EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000218823 (Gene tree)
Gene ID: 56903
Gene Symbol: PAPOLB
Alias: PAPT
Full Name: poly(A) polymerase beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 4,262 bases
Position: chr7:4,857,733-4,861,994
Accession: 15970
RBP type: canonical RBP
Summary: (Poly(A) Polymerase Beta) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include RNA binding and polynucleotide adenylyltransferase activity. An important paralog of this gene is PAPOLA.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000384700	PAP_RNA-bind	PF04926.15	1.8e-25	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27802063	In silico analysis of candidate proteins sharing homology with Streptococcus agalactiae proteins and their role in male infertility.	Syst Biol Reprod Med	2017 Feb	Parida R	doi: 10.1080/19396368.2016.1243741
11087630	Identification of a novel isoform of poly(A) polymerase, TPAP, specifically present in the cytoplasm of spermatogenic cells.	Dev Biol	2000 Dec 1	Kashiwabara S	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000404991	PAPOLB-201	4262	-	ENSP00000384700	637 (aa)	-	Q9NRJ5

Gene Model

Click here to download ENSG00000218823's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000218823's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000218823	PAPOLB	80	73.031	ENSG00000115421	PAPOLG	100	78.632
ENSG00000218823	PAPOLB	98	86.080	ENSG00000090060	PAPOLA	98	92.115

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000218823	PAPOLB	100	89.325	ENSANAG00000033074	PAPOLB	100	89.325	Aotus_nancymaae
ENSG00000218823	PAPOLB	98	86.517	ENSBTAG00000052734	PAPOLB	91	86.517	Bos_taurus
ENSG00000218823	PAPOLB	77	82.787	ENSCPOG00000021527	PAPOLB	96	75.912	Cavia_porcellus
ENSG00000218823	PAPOLB	98	82.343	ENSCLAG00000004689	PAPOLB	95	84.245	Chinchilla_lanigera
ENSG00000218823	PAPOLB	96	84.339	ENSDNOG00000033378	PAPOLB	86	84.768	Dasypus_novemcinctus
ENSG00000218823	PAPOLB	96	86.016	ENSDORG00000001140	Papolb	100	84.882	Dipodomys_ordii
ENSG00000218823	PAPOLB	95	86.401	ENSEASG00005021531	PAPOLB	90	85.393	Equus_asinus_asinus
ENSG00000218823	PAPOLB	96	76.066	ENSHGLG00000002987	-	100	75.817	Heterocephalus_glaber_female
ENSG00000218823	PAPOLB	98	85.233	ENSJJAG00000012212	Papolb	90	85.233	Jaculus_jaculus
ENSG00000218823	PAPOLB	86	97.431	ENSMFAG00000031074	PAPOLB	99	97.431	Macaca_fascicularis
ENSG00000218823	PAPOLB	99	96.378	ENSMMUG00000043732	PAPOLB	91	96.378	Macaca_mulatta
ENSG00000218823	PAPOLB	98	87.179	MGP_CAROLIEiJ_G0027962	Papolb	97	87.179	Mus_caroli
ENSG00000218823	PAPOLB	98	87.019	ENSMUSG00000074817	Papolb	97	87.019	Mus_musculus
ENSG00000218823	PAPOLB	98	86.378	MGP_PahariEiJ_G0024534	Papolb	97	86.378	Mus_pahari
ENSG00000218823	PAPOLB	98	87.019	MGP_SPRETEiJ_G0028966	Papolb	97	87.019	Mus_spretus
ENSG00000218823	PAPOLB	98	84.887	ENSMLUG00000029802	PAPOLB	94	84.887	Myotis_lucifugus
ENSG00000218823	PAPOLB	98	83.146	ENSODEG00000009844	PAPOLB	92	82.825	Octodon_degus
ENSG00000218823	PAPOLB	95	83.580	ENSOCUG00000022988	PAPOLB	100	87.766	Oryctolagus_cuniculus
ENSG00000218823	PAPOLB	98	89.888	ENSOGAG00000031103	PAPOLB	88	89.888	Otolemur_garnettii
ENSG00000218823	PAPOLB	99	98.728	ENSPTRG00000045383	PAPOLB	92	98.728	Pan_troglodytes
ENSG00000218823	PAPOLB	96	88.506	ENSUMAG00000007631	PAPOLB	95	88.742	Ursus_maritimus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0004652	polynucleotide adenylyltransferase activity	21873635.	IBA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0006378	mRNA polyadenylation	21873635.	IBA	Process
GO:0046872	metal ion binding	-	IEA	Function