EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000213203 (Gene tree)
Gene ID: 170575
Gene Symbol: GIMAP1
Alias: HIMAP1|IMAP38|IMAP1|IAN2
Full Name: GTPase, IMAP family member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 7,728 bases
Position: chr7:150,716,557-150,724,284
Accession: 23237
RBP type: canonical RBP
Summary: This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene is thought to be involved in the differentiation of T helper (Th) cells of the Th1 lineage, and the related mouse gene has been shown to be critical for the development of mature B and T lymphocytes. Read-through transcription exists between this gene and the downstream GIMAP5 (GTPase, IMAP family member 5) gene. [provided by RefSeq, Dec 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000302833	MMR_HSR1	PF01926.23	6.5e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000464461	GIMAP1-202	560	-	-	- (aa)	-	-
ENST00000307194	GIMAP1-201	4420	-	ENSP00000302833	306 (aa)	-	Q8WWP7

Gene Model

Click here to download ENSG00000213203's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000213203	Electrocardiography	8.81822629021922E-5	17903306
ENSG00000213203	Electrocardiography	8.81822629021922E-5	17903306

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000213203's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000213203	GIMAP1	83	83.004	ENSANAG00000019932	GIMAP1	100	83.004	Aotus_nancymaae
ENSG00000213203	GIMAP1	84	84.436	ENSCJAG00000042381	-	100	82.699	Callithrix_jacchus
ENSG00000213203	GIMAP1	100	80.719	ENSCJAG00000010517	-	100	80.719	Callithrix_jacchus
ENSG00000213203	GIMAP1	94	56.747	ENSCAPG00000011595	GIMAP1	99	56.747	Cavia_aperea
ENSG00000213203	GIMAP1	99	56.536	ENSCPOG00000021304	GIMAP1	99	56.536	Cavia_porcellus
ENSG00000213203	GIMAP1	100	84.641	ENSCCAG00000028169	-	100	84.641	Cebus_capucinus
ENSG00000213203	GIMAP1	99	83.775	ENSCCAG00000036204	-	99	83.775	Cebus_capucinus
ENSG00000213203	GIMAP1	100	86.275	ENSCSAG00000006869	GIMAP1	100	86.275	Chlorocebus_sabaeus
ENSG00000213203	GIMAP1	100	86.275	ENSCANG00000029700	GIMAP1	100	86.275	Colobus_angolensis_palliatus
ENSG00000213203	GIMAP1	74	69.469	ENSECAG00000019232	-	83	69.469	Equus_caballus
ENSG00000213203	GIMAP1	96	68.475	ENSHGLG00000012811	GIMAP1	96	68.475	Heterocephalus_glaber_female
ENSG00000213203	GIMAP1	96	67.797	ENSHGLG00100003607	GIMAP1	96	67.797	Heterocephalus_glaber_male
ENSG00000213203	GIMAP1	100	86.601	ENSMFAG00000035498	-	100	86.601	Macaca_fascicularis
ENSG00000213203	GIMAP1	100	86.275	ENSMNEG00000044901	-	100	86.275	Macaca_nemestrina
ENSG00000213203	GIMAP1	99	59.406	ENSMOCG00000007377	Gimap1	99	59.406	Microtus_ochrogaster
ENSG00000213203	GIMAP1	97	47.368	ENSMODG00000003627	-	73	49.823	Monodelphis_domestica
ENSG00000213203	GIMAP1	95	64.948	ENSNGAG00000001314	Gimap1	96	65.172	Nannospalax_galili
ENSG00000213203	GIMAP1	100	92.157	ENSNLEG00000029987	GIMAP1	100	92.157	Nomascus_leucogenys
ENSG00000213203	GIMAP1	78	56.250	ENSMEUG00000002865	-	100	56.250	Notamacropus_eugenii
ENSG00000213203	GIMAP1	100	70.033	ENSOCUG00000028062	-	100	70.033	Oryctolagus_cuniculus
ENSG00000213203	GIMAP1	100	78.431	ENSPANG00000021224	-	100	78.431	Papio_anubis
ENSG00000213203	GIMAP1	63	54.872	ENSPSIG00000004967	-	92	54.872	Pelodiscus_sinensis
ENSG00000213203	GIMAP1	67	52.913	ENSPSIG00000005330	-	94	52.913	Pelodiscus_sinensis
ENSG00000213203	GIMAP1	82	50.394	ENSPSIG00000012917	-	99	50.394	Pelodiscus_sinensis
ENSG00000213203	GIMAP1	100	94.118	ENSPPYG00000029696	GIMAP1	88	94.118	Pongo_abelii
ENSG00000213203	GIMAP1	100	85.621	ENSRBIG00000029909	GIMAP1	100	85.621	Rhinopithecus_bieti
ENSG00000213203	GIMAP1	100	85.294	ENSRROG00000030188	GIMAP1	100	85.294	Rhinopithecus_roxellana
ENSG00000213203	GIMAP1	99	82.508	ENSSBOG00000025758	-	99	82.508	Saimiri_boliviensis_boliviensis
ENSG00000213203	GIMAP1	99	79.538	ENSSBOG00000030385	-	97	79.538	Saimiri_boliviensis_boliviensis
ENSG00000213203	GIMAP1	81	56.855	ENSSHAG00000010554	-	84	56.855	Sarcophilus_harrisii

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0005525	GTP binding	21873635.	IBA	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	IEA	Component
GO:0016021	integral component of membrane	-	IEA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr7	150720496	Silent	novel	D164D	0.18
BLCA	chr7	150719090	Missense_Mutation	NA	G15S	0.44
BLCA	chr7	150720344	Missense_Mutation	NA	A114T	0.21
BLCA	chr7	150720124	Silent	novel	K40K	0.45
BLCA	chr7	150720061	Silent	rs144542417	N19N	0.45
BLCA	chr7	150720863	Missense_Mutation	NA	L287V	0.27
BLCA	chr7	150720417	Missense_Mutation	novel	M138T	0.09
BLCA	chr7	150720207	Missense_Mutation	novel	T68M	0.16	MMR_HSR1
BLCA	chr7	150720336	Missense_Mutation	novel	G111E	0.23
BRCA	chr7	150720726	Missense_Mutation	rs537240577	R241Q	0.32
BRCA	chr7	150720236	Missense_Mutation	NA	V78M	0.16	MMR_HSR1
BRCA	chr7	150720353	Silent	NA	L117L	0.23
BRCA	chr7	150720184	Silent	novel	T60T	0.25
BRCA	chr7	150720379	Silent	rs750429019	T125T	0.11
BRCA	chr7	150720088	Silent	novel	R28R	0.2
BRCA	chr7	150720549	Missense_Mutation	NA	G182V	0.2
CESC	chr7	150720529	Silent	NA	R175R	0.25
CESC	chr7	150720323	Missense_Mutation	NA	L107I	0.29
COAD	chr7	150720421	Missense_Mutation	novel	F139L	0.28
COAD	chr7	150720902	Missense_Mutation	rs752300708	V300I	0.32
COAD	chr7	150720343	Silent	rs370175882	H113H	0.49
COAD	chr7	150720454	Silent	NA	V150V	0.45
COAD	chr7	150720128	Missense_Mutation	rs750341190	A42T	0.2	MMR_HSR1
COAD	chr7	150720529	Silent	NA	R175R	0.38
COAD	chr7	150720621	Missense_Mutation	rs780854861	G206E	0.18
COAD	chr7	150720688	Silent	NA	A228A	0.09
COAD	chr7	150720380	Missense_Mutation	rs374968861	A126T	0.49
COAD	chr7	150720375	Missense_Mutation	NA	F124S	0.15
COAD	chr7	150720527	Missense_Mutation	NA	R175C	0.13
COAD	chr7	150720588	Missense_Mutation	NA	R195Q	0.33
COAD	chr7	150720318	Missense_Mutation	NA	Y105C	0.2
COAD	chr7	150720900	Missense_Mutation	NA	A299V	0.32
COAD	chr7	150720587	Missense_Mutation	NA	R195W	0.15
GBM	chr7	150720380	Missense_Mutation	rs374968861	A126T	0.15
GBM	chr7	150720156	Missense_Mutation	novel	R51I	0.19	MMR_HSR1
GBM	chr7	150720346	Silent	rs754697498	A114A	0.38
GBM	chr7	150720856	Silent	rs770099581	G284G	0.3
HNSC	chr7	150719062	Missense_Mutation	novel	K5N	0.32
HNSC	chr7	150720299	Missense_Mutation	novel	E99K	0.31
HNSC	chr7	150720519	Missense_Mutation	rs142041443	R172Q	0.28
HNSC	chr7	150720451	Silent	rs150494282	I149I	0.09
KIRP	chr7	150720207	Missense_Mutation	novel	T68M	0.19	MMR_HSR1
LGG	chr7	150720271	Silent	novel	S89S	0.24
LGG	chr7	150720422	Missense_Mutation	novel	G140R	0.5
LIHC	chr7	150720886	Missense_Mutation	novel	R294S	0.35
LIHC	chr7	150720817	Silent	novel	P271P	0.12
LIHC	chr7	150719063	Missense_Mutation	NA	M6L	0.48
LIHC	chr7	150720195	Missense_Mutation	rs142046758	R64K	0.11	MMR_HSR1
LUAD	chr7	150719075	Nonsense_Mutation	novel	E10*	0.08
LUAD	chr7	150720328	Silent	NA	S108S	0.18
LUAD	chr7	150720355	Silent	NA	L117L	0.45
LUAD	chr7	150720086	Missense_Mutation	rs777141777	R28W	0.39
LUAD	chr7	150720343	Missense_Mutation	NA	H113Q	0.24
LUAD	chr7	150720207	Missense_Mutation	novel	T68M	0.16	MMR_HSR1
LUAD	chr7	150720232	Missense_Mutation	novel	C76W	0.35	MMR_HSR1
LUAD	chr7	150720204	Missense_Mutation	novel	T67N	0.17	MMR_HSR1
LUAD	chr7	150720582	Missense_Mutation	NA	T193N	0.16
LUAD	chr7	150720547	Frame_Shift_Ins	novel	*R184Pfs6**	0.51
LUAD	chr7	150720216	Missense_Mutation	NA	R71H	0.53	MMR_HSR1
LUAD	chr7	150720148	Silent	rs751279373	L48L	0.32
LUAD	chr7	150720478	Silent	NA	A158A	0.1
LUAD	chr7	150720074	Missense_Mutation	NA	Q24K	0.28
LUAD	chr7	150720611	Nonsense_Mutation	novel	Q203*	0.37
LUAD	chr7	150720555	Missense_Mutation	novel	R184L	0.17
LUSC	chr7	150720963	3'UTR	novel		0.35
LUSC	chr7	150720355	Silent	NA	L117L	0.23
LUSC	chr7	150720920	Missense_Mutation	novel	D306N	0.09
LUSC	chr7	150720422	Missense_Mutation	novel	G140R	0.14
LUSC	chr7	150720159	Missense_Mutation	novel	R52L	0.2	MMR_HSR1
LUSC	chr7	150720690	Missense_Mutation	novel	Q229R	0.27
LUSC	chr7	150720945	3'UTR	novel		0.32
LUSC	chr7	150720087	Missense_Mutation	NA	R28Q	0.46
LUSC	chr7	150720848	Silent	NA	L282L	0.13
LUSC	chr7	150720582	Missense_Mutation	novel	T193S	0.23
LUSC	chr7	150720329	Missense_Mutation	NA	A109T	0.15
LUSC	chr7	150719077	Missense_Mutation	novel	E10D	0.37
LUSC	chr7	150720915	Missense_Mutation	NA	G304V	0.18
LUSC	chr7	150720135	Missense_Mutation	NA	G44A	0.21	MMR_HSR1
LUSC	chr7	150720832	Silent	novel	L276L	0.21
LUSC	chr7	150720833	Missense_Mutation	novel	G277C	0.21
MESO	chr7	150720646	Silent	novel	E214E	0.37
OV	chr7	150720368	Missense_Mutation	novel	G122C	0.41
OV	chr7	150720069	Missense_Mutation	NA	S22Y	0.18
OV	chr7	150720529	Silent	NA	R175R	0.44
OV	chr7	150720346	Silent	rs754697498	A114A	0.59
PAAD	chr7	150720509	Missense_Mutation	novel	T169P	0.22
PAAD	chr7	150720130	Silent	novel	A42A	0.2
PAAD	chr7	150720608	Missense_Mutation	novel	E202K	0.15
PRAD	chr7	150720303	Missense_Mutation	NA	E100A	0.09
SKCM	chr7	150720290	Missense_Mutation	NA	P96S	0.31
SKCM	chr7	150719055	Missense_Mutation	rs773050722	G3E	0.44
SKCM	chr7	150720323	Missense_Mutation	rs371565531	L107F	0.33
SKCM	chr7	150720422	Missense_Mutation	novel	G140R	0.18
SKCM	chr7	150719058	Missense_Mutation	rs746747085	R4K	0.1
SKCM	chr7	150720118	Silent	NA	A38A	0.15
SKCM	chr7	150720817	Silent	NA	P271P	1
SKCM	chr7	150720928	3'UTR	novel		0.6
SKCM	chr7	150720105	Missense_Mutation	novel	G34E	0.2	MMR_HSR1
SKCM	chr7	150720106	Silent	novel	G34G	0.2
SKCM	chr7	150720936	3'UTR	novel		0.2
SKCM	chr7	150719068	Silent	rs576760161	A7A	0.3
SKCM	chr7	150720691	Silent	NA	Q229Q	0.29
SKCM	chr7	150720451	Silent	rs150494282	I149I	0.21
SKCM	chr7	150719052	Missense_Mutation	NA	G2E	0.24
SKCM	chr7	150720361	Silent	NA	T119T	0.49
SKCM	chr7	150720421	Silent	NA	F139F	0.17
SKCM	chr7	150720898	Silent	NA	E298E	0.24
SKCM	chr7	150720815	Missense_Mutation	NA	P271S	0.35
SKCM	chr7	150720371	Missense_Mutation	rs781514490	R123W	0.07
SKCM	chr7	150720082	Silent	NA	S26S	0.08
SKCM	chr7	150720121	Silent	NA	G39G	0.2
SKCM	chr7	150720621	Missense_Mutation	rs780854861	G206E	0.48
SKCM	chr7	150720852	Missense_Mutation	NA	G283E	0.27
SKCM	chr7	150720798	Nonsense_Mutation	NA	W265*	0.29
SKCM	chr7	150720900	Missense_Mutation	NA	A299V	0.45
SKCM	chr7	150720421	Silent	NA	F139F	0.36
SKCM	chr7	150720671	Missense_Mutation	rs758913531	E223K	0.64
SKCM	chr7	150720898	Silent	NA	E298E	0.19
SKCM	chr7	150720394	Silent	NA	Q130Q	0.3
SKCM	chr7	150720574	Silent	NA	N190N	0.14
SKCM	chr7	150720423	Missense_Mutation	novel	G140E	0.08
SKCM	chr7	150720087	Missense_Mutation	NA	R28Q	0.07
SKCM	chr7	150720979	3'UTR	novel		0.57
SKCM	chr7	150720933	3'UTR	rs780255705		0.55
SKCM	chr7	150720624	Missense_Mutation	novel	M207K	0.29
SKCM	chr7	150720625	Missense_Mutation	novel	M207I	0.29
SKCM	chr7	150720290	Missense_Mutation	NA	P96S	0.16
SKCM	chr7	150720655	Silent	rs777018083	G217G	0.77
SKCM	chr7	150720376	Silent	NA	F124F	0.41
SKCM	chr7	150720385	Silent	novel	Q127Q	0.39
SKCM	chr7	150720514	Silent	NA	E170E	0.21
SKCM	chr7	150719059	Silent	NA	R4R	0.23
SKCM	chr7	150720239	Missense_Mutation	NA	E79K	0.24	MMR_HSR1
SKCM	chr7	150720134	Missense_Mutation	NA	G44W	0.25	MMR_HSR1
SKCM	chr7	150720433	Silent	NA	V143V	0.21
SKCM	chr7	150719054	Missense_Mutation	novel	G3R	0.09
SKCM	chr7	150720898	Silent	NA	E298E	0.55
SKCM	chr7	150720451	Silent	rs150494282	I149I	0.15
SKCM	chr7	150720451	Silent	rs150494282	I149I	0.44
SKCM	chr7	150720875	Silent	NA	L291L	0.59
SKCM	chr7	150719050	Translation_Start_Site	novel	M1?	0.67
STAD	chr7	150720528	Missense_Mutation	rs368249123	R175H	0.21
STAD	chr7	150720792	Missense_Mutation	NA	R263Q	0.36
STAD	chr7	150720620	Missense_Mutation	NA	G206W	0.18
STAD	chr7	150720720	Missense_Mutation	NA	R239Q	0.19
STAD	chr7	150719046	5'UTR	novel		0.19
STAD	chr7	150720530	Missense_Mutation	NA	E176K	0.61
STAD	chr7	150719058	Missense_Mutation	NA	R4M	0.2
STAD	chr7	150720064	Silent	NA	A20A	0.24
STAD	chr7	150720929	3'UTR	novel		0.26
STAD	chr7	150720792	Missense_Mutation	NA	R263Q	0.5
THCA	chr7	150720379	Silent	rs750429019	T125T	0.35
UCEC	chr7	150720159	Missense_Mutation	NA	R52Q	0.36	MMR_HSR1
UCEC	chr7	150720688	Silent	NA	A228A	0.38
UCEC	chr7	150720128	Missense_Mutation	rs750341190	A42T	0.37	MMR_HSR1
UCEC	chr7	150720302	Frame_Shift_Del	NA	*R101Vfs17**	0.17
UCEC	chr7	150720421	Silent	NA	F139F	0.16
UCEC	chr7	150720394	Missense_Mutation	novel	Q130H	0.08
UCEC	chr7	150720518	Missense_Mutation	novel	R172W	0.08
UCEC	chr7	150720289	Missense_Mutation	novel	D95E	0.33
UCEC	chr7	150720513	Missense_Mutation	novel	E170G	0.26
UCEC	chr7	150720893	Missense_Mutation	novel	S297P	0.67
UCEC	chr7	150719078	Nonsense_Mutation	novel	E11*	0.34
UCEC	chr7	150719078	Nonsense_Mutation	novel	E11*	0.18
UCEC	chr7	150720316	Silent	rs774082093	C104C	0.4
UCEC	chr7	150720372	Missense_Mutation	NA	R123Q	0.1
UCEC	chr7	150720720	Missense_Mutation	NA	R239Q	0.25
UCEC	chr7	150720527	Missense_Mutation	NA	R175C	0.38
UCEC	chr7	150719055	Missense_Mutation	novel	G3V	0.45
UCEC	chr7	150720659	Missense_Mutation	novel	H219N	0.67
UCEC	chr7	150721046	3'UTR	novel		0.44
UCEC	chr7	150720329	Missense_Mutation	novel	A109P	0.25
UCEC	chr7	150720810	Missense_Mutation	novel	K269R	0.35
UCEC	chr7	150720087	Missense_Mutation	NA	R28Q	0.31
UCEC	chr7	150720452	Missense_Mutation	NA	V150I	0.31
UCEC	chr7	150720364	Silent	novel	Q120Q	0.12
UCEC	chr7	150720256	Silent	rs754787299	P84P	0.5
UCEC	chr7	150720966	3'UTR	novel		0.25
UCS	chr7	150720554	Missense_Mutation	novel	R184W	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0778	0.12261
CESC	DEL	0.1797	0.0016147
DLBC	DEL	0.0833	0.03486
HNSC	DEL	0.2031	1.1399e-22
KIRC	AMP	0.2898	0.075418
LAML	DEL	0.1309	3.4101e-05
LGG	AMP	0.3119	1.5525e-07
LIHC	DEL	0.0757	0.24831
OV	AMP	0.4767	1.5763e-13
PAAD	DEL	0.0652	0.049388
TGCT	DEL	0.0733	0.11738
THCA	DEL	0	0.27619
UCEC	DEL	0.0965	0.0001859
UCS	DEL	0.3393	0.10142

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
SARC	0.00012	Kaplan-Meier Survival Analysis
HNSC	0.0025	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
PAAD	0.0073	Kaplan-Meier Survival Analysis
CESC	0.0016	Kaplan-Meier Survival Analysis
LAML	0.012	Kaplan-Meier Survival Analysis
UCEC	0.0028	Kaplan-Meier Survival Analysis
LIHC	0.00019	Kaplan-Meier Survival Analysis
DLBC	0.021	Kaplan-Meier Survival Analysis
LGG	0.0061	Kaplan-Meier Survival Analysis
LUAD	0.0008	Kaplan-Meier Survival Analysis
UVM	0.00054	Kaplan-Meier Survival Analysis