EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000213639 (Gene tree)
Gene ID: 5500
Gene Symbol: PPP1CB
Alias: PP1B|PP-1B|PP1beta
Full Name: protein phosphatase 1 catalytic subunit beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 51,301 bases
Position: chr2:28,751,640-28,802,940
Accession: 9282
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26598648	Proteomic Analysis of Dynein-Interacting Proteins in Amyotrophic Lateral Sclerosis Synaptosomes Reveals Alterations in the RNA-Binding Protein Staufen1.	Mol Cell Proteomics	2016 Feb	Gershoni-Emek N	doi: 10.1074/mcp.M115.049965

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000464273	PPP1CB-209	577	-	-	- (aa)	-	-
ENST00000358506	PPP1CB-202	4771	-	ENSP00000351298	327 (aa)	-	P62140
ENST00000441461	PPP1CB-207	584	-	ENSP00000414918	138 (aa)	-	C9JP48
ENST00000455580	PPP1CB-208	721	-	ENSP00000390715	169 (aa)	-	E7ETD8
ENST00000420282	PPP1CB-205	570	-	ENSP00000398839	125 (aa)	-	C9J9S3
ENST00000296122	PPP1CB-201	3527	-	ENSP00000296122	327 (aa)	-	P62140
ENST00000418910	PPP1CB-204	281	-	ENSP00000388056	82 (aa)	-	H0Y3Y6
ENST00000395366	PPP1CB-203	4893	-	ENSP00000378769	327 (aa)	-	P62140
ENST00000427786	PPP1CB-206	569	-	ENSP00000394589	64 (aa)	-	F8WE71

Gene Model

Click here to download ENSG00000213639's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04218	Cellular senescence	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04270	Vascular smooth muscle contraction	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa04510	Focal adhesion	KEGG
hsa04611	Platelet activation	KEGG
hsa04720	Long-term potentiation	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04750	Inflammatory mediator regulation of TRP channels	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa04931	Insulin resistance	KEGG
hsa05031	Amphetamine addiction	KEGG
hsa05034	Alcoholism	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG
hsa05205	Proteoglycans in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000213639	Blood Pressure	9.94212450016185E-5	17903302
ENSG00000213639	Magnesium	3.0440000E-005	-
ENSG00000213639	Body Mass Index	9E-7	25673413

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000213639	rs6547872	2	28755208	?	Body mass index	30595370			EFO_0004340

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000213639's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000164	protein phosphatase type 1 complex	-	IEA	Component
GO:0000784	nuclear chromosome, telomeric region	24270157.	IDA	Component
GO:0004722	protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0005515	protein binding	11067852.17511879.18586956.20424263.20516061.20926688.21516116.21998301.23414517.23555304.25416956.25544563.25785436.25910212.26496610.26871637.27107012.27173435.28296156.28330616.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005977	glycogen metabolic process	-	IEA	Process
GO:0005979	regulation of glycogen biosynthetic process	-	IEA	Process
GO:0005981	regulation of glycogen catabolic process	-	IEA	Process
GO:0006470	protein dephosphorylation	-	ISS	Process
GO:0016791	phosphatase activity	-	ISS	Function
GO:0017018	myosin phosphatase activity	-	ISS	Function
GO:0019901	protein kinase binding	20354225.	IPI	Function
GO:0030155	regulation of cell adhesion	20354225.	IDA	Process
GO:0032922	circadian regulation of gene expression	21873635.	IBA	Process
GO:0032922	circadian regulation of gene expression	-	ISS	Process
GO:0042587	glycogen granule	-	IEA	Component
GO:0042752	regulation of circadian rhythm	21873635.	IBA	Process
GO:0042752	regulation of circadian rhythm	21712997.	IMP	Process
GO:0043153	entrainment of circadian clock by photoperiod	-	ISS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0050115	myosin-light-chain-phosphatase activity	20354225.	IDA	Function
GO:0051301	cell division	-	IEA	Process
GO:0070062	extracellular exosome	19199708.	HDA	Component
GO:0072357	PTW/PP1 phosphatase complex	20354225.20516061.	IDA	Component