EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000218891 (Gene tree)
Gene ID: 163033
Gene Symbol: ZNF579
Alias: FLJ35453
Full Name: zinc finger protein 579
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 4,130 bases
Position: chr19:55,576,770-55,580,899
Accession: 26646
RBP type: non-canonical RBP
Summary: (Zinc Finger Protein 579) is a Protein Coding gene. An important paralog of this gene is ZNF850.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000325421	ZNF579-201	2899	XM_017026409	ENSP00000320188	562 (aa)	XP_016881898	Q8NAF0
ENST00000592239	ZNF579-202	497	-	ENSP00000465146	15 (aa)	-	K7EJF4

Gene Model

Click here to download ENSG00000218891's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000218891	Periodontitis	5E-6	24024966

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000218891	rs149546760	19	55579966	C	Periodontitis (Mean PAL)	24024966	[0.19-0.48] unit decrease	0.339	EFO_0000649

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000218891's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BRCA	chr19	55577896	3'UTR	novel		0.13
BRCA	chr19	55578041	Silent	rs780161065	F533F	0.33
CESC	chr19	55578052	Missense_Mutation	rs192618440	A530S	0.15
CESC	chr19	55577964	Frame_Shift_Del	novel	*G559Afs16**	0.22
CESC	chr19	55578140	Silent	NA	L500L	0.19
CESC	chr19	55578764	Frame_Shift_Ins	novel	*H292Qfs221**	0.07
CESC	chr19	55577755	3'UTR	novel		0.4
CESC	chr19	55578286	Missense_Mutation	novel	R452C	0.46
CHOL	chr19	55577731	3'UTR	novel		0.09
COAD	chr19	55578711	Missense_Mutation	novel	A310V	0.21
COAD	chr19	55578852	Missense_Mutation	NA	P263L	0.29
COAD	chr19	55578854	Frame_Shift_Del	NA	*P264Rfs141**	0.3
COAD	chr19	55578162	Missense_Mutation	NA	A493V	0.26
COAD	chr19	55578103	Missense_Mutation	NA	S513T	0.24
ESCA	chr19	55577710	3'UTR	novel		0.65
ESCA	chr19	55577646	3'UTR	novel		0.5
ESCA	chr19	55578664	Silent	novel	L326L	0.25
ESCA	chr19	55578128	Silent	novel	L504L	0.18
KIRP	chr19	55577992	Missense_Mutation	novel	S550R	0.24
LGG	chr19	55578852	Missense_Mutation	NA	P263L	0.63
LIHC	chr19	55579532	Frame_Shift_Ins	novel	*A37Rfs5**	0.26
LUAD	chr19	55578649	Missense_Mutation	NA	A331S	0.29
LUAD	chr19	55578686	Silent	rs764328007	R318R	0.15
LUSC	chr19	55578606	Nonsense_Mutation	NA	S345*	0.76
LUSC	chr19	55578905	Silent	NA	L245L	0.71
LUSC	chr19	55578706	Missense_Mutation	novel	Y312D	0.33
LUSC	chr19	55578649	Missense_Mutation	NA	A331T	0.17
MESO	chr19	55578802	Missense_Mutation	rs781120747	A280T	0.33
PRAD	chr19	55578785	Silent	NA	L285L	0.1
SKCM	chr19	55578650	Silent	NA	P330P	0.54
SKCM	chr19	55578849	Missense_Mutation	NA	P264L	0.29
SKCM	chr19	55578674	Silent	NA	P322P	0.21
SKCM	chr19	55578913	Missense_Mutation	rs779941802	G243S	0.31
STAD	chr19	55578585	Frame_Shift_Del	NA	*G352Afs53**	0.36
STAD	chr19	55578849	Frame_Shift_Del	novel	*P264Rfs141**	0.5
STAD	chr19	55578678	Missense_Mutation	novel	G321D	0.2
STAD	chr19	55578848	Silent	rs543991379	P264P	0.35
THYM	chr19	55578284	Silent	novel	R452R	0.17
UCEC	chr19	55577810	3'UTR	novel		0.08
UCEC	chr19	55578138	Missense_Mutation	NA	P501L	0.38
UCEC	chr19	55578854	Frame_Shift_Del	NA	*P264Rfs141**	0.44
UCEC	chr19	55578128	Silent	novel	L504L	0.17
UCEC	chr19	55577602	3'UTR	novel		0.48
UCEC	chr19	55578176	Silent	novel	P488P	0.22
UCEC	chr19	55577930	3'UTR	novel		0.36
UCEC	chr19	55577974	Missense_Mutation	novel	G556W	0.1
UCEC	chr19	55577536	3'UTR	novel		0.29
UCEC	chr19	55577797	3'UTR	novel		0.46
UCEC	chr19	55578017	Silent	rs750678932	F541F	0.37
UCEC	chr19	55577710	3'UTR	novel		0.33
UCEC	chr19	55577707	3'UTR	novel		0.37
UCEC	chr19	55577536	3'UTR	novel		0.39
UCEC	chr19	55578849	Frame_Shift_Del	novel	*P264Rfs141**	0.5
UCEC	chr19	55577855	3'UTR	novel		0.38
UCEC	chr19	55578196	Missense_Mutation	novel	T482A	0.4
UCEC	chr19	55577922	3'UTR	novel		0.39
UCEC	chr19	55578080	Silent	novel	S520S	0.36
UCEC	chr19	55578678	Missense_Mutation	novel	G321D	0.42

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3162	0.013691
BRCA	AMP	0.1935	0.0014488
CESC	DEL	0.0678	0.027508
DLBC	AMP	0.1667	0.017368
KIRP	DEL	0.0486	0.054726
LGG	DEL	0.5029	1.4433e-28
PAAD	DEL	0.0707	0.035089
PRAD	AMP	0.0305	0.17703
READ	DEL	0.103	0.23023
TGCT	DEL	0.2867	0.0046229
UCS	DEL	0.1607	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00014	Kaplan-Meier Survival Analysis
SARC	0.0031	Kaplan-Meier Survival Analysis
ACC	0.0086	Kaplan-Meier Survival Analysis
PRAD	0.018	Kaplan-Meier Survival Analysis
BRCA	0.03	Kaplan-Meier Survival Analysis
PAAD	0.0076	Kaplan-Meier Survival Analysis
BLCA	0.0043	Kaplan-Meier Survival Analysis
CESC	0.0099	Kaplan-Meier Survival Analysis
UCEC	0.035	Kaplan-Meier Survival Analysis
LUAD	0.047	Kaplan-Meier Survival Analysis
UVM	0.016	Kaplan-Meier Survival Analysis