EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000213719 (Gene tree)
Gene ID: 1192
Gene Symbol: CLIC1
Alias: NCC27|p64CLCP|G6
Full Name: chloride intracellular channel 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 9,183 bases
Position: chr6:31,730,581-31,739,763
Accession: 2062
RBP type: non-canonical RBP
Summary: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000375779	CLIC1-206	1127	-	ENSP00000364934	241 (aa)	-	O00299
ENST00000395892	CLIC1-209	1197	-	ENSP00000379229	241 (aa)	-	O00299
ENST00000616760	CLIC1-210	1098	-	ENSP00000479808	241 (aa)	-	O00299
ENST00000375784	CLIC1-208	1254	-	ENSP00000364940	241 (aa)	-	O00299
ENST00000375780	CLIC1-207	1560	-	ENSP00000364935	241 (aa)	-	O00299

Gene Model

Click here to download ENSG00000213719's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000213719	rs145269503	6	31737349	A	Mean platelet volume	27863252	[0.13-0.18] unit decrease	0.1547004	EFO_0004584
ENSG00000213719	rs28381344	6	31739749	?	Strep throat	28928442	[0.041-0.098] unit decrease	0.0694	EFO_0008408
ENSG00000213719	rs28381344	6	31739749	A	Neuroticism	30643256	[0.014-0.028] unit increase	0.020618176	EFO_0007660
ENSG00000213719	rs28381344	6	31739749	A	Depressive symptoms	30643256	[0.0087-0.0179] unit increase	0.013281214	EFO_0007006

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000213719's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000213719	CLIC1	100	98.340	ENSMUSG00000007041	Clic1	100	98.340	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005244	voltage-gated ion channel activity	-	IEA	Function
GO:0005254	chloride channel activity	21873635.	IBA	Function
GO:0005254	chloride channel activity	9139710.	IDA	Function
GO:0005515	protein binding	12163479.12681486.24338975.	IPI	Function
GO:0005615	extracellular space	22664934.	HDA	Component
GO:0005634	nucleus	16791210.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	16130169.	TAS	Component
GO:0005635	nuclear envelope	9139710.	IDA	Component
GO:0005737	cytoplasm	16791210.	HDA	Component
GO:0005737	cytoplasm	10793131.	IDA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0005903	brush border	10793131.	TAS	Component
GO:0006821	chloride transport	9139710.	IDA	Process
GO:0007165	signal transduction	16130169.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0031965	nuclear membrane	-	IEA	Component
GO:0031982	vesicle	19190083.	HDA	Component
GO:0034707	chloride channel complex	-	IEA	Component
GO:0034765	regulation of ion transmembrane transport	-	IEA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045669	positive regulation of osteoblast differentiation	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	12681486.	IDA	Component
GO:0051726	regulation of cell cycle	-	IEA	Process
GO:0051881	regulation of mitochondrial membrane potential	-	IEA	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0070062	extracellular exosome	15326289.	IDA	Component
GO:0070527	platelet aggregation	23382103.	HMP	Process
GO:0072562	blood microparticle	22516433.	HDA	Component
GO:1902476	chloride transmembrane transport	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29061300	MtHsp70-CLIC1-pulsed dendritic cells enhance the immune response against ovarian cancer.	Biochem Biophys Res Commun	2017 Dec 9	Yu W	doi: 10.1016/j.bbrc.2017.10.094
28944858	Decreased expression of hsamiR372 predicts poor prognosis in patients with gallbladder cancer by affecting chloride intracellular channel 1.	Mol Med Rep	2017 Nov	Zhou N	doi: 10.3892/mmr.2017.7520
22173998	PA28β regulates cell invasion of gastric cancer via modulating the expression of chloride intracellular channel 1.	J Cell Biochem	2012 May	Zheng DL	doi: 10.1002/jcb.24022.
25205595	Relocation of CLIC1 promotes tumor cell invasion and colonization of fibrin.	Mol Cancer Res	2015 Feb	Gurski LA	doi: 10.1158/1541-7786.MCR-14-0249
25546839	Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC1 AND CLIC4) proteins in tumor development and as novel therapeutic targets.	Biochim Biophys Acta	2015 Oct	Peretti M	doi: 10.1016/j.bbamem.2014.12.012
18710659	Expression of chloride intracellular channel protein 1 (CLIC1) and tumor protein D52 (TPD52) as potential biomarkers for colorectal cancer.	Clin Biochem	2008 Oct	Petrova DT	doi: 10.1016/j.clinbiochem.2008.07.012
20461716	Chloride intracellular channel 1 identified using proteomic analysis plays an important role in the radiosensitivity of HEp-2 cells via reactive oxygen species production.	Proteomics	2010 Jul	Kim JS	doi: 10.1002/pmic.200900523.
25227665	CLIC1 overexpression is associated with poor prognosis in gallbladder cancer.	Tumour Biol	2015 Jan	Ding Q	doi: 10.1007/s13277-014-2606-5
25279971	Chloride intracellular channel 1 regulates prostate cancer cell proliferation and migration through the MAPK/ERK pathway.	Cancer Biother Radiopharm	2014 Oct	Tian Y	doi: 10.1089/cbr.2014.1666.
23792823	Protein isoform-specific validation defines multiple chloride intracellular channel and tropomyosin isoforms as serological biomarkers of ovarian cancer.	J Proteomics	2013 Aug 26	Tang HY	doi: 10.1016/j.jprot.2013.06.016
22791942	Function of chloride intracellular channel 1 in gastric cancer cells.	World J Gastroenterol	2012 Jun 28	Ma PF	doi: 10.3748/wjg.v18.i24.3070.
22426742	Regulation of colon cancer cell migration and invasion by CLIC1-mediated RVD.	Mol Cell Biochem	2012 Jun	Wang P	doi: 10.1007/s11010-012-1271-5
25920608	Chloride intracellular channel 1 (CLIC1) is activated and functions as an oncogene in pancreatic cancer.	Med Oncol	2015 Jun	Lu J	doi: 10.1007/s12032-015-0616-9
24587680	Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway.	World J Gastroenterol	2014 Feb 28	Wang P	doi: 10.3748/wjg.v20.i8.2071.
27825122	Identification and validation of differentially expressed proteins in epithelial ovarian cancers using quantitative proteomics.	Oncotarget	2016 Dec 13	Qu H	doi: 10.18632/oncotarget.13077.
29669336	CLIC1 Promotes the Progression of Gastric Cancer by Regulating the MAPK/AKT Pathways.	Cell Physiol Biochem	2018	Li BP	doi: 10.1159/000488822

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	31734195	Silent	novel	L36L	0.43
BLCA	chr6	31736343	5'UTR	novel		0.32
BLCA	chr6	31734232	Missense_Mutation	novel	C24F	0.12
BLCA	chr6	31736268	Silent	rs200422429	F11F	0.4
BLCA	chr6	31732293	Missense_Mutation	novel	S163C	0.25
BLCA	chr6	31733897	Missense_Mutation	novel	E72K	0.55
BRCA	chr6	31732297	Missense_Mutation	novel	V162I	0.05
BRCA	chr6	31736305	5'UTR	novel		0.42
BRCA	chr6	31736546	Splice_Region	novel		0.6
BRCA	chr6	31734180	Missense_Mutation	NA	F41L	0.34
BRCA	chr6	31736380	5'UTR	novel		0.24
BRCA	chr6	31736482	Intron	novel		0.7
CESC	chr6	31736374	5'UTR	novel		0.49
CESC	chr6	31733564	Splice_Site	novel	X128_splice	0.12
COAD	chr6	31730672	3'UTR	novel		0.38
COAD	chr6	31730901	Missense_Mutation	novel	C223R	0.28
GBM	chr6	31730731	3'UTR	novel		0.28
HNSC	chr6	31733586	Missense_Mutation	novel	S121L	0.08
HNSC	chr6	31733569	Missense_Mutation	rs151146724	D127N	0.11
HNSC	chr6	31732274	Silent	novel	D169D	0.28
HNSC	chr6	31730925	Missense_Mutation	rs764853833	A215T	0.18
KIRC	chr6	31736404	5'UTR	novel		0.53
LGG	chr6	31730973	Missense_Mutation	NA	I199V	0.34
LUAD	chr6	31730867	Missense_Mutation	novel	E234V	0.17
LUAD	chr6	31730794	3'UTR	novel		0.33
LUAD	chr6	31733660	Silent	novel	L96L	0.13
LUAD	chr6	31732322	Missense_Mutation	novel	D153E	0.07
LUSC	chr6	31736338	5'UTR	novel		0.07
OV	chr6	31736289	Silent	NA	E4E	0.2
OV	chr6	31730913	Missense_Mutation	novel	F219V	0.21
OV	chr6	31736271	Missense_Mutation	novel	L10F	0.53
SKCM	chr6	31732223	Silent	NA	I186I	0.57
SKCM	chr6	31733839	Missense_Mutation	novel	P91L	0.5
SKCM	chr6	31733840	Missense_Mutation	novel	P91S	0.5
SKCM	chr6	31730969	Missense_Mutation	NA	P200L	0.39
SKCM	chr6	31736436	Intron	novel		0.24
SKCM	chr6	31730959	Silent	NA	F203F	0.14
SKCM	chr6	31736319	5'UTR	novel		0.32
STAD	chr6	31732268	Missense_Mutation	novel	N171K	0.26
STAD	chr6	31732321	Missense_Mutation	novel	E154K	0.15
STAD	chr6	31733925	Frame_Shift_Del	NA	*Q63Sfs37**	0.22
STAD	chr6	31730926	Silent	rs752246685	Y214Y	0.16
STAD	chr6	31736285	Missense_Mutation	NA	P6S	0.23
STAD	chr6	31733923	Missense_Mutation	NA	Q63R	0.24
THCA	chr6	31736449	Intron	novel		0.13
UCEC	chr6	31733925	Frame_Shift_Del	NA	*Q63Sfs37**	0.32
UCEC	chr6	31730911	Silent	NA	F219F	0.28
UCEC	chr6	31736326	5'UTR	novel		0.14
UCEC	chr6	31736457	Intron	novel		0.4
UCEC	chr6	31730717	3'UTR	novel		0.5
UCEC	chr6	31730985	Missense_Mutation	novel	R195W	0.39
UCEC	chr6	31734203	Missense_Mutation	rs570496971	L34M	0.19
UCEC	chr6	31734250	Missense_Mutation	novel	G18E	0.32
UCEC	chr6	31730911	Missense_Mutation	novel	F219L	0.45
UCEC	chr6	31732306	Missense_Mutation	novel	D159N	0.31
UCEC	chr6	31730949	Missense_Mutation	novel	H207Y	0.39
UCEC	chr6	31733885	Missense_Mutation	NA	D76N	0.38
UCEC	chr6	31730945	Missense_Mutation	novel	R208Q	0.38
UCEC	chr6	31732229	Silent	novel	L184L	0.18
UCEC	chr6	31730929	Silent	novel	A213A	0.24
UCEC	chr6	31733959	Missense_Mutation	rs775982328	R51Q	0.09
UCEC	chr6	31730911	Silent	NA	F219F	0.34
UCEC	chr6	31736262	Missense_Mutation	novel	K13N	0.14
UCS	chr6	31733871	Missense_Mutation	novel	I80M	0.65

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.1042	0.011841

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0049	Kaplan-Meier Survival Analysis
ACC	0.0048	Kaplan-Meier Survival Analysis
HNSC	0.022	Kaplan-Meier Survival Analysis
KIRP	0.038	Kaplan-Meier Survival Analysis
PAAD	0.00082	Kaplan-Meier Survival Analysis
LAML	0.0003	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.045	Kaplan-Meier Survival Analysis
OV	0.007	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742