42
UCEC	chr18	8638256	Nonsense_Mutation	NA	C243*	0.25	MMR_HSR1
UCEC	chr18	8638301	3'UTR	novel		0.09
UCEC	chr18	8638301	3'UTR	novel		0.13
UCEC	chr18	8638313	3'UTR	rs766807365		0.12
UCEC	chr18	8638748	3'UTR	novel		0.29
UCEC	chr18	8638321	3'UTR	novel		0.39
UCEC	chr18	8638710	3'UTR	novel		0.52
UCEC	chr18	8638600	3'UTR	novel		0.24
UCEC	chr18	8638490	3'UTR	novel		0.21
UCEC	chr18	8635557	Missense_Mutation	novel	L151I	0.67	MMR_HSR1
UCEC	chr18	8638412	3'UTR	novel		0.31
UCEC	chr18	8624960	Frame_Shift_Del	novel	*V84Rfs8**	0.18
UCEC	chr18	8638307	3'UTR	novel		0.67
UCEC	chr18	8609940	Nonsense_Mutation	novel	C71*	0.33
UCEC	chr18	8633315	Missense_Mutation	novel	K138N	0.42
UCEC	chr18	8638353	3'UTR	novel		0.19
UCEC	chr18	8636339	Silent	NA	V201V	0.37
UCEC	chr18	8639327	3'UTR	novel		0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	DEL	0.2772	0.10154

Survival Analysis

Cancer	P-value	Q-value
THYM	0.015	Kaplan-Meier Survival Analysis
ACC	0.035	Kaplan-Meier Survival Analysis
HNSC	0.02	Kaplan-Meier Survival Analysis
SKCM	0.00044	Kaplan-Meier Survival Analysis
CESC	0.034	Kaplan-Meier Survival Analysis
LIHC	0.031	Kaplan-Meier Survival Analysis
OV	0.002	Kaplan-Meier Survival Analysis