EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000211460 (Gene tree)
Gene ID: 7247
Gene Symbol: TSN
Alias: TRSLN|BCLF-1|REHF-1
Full Name: translin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 30,751 bases
Position: chr2:121,737,103-121,767,853
Accession: 12379
RBP type: canonical RBP
Summary: This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000374332	Translin	PF01997.16	4.8e-56	1	1
ENSP00000387263	Translin	PF01997.16	2.2e-54	1	1
ENSP00000399735	Translin	PF01997.16	2.7e-35	1	1
ENSP00000437728	Translin	PF01997.16	1e-18	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10824978	Intracellular and intercellular transport of many germ cell mRNAs is mediated by the DNA- and RNA-binding protein, testis-brain-RNA-binding protein (TB-RBP).	Mol Reprod Dev	2000 Jun	Hecht NB	-
12051831	A TB-RBP and Ter ATPase complex accompanies specific mRNAs from nuclei through the nuclear pores and into intercellular bridges in mouse male germ cells.	Dev Biol	2002 Jun 15	Morales CR	-
11691931	Altering the GTP binding site of the DNA/RNA-binding protein, Translin/TB-RBP, decreases RNA binding and may create a dominant negative phenotype.	Nucleic Acids Res	2001 Nov 1	Chennathukuzhi VM	-
10082876	Testis-brain RNA-binding protein (Translin) is primarily expressed in neurons of the mouse brain.	Brain Res	1999 Feb 20	Wu XQ	-
9733578	The DNA/RNA-binding protein, TB-RBP, moves from the nucleus to the cytoplasm and through intercellular bridges in male germ cells.	Dev Biol	1998 Sep 1	Morales CR	-
9512538	Dimerization of the testis brain RNA-binding protein (translin) is mediated through its C-terminus and is required for DNA- and RNA-binding.	Nucleic Acids Res	1998 Apr 1	Wu XQ	-
7578697	Testis-brain RNA-binding protein, a testicular translational regulatory RNA-binding protein, is present in the brain and binds to the 3' untranslated regions of transported brain mRNAs.	Biol Reprod	1995 Sep	Han JR	-
11027506	Part of Xenopus translin is localized in the centrosomes during mitosis.	Biochem Biophys Res Commun	2000 Sep 24	Castro A	-
10684815	Mouse testis brain ribonucleic acid-binding protein/translin colocalizes with microtubules and is immunoprecipitated with messenger ribonucleic acids encoding myelin basic protein, alpha calmodulin kinase II, and protamines 1 and 2.	Biol Reprod	2000 Mar	Wu XQ	-
15138261	The relative levels of translin-associated factor X (TRAX) and testis brain RNA-binding protein determine their nucleocytoplasmic distribution in male germ cells.	J Biol Chem	2004 Jul 23	Cho YS	-
9636644	BC1 RNA protein particles in mouse brain contain two y-,h-element-binding proteins, translin and a 37 kDa protein.	Biochem Biophys Res Commun	1998 Jun 9	Muramatsu T	-
9491373	The RNA- and DNA-binding protein TB-RBP is spatially and developmentally regulated during spermatogenesis.	Mol Reprod Dev	1998 Mar	Gu W	-
10523505	The suppression of testis-brain RNA binding protein and kinesin heavy chain disrupts mRNA sorting in dendrites.	J Cell Sci	1999 Nov	Severt WL	-
10471275	Protein-protein interactions between the testis brain RNA-binding protein and the transitional endoplasmic reticulum ATPase, a cytoskeletal gamma actin and Trax in male germ cells and the brain.	Biochemistry	1999 Aug 31	Wu XQ	-
7568171	Testis/brain RNA-binding protein attaches translationally repressed and transported mRNAs to microtubules.	Proc Natl Acad Sci U S A	1995 Oct 10	Han JR	-
12944470	Mice deficient for testis-brain RNA-binding protein exhibit a coordinate loss of TRAX, reduced fertility, altered gene expression in the brain, and behavioral changes.	Mol Cell Biol	2003 Sep	Chennathukuzhi V	-
12604635	Mouse testis brain RNA-binding protein/translin selectively binds to the messenger RNA of the fibrous sheath protein glyceraldehyde 3-phosphate dehydrogenase-S and suppresses its translation in vitro.	Biol Reprod	2003 Mar	Yang J	-
12079346	Crystal structure of TB-RBP, a novel RNA-binding and regulating protein.	J Mol Biol	2002 Jun 21	Pascal JM	-
15987823	Meiotic messenger RNA and noncoding RNA targets of the RNA-binding protein Translin (TSN) in mouse testis.	Biol Reprod	2005 Oct	Cho YS	-
15474041	Translin associated protein X is essential for cellular proliferation.	FEBS Lett	2004 Oct 8	Yang S	-
14673085	The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells.	Proc Natl Acad Sci U S A	2003 Dec 23	Chennathukuzhi V	-
18567644	The DNA/RNA-binding protein, translin, binds microRNA122a and increases its in vivo stability.	J Androl	2008 Sep-Oct	Yu Z	doi: 10.2164/jandrol.108.005090
19805324	Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation.	Proc Natl Acad Sci U S A	2009 Sep 22	Chiaruttini C	doi: 10.1073/pnas.0902833106
18424275	The Translin/Trax RNA binding complex: clues to function in the nervous system.	Biochim Biophys Acta	2008 Aug	Li Z	doi: 10.1016/j.bbagrm.2008.03.008
17028328	Functional characterization of Drosophila Translin and Trax.	Genetics	2006 Nov	Claussen M	-
20450889	Analysis of nucleic acid binding by a recombinant translin-trax complex.	Biochem Biophys Res Commun	2010 Jun 4	Lluis M	doi: 10.1016/j.bbrc.2010.04.166
25433126	A novel open-barrel structure of octameric translin reveals a potential RNA entryway.	J Mol Biol	2015 Feb 27	Eliahoo E	doi: 10.1016/j.jmb.2014.11.013
28797959	C-terminal residues of rice translin are essential for octamer formation and nucleic acid binding.	Plant Physiol Biochem	2017 Sep	Gupta A	doi: 10.1016/j.plaphy.2017.08.004
30172368	Translin modulates mesenchymal cell proliferation and differentiation in mice.	Biochem Biophys Res Commun	2018 Sep 26	Ikeuchi Y	doi: 10.1016/j.bbrc.2018.08.141
14741401	High affinity binding of the Translin/Trax complex to RNA does not require the presence of Y or H elements.	Brain Res Mol Brain Res	2004 Jan 5	Li Z	-
9159125	The RNA-binding protein, TB-RBP, is the mouse homologue of translin, a recombination protein associated with chromosomal translocations.	Proc Natl Acad Sci U S A	1997 May 27	Wu XQ	-
12358744	Trax is a component of the Translin-containing RNA binding complex.	J Neurochem	2002 Oct	Finkenstadt PM	-
16495445	Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin.	J Neurosci	2006 Feb 22	Stein JM	-
16411762	GTP-induced conformational changes in translin: a comparison between human and Drosophila proteins.	Biochemistry	2006 Jan 24	Sengupta K	-
11389888	Masking of the Translin/Trax complex by endogenous RNA.	FEBS Lett	2001 Jun 1	Finkenstadt PM	-
10987859	Somatodendritic localization of Translin, a component of the Translin/Trax RNA binding complex.	J Neurochem	2000 Oct	Finkenstadt PM	-
16218753	Conformational changes induced in the human protein translin and in the single-stranded oligodeoxynucleotides d(GT)(12) and d(TTAGGG)(5) upon binding of these oligodeoxynucleotides by translin.	J Biomol Struct Dyn	2005 Dec	Kaluzhny D	-
20081200	Mapping of interaction sites of the Schizosaccharomyces pombe protein Translin with nucleic acids and proteins: a combined molecular genetics and bioinformatics study.	Nucleic Acids Res	2010 May	Eliahoo E	doi: 10.1093/nar/gkp1230
17905928	Noncoding RNAs of the mammalian testis: the meiotic transcripts Nct1 and Nct2 encode piRNAs.	Ann N Y Acad Sci	2007 Dec	Iguchi N	-
21637842	Search for limiting factors in the RNAi pathway in silkmoth tissues and the Bm5 cell line: the RNA-binding proteins R2D2 and Translin.	PLoS One	2011	Swevers L	doi: 10.1371/journal.pone.0020250
21198640	Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms.	J Neurochem	2011 Mar	Wu YC	doi: 10.1111/j.1471-4159.2010.07166.x
24863060	Characterization of a plant (rice) translin and its comparative analysis with human translin.	Planta	2014 Aug	Chittela RK	doi: 10.1007/s00425-014-2092-4
24382491	Identification of proteins that form specific complexes with the highly conserved protein Translin in Schizosaccharomyces pombe.	Biochim Biophys Acta	2014 Apr	Eliahoo E	doi: 10.1016/j.bbapap.2013.12.016
23980029	Conformational transitions in human translin enable nucleic acid binding.	Nucleic Acids Res	2013 Nov	Perez-Cano L	doi: 10.1093/nar/gkt765
29860349	Structural insights into Drosophila-C3PO complex assembly and 'Dynamic Side Port' model in substrate entry and release.	Nucleic Acids Res	2018 Sep 19	Mo X	doi: 10.1093/nar/gky465.
11032866	The single-stranded DNA- and RNA-binding proteins pur alpha and pur beta link BC1 RNA to microtubules through binding to the dendrite-targeting RNA motifs.	J Neurochem	2000 Nov	Ohashi S	-
27183912	Translin and Trax differentially regulate telomere-associated transcript homeostasis.	Oncotarget	2016 Jun 7	Gomez-Escobar N	doi: 10.18632/oncotarget.9278.
11278549	Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA.	J Biol Chem	2001 Apr 20	Chennathukuzhi VM	-
15039555	Structure of human translin at 2.2 A resolution.	Acta Crystallogr D Biol Crystallogr	2004 Apr	Sugiura I	-
22427937	Identification of nucleic acid binding sites on translin-associated factor X (TRAX) protein.	PLoS One	2012	Gupta GD	doi: 10.1371/journal.pone.0033035
25659154	ABCE1 is a highly conserved RNA silencing suppressor.	PLoS One	2015 Feb 6	Karblane K	doi: 10.1371/journal.pone.0116702
27020744	translin Is Required for Metabolic Regulation of Sleep.	Curr Biol	2016 Apr 4	Murakami K	doi: 10.1016/j.cub.2016.02.013
26862135	RNA-induced silencing attenuates G protein-mediated calcium signals.	FASEB J	2016 May	Philip F	doi: 10.1096/fj.201500140
26746047	Phospholipase Cβ connects G protein signaling with RNA interference.	Adv Biol Regul	2016 May	Scarlata S	doi: 10.1016/j.jbior.2015.11.006

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000389682	TSN-201	3420	-	ENSP00000374332	228 (aa)	-	Q15631
ENST00000536142	TSN-212	3328	-	ENSP00000437728	148 (aa)	-	Q15631
ENST00000490104	TSN-208	2717	-	ENSP00000487702	92 (aa)	-	A0A0J9YVW2
ENST00000495112	TSN-210	605	-	-	- (aa)	-	-
ENST00000481818	TSN-206	421	-	-	- (aa)	-	-
ENST00000490717	TSN-209	560	-	ENSP00000487833	36 (aa)	-	A0A0J9YX41
ENST00000483698	TSN-207	555	-	-	- (aa)	-	-
ENST00000478165	TSN-205	578	-	ENSP00000488237	36 (aa)	-	A0A0J9YX41
ENST00000409193	TSN-202	1436	-	ENSP00000387263	223 (aa)	-	E9PGT1
ENST00000467324	TSN-204	2843	-	ENSP00000487808	36 (aa)	-	A0A0J9YX41
ENST00000455432	TSN-203	555	-	ENSP00000399735	185 (aa)	-	H7C1D4
ENST00000498545	TSN-211	1118	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000211460's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000211460	Maximal Midexpiratory Flow Rate	2.04139462139985E-7	17903307
ENSG00000211460	Respiratory Function Tests	5.12229270916112E-8	17903307
ENSG00000211460	Respiratory Function Tests	2.83926788283911E-6	17903307
ENSG00000211460	Respiratory Function Tests	9.04940011428691E-6	17903307
ENSG00000211460	Triglycerides	6.22451032061117E-6	17903299
ENSG00000211460	Triglycerides	8.18857742262849E-6	17903299
ENSG00000211460	Cholesterol	1.10156409879717E-6	17903299
ENSG00000211460	Erythrocyte Indices	8.40467800692523E-7	17903294
ENSG00000211460	Erythrocyte Indices	5.1483382605609E-6	17903294
ENSG00000211460	Erythrocyte Indices	2.16492060428614E-6	17903294
ENSG00000211460	Heart Rate	7.71774371075562E-5	17903306
ENSG00000211460	Varicose Veins	7.25392576788214E-20	-
ENSG00000211460	Audiometry, Pure-Tone	7.47302124041352E-7	-
ENSG00000211460	Life Expectancy	1.9940344255456E-6	17903295
ENSG00000211460	Life Expectancy	3.66222477250823E-6	17903295
ENSG00000211460	Attention Deficit Disorder with Hyperactivity	9.2450000E-006	18937294
ENSG00000211460	Attention Deficit Disorder with Hyperactivity	1.3100000E-004	18937294
ENSG00000211460	Attention Deficit Disorder with Hyperactivity	3.7620000E-005	18937294
ENSG00000211460	Stroke	6.3949923E-004	19369658
ENSG00000211460	Stroke	3.9884901E-004	19369658
ENSG00000211460	Body Height	2.599e-005	18193045
ENSG00000211460	Body Height	8.945e-005	18193045
ENSG00000211460	Body Height	8.945e-005	18193045
ENSG00000211460	Erythrocyte Indices	6.617e-005	-
ENSG00000211460	Erythrocyte Count	2.983e-005	-
ENSG00000211460	Erythrocyte Count	2.983e-005	-
ENSG00000211460	Erythrocyte Count	7.207e-006	-
ENSG00000211460	Personality	4.301e-005	-
ENSG00000211460	Waist-Hip Ratio	2.0830000E-005	-
ENSG00000211460	Waist-Hip Ratio	4.2280000E-005	-
ENSG00000211460	Waist-Hip Ratio	2.7170000E-006	-
ENSG00000211460	Waist-Hip Ratio	3.5170000E-005	-
ENSG00000211460	Waist-Hip Ratio	5.4710000E-006	-
ENSG00000211460	monocyte chemoattractant protein 1 (66-77)	3.2550000E-005	-
ENSG00000211460	Fetal Hemoglobin	4.7400000E-005	20018918
ENSG00000211460	Urine	9.1252822E-005	-
ENSG00000211460	Leukoaraiosis	8.2074052E-005	-
ENSG00000211460	Platelet Function Tests	6.2100000E-006	-
ENSG00000211460	Platelet Function Tests	7.7800000E-006	-
ENSG00000211460	Platelet Function Tests	1.9509400E-005	-
ENSG00000211460	Platelet Function Tests	2.0435200E-005	-
ENSG00000211460	Platelet Function Tests	2.3490300E-005	-
ENSG00000211460	Platelet Function Tests	3.3778700E-005	-
ENSG00000211460	Platelet Function Tests	3.1463972E-006	-
ENSG00000211460	Platelet Function Tests	1.2869700E-005	-
ENSG00000211460	Platelet Function Tests	6.8519676E-006	-
ENSG00000211460	Platelet Function Tests	1.3789565E-006	-
ENSG00000211460	Platelet Function Tests	3.2258057E-008	-
ENSG00000211460	Platelet Function Tests	2.0986799E-006	-
ENSG00000211460	Interleukin-12	6.8280000E-005	-
ENSG00000211460	Interleukin-12	4.7850000E-005	-
ENSG00000211460	Interleukin-12	7.9950000E-005	-
ENSG00000211460	Interleukin-12	2.2190000E-005	-
ENSG00000211460	Macrophage Inflammatory Proteins	7.7780000E-006	-
ENSG00000211460	Macrophage Inflammatory Proteins	5.1180000E-005	-
ENSG00000211460	Macrophage Inflammatory Proteins	1.9320000E-005	-
ENSG00000211460	Blood Pressure	2.5423714E-005	-
ENSG00000211460	Blood Pressure	2.4743025E-005	-
ENSG00000211460	Blood Pressure	2.4940851E-005	-
ENSG00000211460	Bronchodilator Agents	1E-6	26634245
ENSG00000211460	Lung Volume Measurements	1E-6	26634245
ENSG00000211460	Pulmonary Disease, Chronic Obstructive	1E-6	26634245
ENSG00000211460	Corpus Striatum	5E-6	22903471
ENSG00000211460	Bronchodilator Agents	4E-7	26634245
ENSG00000211460	Lung Volume Measurements	4E-7	26634245
ENSG00000211460	Pulmonary Disease, Chronic Obstructive	4E-7	26634245
ENSG00000211460	Bronchodilator Agents	1E-7	26634245
ENSG00000211460	Forced Expiratory Volume	1E-7	26634245
ENSG00000211460	Bronchodilator Agents	5E-7	26634245
ENSG00000211460	Lung Volume Measurements	5E-7	26634245
ENSG00000211460	Pulmonary Disease, Chronic Obstructive	5E-7	26634245
ENSG00000211460	Corpus Striatum	5E-6	22903471
ENSG00000211460	Corpus Striatum	4E-6	22903471
ENSG00000211460	Bronchodilator Agents	2E-6	26634245
ENSG00000211460	Lung Volume Measurements	2E-6	26634245
ENSG00000211460	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000211460	Corpus Striatum	6E-6	22903471
ENSG00000211460	Schizophrenia	8E-6	26198764
ENSG00000211460	Alzheimer Disease	8E-10	26993346
ENSG00000211460	Neurodegenerative Diseases	8E-10	26993346
ENSG00000211460	Bronchodilator Agents	1E-6	26634245
ENSG00000211460	Lung Volume Measurements	1E-6	26634245
ENSG00000211460	Pulmonary Disease, Chronic Obstructive	1E-6	26634245
ENSG00000211460	Bronchodilator Agents	1E-6	26634245
ENSG00000211460	Lung Volume Measurements	1E-6	26634245
ENSG00000211460	Pulmonary Disease, Chronic Obstructive	1E-6	26634245
ENSG00000211460	Bronchodilator Agents	4E-7	26634245
ENSG00000211460	Lung Volume Measurements	4E-7	26634245
ENSG00000211460	Cytokines	1E-8	22610502
ENSG00000211460	Vaccine Potency	1E-8	22610502
ENSG00000211460	Attention Deficit Disorder with Hyperactivity	9E-6	18821565
ENSG00000211460	Alzheimer Disease	3E-6	27770636
ENSG00000211460	Erectile Dysfunction	1E-6	20932654
ENSG00000211460	Prostatic Neoplasms	1E-6	20932654
ENSG00000211460	Electromagnetic Radiation	1E-6	20932654
ENSG00000211460	Attention Deficit Disorder with Hyperactivity	9E-6	23527680
ENSG00000211460	Bone Density	2E-6	28181694
ENSG00000211460	Bronchodilator Agents	5E-6	26634245
ENSG00000211460	Lung Volume Measurements	5E-6	26634245
ENSG00000211460	Antigens	8E-7	24962563
ENSG00000211460	Immunoglobulin G	8E-7	24962563
ENSG00000211460	Bronchodilator Agents	4E-6	26634245
ENSG00000211460	Lung Volume Measurements	4E-6	26634245
ENSG00000211460	Pulmonary Disease, Chronic Obstructive	4E-6	26634245
ENSG00000211460	Bronchodilator Agents	5E-7	26634245
ENSG00000211460	Lung Volume Measurements	5E-7	26634245
ENSG00000211460	Pulmonary Disease, Chronic Obstructive	5E-7	26634245
ENSG00000211460	Electrocardiography	7E-7	27958378
ENSG00000211460	Sulfonylurea Compounds	7E-7	27958378

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000211460's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000211460	TSN	98	79.018	ENSAPOG00000002063	tsn	99	79.018	Acanthochromis_polyacanthus
ENSG00000211460	TSN	100	99.123	ENSAMEG00000005055	TSN	100	99.123	Ailuropoda_melanoleuca
ENSG00000211460	TSN	98	79.464	ENSACIG00000021694	tsn	99	79.464	Amphilophus_citrinellus
ENSG00000211460	TSN	98	79.018	ENSAOCG00000015574	tsn	99	80.693	Amphiprion_ocellaris
ENSG00000211460	TSN	98	79.018	ENSAPEG00000001677	tsn	99	79.018	Amphiprion_percula
ENSG00000211460	TSN	99	77.333	ENSATEG00000004115	tsn	99	77.333	Anabas_testudineus
ENSG00000211460	TSN	60	30.519	ENSAPLG00000013433	-	53	30.519	Anas_platyrhynchos
ENSG00000211460	TSN	94	84.932	ENSACAG00000004757	TSN	99	84.932	Anolis_carolinensis
ENSG00000211460	TSN	100	99.561	ENSANAG00000026842	TSN	100	99.561	Aotus_nancymaae
ENSG00000211460	TSN	98	79.464	ENSACLG00000020831	tsn	99	79.464	Astatotilapia_calliptera
ENSG00000211460	TSN	98	78.125	ENSAMXG00000035417	tsn	99	78.125	Astyanax_mexicanus
ENSG00000211460	TSN	100	99.561	ENSBTAG00000006059	TSN	100	99.561	Bos_taurus
ENSG00000211460	TSN	100	99.561	ENSCJAG00000047222	-	100	99.561	Callithrix_jacchus
ENSG00000211460	TSN	100	99.123	ENSCJAG00000044533	-	100	99.123	Callithrix_jacchus
ENSG00000211460	TSN	76	90.265	ENSCJAG00000008511	-	88	90.265	Callithrix_jacchus
ENSG00000211460	TSN	99	99.119	ENSCAFG00000004700	TSN	94	99.119	Canis_familiaris
ENSG00000211460	TSN	100	99.123	ENSCAFG00020011747	TSN	100	99.123	Canis_lupus_dingo
ENSG00000211460	TSN	100	99.561	ENSCHIG00000010715	TSN	100	99.561	Capra_hircus
ENSG00000211460	TSN	100	99.123	ENSTSYG00000004395	TSN	100	99.123	Carlito_syrichta
ENSG00000211460	TSN	92	81.068	ENSCAPG00000015595	TSN	81	81.068	Cavia_aperea
ENSG00000211460	TSN	100	100.000	ENSCPOG00000035645	TSN	100	100.000	Cavia_porcellus
ENSG00000211460	TSN	92	81.818	ENSCCAG00000034886	-	84	85.526	Cebus_capucinus
ENSG00000211460	TSN	100	99.324	ENSCCAG00000026371	TSN	100	99.324	Cebus_capucinus
ENSG00000211460	TSN	100	100.000	ENSCATG00000032155	TSN	100	100.000	Cercocebus_atys
ENSG00000211460	TSN	100	100.000	ENSCLAG00000006171	TSN	100	100.000	Chinchilla_lanigera
ENSG00000211460	TSN	100	100.000	ENSCSAG00000016712	TSN	100	100.000	Chlorocebus_sabaeus
ENSG00000211460	TSN	86	89.764	ENSCPBG00000013741	-	80	88.079	Chrysemys_picta_bellii
ENSG00000211460	TSN	97	76.577	ENSCPBG00000018116	-	97	76.577	Chrysemys_picta_bellii
ENSG00000211460	TSN	95	45.161	ENSCING00000012612	-	99	45.161	Ciona_intestinalis
ENSG00000211460	TSN	97	43.498	ENSCSAVG00000009485	-	99	43.498	Ciona_savignyi
ENSG00000211460	TSN	100	100.000	ENSCANG00000041881	TSN	100	100.000	Colobus_angolensis_palliatus
ENSG00000211460	TSN	100	99.123	ENSCGRG00001018233	Tsn	100	99.123	Cricetulus_griseus_chok1gshd
ENSG00000211460	TSN	100	99.123	ENSCGRG00000008331	Tsn	100	99.123	Cricetulus_griseus_crigri
ENSG00000211460	TSN	98	76.233	ENSCSEG00000005825	tsn	98	76.233	Cynoglossus_semilaevis
ENSG00000211460	TSN	98	70.536	ENSCVAG00000022024	tsn	99	70.982	Cyprinodon_variegatus
ENSG00000211460	TSN	98	79.464	ENSDARG00000041830	tsn	99	79.464	Danio_rerio
ENSG00000211460	TSN	100	99.123	ENSDNOG00000025740	TSN	100	99.123	Dasypus_novemcinctus
ENSG00000211460	TSN	100	99.561	ENSDORG00000026251	-	100	99.561	Dipodomys_ordii
ENSG00000211460	TSN	95	52.778	FBgn0033528	trsn	91	52.778	Drosophila_melanogaster
ENSG00000211460	TSN	100	99.561	ENSEASG00005004774	TSN	100	99.561	Equus_asinus_asinus
ENSG00000211460	TSN	100	99.561	ENSECAG00000015930	TSN	100	99.561	Equus_caballus
ENSG00000211460	TSN	78	98.851	ENSEEUG00000013935	TSN	100	98.851	Erinaceus_europaeus
ENSG00000211460	TSN	98	79.821	ENSELUG00000007669	tsn	98	79.821	Esox_lucius
ENSG00000211460	TSN	76	74.118	ENSFCAG00000022306	-	96	74.118	Felis_catus
ENSG00000211460	TSN	100	99.123	ENSFCAG00000027149	TSN	100	99.123	Felis_catus
ENSG00000211460	TSN	93	86.058	ENSFALG00000013247	TSN	96	82.805	Ficedula_albicollis
ENSG00000211460	TSN	100	100.000	ENSFDAG00000012302	TSN	100	100.000	Fukomys_damarensis
ENSG00000211460	TSN	98	78.571	ENSFHEG00000015531	tsn	99	78.571	Fundulus_heteroclitus
ENSG00000211460	TSN	98	77.232	ENSGMOG00000009247	tsn	99	77.232	Gadus_morhua
ENSG00000211460	TSN	100	86.463	ENSGALG00000011652	TSN	100	86.463	Gallus_gallus
ENSG00000211460	TSN	98	78.571	ENSGAFG00000003816	tsn	99	78.571	Gambusia_affinis
ENSG00000211460	TSN	97	78.378	ENSGACG00000000235	tsn	97	78.378	Gasterosteus_aculeatus
ENSG00000211460	TSN	100	100.000	ENSGGOG00000002216	TSN	100	100.000	Gorilla_gorilla
ENSG00000211460	TSN	98	78.571	ENSHBUG00000002340	tsn	84	78.571	Haplochromis_burtoni
ENSG00000211460	TSN	100	100.000	ENSHGLG00000007038	TSN	100	100.000	Heterocephalus_glaber_female
ENSG00000211460	TSN	100	100.000	ENSHGLG00100000069	TSN	100	100.000	Heterocephalus_glaber_male
ENSG00000211460	TSN	98	78.027	ENSHCOG00000001756	tsn	99	78.027	Hippocampus_comes
ENSG00000211460	TSN	98	79.018	ENSIPUG00000021370	tsn	99	79.018	Ictalurus_punctatus
ENSG00000211460	TSN	100	100.000	ENSSTOG00000000972	TSN	100	100.000	Ictidomys_tridecemlineatus
ENSG00000211460	TSN	100	99.123	ENSJJAG00000006730	Tsn	100	99.123	Jaculus_jaculus
ENSG00000211460	TSN	98	79.018	ENSKMAG00000004996	tsn	99	79.018	Kryptolebias_marmoratus
ENSG00000211460	TSN	100	78.070	ENSLBEG00000012620	tsn	100	78.070	Labrus_bergylta
ENSG00000211460	TSN	98	59.031	ENSLACG00000005246	TSN	99	59.031	Latimeria_chalumnae
ENSG00000211460	TSN	98	79.464	ENSLOCG00000002191	tsn	97	79.464	Lepisosteus_oculatus
ENSG00000211460	TSN	100	91.342	ENSLAFG00000032428	TSN	100	91.342	Loxodonta_africana
ENSG00000211460	TSN	100	100.000	ENSMFAG00000044217	TSN	100	100.000	Macaca_fascicularis
ENSG00000211460	TSN	100	100.000	ENSMMUG00000021119	TSN	100	100.000	Macaca_mulatta
ENSG00000211460	TSN	100	100.000	ENSMNEG00000040632	TSN	100	100.000	Macaca_nemestrina
ENSG00000211460	TSN	84	100.000	ENSMLEG00000038656	TSN	96	100.000	Mandrillus_leucophaeus
ENSG00000211460	TSN	98	78.571	ENSMAMG00000019536	tsn	99	78.571	Mastacembelus_armatus
ENSG00000211460	TSN	98	79.464	ENSMZEG00005018715	tsn	84	79.464	Maylandia_zebra
ENSG00000211460	TSN	77	86.628	ENSMGAG00000011956	TSN	88	86.628	Meleagris_gallopavo
ENSG00000211460	TSN	92	98.544	ENSMAUG00000018800	Tsn	100	98.544	Mesocricetus_auratus
ENSG00000211460	TSN	100	100.000	ENSMICG00000015793	TSN	100	100.000	Microcebus_murinus
ENSG00000211460	TSN	100	98.246	ENSMOCG00000013248	Tsn	100	98.246	Microtus_ochrogaster
ENSG00000211460	TSN	89	79.798	ENSMMOG00000019661	tsn	99	78.218	Mola_mola
ENSG00000211460	TSN	100	93.013	ENSMODG00000000147	TSN	100	93.013	Monodelphis_domestica
ENSG00000211460	TSN	98	78.571	ENSMALG00000001827	tsn	99	78.571	Monopterus_albus
ENSG00000211460	TSN	100	98.684	ENSMUSG00000026374	Tsn	100	98.684	Mus_musculus
ENSG00000211460	TSN	100	98.684	MGP_PahariEiJ_G0027742	Tsn	100	98.684	Mus_pahari
ENSG00000211460	TSN	100	98.684	MGP_SPRETEiJ_G0015313	Tsn	100	98.684	Mus_spretus
ENSG00000211460	TSN	100	99.123	ENSMPUG00000001056	TSN	100	99.123	Mustela_putorius_furo
ENSG00000211460	TSN	92	99.029	ENSMLUG00000012656	TSN	100	99.029	Myotis_lucifugus
ENSG00000211460	TSN	55	31.206	ENSMLUG00000028551	-	83	31.206	Myotis_lucifugus
ENSG00000211460	TSN	100	99.123	ENSNGAG00000010353	Tsn	100	99.123	Nannospalax_galili
ENSG00000211460	TSN	98	79.018	ENSNBRG00000001193	tsn	99	79.018	Neolamprologus_brichardi
ENSG00000211460	TSN	100	100.000	ENSNLEG00000032773	TSN	100	100.000	Nomascus_leucogenys
ENSG00000211460	TSN	85	96.032	ENSMEUG00000006228	TSN	100	72.807	Notamacropus_eugenii
ENSG00000211460	TSN	62	78.417	ENSOPRG00000004858	-	99	78.417	Ochotona_princeps
ENSG00000211460	TSN	100	100.000	ENSODEG00000008386	-	100	100.000	Octodon_degus
ENSG00000211460	TSN	100	80.702	ENSODEG00000005998	-	100	80.702	Octodon_degus
ENSG00000211460	TSN	98	79.464	ENSONIG00000017060	tsn	99	79.464	Oreochromis_niloticus
ENSG00000211460	TSN	93	93.237	ENSOANG00000003457	TSN	100	93.237	Ornithorhynchus_anatinus
ENSG00000211460	TSN	100	99.561	ENSOCUG00000023529	TSN	100	99.561	Oryctolagus_cuniculus
ENSG00000211460	TSN	98	79.018	ENSORLG00000010049	tsn	99	79.018	Oryzias_latipes
ENSG00000211460	TSN	86	73.438	ENSORLG00020017000	-	84	74.306	Oryzias_latipes_hni
ENSG00000211460	TSN	98	78.571	ENSORLG00020016476	tsn	99	78.571	Oryzias_latipes_hni
ENSG00000211460	TSN	98	78.571	ENSORLG00015019192	tsn	99	78.571	Oryzias_latipes_hsok
ENSG00000211460	TSN	98	79.018	ENSOMEG00000016335	tsn	99	79.018	Oryzias_melastigma
ENSG00000211460	TSN	100	100.000	ENSOGAG00000030436	TSN	100	100.000	Otolemur_garnettii
ENSG00000211460	TSN	100	99.561	ENSOARG00000013339	TSN	100	99.561	Ovis_aries
ENSG00000211460	TSN	100	100.000	ENSPPAG00000032878	TSN	100	100.000	Pan_paniscus
ENSG00000211460	TSN	96	65.455	ENSPPRG00000004174	-	94	65.455	Panthera_pardus
ENSG00000211460	TSN	100	99.123	ENSPPRG00000006531	TSN	99	99.123	Panthera_pardus
ENSG00000211460	TSN	100	91.892	ENSPTIG00000012953	TSN	99	91.892	Panthera_tigris_altaica
ENSG00000211460	TSN	100	100.000	ENSPTRG00000012420	TSN	100	100.000	Pan_troglodytes
ENSG00000211460	TSN	100	100.000	ENSPANG00000000733	TSN	100	100.000	Papio_anubis
ENSG00000211460	TSN	98	78.125	ENSPKIG00000002005	tsn	99	78.125	Paramormyrops_kingsleyae
ENSG00000211460	TSN	78	88.571	ENSPSIG00000006064	TSN	96	88.571	Pelodiscus_sinensis
ENSG00000211460	TSN	96	79.091	ENSPMGG00000015287	tsn	97	79.091	Periophthalmus_magnuspinnatus
ENSG00000211460	TSN	97	66.968	ENSPMAG00000009161	tsn	95	66.968	Petromyzon_marinus
ENSG00000211460	TSN	93	95.652	ENSPCIG00000023491	TSN	100	95.631	Phascolarctos_cinereus
ENSG00000211460	TSN	98	79.018	ENSPFOG00000016063	tsn	99	79.018	Poecilia_formosa
ENSG00000211460	TSN	98	79.018	ENSPLAG00000010654	tsn	99	79.018	Poecilia_latipinna
ENSG00000211460	TSN	98	78.571	ENSPMEG00000023570	tsn	99	78.571	Poecilia_mexicana
ENSG00000211460	TSN	98	78.571	ENSPREG00000003481	tsn	99	78.571	Poecilia_reticulata
ENSG00000211460	TSN	100	100.000	ENSPPYG00000012774	TSN	100	100.000	Pongo_abelii
ENSG00000211460	TSN	78	97.701	ENSPCAG00000003549	TSN	100	97.701	Procavia_capensis
ENSG00000211460	TSN	100	100.000	ENSPCOG00000011045	TSN	100	100.000	Propithecus_coquereli
ENSG00000211460	TSN	100	99.561	ENSPVAG00000016702	TSN	100	99.561	Pteropus_vampyrus
ENSG00000211460	TSN	98	79.464	ENSPNYG00000012396	tsn	84	79.464	Pundamilia_nyererei
ENSG00000211460	TSN	98	78.125	ENSPNAG00000018140	tsn	99	78.125	Pygocentrus_nattereri
ENSG00000211460	TSN	100	99.123	ENSRNOG00000002319	Tsn	100	99.123	Rattus_norvegicus
ENSG00000211460	TSN	100	100.000	ENSRBIG00000041316	TSN	100	100.000	Rhinopithecus_bieti
ENSG00000211460	TSN	100	100.000	ENSRROG00000029954	TSN	100	100.000	Rhinopithecus_roxellana
ENSG00000211460	TSN	100	100.000	ENSSBOG00000028579	TSN	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000211460	TSN	85	94.444	ENSSBOG00000015719	-	83	94.702	Saimiri_boliviensis_boliviensis
ENSG00000211460	TSN	100	96.053	ENSSHAG00000011707	TSN	100	96.053	Sarcophilus_harrisii
ENSG00000211460	TSN	98	78.027	ENSSFOG00015020668	tsn	98	78.027	Scleropages_formosus
ENSG00000211460	TSN	98	78.125	ENSSMAG00000005822	tsn	99	78.125	Scophthalmus_maximus
ENSG00000211460	TSN	98	78.125	ENSSDUG00000011388	tsn	99	78.125	Seriola_dumerili
ENSG00000211460	TSN	98	78.125	ENSSLDG00000008206	tsn	99	78.125	Seriola_lalandi_dorsalis
ENSG00000211460	TSN	100	66.667	ENSSARG00000007193	-	100	66.667	Sorex_araneus
ENSG00000211460	TSN	100	85.088	ENSSPUG00000017518	TSN	100	85.088	Sphenodon_punctatus
ENSG00000211460	TSN	96	80.455	ENSSPAG00000009283	tsn	97	80.455	Stegastes_partitus
ENSG00000211460	TSN	100	98.246	ENSSSCG00000015729	TSN	100	98.246	Sus_scrofa
ENSG00000211460	TSN	99	84.000	ENSTGUG00000004445	TSN	98	84.000	Taeniopygia_guttata
ENSG00000211460	TSN	97	77.376	ENSTRUG00000013691	tsn	98	77.376	Takifugu_rubripes
ENSG00000211460	TSN	97	76.923	ENSTNIG00000015707	tsn	97	76.923	Tetraodon_nigroviridis
ENSG00000211460	TSN	100	99.123	ENSTBEG00000015319	TSN	100	99.123	Tupaia_belangeri
ENSG00000211460	TSN	100	99.561	ENSTTRG00000005854	TSN	100	99.561	Tursiops_truncatus
ENSG00000211460	TSN	100	99.123	ENSUAMG00000021618	TSN	100	99.123	Ursus_americanus
ENSG00000211460	TSN	100	97.807	ENSUMAG00000008516	TSN	100	97.807	Ursus_maritimus
ENSG00000211460	TSN	70	72.868	ENSVPAG00000009874	-	100	72.868	Vicugna_pacos
ENSG00000211460	TSN	99	93.694	ENSVVUG00000027555	TSN	99	99.029	Vulpes_vulpes
ENSG00000211460	TSN	99	77.333	ENSXETG00000000838	tsn	99	77.333	Xenopus_tropicalis
ENSG00000211460	TSN	84	74.194	ENSXCOG00000018514	tsn	95	74.194	Xiphophorus_couchianus
ENSG00000211460	TSN	98	79.018	ENSXMAG00000022538	tsn	99	79.018	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	7663511.	TAS	Function
GO:0003697	single-stranded DNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	-	IEA	Function
GO:0004521	endoribonuclease activity	21873635.	IBA	Function
GO:0005515	protein binding	21988832.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006310	DNA recombination	7663511.	TAS	Process
GO:0030422	production of siRNA involved in RNA interference	-	TAS	Process
GO:0042802	identical protein binding	21988832.	IPI	Function
GO:0043565	sequence-specific DNA binding	21873635.	IBA	Function
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process