EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000213079 (Gene tree)
Gene ID: 22828
Gene Symbol: SCAF8
Alias: KIAA1116|RBM16
Full Name: SR-related CTD associated factor 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 100,920 bases
Position: chr6:154,733,325-154,834,244
Accession: 20959
RBP type: canonical RBP
Summary: (SR-Related CTD Associated Factor 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SCAF4.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000356146	RRM_1	PF00076.22	6.4e-09	1	1
ENSP00000356154	RRM_1	PF00076.22	6.6e-09	1	1
ENSP00000413098	RRM_1	PF00076.22	6.9e-09	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000461219	SCAF8-204	677	-	-	- (aa)	-	-
ENST00000367186	SCAF8-202	4908	-	ENSP00000356154	1337 (aa)	-	Q9UPN6
ENST00000417268	SCAF8-203	4944	-	ENSP00000413098	1349 (aa)	-	A0A0A0MT33
ENST00000367178	SCAF8-201	5057	-	ENSP00000356146	1271 (aa)	-	Q9UPN6
ENST00000479234	SCAF8-206	281	-	-	- (aa)	-	-
ENST00000464628	SCAF8-205	468	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000213079's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000213079	Alpha-Globulins	2.6270000E-005	-
ENSG00000213079	Colorectal Neoplasms	2E-7	26621817
ENSG00000213079	Endometrial Neoplasms	2E-7	26621817

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000213079	rs7740797	6	154800125	G	Colorectal or endometrial cancer	26621817	[1.07-1.16]	1.12	EFO_0005842\|EFO_0004230

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000213079's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000213079	SCAF8	87	68.825	ENSAPOG00000015527	SCAF8	77	68.465	Acanthochromis_polyacanthus
ENSG00000213079	SCAF8	100	94.969	ENSAMEG00000007583	SCAF8	99	95.534	Ailuropoda_melanoleuca
ENSG00000213079	SCAF8	87	68.825	ENSAOCG00000002421	SCAF8	76	68.465	Amphiprion_ocellaris
ENSG00000213079	SCAF8	88	65.745	ENSATEG00000006959	SCAF8	97	65.102	Anabas_testudineus
ENSG00000213079	SCAF8	100	79.345	ENSAPLG00000005765	SCAF8	100	79.345	Anas_platyrhynchos
ENSG00000213079	SCAF8	99	74.450	ENSACAG00000005282	SCAF8	99	74.430	Anolis_carolinensis
ENSG00000213079	SCAF8	100	98.820	ENSANAG00000036184	SCAF8	100	98.820	Aotus_nancymaae
ENSG00000213079	SCAF8	86	69.184	ENSACLG00000018828	SCAF8	80	68.780	Astatotilapia_calliptera
ENSG00000213079	SCAF8	100	95.279	ENSBTAG00000031917	SCAF8	100	95.279	Bos_taurus
ENSG00000213079	SCAF8	100	98.355	ENSCJAG00000012631	SCAF8	100	98.355	Callithrix_jacchus
ENSG00000213079	SCAF8	99	96.440	ENSCAFG00000000570	SCAF8	100	96.530	Canis_familiaris
ENSG00000213079	SCAF8	99	96.437	ENSCAFG00020015048	SCAF8	99	96.369	Canis_lupus_dingo
ENSG00000213079	SCAF8	100	95.358	ENSCHIG00000025041	SCAF8	100	95.358	Capra_hircus
ENSG00000213079	SCAF8	99	97.070	ENSTSYG00000010991	SCAF8	99	95.942	Carlito_syrichta
ENSG00000213079	SCAF8	79	70.370	ENSCAPG00000003300	SCAF8	85	98.684	Cavia_aperea
ENSG00000213079	SCAF8	99	88.073	ENSCPOG00000022216	-	99	87.283	Cavia_porcellus
ENSG00000213079	SCAF8	100	98.348	ENSCCAG00000024952	SCAF8	100	98.375	Cebus_capucinus
ENSG00000213079	SCAF8	100	99.213	ENSCATG00000035361	SCAF8	100	99.213	Cercocebus_atys
ENSG00000213079	SCAF8	100	95.047	ENSCLAG00000004910	SCAF8	100	95.563	Chinchilla_lanigera
ENSG00000213079	SCAF8	100	97.755	ENSCSAG00000013430	SCAF8	100	99.381	Chlorocebus_sabaeus
ENSG00000213079	SCAF8	100	75.382	ENSCPBG00000016330	SCAF8	100	82.166	Chrysemys_picta_bellii
ENSG00000213079	SCAF8	100	99.135	ENSCANG00000039499	SCAF8	100	99.160	Colobus_angolensis_palliatus
ENSG00000213079	SCAF8	100	91.981	ENSCGRG00001020167	Scaf8	100	91.981	Cricetulus_griseus_chok1gshd
ENSG00000213079	SCAF8	99	91.845	ENSCGRG00000004120	Scaf8	99	91.918	Cricetulus_griseus_crigri
ENSG00000213079	SCAF8	87	66.145	ENSCSEG00000000043	-	78	67.349	Cynoglossus_semilaevis
ENSG00000213079	SCAF8	82	67.104	ENSCVAG00000000925	SCAF8	77	66.579	Cyprinodon_variegatus
ENSG00000213079	SCAF8	96	90.074	ENSDNOG00000025271	SCAF8	100	93.683	Dasypus_novemcinctus
ENSG00000213079	SCAF8	99	93.454	ENSDORG00000006391	Scaf8	100	93.454	Dipodomys_ordii
ENSG00000213079	SCAF8	100	96.619	ENSEASG00005018879	SCAF8	100	96.749	Equus_asinus_asinus
ENSG00000213079	SCAF8	100	96.774	ENSECAG00000005540	SCAF8	100	96.827	Equus_caballus
ENSG00000213079	SCAF8	88	65.000	ENSELUG00000002779	SCAF8	75	64.988	Esox_lucius
ENSG00000213079	SCAF8	100	97.089	ENSFCAG00000023424	SCAF8	100	97.089	Felis_catus
ENSG00000213079	SCAF8	100	78.738	ENSFALG00000012433	SCAF8	100	78.988	Ficedula_albicollis
ENSG00000213079	SCAF8	99	95.959	ENSFDAG00000010335	SCAF8	99	95.959	Fukomys_damarensis
ENSG00000213079	SCAF8	85	68.804	ENSFHEG00000008284	SCAF8	77	68.434	Fundulus_heteroclitus
ENSG00000213079	SCAF8	60	68.594	ENSGMOG00000018812	SCAF8	66	70.696	Gadus_morhua
ENSG00000213079	SCAF8	99	79.751	ENSGALG00000013635	SCAF8	99	79.361	Gallus_gallus
ENSG00000213079	SCAF8	85	68.550	ENSGAFG00000018033	SCAF8	78	65.233	Gambusia_affinis
ENSG00000213079	SCAF8	93	54.255	ENSGACG00000006909	SCAF8	100	55.237	Gasterosteus_aculeatus
ENSG00000213079	SCAF8	63	72.783	ENSGAGG00000017820	-	88	72.783	Gopherus_agassizii
ENSG00000213079	SCAF8	100	99.852	ENSGGOG00000008645	SCAF8	100	99.852	Gorilla_gorilla
ENSG00000213079	SCAF8	86	69.062	ENSHBUG00000019537	SCAF8	80	68.659	Haplochromis_burtoni
ENSG00000213079	SCAF8	100	95.597	ENSHGLG00000003619	SCAF8	100	95.597	Heterocephalus_glaber_female
ENSG00000213079	SCAF8	100	94.969	ENSHGLG00100004708	SCAF8	100	95.563	Heterocephalus_glaber_male
ENSG00000213079	SCAF8	99	96.598	ENSSTOG00000026043	SCAF8	100	96.688	Ictidomys_tridecemlineatus
ENSG00000213079	SCAF8	100	92.925	ENSJJAG00000020480	Scaf8	100	92.925	Jaculus_jaculus
ENSG00000213079	SCAF8	87	68.351	ENSKMAG00000012767	SCAF8	78	67.990	Kryptolebias_marmoratus
ENSG00000213079	SCAF8	62	76.296	ENSLBEG00000012484	-	63	76.429	Labrus_bergylta
ENSG00000213079	SCAF8	88	75.761	ENSLACG00000001394	SCAF8	99	63.162	Latimeria_chalumnae
ENSG00000213079	SCAF8	100	61.532	ENSLOCG00000016856	SCAF8	100	60.672	Lepisosteus_oculatus
ENSG00000213079	SCAF8	100	93.794	ENSLAFG00000000022	SCAF8	100	94.344	Loxodonta_africana
ENSG00000213079	SCAF8	100	99.371	ENSMFAG00000032738	SCAF8	100	99.371	Macaca_fascicularis
ENSG00000213079	SCAF8	100	99.371	ENSMMUG00000015163	SCAF8	100	99.371	Macaca_mulatta
ENSG00000213079	SCAF8	100	99.371	ENSMNEG00000043466	SCAF8	100	99.371	Macaca_nemestrina
ENSG00000213079	SCAF8	99	99.207	ENSMLEG00000034845	SCAF8	100	99.220	Mandrillus_leucophaeus
ENSG00000213079	SCAF8	83	65.478	ENSMAMG00000009457	SCAF8	76	64.586	Mastacembelus_armatus
ENSG00000213079	SCAF8	86	69.062	ENSMZEG00005005698	SCAF8	80	68.659	Maylandia_zebra
ENSG00000213079	SCAF8	99	79.782	ENSMGAG00000012762	SCAF8	100	79.549	Meleagris_gallopavo
ENSG00000213079	SCAF8	99	91.442	ENSMAUG00000009513	Scaf8	100	91.442	Mesocricetus_auratus
ENSG00000213079	SCAF8	100	96.384	ENSMICG00000028965	SCAF8	100	96.442	Microcebus_murinus
ENSG00000213079	SCAF8	100	92.453	ENSMOCG00000014950	Scaf8	100	92.453	Microtus_ochrogaster
ENSG00000213079	SCAF8	84	65.228	ENSMMOG00000002216	SCAF8	78	64.213	Mola_mola
ENSG00000213079	SCAF8	99	86.798	ENSMODG00000008301	SCAF8	100	86.919	Monodelphis_domestica
ENSG00000213079	SCAF8	87	67.866	ENSMALG00000011584	SCAF8	78	68.402	Monopterus_albus
ENSG00000213079	SCAF8	100	91.345	MGP_CAROLIEiJ_G0021016	Scaf8	100	91.345	Mus_caroli
ENSG00000213079	SCAF8	100	91.424	ENSMUSG00000046201	Scaf8	100	91.424	Mus_musculus
ENSG00000213079	SCAF8	100	92.132	MGP_PahariEiJ_G0023334	Scaf8	100	92.132	Mus_pahari
ENSG00000213079	SCAF8	100	94.659	ENSMPUG00000001974	SCAF8	100	96.285	Mustela_putorius_furo
ENSG00000213079	SCAF8	100	93.784	ENSMLUG00000029190	SCAF8	100	93.784	Myotis_lucifugus
ENSG00000213079	SCAF8	100	93.160	ENSNGAG00000012332	Scaf8	100	93.160	Nannospalax_galili
ENSG00000213079	SCAF8	100	52.810	ENSNBRG00000009067	SCAF8	100	52.746	Neolamprologus_brichardi
ENSG00000213079	SCAF8	100	98.509	ENSNLEG00000015509	SCAF8	99	98.192	Nomascus_leucogenys
ENSG00000213079	SCAF8	70	92.910	ENSOPRG00000018413	-	76	92.929	Ochotona_princeps
ENSG00000213079	SCAF8	100	95.679	ENSODEG00000007296	SCAF8	100	95.679	Octodon_degus
ENSG00000213079	SCAF8	100	55.281	ENSONIG00000008119	SCAF8	100	55.220	Oreochromis_niloticus
ENSG00000213079	SCAF8	99	96.598	ENSOCUG00000026063	SCAF8	100	96.688	Oryctolagus_cuniculus
ENSG00000213079	SCAF8	86	68.927	ENSORLG00000017358	SCAF8	78	68.927	Oryzias_latipes
ENSG00000213079	SCAF8	86	69.051	ENSORLG00020002214	SCAF8	78	67.788	Oryzias_latipes_hni
ENSG00000213079	SCAF8	86	69.174	ENSORLG00015015779	SCAF8	78	69.174	Oryzias_latipes_hsok
ENSG00000213079	SCAF8	93	56.766	ENSOMEG00000015471	SCAF8	77	66.053	Oryzias_melastigma
ENSG00000213079	SCAF8	100	96.559	ENSOGAG00000034223	SCAF8	100	96.559	Otolemur_garnettii
ENSG00000213079	SCAF8	99	95.166	ENSOARG00000004159	SCAF8	100	95.166	Ovis_aries
ENSG00000213079	SCAF8	100	99.843	ENSPPAG00000039826	SCAF8	100	99.843	Pan_paniscus
ENSG00000213079	SCAF8	100	97.168	ENSPPRG00000023175	SCAF8	100	97.168	Panthera_pardus
ENSG00000213079	SCAF8	99	97.070	ENSPTIG00000014836	SCAF8	100	97.070	Panthera_tigris_altaica
ENSG00000213079	SCAF8	100	99.852	ENSPTRG00000018727	SCAF8	100	99.852	Pan_troglodytes
ENSG00000213079	SCAF8	100	99.213	ENSPANG00000017489	SCAF8	100	99.102	Papio_anubis
ENSG00000213079	SCAF8	100	56.929	ENSPKIG00000021212	SCAF8	100	57.078	Paramormyrops_kingsleyae
ENSG00000213079	SCAF8	89	74.265	ENSPSIG00000008614	SCAF8	95	76.972	Pelodiscus_sinensis
ENSG00000213079	SCAF8	99	92.155	ENSPEMG00000010531	Scaf8	100	92.155	Peromyscus_maniculatus_bairdii
ENSG00000213079	SCAF8	100	87.588	ENSPCIG00000001141	SCAF8	100	87.588	Phascolarctos_cinereus
ENSG00000213079	SCAF8	100	54.767	ENSPFOG00000004176	SCAF8	100	55.057	Poecilia_formosa
ENSG00000213079	SCAF8	85	69.051	ENSPLAG00000021432	SCAF8	77	68.557	Poecilia_latipinna
ENSG00000213079	SCAF8	85	69.297	ENSPMEG00000007591	SCAF8	84	68.258	Poecilia_mexicana
ENSG00000213079	SCAF8	85	69.051	ENSPREG00000000652	SCAF8	77	68.557	Poecilia_reticulata
ENSG00000213079	SCAF8	100	98.193	ENSPPYG00000017121	SCAF8	100	98.193	Pongo_abelii
ENSG00000213079	SCAF8	85	97.152	ENSPCAG00000013044	SCAF8	90	97.152	Procavia_capensis
ENSG00000213079	SCAF8	100	96.698	ENSPCOG00000002067	SCAF8	100	96.637	Propithecus_coquereli
ENSG00000213079	SCAF8	99	92.412	ENSPVAG00000005582	SCAF8	100	93.450	Pteropus_vampyrus
ENSG00000213079	SCAF8	86	69.184	ENSPNYG00000007277	SCAF8	80	68.780	Pundamilia_nyererei
ENSG00000213079	SCAF8	86	68.543	ENSPNAG00000024740	SCAF8	82	68.911	Pygocentrus_nattereri
ENSG00000213079	SCAF8	100	91.660	ENSRNOG00000016919	Scaf8	100	91.660	Rattus_norvegicus
ENSG00000213079	SCAF8	100	99.135	ENSRBIG00000035769	SCAF8	100	99.135	Rhinopithecus_bieti
ENSG00000213079	SCAF8	100	99.213	ENSRROG00000013580	SCAF8	100	99.213	Rhinopithecus_roxellana
ENSG00000213079	SCAF8	100	98.348	ENSSBOG00000027023	SCAF8	100	98.348	Saimiri_boliviensis_boliviensis
ENSG00000213079	SCAF8	100	86.892	ENSSHAG00000009915	SCAF8	100	86.892	Sarcophilus_harrisii
ENSG00000213079	SCAF8	100	54.573	ENSSFOG00015009481	SCAF8	93	70.263	Scleropages_formosus
ENSG00000213079	SCAF8	87	67.947	ENSSMAG00000008275	SCAF8	77	67.347	Scophthalmus_maximus
ENSG00000213079	SCAF8	100	77.660	ENSSPUG00000015219	SCAF8	100	77.946	Sphenodon_punctatus
ENSG00000213079	SCAF8	100	96.145	ENSSSCG00000004070	SCAF8	100	96.145	Sus_scrofa
ENSG00000213079	SCAF8	99	80.189	ENSTGUG00000011151	SCAF8	100	80.425	Taeniopygia_guttata
ENSG00000213079	SCAF8	85	67.857	ENSTRUG00000009243	SCAF8	78	67.857	Takifugu_rubripes
ENSG00000213079	SCAF8	93	65.343	ENSTNIG00000016885	SCAF8	100	65.306	Tetraodon_nigroviridis
ENSG00000213079	SCAF8	99	95.638	ENSTTRG00000014538	SCAF8	100	95.638	Tursiops_truncatus
ENSG00000213079	SCAF8	100	96.538	ENSUAMG00000024736	SCAF8	99	96.511	Ursus_americanus
ENSG00000213079	SCAF8	98	96.549	ENSUMAG00000013404	SCAF8	100	96.549	Ursus_maritimus
ENSG00000213079	SCAF8	67	83.023	ENSVPAG00000012465	SCAF8	99	85.104	Vicugna_pacos
ENSG00000213079	SCAF8	99	96.516	ENSVVUG00000007532	SCAF8	100	96.606	Vulpes_vulpes
ENSG00000213079	SCAF8	100	61.408	ENSXETG00000013132	scaf8	100	61.425	Xenopus_tropicalis
ENSG00000213079	SCAF8	85	69.174	ENSXMAG00000019192	SCAF8	78	68.681	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000993	RNA polymerase II complex binding	21873635.	IBA	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005681	spliceosomal complex	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006369	termination of RNA polymerase II transcription	21873635.	IBA	Process
GO:0006378	mRNA polyadenylation	21873635.	IBA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0016363	nuclear matrix	-	ISS	Component
GO:0043175	RNA polymerase core enzyme binding	18550522.	IPI	Function