EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000214026 (Gene tree)
Gene ID: 6150
Gene Symbol: MRPL23
Alias: L23MRP|RPL23L
Full Name: mitochondrial ribosomal protein L23
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 66,746 bases
Position: chr11:1,947,272-2,014,017
Accession: 10322
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000370930	Ribosomal_L23	PF00276.20	4.4e-13	1	1
ENSP00000380466	Ribosomal_L23	PF00276.20	4.4e-13	1	1
ENSP00000380462	Ribosomal_L23	PF00276.20	1.7e-11	1	1
ENSP00000380465	Ribosomal_L23	PF00276.20	2.2e-11	1	1
ENSP00000370925	Ribosomal_L23	PF00276.20	3.3e-11	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000486931	MRPL23-210	745	-	-	- (aa)	-	-
ENST00000381514	MRPL23-201	919	-	ENSP00000370925	163 (aa)	-	A6NJD9
ENST00000381519	MRPL23-202	643	-	ENSP00000370930	153 (aa)	-	Q16540
ENST00000462288	MRPL23-207	659	-	-	- (aa)	-	-
ENST00000397297	MRPL23-204	613	XM_011520276	ENSP00000380465	191 (aa)	XP_011518578	A8MYK1
ENST00000466346	MRPL23-208	736	-	-	- (aa)	-	-
ENST00000397294	MRPL23-203	551	XM_011520273	ENSP00000380462	166 (aa)	XP_011518575	A8MVT4
ENST00000484918	MRPL23-209	232	-	-	- (aa)	-	-
ENST00000429295	MRPL23-206	805	-	ENSP00000407156	118 (aa)	-	H7C2P7
ENST00000397298	MRPL23-205	736	XM_006718271	ENSP00000380466	153 (aa)	XP_006718334	Q16540

Gene Model

Click here to download ENSG00000214026's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000214026	DNA Methylation	5E-7	23725790

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	EFO ID
ENSG00000214026	rs10769945	11	1963897	T	DNA methylation (variation)	23725790	GO_0006306
ENSG00000214026	rs217719	11	1973993	A	Systolic blood pressure x alcohol consumption interaction (2df test)	29912962	EFO_0006335\|EFO_0004329
ENSG00000214026	rs217719	11	1973993	A	Mean arterial pressure x alcohol consumption interaction (2df test)	29912962	EFO_0006340\|EFO_0004329
ENSG00000214026	rs10840138	11	1980665	T	Mean arterial pressure x alcohol consumption interaction (2df test)	29912962	EFO_0006340\|EFO_0004329

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000214026's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000214026	MRPL23	97	64.430	ENSAPOG00000013198	mrpl23	97	64.430	Acanthochromis_polyacanthus
ENSG00000214026	MRPL23	100	81.818	ENSAMEG00000002153	-	100	81.818	Ailuropoda_melanoleuca
ENSG00000214026	MRPL23	100	64.706	ENSACIG00000024327	mrpl23	100	64.706	Amphilophus_citrinellus
ENSG00000214026	MRPL23	100	62.092	ENSAOCG00000013679	mrpl23	100	62.092	Amphiprion_ocellaris
ENSG00000214026	MRPL23	100	62.092	ENSAPEG00000010298	mrpl23	100	62.092	Amphiprion_percula
ENSG00000214026	MRPL23	99	63.158	ENSATEG00000019314	mrpl23	99	63.158	Anabas_testudineus
ENSG00000214026	MRPL23	75	59.130	ENSAPLG00000012955	-	100	59.130	Anas_platyrhynchos
ENSG00000214026	MRPL23	80	77.660	ENSACAG00000009700	-	100	76.842	Anolis_carolinensis
ENSG00000214026	MRPL23	96	88.435	ENSANAG00000010507	-	97	88.435	Aotus_nancymaae
ENSG00000214026	MRPL23	97	63.758	ENSACLG00000002565	mrpl23	97	63.758	Astatotilapia_calliptera
ENSG00000214026	MRPL23	80	68.085	ENSAMXG00000016759	mrpl23	97	48.571	Astyanax_mexicanus
ENSG00000214026	MRPL23	69	83.178	ENSBTAG00000000103	MRPL23	100	83.178	Bos_taurus
ENSG00000214026	MRPL23	90	34.694	WBGene00020348	mrpl-23	92	34.694	Caenorhabditis_elegans
ENSG00000214026	MRPL23	100	81.818	ENSCAFG00000010086	-	100	81.818	Canis_familiaris
ENSG00000214026	MRPL23	100	81.818	ENSCAFG00020017439	-	100	81.818	Canis_lupus_dingo
ENSG00000214026	MRPL23	100	83.117	ENSCHIG00000019224	-	100	83.117	Capra_hircus
ENSG00000214026	MRPL23	99	82.119	ENSTSYG00000030664	-	99	82.119	Carlito_syrichta
ENSG00000214026	MRPL23	96	65.986	ENSCAPG00000012400	-	100	65.986	Cavia_aperea
ENSG00000214026	MRPL23	100	79.739	ENSCPOG00000035162	-	100	79.739	Cavia_porcellus
ENSG00000214026	MRPL23	100	88.889	ENSCCAG00000021662	-	100	88.889	Cebus_capucinus
ENSG00000214026	MRPL23	100	81.046	ENSCATG00000019817	-	95	81.046	Cercocebus_atys
ENSG00000214026	MRPL23	96	92.517	ENSCATG00000037780	-	95	92.517	Cercocebus_atys
ENSG00000214026	MRPL23	100	81.046	ENSCLAG00000015446	-	100	81.046	Chinchilla_lanigera
ENSG00000214026	MRPL23	96	91.892	ENSCSAG00000019043	-	96	91.892	Chlorocebus_sabaeus
ENSG00000214026	MRPL23	100	93.464	ENSCSAG00000009837	-	100	93.464	Chlorocebus_sabaeus
ENSG00000214026	MRPL23	97	67.114	ENSCPBG00000007389	-	97	67.114	Chrysemys_picta_bellii
ENSG00000214026	MRPL23	88	31.250	ENSCING00000002791	-	79	30.714	Ciona_intestinalis
ENSG00000214026	MRPL23	96	92.517	ENSCANG00000032318	-	100	92.517	Colobus_angolensis_palliatus
ENSG00000214026	MRPL23	100	84.967	ENSCGRG00001000462	Mrpl23	100	84.967	Cricetulus_griseus_chok1gshd
ENSG00000214026	MRPL23	100	84.967	ENSCGRG00000002207	Mrpl23	100	84.967	Cricetulus_griseus_crigri
ENSG00000214026	MRPL23	97	62.838	ENSCSEG00000008738	mrpl23	100	62.838	Cynoglossus_semilaevis
ENSG00000214026	MRPL23	97	63.087	ENSCVAG00000002822	mrpl23	97	63.087	Cyprinodon_variegatus
ENSG00000214026	MRPL23	100	61.438	ENSDARG00000045696	mrpl23	100	61.438	Danio_rerio
ENSG00000214026	MRPL23	99	63.816	ENSDNOG00000047306	-	99	63.816	Dasypus_novemcinctus
ENSG00000214026	MRPL23	100	78.431	ENSDORG00000027504	Mrpl23	100	79.577	Dipodomys_ordii
ENSG00000214026	MRPL23	96	43.624	FBgn0035335	mRpL23	97	43.624	Drosophila_melanogaster
ENSG00000214026	MRPL23	97	81.457	ENSEASG00005000456	-	54	81.879	Equus_asinus_asinus
ENSG00000214026	MRPL23	100	82.581	ENSECAG00000024486	-	53	82.581	Equus_caballus
ENSG00000214026	MRPL23	100	62.987	ENSELUG00000022256	RM23	100	62.987	Esox_lucius
ENSG00000214026	MRPL23	100	81.818	ENSFCAG00000018795	-	100	81.818	Felis_catus
ENSG00000214026	MRPL23	95	67.586	ENSFALG00000011598	-	95	68.027	Ficedula_albicollis
ENSG00000214026	MRPL23	100	83.007	ENSFDAG00000013606	-	100	83.007	Fukomys_damarensis
ENSG00000214026	MRPL23	97	63.758	ENSFHEG00000010978	mrpl23	92	63.946	Fundulus_heteroclitus
ENSG00000214026	MRPL23	95	59.310	ENSGMOG00000004509	mrpl23	100	59.310	Gadus_morhua
ENSG00000214026	MRPL23	100	67.974	ENSGALG00000006561	-	71	67.974	Gallus_gallus
ENSG00000214026	MRPL23	97	64.430	ENSGAFG00000021827	mrpl23	97	64.430	Gambusia_affinis
ENSG00000214026	MRPL23	97	63.087	ENSGACG00000011130	mrpl23	97	63.087	Gasterosteus_aculeatus
ENSG00000214026	MRPL23	97	66.443	ENSGAGG00000023827	-	97	66.443	Gopherus_agassizii
ENSG00000214026	MRPL23	96	99.320	ENSGGOG00000000333	-	100	96.216	Gorilla_gorilla
ENSG00000214026	MRPL23	97	63.514	ENSHBUG00000023397	mrpl23	97	63.087	Haplochromis_burtoni
ENSG00000214026	MRPL23	100	81.699	ENSHGLG00000016722	-	100	81.699	Heterocephalus_glaber_female
ENSG00000214026	MRPL23	100	81.699	ENSHGLG00100003075	-	100	81.699	Heterocephalus_glaber_male
ENSG00000214026	MRPL23	97	62.416	ENSHCOG00000009092	mrpl23	97	62.416	Hippocampus_comes
ENSG00000214026	MRPL23	100	62.092	ENSIPUG00000005383	mrpl23	100	62.092	Ictalurus_punctatus
ENSG00000214026	MRPL23	100	79.739	ENSSTOG00000024573	-	100	79.739	Ictidomys_tridecemlineatus
ENSG00000214026	MRPL23	100	84.314	ENSJJAG00000003519	Mrpl23	100	84.314	Jaculus_jaculus
ENSG00000214026	MRPL23	99	61.184	ENSKMAG00000001599	mrpl23	99	61.184	Kryptolebias_marmoratus
ENSG00000214026	MRPL23	97	62.416	ENSLBEG00000002580	mrpl23	97	62.416	Labrus_bergylta
ENSG00000214026	MRPL23	100	66.013	ENSLACG00000011528	mrpl23	100	66.013	Latimeria_chalumnae
ENSG00000214026	MRPL23	100	65.359	ENSLOCG00000001825	mrpl23	100	65.359	Lepisosteus_oculatus
ENSG00000214026	MRPL23	100	92.157	ENSMFAG00000034529	-	100	92.157	Macaca_fascicularis
ENSG00000214026	MRPL23	71	83.333	ENSMFAG00000039715	-	100	83.333	Macaca_fascicularis
ENSG00000214026	MRPL23	100	90.196	ENSMMUG00000031268	MRPL23	100	90.196	Macaca_mulatta
ENSG00000214026	MRPL23	100	91.503	ENSMNEG00000036690	-	100	91.503	Macaca_nemestrina
ENSG00000214026	MRPL23	71	84.259	ENSMNEG00000033446	-	100	84.259	Macaca_nemestrina
ENSG00000214026	MRPL23	96	91.837	ENSMLEG00000015767	-	100	91.837	Mandrillus_leucophaeus
ENSG00000214026	MRPL23	99	62.500	ENSMAMG00000003609	mrpl23	99	62.500	Mastacembelus_armatus
ENSG00000214026	MRPL23	100	61.392	ENSMZEG00005017456	mrpl23	100	61.392	Maylandia_zebra
ENSG00000214026	MRPL23	99	69.079	ENSMGAG00000007978	-	100	69.079	Meleagris_gallopavo
ENSG00000214026	MRPL23	96	85.034	ENSMAUG00000018693	Mrpl23	100	85.034	Mesocricetus_auratus
ENSG00000214026	MRPL23	96	81.633	ENSMICG00000042091	-	97	79.245	Microcebus_murinus
ENSG00000214026	MRPL23	100	85.621	ENSMOCG00000018436	Mrpl23	100	85.621	Microtus_ochrogaster
ENSG00000214026	MRPL23	100	61.290	ENSMMOG00000018097	mrpl23	100	61.290	Mola_mola
ENSG00000214026	MRPL23	100	76.471	ENSMODG00000003437	-	100	76.471	Monodelphis_domestica
ENSG00000214026	MRPL23	97	64.189	ENSMALG00000014571	mrpl23	100	64.189	Monopterus_albus
ENSG00000214026	MRPL23	100	84.416	MGP_CAROLIEiJ_G0030727	Mrpl23	100	84.416	Mus_caroli
ENSG00000214026	MRPL23	100	83.766	ENSMUSG00000037772	Mrpl23	100	83.766	Mus_musculus
ENSG00000214026	MRPL23	100	84.314	MGP_PahariEiJ_G0013923	Mrpl23	100	84.314	Mus_pahari
ENSG00000214026	MRPL23	100	84.416	MGP_SPRETEiJ_G0031836	Mrpl23	100	84.416	Mus_spretus
ENSG00000214026	MRPL23	100	74.675	ENSMPUG00000002923	-	99	74.675	Mustela_putorius_furo
ENSG00000214026	MRPL23	96	81.333	ENSMPUG00000005658	-	96	82.667	Mustela_putorius_furo
ENSG00000214026	MRPL23	98	67.742	ENSNGAG00000012877	-	93	78.906	Nannospalax_galili
ENSG00000214026	MRPL23	100	78.710	ENSNGAG00000023444	-	100	78.710	Nannospalax_galili
ENSG00000214026	MRPL23	97	63.758	ENSNBRG00000007183	mrpl23	97	63.758	Neolamprologus_brichardi
ENSG00000214026	MRPL23	100	96.732	ENSNLEG00000026950	-	100	96.732	Nomascus_leucogenys
ENSG00000214026	MRPL23	83	81.633	ENSOPRG00000018353	-	97	65.161	Ochotona_princeps
ENSG00000214026	MRPL23	99	79.085	ENSODEG00000017262	-	99	79.085	Octodon_degus
ENSG00000214026	MRPL23	99	70.130	ENSODEG00000012131	-	99	70.130	Octodon_degus
ENSG00000214026	MRPL23	100	62.092	ENSONIG00000014500	mrpl23	96	62.092	Oreochromis_niloticus
ENSG00000214026	MRPL23	98	63.333	ENSORLG00000025383	mrpl23	98	63.333	Oryzias_latipes
ENSG00000214026	MRPL23	99	63.576	ENSORLG00020008379	mrpl23	100	61.783	Oryzias_latipes_hni
ENSG00000214026	MRPL23	96	63.946	ENSOMEG00000019132	mrpl23	76	63.946	Oryzias_melastigma
ENSG00000214026	MRPL23	100	83.660	ENSOGAG00000029988	-	100	83.660	Otolemur_garnettii
ENSG00000214026	MRPL23	90	81.295	ENSOARG00000000706	-	86	81.295	Ovis_aries
ENSG00000214026	MRPL23	100	99.346	ENSPPAG00000034414	-	100	99.346	Pan_paniscus
ENSG00000214026	MRPL23	97	81.333	ENSPPRG00000013232	-	98	81.333	Panthera_pardus
ENSG00000214026	MRPL23	100	99.346	ENSPTRG00000033746	MRPL23	100	99.346	Pan_troglodytes
ENSG00000214026	MRPL23	100	92.810	ENSPANG00000018813	-	100	92.810	Papio_anubis
ENSG00000214026	MRPL23	100	62.745	ENSPKIG00000001102	mrpl23	100	62.745	Paramormyrops_kingsleyae
ENSG00000214026	MRPL23	84	64.062	ENSPSIG00000012834	-	100	64.062	Pelodiscus_sinensis
ENSG00000214026	MRPL23	100	59.477	ENSPMGG00000006407	mrpl23	100	59.477	Periophthalmus_magnuspinnatus
ENSG00000214026	MRPL23	100	81.046	ENSPEMG00000018572	Mrpl23	100	82.353	Peromyscus_maniculatus_bairdii
ENSG00000214026	MRPL23	100	59.740	ENSPMAG00000005259	mrpl23	100	59.740	Petromyzon_marinus
ENSG00000214026	MRPL23	80	87.234	ENSPCIG00000027047	-	64	86.275	Phascolarctos_cinereus
ENSG00000214026	MRPL23	98	64.000	ENSPFOG00000014159	mrpl23	97	64.000	Poecilia_formosa
ENSG00000214026	MRPL23	99	64.901	ENSPLAG00000023456	mrpl23	99	64.901	Poecilia_latipinna
ENSG00000214026	MRPL23	97	65.101	ENSPMEG00000012252	mrpl23	97	65.101	Poecilia_mexicana
ENSG00000214026	MRPL23	97	64.430	ENSPREG00000019951	mrpl23	96	64.430	Poecilia_reticulata
ENSG00000214026	MRPL23	100	97.386	ENSPPYG00000002918	-	100	97.386	Pongo_abelii
ENSG00000214026	MRPL23	96	82.313	ENSPCOG00000026555	-	100	82.313	Propithecus_coquereli
ENSG00000214026	MRPL23	79	89.247	ENSPVAG00000000331	-	92	68.919	Pteropus_vampyrus
ENSG00000214026	MRPL23	97	63.758	ENSPNYG00000015541	mrpl23	97	63.758	Pundamilia_nyererei
ENSG00000214026	MRPL23	100	60.784	ENSPNAG00000010548	mrpl23	100	60.784	Pygocentrus_nattereri
ENSG00000214026	MRPL23	100	84.314	ENSRNOG00000020354	Mrpl23	100	84.314	Rattus_norvegicus
ENSG00000214026	MRPL23	100	93.976	ENSRBIG00000041638	-	100	93.464	Rhinopithecus_bieti
ENSG00000214026	MRPL23	100	90.323	ENSRROG00000004661	-	100	93.197	Rhinopithecus_roxellana
ENSG00000214026	MRPL23	96	88.435	ENSSBOG00000025338	-	100	72.785	Saimiri_boliviensis_boliviensis
ENSG00000214026	MRPL23	96	76.190	ENSSHAG00000002716	-	100	76.190	Sarcophilus_harrisii
ENSG00000214026	MRPL23	100	63.399	ENSSFOG00015002519	mrpl23	100	63.399	Scleropages_formosus
ENSG00000214026	MRPL23	100	61.935	ENSSMAG00000009264	mrpl23	100	61.935	Scophthalmus_maximus
ENSG00000214026	MRPL23	97	65.541	ENSSDUG00000019634	mrpl23	100	65.541	Seriola_dumerili
ENSG00000214026	MRPL23	97	65.101	ENSSLDG00000012055	mrpl23	97	65.101	Seriola_lalandi_dorsalis
ENSG00000214026	MRPL23	100	66.013	ENSSPUG00000002656	-	100	66.013	Sphenodon_punctatus
ENSG00000214026	MRPL23	96	65.986	ENSSPAG00000001601	mrpl23	99	65.986	Stegastes_partitus
ENSG00000214026	MRPL23	100	79.221	ENSSSCG00000038364	-	100	79.221	Sus_scrofa
ENSG00000214026	MRPL23	96	66.667	ENSTGUG00000009338	MRPL23	100	66.667	Taeniopygia_guttata
ENSG00000214026	MRPL23	97	61.074	ENSTRUG00000009637	mrpl23	97	61.074	Takifugu_rubripes
ENSG00000214026	MRPL23	79	65.591	ENSTNIG00000010463	mrpl23	100	65.591	Tetraodon_nigroviridis
ENSG00000214026	MRPL23	79	91.398	ENSTTRG00000009281	-	94	71.875	Tursiops_truncatus
ENSG00000214026	MRPL23	100	81.818	ENSUAMG00000020867	-	96	83.784	Ursus_americanus
ENSG00000214026	MRPL23	100	81.818	ENSUMAG00000006227	-	85	81.818	Ursus_maritimus
ENSG00000214026	MRPL23	100	79.870	ENSVVUG00000002581	-	78	79.870	Vulpes_vulpes
ENSG00000214026	MRPL23	100	64.052	ENSXETG00000014017	mrpl23	100	64.052	Xenopus_tropicalis
ENSG00000214026	MRPL23	100	53.896	ENSXCOG00000020628	mrpl23	100	53.896	Xiphophorus_couchianus
ENSG00000214026	MRPL23	97	64.430	ENSXMAG00000015496	mrpl23	97	64.430	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001650	fibrillar center	-	IDA	Component
GO:0003723	RNA binding	8541832.	TAS	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0006412	translation	8541832.	TAS	Process
GO:0032543	mitochondrial translation	21873635.	IBA	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process