EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000206562 (Gene tree)
Gene ID: 131965
Gene Symbol: METTL6
Alias: MGC24132
Full Name: methyltransferase like 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 59,504 bases
Position: chr3:15,381,063-15,440,566
Accession: 28343
RBP type: canonical RBP
Summary: METTL6 (Methyltransferase Like 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is METTL2B.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000373300	Methyltransf_31	PF13847.6	1.4e-09	1	1
ENSP00000407613	Methyltransf_31	PF13847.6	1.4e-09	1	1
ENSP00000373299	Methyltransf_31	PF13847.6	6.3e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000584799	METTL6-209	742	-	-	- (aa)	-	-
ENST00000458728	METTL6-206	564	-	ENSP00000400885	105 (aa)	-	H7C1L4
ENST00000453819	METTL6-205	615	-	ENSP00000412006	158 (aa)	-	H7C3H9
ENST00000383789	METTL6-201	1413	XM_006712972	ENSP00000373299	240 (aa)	XP_006713035	Q8TCB7
ENST00000450816	METTL6-204	1221	XM_017005719	ENSP00000410726	239 (aa)	XP_016861208	B4DDX3
ENST00000489881	METTL6-208	618	-	-	- (aa)	-	-
ENST00000383790	METTL6-202	1335	XM_006712970	ENSP00000373300	284 (aa)	XP_006713033	Q8TCB7
ENST00000443029	METTL6-203	4020	XM_005264867	ENSP00000407613	284 (aa)	XP_005264924	Q8TCB7
ENST00000598878	METTL6-210	880	-	ENSP00000471485	137 (aa)	-	M0R0W0
ENST00000485131	METTL6-207	604	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000206562's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000206562	Uric Acid	5E-6	18759275

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000206562	rs6442522	3	15399049	?	Uric acid levels	18759275	[NR] mg/dl increase in uric acid levels	0.05	EFO_0004761

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000206562's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000206562	METTL6	96	76.471	ENSAPOG00000008327	mettl6	81	79.263	Acanthochromis_polyacanthus
ENSG00000206562	METTL6	100	91.901	ENSAMEG00000008819	METTL6	100	91.901	Ailuropoda_melanoleuca
ENSG00000206562	METTL6	87	82.418	ENSACIG00000006254	mettl6	97	76.226	Amphilophus_citrinellus
ENSG00000206562	METTL6	95	77.037	ENSAOCG00000006409	mettl6	97	77.037	Amphiprion_ocellaris
ENSG00000206562	METTL6	95	76.296	ENSAPEG00000002434	mettl6	97	76.296	Amphiprion_percula
ENSG00000206562	METTL6	95	74.349	ENSATEG00000020794	mettl6	91	74.349	Anabas_testudineus
ENSG00000206562	METTL6	94	81.955	ENSAPLG00000003082	METTL6	99	81.955	Anas_platyrhynchos
ENSG00000206562	METTL6	95	81.111	ENSACAG00000002806	METTL6	91	81.111	Anolis_carolinensis
ENSG00000206562	METTL6	100	96.479	ENSANAG00000024487	-	100	96.479	Aotus_nancymaae
ENSG00000206562	METTL6	91	77.220	ENSACLG00000003697	mettl6	89	77.220	Astatotilapia_calliptera
ENSG00000206562	METTL6	87	80.220	ENSAMXG00000038225	mettl6	89	73.846	Astyanax_mexicanus
ENSG00000206562	METTL6	100	90.493	ENSBTAG00000023375	METTL6	100	90.493	Bos_taurus
ENSG00000206562	METTL6	91	43.396	WBGene00014205	ZK1058.5	95	43.396	Caenorhabditis_elegans
ENSG00000206562	METTL6	100	96.127	ENSCJAG00000003415	METTL6	100	96.444	Callithrix_jacchus
ENSG00000206562	METTL6	97	93.091	ENSCAFG00000006021	-	100	93.091	Canis_familiaris
ENSG00000206562	METTL6	97	93.091	ENSCAFG00020027381	-	100	93.091	Canis_lupus_dingo
ENSG00000206562	METTL6	100	89.085	ENSCHIG00000021242	METTL6	100	89.085	Capra_hircus
ENSG00000206562	METTL6	90	90.426	ENSTSYG00000026099	METTL6	93	81.439	Carlito_syrichta
ENSG00000206562	METTL6	95	90.706	ENSCPOG00000037082	METTL6	100	90.706	Cavia_porcellus
ENSG00000206562	METTL6	85	95.122	ENSCCAG00000026438	METTL6	100	95.122	Cebus_capucinus
ENSG00000206562	METTL6	100	94.366	ENSCATG00000038487	METTL6	100	94.366	Cercocebus_atys
ENSG00000206562	METTL6	98	89.568	ENSCLAG00000004710	METTL6	97	89.568	Chinchilla_lanigera
ENSG00000206562	METTL6	100	95.423	ENSCSAG00000010155	METTL6	100	95.423	Chlorocebus_sabaeus
ENSG00000206562	METTL6	94	82.090	ENSCPBG00000022804	METTL6	90	82.090	Chrysemys_picta_bellii
ENSG00000206562	METTL6	86	66.667	ENSCING00000007345	-	96	58.052	Ciona_intestinalis
ENSG00000206562	METTL6	89	62.366	ENSCSAVG00000005179	-	97	57.692	Ciona_savignyi
ENSG00000206562	METTL6	100	94.718	ENSCANG00000034760	METTL6	100	94.718	Colobus_angolensis_palliatus
ENSG00000206562	METTL6	96	88.971	ENSCGRG00001000127	Mettl6	99	88.971	Cricetulus_griseus_chok1gshd
ENSG00000206562	METTL6	96	88.686	ENSCGRG00000014192	Mettl6	98	88.686	Cricetulus_griseus_crigri
ENSG00000206562	METTL6	91	76.357	ENSCSEG00000009907	mettl6	89	76.357	Cynoglossus_semilaevis
ENSG00000206562	METTL6	92	78.077	ENSCVAG00000019257	mettl6	88	78.077	Cyprinodon_variegatus
ENSG00000206562	METTL6	93	73.585	ENSDARG00000070085	mettl6	93	73.585	Danio_rerio
ENSG00000206562	METTL6	100	89.085	ENSDNOG00000038011	METTL6	100	89.085	Dasypus_novemcinctus
ENSG00000206562	METTL6	95	89.299	ENSDORG00000014113	Mettl6	99	89.299	Dipodomys_ordii
ENSG00000206562	METTL6	88	64.130	FBgn0085224	CG34195	94	55.970	Drosophila_melanogaster
ENSG00000206562	METTL6	88	88.043	ENSETEG00000004572	METTL6	100	88.333	Echinops_telfairi
ENSG00000206562	METTL6	100	93.310	ENSECAG00000024591	METTL6	100	93.310	Equus_caballus
ENSG00000206562	METTL6	88	89.130	ENSEEUG00000002039	METTL6	100	90.179	Erinaceus_europaeus
ENSG00000206562	METTL6	94	76.119	ENSELUG00000009990	mettl6	88	76.119	Esox_lucius
ENSG00000206562	METTL6	100	92.606	ENSFCAG00000022284	METTL6	100	92.606	Felis_catus
ENSG00000206562	METTL6	94	80.970	ENSFALG00000009096	METTL6	92	80.970	Ficedula_albicollis
ENSG00000206562	METTL6	97	89.130	ENSFDAG00000005431	METTL6	98	89.130	Fukomys_damarensis
ENSG00000206562	METTL6	95	75.926	ENSFHEG00000000129	mettl6	85	75.926	Fundulus_heteroclitus
ENSG00000206562	METTL6	90	73.725	ENSGMOG00000015961	mettl6	88	73.725	Gadus_morhua
ENSG00000206562	METTL6	94	81.716	ENSGALG00000040665	METTL6	92	81.716	Gallus_gallus
ENSG00000206562	METTL6	91	77.992	ENSGAFG00000011492	mettl6	91	74.906	Gambusia_affinis
ENSG00000206562	METTL6	90	81.915	ENSGACG00000001695	mettl6	83	72.941	Gasterosteus_aculeatus
ENSG00000206562	METTL6	88	86.957	ENSGAGG00000007034	METTL6	91	65.693	Gopherus_agassizii
ENSG00000206562	METTL6	100	98.592	ENSGGOG00000024436	METTL6	100	98.592	Gorilla_gorilla
ENSG00000206562	METTL6	91	76.448	ENSHBUG00000014557	mettl6	96	76.448	Haplochromis_burtoni
ENSG00000206562	METTL6	97	90.217	ENSHGLG00000006022	METTL6	98	90.217	Heterocephalus_glaber_female
ENSG00000206562	METTL6	97	90.217	ENSHGLG00100016967	METTL6	98	90.217	Heterocephalus_glaber_male
ENSG00000206562	METTL6	86	72.131	ENSHCOG00000013637	mettl6	77	72.131	Hippocampus_comes
ENSG00000206562	METTL6	91	74.031	ENSIPUG00000023344	METTL6	91	74.031	Ictalurus_punctatus
ENSG00000206562	METTL6	99	91.815	ENSSTOG00000014974	METTL6	97	91.815	Ictidomys_tridecemlineatus
ENSG00000206562	METTL6	96	89.744	ENSJJAG00000018567	Mettl6	92	89.744	Jaculus_jaculus
ENSG00000206562	METTL6	96	75.368	ENSKMAG00000017283	mettl6	93	75.368	Kryptolebias_marmoratus
ENSG00000206562	METTL6	96	73.162	ENSLBEG00000019317	mettl6	99	73.162	Labrus_bergylta
ENSG00000206562	METTL6	94	76.316	ENSLACG00000011432	METTL6	85	76.316	Latimeria_chalumnae
ENSG00000206562	METTL6	94	76.316	ENSLOCG00000001835	mettl6	92	76.316	Lepisosteus_oculatus
ENSG00000206562	METTL6	100	89.437	ENSLAFG00000006149	METTL6	99	89.437	Loxodonta_africana
ENSG00000206562	METTL6	100	94.366	ENSMFAG00000000654	METTL6	100	94.366	Macaca_fascicularis
ENSG00000206562	METTL6	100	94.366	ENSMMUG00000004933	METTL6	100	94.366	Macaca_mulatta
ENSG00000206562	METTL6	100	94.366	ENSMNEG00000035936	METTL6	100	94.366	Macaca_nemestrina
ENSG00000206562	METTL6	100	94.718	ENSMLEG00000036079	METTL6	100	94.718	Mandrillus_leucophaeus
ENSG00000206562	METTL6	95	73.333	ENSMAMG00000013872	mettl6	89	73.333	Mastacembelus_armatus
ENSG00000206562	METTL6	91	76.834	ENSMZEG00005009711	mettl6	89	76.834	Maylandia_zebra
ENSG00000206562	METTL6	94	80.970	ENSMGAG00000011326	METTL6	92	80.970	Meleagris_gallopavo
ENSG00000206562	METTL6	98	86.282	ENSMOCG00000017391	Mettl6	98	86.282	Microtus_ochrogaster
ENSG00000206562	METTL6	87	84.615	ENSMMOG00000002738	mettl6	98	73.507	Mola_mola
ENSG00000206562	METTL6	92	82.308	ENSMODG00000014536	METTL6	88	82.308	Monodelphis_domestica
ENSG00000206562	METTL6	95	75.556	ENSMALG00000008691	mettl6	89	75.556	Monopterus_albus
ENSG00000206562	METTL6	100	92.606	ENSMPUG00000001741	METTL6	100	92.606	Mustela_putorius_furo
ENSG00000206562	METTL6	100	91.549	ENSMLUG00000002743	METTL6	100	91.549	Myotis_lucifugus
ENSG00000206562	METTL6	99	86.429	ENSNGAG00000015822	Mettl6	97	86.429	Nannospalax_galili
ENSG00000206562	METTL6	94	75.281	ENSNBRG00000013484	mettl6	99	75.281	Neolamprologus_brichardi
ENSG00000206562	METTL6	100	97.535	ENSNLEG00000001595	METTL6	100	97.535	Nomascus_leucogenys
ENSG00000206562	METTL6	87	86.813	ENSOPRG00000006445	METTL6	99	70.714	Ochotona_princeps
ENSG00000206562	METTL6	98	87.050	ENSODEG00000008650	METTL6	97	87.050	Octodon_degus
ENSG00000206562	METTL6	93	76.604	ENSONIG00000006718	mettl6	97	76.604	Oreochromis_niloticus
ENSG00000206562	METTL6	95	83.704	ENSOANG00000006755	METTL6	97	83.704	Ornithorhynchus_anatinus
ENSG00000206562	METTL6	99	88.929	ENSOCUG00000016078	METTL6	100	88.929	Oryctolagus_cuniculus
ENSG00000206562	METTL6	94	75.940	ENSORLG00000015510	mettl6	86	75.940	Oryzias_latipes
ENSG00000206562	METTL6	87	83.516	ENSORLG00020016946	mettl6	92	75.746	Oryzias_latipes_hni
ENSG00000206562	METTL6	87	83.516	ENSORLG00015022868	mettl6	98	75.373	Oryzias_latipes_hsok
ENSG00000206562	METTL6	94	75.655	ENSOMEG00000018462	mettl6	90	75.655	Oryzias_melastigma
ENSG00000206562	METTL6	100	90.845	ENSOGAG00000013962	METTL6	100	90.845	Otolemur_garnettii
ENSG00000206562	METTL6	99	88.256	ENSOARG00000015059	METTL6	86	88.256	Ovis_aries
ENSG00000206562	METTL6	100	99.296	ENSPPAG00000039377	METTL6	100	99.296	Pan_paniscus
ENSG00000206562	METTL6	100	92.958	ENSPPRG00000014661	METTL6	100	92.958	Panthera_pardus
ENSG00000206562	METTL6	100	92.958	ENSPTIG00000015336	METTL6	100	92.958	Panthera_tigris_altaica
ENSG00000206562	METTL6	100	99.296	ENSPTRG00000030297	METTL6	100	99.296	Pan_troglodytes
ENSG00000206562	METTL6	100	94.366	ENSPANG00000008253	METTL6	100	94.366	Papio_anubis
ENSG00000206562	METTL6	92	75.769	ENSPKIG00000013289	mettl6	83	75.769	Paramormyrops_kingsleyae
ENSG00000206562	METTL6	94	82.397	ENSPSIG00000012114	METTL6	91	82.397	Pelodiscus_sinensis
ENSG00000206562	METTL6	94	73.034	ENSPMGG00000018325	mettl6	90	73.034	Periophthalmus_magnuspinnatus
ENSG00000206562	METTL6	94	89.179	ENSPEMG00000006627	Mettl6	99	86.364	Peromyscus_maniculatus_bairdii
ENSG00000206562	METTL6	93	69.811	ENSPMAG00000009157	mettl6	93	69.811	Petromyzon_marinus
ENSG00000206562	METTL6	94	75.373	ENSPFOG00000018379	mettl6	85	75.373	Poecilia_formosa
ENSG00000206562	METTL6	94	75.373	ENSPLAG00000022440	mettl6	85	75.373	Poecilia_latipinna
ENSG00000206562	METTL6	91	77.220	ENSPMEG00000009571	mettl6	77	77.220	Poecilia_mexicana
ENSG00000206562	METTL6	95	76.296	ENSPREG00000019112	mettl6	88	76.208	Poecilia_reticulata
ENSG00000206562	METTL6	98	98.566	ENSPPYG00000014090	METTL6	99	98.566	Pongo_abelii
ENSG00000206562	METTL6	88	90.217	ENSPCAG00000016861	METTL6	100	90.625	Procavia_capensis
ENSG00000206562	METTL6	100	92.958	ENSPCOG00000015487	METTL6	100	92.958	Propithecus_coquereli
ENSG00000206562	METTL6	100	84.859	ENSPVAG00000000735	METTL6	100	84.859	Pteropus_vampyrus
ENSG00000206562	METTL6	91	76.357	ENSPNYG00000011923	mettl6	96	76.357	Pundamilia_nyererei
ENSG00000206562	METTL6	93	76.515	ENSPNAG00000023163	mettl6	91	76.515	Pygocentrus_nattereri
ENSG00000206562	METTL6	98	86.643	ENSRNOG00000057372	Mettl6	97	86.643	Rattus_norvegicus
ENSG00000206562	METTL6	100	95.423	ENSRBIG00000044482	METTL6	100	95.423	Rhinopithecus_bieti
ENSG00000206562	METTL6	100	95.423	ENSRROG00000029409	METTL6	100	95.423	Rhinopithecus_roxellana
ENSG00000206562	METTL6	100	95.070	ENSSBOG00000029385	METTL6	100	95.070	Saimiri_boliviensis_boliviensis
ENSG00000206562	METTL6	95	82.593	ENSSHAG00000006443	METTL6	91	82.593	Sarcophilus_harrisii
ENSG00000206562	METTL6	94	73.134	ENSSFOG00015013082	mettl6	98	74.330	Scleropages_formosus
ENSG00000206562	METTL6	87	84.615	ENSSMAG00000016506	mettl6	85	77.992	Scophthalmus_maximus
ENSG00000206562	METTL6	87	83.516	ENSSDUG00000002600	mettl6	89	74.444	Seriola_dumerili
ENSG00000206562	METTL6	87	83.516	ENSSLDG00000013783	mettl6	90	74.815	Seriola_lalandi_dorsalis
ENSG00000206562	METTL6	95	80.370	ENSSPUG00000011787	METTL6	91	80.370	Sphenodon_punctatus
ENSG00000206562	METTL6	94	77.154	ENSSPAG00000023289	mettl6	99	77.154	Stegastes_partitus
ENSG00000206562	METTL6	100	91.549	ENSSSCG00000011190	METTL6	100	91.549	Sus_scrofa
ENSG00000206562	METTL6	94	82.090	ENSTGUG00000003954	METTL6	100	82.090	Taeniopygia_guttata
ENSG00000206562	METTL6	94	76.768	ENSTRUG00000003971	mettl6	68	70.886	Takifugu_rubripes
ENSG00000206562	METTL6	87	83.516	ENSTNIG00000012988	mettl6	99	72.628	Tetraodon_nigroviridis
ENSG00000206562	METTL6	100	90.493	ENSTTRG00000014366	METTL6	100	90.493	Tursiops_truncatus
ENSG00000206562	METTL6	100	91.901	ENSUAMG00000027893	METTL6	100	91.901	Ursus_americanus
ENSG00000206562	METTL6	100	91.901	ENSUMAG00000017889	METTL6	100	91.901	Ursus_maritimus
ENSG00000206562	METTL6	100	86.972	ENSVPAG00000010027	METTL6	100	86.972	Vicugna_pacos
ENSG00000206562	METTL6	97	92.727	ENSVVUG00000001779	-	100	92.727	Vulpes_vulpes
ENSG00000206562	METTL6	92	90.038	ENSVVUG00000013972	-	97	90.038	Vulpes_vulpes
ENSG00000206562	METTL6	87	85.714	ENSXETG00000012544	mettl6	90	77.985	Xenopus_tropicalis
ENSG00000206562	METTL6	92	75.000	ENSXCOG00000004568	mettl6	82	75.000	Xiphophorus_couchianus
ENSG00000206562	METTL6	92	75.573	ENSXMAG00000013302	mettl6	83	75.573	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002946	tRNA C5-cytosine methylation	-	IEA	Process
GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	-	IEA	Function